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Donahue KE, Gartlehner G, Schulman ER, et al. Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2018 Jul. (Comparative Effectiveness Review, No. 211.)

Cover of Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update

Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update [Internet].

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Appendix BExcluded Articles

  • X1 – Ineligible publication type
  • X2 – Population ages <19 yrs old
  • X3 – ≥50% patients have RA >2 yrs duration or non-RA diagnosis
  • X4 – Ineligible or no drug(s)
  • X5 – Ineligible or no comparator(s)
  • X6 – Ineligible or no outcome(s)
  • X7 – Ineligible treatment duration (<3 months of treatment)
  • X8 – Ineligible setting
  • X9 – Ineligible study design
  • X10 – Non-English language
  • X11 – Study protocol or abstract-only record (otherwise eligible)
  • X12 – Eligible except early RA up to 2 yrs
  • X13 – Excluded primary or companion article, to be cited in review
  • X14 – Irretrievable
  • X15 – Duplicate
  • X16 – Placebo-controlled study not usable in NWMA
1.
Allaart C, Lems W, Huizinga T. The BeSt way of withdrawing biologic agents. Clin Exp Rheumatol; 2014. p. S14–8. Exclusion Code: X1. [PubMed: 24129130]
2.
Askling J, Smith M. Anti-TNFα therapy did not increase short- or medium-term risk for cancer in patients with rheumatoid arthritis. Ann Intern Med. 2010;152(10):JC5–13. Exclusion Code: X1. [PubMed: 20479018]
3.
Brown G, Wang E, Leon A, et al. Tumor necrosis factor-alpha inhibitor-induced psoriasis: Systematic review of clinical features, histopathological findings, and management experience. J Am Acad Dermatol. 2017 Feb;76(2):334–41. doi: 10.1016/j.jaad.2016.08.012. PMID: 27720274 Exclusion Code: X1. [PubMed: 27720274] [CrossRef]
4.
Curtis JR, Perez-Gutthann S, Suissa S, et al. Tocilizumab in rheumatoid arthritis: a case study of safety evaluations of a large postmarketing data set from multiple data sources. Semin Arthritis Rheum. 2015 Feb;44(4):381–8. doi: 10.1016/j.semarthrit.2014.07.006. PMID: 25300699 Exclusion Code: X1. [PubMed: 25300699] [CrossRef]
5.
Furst DE. The risk of infections with biologic therapies for rheumatoid arthritis. Semin Arthritis Rheum. 2010 Apr;39(5):327–46. doi: 10.1016/j.semarthrit.2008.10.002. PMID: 19117595. Exclusion Code: X1. [PubMed: 19117595] [CrossRef]
6.
Gualtierotti R, Casella F. Is it safe to withdraw etanercept in established rheumatoid arthritis after low disease activity achievement? Intern Emerg Med; 2014. p. 223–4. Exclusion Code: X1. [PubMed: 24307478]
7.
Henness S, Yang LP. Modified-Release Prednisone: in Patients with Rheumatoid Arthritis. p. 2067. Exclusion Code: X1. [PubMed: 24249648]
8.
Hetland ML. Modern treatment strategies in rheumatoid arthritis. Dan Med Bull. 2011 Nov;58(11):B4320. PMID: 22047935. Exclusion Code: X1. [PubMed: 22047935]
9.
Jacobs J, Bijlsma J, Laar J. Glucocorticoids in early rheumatoid arthritis: are the benefits of joint-sparing effects offset by the adverse effect of osteoporosis? the effects on bone in the utrecht study and the CAMERA-II study. Neuroimmunomodulation; 2015. p. 66–71. Exclusion Code: X1. [PubMed: 25228126]
10.
Keystone E, Haraoui B, Bykerk V. Role of adalimumab in the treatment of early rheumatoid arthritis. Clin Exp Rheumatol; 2012. p. S198–9. Exclusion Code: X1. [PubMed: 14969077]
11.
Mohan AK, Cote TR, Block JA, et al. Tuberculosis following the use of etanercept, a tumor necrosis factor inhibitor. Clin Infect Dis. 2004 Aug 1;39(3):295–9. PMID: 15306993. Exclusion Code: X1. [PubMed: 15306993]
12.
Pincus T. The clinical efficacy of 3 mg/day prednisone in patients with rheumatoid arthritis: evidence from a randomized, double-blind, placebo-controlled withdrawal clinical trial. Clin Exp Rheumatol; 2012. p. S73–6. Exclusion Code: X1. [PubMed: 22018188]
13.
Rantalaiho V, Puolakka K, Korpela M, et al. Long-term results of the FIN-RACo trial; treatment with a combination of traditional disease-modifying anti-rheumatic drugs is an excellent option in early rheumatoid arthritis. Clin Exp Rheumatol. 2012 Jul-Aug;30(4 Suppl 73):S27–31. PMID: 23073350. Exclusion Code: X1. [PubMed: 23073350]
14.
