Abstract
Rat and human feces are able to reduce nitro group from Benznidazole (N-benzyl-2-nitro-1-imidazole acetamide) and Nifurtimox (4[5-nitrofurfurylidene)-amino)-3-methylthiomorpholine-1,1-dioxide), two chemotherapeutic agents against Chagas' disease. Feces from rats treated with neomycin sulfate lack nitroreductase activity evidencing the bacterial origin of the enzyme.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Feces / analysis*
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Humans
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Male
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Neomycin / pharmacology
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Nifurtimox / metabolism*
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Nitro Compounds / metabolism*
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Nitrofurans / metabolism*
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Nitroimidazoles / metabolism*
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Nitroreductases
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Oxidation-Reduction
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Oxidoreductases / metabolism
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Rats
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Rats, Inbred Strains
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Species Specificity
Substances
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Nitro Compounds
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Nitrofurans
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Nitroimidazoles
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Oxidoreductases
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Nitroreductases
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Neomycin
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Nifurtimox
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benzonidazole