Structured Abstract

Contents

• Preface
• Acknowledgments
• Key Informants
• Technical Expert Panel
• Peer Reviewers
• Executive Summary
• Introduction
  • Background
  • Current Challenges and Controversies in Diagnosing These Conditions
  • Current Challenges and Controversies in Treating These Disorders
  • Organization of This Report
• Methods
  • Topic Refinement and Protocol Review
  • Literature Search Strategy
  • Study Selection
  • Data Abstraction
  • Risk-of-Bias Assessment
  • Data Synthesis
  • Strength of the Body of Evidence
  • Applicability
  • Peer Review and Public Commentary
• Results: Overview and Efficacy and Effectiveness of Interventions To Manage Patients With Binge-Eating Disorder
  • Overview of Presentation of Results
  • Literature Search Results
  • Binge-Eating Disorder: Overview
  • KQ 1 Effectiveness of Interventions for Binge-Eating Disorder
  • KQ 2 Harms Associated With Treatments or Combinations of Treatments
  • KQ 3 Differences in the Effectiveness of Treatments or Combinations of Treatments for Subgroups of Adults With Binge-Eating Disorder
• Results: Loss-of-Control Eating
  • Introduction
  • LOC Eating Among Bariatric Surgery Patients
  • LOC Eating Among Children
• Results: Course of Illness
  • Introduction
  • Binge-Eating Disorder
  • Loss-of-Control Eating Among Bariatric Surgery Patients
  • Loss-of-Control Eating Among Children
• Discussion
  • Key Findings and Strength of Evidence
  • Findings in Relation to What Is Already Known
  • Implications for Clinical and Policy Decisionmaking
  • Applicability
  • Limitations of the Review Process
  • Limitations of the Evidence Base
  • Research Gaps
  • Conclusions
• References
• Appendix A Search Strategy
• Appendix B Criteria for Exclusion at the Full Text Review Stage
• Appendix C Excluded Studies
• Appendix D Risk of Bias Tables
• Appendix E Evidence Tables
• Appendix F Strength of Evidence Tables
• Appendix G Abbreviations

Prepared for: Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services¹, Contract No. 290-2012-00008-I, Prepared by: RTI International–University of North Carolina Evidence-based Practice Center, Research Triangle Park, NC

Suggested citation:

Berkman ND, Brownley KA, Peat CM, Lohr KN, Cullen KE, Morgan LC, Bann CM, Wallace IF, Bulik CM. Management and Outcomes of Binge-Eating Disorder. Comparative Effectiveness Review No. 160. (Prepared by the RTI International–University of North Carolina Evidence-based Practice Center under Contract No. 290-2012-00008-I.) AHRQ Publication No. 15(16)-EHC030-EF. Rockville, MD: Agency for Healthcare Research and Quality; December 2015. www.effectivehealthcare.ahrq.gov/reports/final.cfm.

This report may periodically be assessed for the currency of conclusions. If an assessment is done, the resulting surveillance report describing the methodology and findings will be found on the Effective Health Care Program Web site at www.effectivehealthcare.ahrq.gov. Search on the title of the report.

Two of the coinvestigators on this report have a financial conflict of interest in the subject matter (ongoing grants and consultancy to a pharmaceutical company; ongoing National Institute of Mental Health grants). Neither was a reviewer of any of her own studies or any studies in the drug class in which a financial conflict of interest is held. The lead investigator, who has no affiliation or financial involvement that conflicts with the material presented in this report, made the final determination in the assessment of studies and the body of evidence. None of the other investigators have any affiliations or financial involvement that conflicts with the material presented in this report.

The information in this report is intended to help health care decisionmakers—patients and clinicians, health system leaders, and policymakers, among others—make well informed decisions and thereby improve the quality of health care services. This report is not intended to be a substitute for the application of clinical judgment. Anyone who makes decisions concerning the provision of clinical care should consider this report in the same way as any medical reference and in conjunction with all other pertinent information, i.e., in the context of available resources and circumstances presented by individual patients.

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This report may periodically be assessed for the currency of conclusions. If an assessment is done, the resulting surveillance report describing the methodology and findings will be found on the Effective Health Care Program Web site at www.effectivehealthcare.ahrq.gov. Search on the title of the report.

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