Riel P. Leflunomide improves the clinical response in patients with active rheumatoid arthritis treated with methotrexate. Clin Exp Rheumatol; 2012. p. 695–6. Exclusion Code: X1. [PubMed: 14740446]
15.
Schafer JA, Kjesbo NK, Gleason PP. Formulary review of 2 new biologic agents: tocilizumab for rheumatoid arthritis and ustekinumab for plaque psoriasis. J Manag Care Pharm. 2010 Jul-Aug;16(6):402–16. doi: 10.18553/jmcp.2010.16.6.402. PMID: 20635831. Exclusion Code: X1. [PMC free article: PMC10437992] [PubMed: 20635831] [CrossRef]
16.
Sokka T, Mäkinen H, Puolakka K, et al. Remission as the treatment goal--the FINRACo trial. Clin Exp Rheumatol; 2012. p. S-74–6. Exclusion Code: X1. [PubMed: 17083766]
17.
van den Broek M, Lems WF, Allaart CF. BeSt practice: the success of early-targeted treatment in rheumatoid arthritis. Clin Exp Rheumatol. 2012 Jul-Aug;30(4 Suppl 73):S35–8. PMID: 23078756. Exclusion Code: X1. [PubMed: 23078756]
18.
Verstappen S, Jacobs J, Bijlsma J. The Utrecht experience with different treatment strategies in early rheumatoid arthritis. Clin Exp Rheumatol; 2012. p. S165–8. Exclusion Code: X1. [PubMed: 14969070]
19.
Woude D, Visser K, Klarenbeek N, et al. Sustained drug-free remission in rheumatoid arthritis after DAS-driven or non-DAS-driven therapy: A comparison of two cohort studies. Rheumatology (United Kingdom); 2012. p. 1120–8. Exclusion Code: X1. [PubMed: 22337939]
20.
Aberumand B, Bykerk V, Schieir O, et al. Treatment response to conventional disease modifying anti-rheumatic drugs (DMARDS) and biologics in seropositive and seronegative patients with early rheumatoid arthritis: Results from catch (Canadian early arthritis cohort). Ann Rheum Dis. 2016;75:683–4. doi: 10.1136/annrheumdis-2016-eular.4483. Exclusion Code: X2. [CrossRef]
21.
Acurcio FA, Machado MA, Moura CS, et al. Medication Persistence of Disease-Modifying Antirheumatic Drugs and Anti-Tumor Necrosis Factor Agents in a Cohort of Patients With Rheumatoid Arthritis in Brazil. Arthritis Care Res (Hoboken). 2016 Oct;68(10):1489–96. doi: 10.1002/acr.22840. PMID: 26814681. Exclusion Code: X2. [PubMed: 26814681] [CrossRef]
22.
Askling J, Fored CM, Baecklund E, et al. Haematopoietic malignancies in rheumatoid arthritis: lymphoma risk and characteristics after exposure to tumour necrosis factor antagonists. Ann Rheum Dis. 2005 Oct;64(10):1414–20. PMID: 15843454. Exclusion Code: X2. [PMC free article: PMC1755232] [PubMed: 15843454]
23.
Brunner H, Ruperto N, Martini A, et al. Identification of optimal subcutaneous doses of tocilizumab in children with polyarticular-course juvenile idiopathic arthritis. Arthritis and Rheumatology. 2017;69:60–1. doi: 10.1002/art.v69.S4. Exclusion Code: X2. [CrossRef]
24.
Cho SK, Sung YK, Kim D, et al. Drug retention and safety of TNF inhibitors in elderly patients with rheumatoid arthritis. BMC Musculoskelet Disord. 2016;17(1):1–8 doi: 10.1186/s12891-016-1185-6. Exclusion Code: X2. [PMC free article: PMC4977640] [PubMed: 27507033] [CrossRef]
25.
Desai RJ, Bateman BT, Huybrechts KF, et al. Risk of serious infections associated with use of immunosuppressive agents in pregnant women with autoimmune inflammatory conditions: cohort study. BMJ. 2017 Mar 06;356:j895. doi: 10.1136/bmj.j895. PMID: 28264814. Exclusion Code: X2. [PMC free article: PMC6168035] [PubMed: 28264814] [CrossRef]
26.
Eccleston C, Cooper TE, Fisher E, et al. Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents. Cochrane Database of Systematic Reviews: John Wiley & Sons, Ltd; 2017. Exclusion Code: X2. [PMC free article: PMC6460508] [PubMed: 28770976]
27.
