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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 98059-61-1
Drug Levels and Effects
Summary of Use during Lactation
Interferon gamma is a normal component of human milk. No data are available on the use of exogenous interferon gamma 1b during breastfeeding. However, the amounts of the similar drugs, interferon alfa and interferon beta-1a, excreted into milk are very low. Any interferon in breastmilk is probably destroyed in the infant's gastrointestinal tract and not absorbed, except perhaps in neonates.
Drug Levels
Maternal Levels. Measurements of the colostrum 6 mothers of preterm infants found an average of 2 ng/L of interferon gamma; two mothers of full-term infants had an average of 2.2 ng/L. At over 30 days postpartum, milk of 3 mothers of preterm infants contained 2.6 ng/L of interferon gamma; the milk of 28 mothers of full-term infants contained an average of 0.7 ng/L.[1]
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Srivastava MD, Srivastava A, Brouhard B, et al. Cytokines in human milk. Res Commun Mol Pathol Pharmacol 1996;93:263-87. [PubMed: 8896040]
Substance Identification
Substance Name
Interferon Gamma-1b
CAS Registry Number
98059-61-1
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Review Interferon Alfacon-1.[Drugs and Lactation Database (...]Review Interferon Alfacon-1.. Drugs and Lactation Database (LactMed®). 2006
- Review Interferon Beta.[Drugs and Lactation Database (...]Review Interferon Beta.. Drugs and Lactation Database (LactMed®). 2006
- Review Peginterferon Alfa.[Drugs and Lactation Database (...]Review Peginterferon Alfa.. Drugs and Lactation Database (LactMed®). 2006
- Review Interferon Alfa.[Drugs and Lactation Database (...]Review Interferon Alfa.. Drugs and Lactation Database (LactMed®). 2006
- Interferon beta-1b reduces interferon gamma-induced antigen-presenting capacity of human glial and B cells.[J Neuroimmunol. 1995]Interferon beta-1b reduces interferon gamma-induced antigen-presenting capacity of human glial and B cells.Jiang H, Milo R, Swoveland P, Johnson KP, Panitch H, Dhib-Jalbut S. J Neuroimmunol. 1995 Aug; 61(1):17-25.
- Interferon Gamma-1b - Drugs and Lactation Database (LactMed®)Interferon Gamma-1b - Drugs and Lactation Database (LactMed®)
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