Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 16037-91-5
Drug Levels and Effects
Summary of Use during Lactation
Limited information indicates that maternal doses of sodium stibogluconate up to 1.4 grams daily produce low levels in milk and would not be expected to cause any adverse effects in breastfed infants,[1] especially if the infant is older than 2 months. However, if withholding nursing during therapy is elected, breastfeeding can be reinstituted 24 to 48 hours after the last dose.
Drug Levels
Maternal Levels. A nursing mother was given 1 dose of sodium stibogluconate 1 gram intravenously, followed by intravenous doses of 1.4 grams (about 20 mg/kg of antimony) daily for 14 days. Numerous milk samples were obtained before and for 25 hours after the fifth and fourteenth doses of the drug. The average of the 2 trough values of antimony in milk was 0.7 mg/L; the average of the 2 peak concentrations was 3.5 mg/L at 4 hours after the dose.[1] (For comparison, average background antimony breastmilk concentrations range from 0.14 to 0.4 mcg/L[2][3]). After the sodium stibogluconate doses, milk antimony levels declined with a half-life of about 6 hours to a value of 0.7 mg/L at 23 hours after the dose.[1] Using the average of the peak and trough values, a fully breastfed infant would receive about 0.3 mg/kg daily of antimony or about 1.6% of the maternal weight-adjusted dosage.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Berman JD, Melby PC, Neva FA. Concentration of Pentostam in human breast milk. Trans R Soc Trop Med Hyg. 1989;83:784-5. [PubMed: 2559511]
- 2.
- Abdulrazzaq YM, Osman N, Nagelkerke N et al. Trace element composition of plasma and breast milk of well-nourished women. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2008;43:329-34. [PubMed: 18205064]
- 3.
- Wappelhorst O, Kuhn I, Heidenreich H, Markert B. Transfer of selected elements from food into human milk. Nutrition. 2002;18:316-22. [PubMed: 11934544]
Substance Identification
Substance Name
Sodium Stibogluconate
CAS Registry Number
16037-91-5
Drug Class
- Breast Feeding
- Anti-Infective Agents
- Antiprotozoal Agents
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
- User and Medical Advice Disclaimer
- Drugs and Lactation Database (LactMed) - Record Format
- LactMed - Database Creation and Peer Review Process
- Fact Sheet. Drugs and Lactation Database (LactMed)
- Drugs and Lactation Database (LactMed) - Glossary
- LactMed Selected References
- Drugs and Lactation Database (LactMed) - About Dietary Supplements
- Breastfeeding Links
- PubChem SubstanceRelated PubChem Substances
- PubMedLinks to PubMed
- Review Sodium Chromate Cr 51.[Drugs and Lactation Database (...]Review Sodium Chromate Cr 51.. Drugs and Lactation Database (LactMed®). 2006
- Review Sodium Picosulfate.[Drugs and Lactation Database (...]Review Sodium Picosulfate.. Drugs and Lactation Database (LactMed®). 2006
- Review Iothalamate.[Drugs and Lactation Database (...]Review Iothalamate.. Drugs and Lactation Database (LactMed®). 2006
- Review Dipyrone.[Drugs and Lactation Database (...]Review Dipyrone.. Drugs and Lactation Database (LactMed®). 2006
- Review Iodohippurate Sodium I 131.[Drugs and Lactation Database (...]Review Iodohippurate Sodium I 131.. Drugs and Lactation Database (LactMed®). 2006
- Sodium Stibogluconate - Drugs and Lactation Database (LactMed®)Sodium Stibogluconate - Drugs and Lactation Database (LactMed®)
Your browsing activity is empty.
Activity recording is turned off.
See more...