In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012.
Loperamide is synthetic opioid that primarily affects opiate receptors in the intestine and is used to treat diarrhea. Loperamide has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury.