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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 88040-23-7
Drug Levels and Effects
Summary of Use during Lactation
Although no published information is available on the use of cefepime during breastfeeding, the levels in breastmilk appear to be low and cephalosporins are generally not be expected to cause serious adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with cephalosporins, but these effects have not been adequately evaluated. Cefepime is acceptable in nursing mothers. The combination of cefepime and enmetazobactam has not been studied in humans during breasteeding, but the same adverse effects should apply.
Drug Levels
Maternal Levels. The manufacturer reports that the concentration of cefepime in breastmilk is about 0.5 mcg/mL, following a single intravenous dose of 1 gram. This is consistent with the low levels of other cephalosporins in breastmilk.
No human information is available on enmetazobactam in breastmilk.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Alternate Drugs to Consider
Substance Identification
Substance Name
Cefepime
CAS Registry Number
88040-23-7
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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