Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 68401-81-0
Drug Levels and Effects
Summary of Use during Lactation
Limited information indicates that ceftizoxime produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with cephalosporins, but these effects have not been adequately evaluated. Ceftizoxime is acceptable in nursing mothers.
Drug Levels
Maternal Levels. After a single 1 gram intravenous dose of ceftizoxime in 2 women, milk levels ranged from 0.31 to 0.43 mg/L from 2 to 8 hours after the dose. The peak milk level occurred at 2 hours after the dose in one and 6 hours after the dose in the other.[1]
Five women were given 1 gram of ceftizoxime intravenously. Average peak milk levels of 0.39 mg/L occurred 3 hours after the dose, although individuals had peak levels ranging from 0.31 mg/L at 3 hours after the dose to 0.83 mg/L at 6 hours after the dose. Four of the women had undetectable milk levels by 6 hours after the dose.[2]
In six women given 1 gram of ceftizoxime intravenously, average milk levels were 0.25 mg/L 1 hour after the dose.[3]
After a single 1 gram intravenous dose in 2 women, ceftizoxime milk levels were measurable only 4 hours after the dose and averaged 0.1 mg/L.[4]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Motomura R, Kohno M, Mori H et al. Basic and clinical studies of ceftizoxime in obstetrics and gynecology. Chemotherapy (Tokyo). 1980;28(suppl 5):888-99.
- 2.
- Takase Z, Inoue K, Shirafuji H et al. Clinical and laboratory studies on ceftizoxime (CZX) in the field of obstetrics and gynecology. Chemotherapy (Tokyo). 1980;28 (Suppl 5):863-73.
- 3.
- Gerding DN, Peterson LR. Comparative tissue and extravascular fluid concentrations of ceftizoxime. J Antimicrob Chemother. 1982;10(suppl C):105-16. [PubMed: 6295995]
- 4.
- Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy. 1984;5:57-60. [PubMed: 6743732]
Substance Identification
Substance Name
Ceftizoxime
CAS Registry Number
68401-81-0
Drug Class
- Breast Feeding
- Anti-Infective Agents
- Antibacterial Agents
- Cephalosporins
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
- User and Medical Advice Disclaimer
- Drugs and Lactation Database (LactMed) - Record Format
- LactMed - Database Creation and Peer Review Process
- Fact Sheet. Drugs and Lactation Database (LactMed)
- Drugs and Lactation Database (LactMed) - Glossary
- LactMed Selected References
- Drugs and Lactation Database (LactMed) - About Dietary Supplements
- Breastfeeding Links
- PubChem SubstanceRelated PubChem Substances
- PubMedLinks to PubMed
- Review Cefotaxime.[Drugs and Lactation Database (...]Review Cefotaxime.. Drugs and Lactation Database (LactMed®). 2006
- Review Cefixime.[Drugs and Lactation Database (...]Review Cefixime.. Drugs and Lactation Database (LactMed®). 2006
- Review Cefditoren.[Drugs and Lactation Database (...]Review Cefditoren.. Drugs and Lactation Database (LactMed®). 2006
- Review Ceftriaxone.[Drugs and Lactation Database (...]Review Ceftriaxone.. Drugs and Lactation Database (LactMed®). 2006
- Review Cefdinir.[Drugs and Lactation Database (...]Review Cefdinir.. Drugs and Lactation Database (LactMed®). 2006
- Ceftizoxime - Drugs and Lactation Database (LactMed®)Ceftizoxime - Drugs and Lactation Database (LactMed®)
Your browsing activity is empty.
Activity recording is turned off.
See more...