Ghosh B, Halder S, Ghosh A, et al. Early rheumatoid arthritis: Clinical and therapeutic evaluation in a tertiary care centre in India. Indian Journal of Rheumatology; 2008. p. 48–51. Exclusion Code: X2.
28.
Gilani ST, Khan DA, Khan FA, et al. Adverse effects of low dose methotrexate in rheumatoid arthritis patients. J Coll Physicians Surg Pak. 2012 Feb;22(2):101–4. . PMID: 22313647. Exclusion Code: X2. [PubMed: 22313647]
29.
Ishiguro N, Atsumi T, Harigai M, et al. Effectiveness and safety of tocilizumab in achieving clinical and functional remission, and sustaining efficacy in biologics-naive patients with rheumatoid arthritis: The FIRST Bio study. Mod Rheumatol. 2017;27(2):217–26. doi: 10.1080/14397595.2016.1206507. Exclusion Code: X2. [PubMed: 27414105] [CrossRef]
30.
Machado-Alba JE, Ruiz AF, Machado-Duque ME. Adverse drug reactions associated with the use of disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis. Rev Panam Salud Publica. 2014 Dec;36(6):396–401. PMID: 25711751. Exclusion Code: X2. [PubMed: 25711751]
31.
Mera-Varela A, Perez-Pampin E. Abatacept therapy in rheumatoid arthritis with interstitial lung disease. J Clin Rheumatol. 2014 Dec;20(8):445–6. doi: 10.1097/rhu.0000000000000084. PMID: 25417684 Exclusion Code: X2. [PubMed: 25417684] [CrossRef]
32.
Rojas-Serrano J, Perez LL, Garcia CG, et al. Current smoking status is associated to a non-ACR 50 response in early rheumatoid arthritis. A cohort study. Clin Rheumatol. 2011 Dec;30(12):1589–93. doi: 10.1007/s10067-011-1775-5. PMID: 21607552 Exclusion Code: X2. [PubMed: 21607552] [CrossRef]
33.
Sirisena D, Marshall T, Deighton C, et al. Multicenter audit on the use of Leflunomide, in isolation or combination and assessment of adverse effects in rheumatoid arthritis patients. Indian Journal of Rheumatology. 2011;6(1):3–6. doi: 10.1016/S0973-3698(11)60044-7. Exclusion Code: X2. [CrossRef]
34.
Widdifield J, Bernatsky S, Paterson JM, et al. Serious infections in a population-based cohort of 86,039 seniors with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2013 Mar;65(3):353–61. doi: 10.1002/acr.21812. PMID: 22833532. Exclusion Code: X2. [PubMed: 22833532] [CrossRef]
35.
Aalbers C, Gerlag D, Vos K, et al. Intraarticular etanercept treatment in inflammatory arthritis: A randomized double-blind placebo-controlled proof of mechanism clinical trial validating TNF as a potential therapeutic target for local treatment. Joint Bone Spine. 2015 Oct;82(5):338–44. doi: 10.1016/j.jbspin.2015.03.002. PMID: 26188879 Exclusion Code: X3. [PubMed: 26188879] [CrossRef]
36.
Aaltonen KJ, Joensuu JT, Pirilä L, et al. Drug survival on tumour necrosis factor inhibitors in patients with rheumatoid arthritis in Finland. Scand J Rheumatol. 2017;46(5):359–63. doi: 10.1080/03009742.2016.1234641. Exclusion Code: X3. [PubMed: 27931158] [CrossRef]
37.
Aaltonen KJ, Joensuu JT, Virkki L, et al. Rates of serious infections and malignancies among patients with rheumatoid arthritis receiving either tumor necrosis factor inhibitor or rituximab therapy. J Rheumatol. 2015 Mar;42(3):372–8. doi: 10.3899/jrheum.140853. PMID: 25593230. Exclusion Code: X3. [PubMed: 25593230] [CrossRef]
38.
Aaltonen KJ, Sokka T, Mottonen T, et al. A nationwide cross-sectional overview of patients with rheumatoid arthritis followed in outpatient specialty clinics in Finland. Scand J Rheumatol. 2014;43(4):286–90. doi: 10.3109/03009742.2013.876512. PMID: 24654994 Exclusion Code: X3. [PubMed: 24654994] [CrossRef]
39.
Aaltonen KJ, Ylikyla S, Tuulikki Joensuu J, et al. Efficacy and effectiveness of tumour necrosis factor inhibitors in the treatment of rheumatoid arthritis in randomized controlled trials and routine clinical practice. Rheumatology (Oxford).2017 May 01;56(5):725–35. doi: 10.1093/rheumatology/kew467. PMID: 28064209 Exclusion Code: X3. [PubMed: 28064209] [CrossRef]
40.
