Abstract
The incidence of cross-reactivity between unfractionated heparin and LMWH, fragmin, in patients with HIT is significantly lower (6/15, 40%) than hitherto reported in the literature. 7/9 patients with a negative cross-reactivity test were treated with dalteparin sodium (Fragmin) without any untoward events.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Chondroitin Sulfates / adverse effects
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Dalteparin / therapeutic use*
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Dermatan Sulfate / adverse effects
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Drug Interactions
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Female
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Heparin / adverse effects*
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Heparin, Low-Molecular-Weight / adverse effects*
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Heparinoids / adverse effects
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Heparitin Sulfate / adverse effects
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Humans
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Male
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Middle Aged
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Thrombocytopenia / chemically induced*
Substances
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Heparin, Low-Molecular-Weight
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Heparinoids
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Dermatan Sulfate
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Heparin
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Chondroitin Sulfates
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Heparitin Sulfate
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danaparoid
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Dalteparin