Purpose: The objective of this short review is to evaluate the efficacy of ferric pyrophosphate citrate and to determine its place in therapy based on the current published literature.
Methods: A literature search was conducted and pared down to yield 4 placebo controlled Phase II and III clinically relevant trials.
Findings: Ferric pyrophosphate citrate is a new intradialytic iron supplementation product that has been found to reduce the dose of erythropoiesis-stimulating agents and intravenous iron supplementation and to increase serum ferritin concentrations.
Implications: This agent may be administered to patients with stage 5 chronic kidney disease receiving hemodialysis as a new iron supplementation option to maintain hemoglobin, transferrin saturation, and ferritin concentrations.
Keywords: anemia; chronic kidney disease; ferric pyrophosphate citrate; hemodialysis; hemoglobin; soluble ferric pyrophosphate.
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