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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 34787-01-4
Drug Levels and Effects
Summary of Use during Lactation
Limited information indicates that ticarcillin produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with penicillins, but these effects have not been adequately evaluated. Ticarcillin is acceptable in nursing mothers.
Drug Levels
Maternal Levels. Only trace levels of ticarcillin were detected for 6 hours after single 1 gram intramuscular doses in 3 women in one study[1][2] and 5 women in another early study.[3]
After ticarcillin doses of 5 grams intravenously three times a day in 10 women, milk levels averaged 2 to 2.5 mg/L. By 12 hours after the last dose, ticarcillin was undetectable in the milk. The total daily intake of a breastfed infant would be negligible.[4]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Matsuda S, Tanno M, Kashiwakura T et al. Laboratory and clinical use of ticarcillin. Chemotherapy (Tokyo). 1977;25:2924-31.
- 2.
- Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy. 1984;5:57-60. [PubMed: 6743732]
- 3.
- Cho N, Nakayama T, Uehara K et al. Laboratory and clinical evaluation of ticarcillin in the field of obstetrics and gynecology. Chemotherapy (Tokyo). 1977;25:2911-23.
- 4.
- von Kobyletzki D, Dalhoff A, Lindemeyer H et al. Ticarcillin serum and tissue concentrations in gynecology and obstetrics. Infection. 1983;11:144-9. [PubMed: 6885173]
Substance Identification
Substance Name
Ticarcillin
CAS Registry Number
34787-01-4
Drug Class
- Breast Feeding
- Anti-Infective Agents
- Antibacterial Agents
- Penicillins
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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