Abasolo L, Leon L, Rodriguez-Rodriguez L, et al. Safety of disease-modifying antirheumatic drugs and biologic agents for rheumatoid arthritis patients in real-life conditions. Semin Arthritis Rheum. 2015 Apr;44(5):506–13. doi: 10.1016/j.semarthrit.2014.11.003. PMID: 25532946 Exclusion Code: X3. [PubMed: 25532946] [CrossRef]
41.
Abdallah H, Hsu JC, Lu P, et al. Pharmacokinetic and Pharmacodynamic Analysis of Subcutaneous Tocilizumab in Patients With Rheumatoid Arthritis From 2 Randomized, Controlled Trials: SUMMACTA and BREVACTA. J Clin Pharmacol. 2017 Apr;57(4):459–68. doi: 10.1002/jcph.826. PMID: 27599663. Exclusion Code: X3. [PMC free article: PMC5363244] [PubMed: 27599663] [CrossRef]
42.
Abdulkader R, Dharmapalaiah C, Rose G, et al. Late-onset neutropenia in patients with rheumatoid arthritis after treatment with rituximab. J Rheumatol. 2014 May;41(5):858–61. doi: 10.3899/jrheum.130526. PMID: 24634201. Exclusion Code: X3. [PubMed: 24634201] [CrossRef]
43.
Abe T, Takeuchi T, Miyasaka N, et al. A multicenter, double-blind, randomized, placebo controlled trial of infliximab combined with low dose methotrexate in Japanese patients with rheumatoid arthritis. J Rheumatol. 2006 Jan;33(1):37–44. PMID: 16395748. Exclusion Code: X3. [PubMed: 16395748]
44.
Accortt NA, Bonafede MM, Collier DH, et al. Risk of Subsequent Infection Among Patients Receiving Tumor Necrosis Factor Inhibitors and Other Disease-Modifying Antirheumatic Drugs. Arthritis Rheumatol. 2016 Jan;68(1):67–76. doi: 10.1002/art.39416. PMID: 26359948. Exclusion Code: X3. [PubMed: 26359948] [CrossRef]
45.
Accortt NA, Chung JB, Bonafede M, et al. Retrospective analysis to describe associations between tumor necrosis factor alpha inhibitors and COPD-related hospitalizations. International Journal of COPD. 2017;12:2085–94. doi: 10.2147/COPD.S127815. Exclusion Code: X3. [PMC free article: PMC5530069] [PubMed: 28790811] [CrossRef]
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47.
Akici A, Aydin V, Kadi E, et al. Increased risk of tuberculosis in patients with rheumatologic diseases managed with anti-TNF-a agents: A nationwide retrospective pharmacoepidemiological cohort study in Turkey. Clin Ther. 2017;39(8):e57. Exclusion Code: X3.
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Alañón Pardo MM, Areas Del Águila VL, Cuadra Díaz JL, et al. Adherence to disease modifying antirheumatic drugs in patients with rheumatoid arthritis. European Journal of Hospital Pharmacy. 2016;23:A45–A6. doi: 10.1136/ejhpharm-2016-000875.104. Exclusion Code: X3. [CrossRef]
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Aletaha D, Bingham CO, Tanaka Y, et al. Efficacy and safety of sirukumab in patients with active rheumatoid arthritis refractory to anti-TNF therapy (SIRROUND-T): a randomised, double-blind, placebo-controlled, parallel-group, multinational, phase 3 study. The Lancet. 2017;389(10075):1206–17. doi: 10.1016/S0140-6736(17)30401-4. Exclusion Code: X3. [PubMed: 28215362] [CrossRef]
53.
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55.
Alonso A, Gonzalez CM, Ballina J, et al. Efficacy and safety of golimumab as add-on therapy to disease-modifying antirheumatic drugs in rheumatoid arthritis: results of the GO-MORE study in Spain. Reumatol Clin. 2015 May-Jun;11(3):144–50. doi: 10.1016/j.reuma.2014.05.002. PMID: 25022442 Exclusion Code: X3. [PubMed: 25022442] [CrossRef]
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Bae SC, Kim J, Choe JY, et al. A phase III, multicentre, randomised, double-blind, active-controlled, parallel-group trial comparing safety and efficacy of HD203, with innovator etanercept, in combination with methotrexate, in patients with rheumatoid arthritis: the HERA study. Ann Rheum Dis. 2017 Jan;76(1):65–71. doi: 10.1136/annrheumdis-2015-207613. PMID: 26905864 Exclusion Code: X3. [PubMed: 26905864] [CrossRef]
77.
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Baker N, Boers M, Hochberg M, et al. Risk of hospitalized infections in patients with rheumatoid arthritis initiating abatacept and other biologics: Analysis of a United States claims database. Ann Rheum Dis. 2016;75:516. doi: 10.1136/annrheumdis-2016-eular.1322. Exclusion Code: X3. [CrossRef]
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