Heparin-induced thrombocytopenia: cross-reactivity between standard heparin, low molecular weight heparin, dalteparin (Fragmin) and heparinoid, danaparoid (Orgaran)

Br J Haematol. 1995 Nov;91(3):736-8. doi: 10.1111/j.1365-2141.1995.tb05377.x.

Abstract

The incidence of cross-reactivity between unfractionated heparin and LMWH, fragmin, in patients with HIT is significantly lower (6/15, 40%) than hitherto reported in the literature. 7/9 patients with a negative cross-reactivity test were treated with dalteparin sodium (Fragmin) without any untoward events.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Chondroitin Sulfates / adverse effects
  • Dalteparin / therapeutic use*
  • Dermatan Sulfate / adverse effects
  • Drug Interactions
  • Female
  • Heparin / adverse effects*
  • Heparin, Low-Molecular-Weight / adverse effects*
  • Heparinoids / adverse effects
  • Heparitin Sulfate / adverse effects
  • Humans
  • Male
  • Middle Aged
  • Thrombocytopenia / chemically induced*

Substances

  • Heparin, Low-Molecular-Weight
  • Heparinoids
  • Dermatan Sulfate
  • Heparin
  • Chondroitin Sulfates
  • Heparitin Sulfate
  • danaparoid
  • Dalteparin