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Report for CCDS3539.1 (current version)

CCDS Status Species Chrom. Gene CCDS Release NCBI Annotation Release Ensembl Annotation Release Links
3539.1 Public Homo sapiens 4 CABS1 24 110 108 CCDS HistoryNCBI Gene:85438Re-query CCDS DB by CCDS ID:3539.1See the combined annotation on chromosome 4 in Sequence Viewer

Public Note for CCDS 3539.1
This CCDS ID represents the human ortholog of the protein described in PMIDs: 19208547 and 19271754. This transcript is supported by AK057459.1. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously in mouse and rat (PMIDs: 19208547 and 19271754, respectively). It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein.

Public since: CCDS release 1, NCBI annotation release 35.1, Ensembl annotation release 23

Review status: Reviewed (by RefSeq, Havana and CCDS collaboration)


Attributes
Nonsense-mediated decay (NMD) candidate

Sequence IDs included in CCDS 3539.1

Original Current Source Nucleotide ID Protein ID MANE Status in CCDS Seq. Status Links
Original member Current member EBI ENST00000273936.6 ENSP00000273936.4 MANE Select Accepted alive Link to Ensembl Transcript Viewer:ENST00000273936.6Link to Ensembl Protein Viewer:ENSP00000273936.4Re-query CCDS DB by Nucleotide ID:ENST00000273936Re-query CCDS DB by Protein ID:ENSP00000273936
Original member Current member NCBI NM_033122.4 NP_149113.3 MANE Select Accepted alive Link to Nucleotide Sequence:NM_033122.4Link to Protein Sequence:NP_149113.3Re-query CCDS DB by Nucleotide ID:NM_033122Re-query CCDS DB by Protein ID:NP_149113Link to BLAST:NP_149113.3

RefSeq Length Related UniProtKB/SwissProt Length Identity Gaps Mismatches
NP_149113.3 395 Q96KC9 395 100% 0 0

Chromosomal Locations for CCDS 3539.1

Assembly GRCh38.p14 (GCF_000001405.40)

On '+' strand of Chromosome 4 (NC_000004.12)
Genome Browser links: Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 4Link to Ensembl Genome Browser on chromosome 4See the combined annotation on chromosome 4 in Sequence Viewer

Chromosome Start Stop Links
4 70335040 70336227 Link to NCBI NucleotideLink to UCSC Genome Browser on chromosome 4Link to Ensembl Genome Browser on chromosome 4

CCDS Sequence Data
Blue highlighting indicates alternating exons.
Red highlighting indicates amino acids encoded across a splice junction.
 
Mouse over the nucleotide or protein sequence below and click on the highlighted codon or residue to select the pair.

Nucleotide Sequence (1188 nt):
ATGGCTGAAGATGGTTTGCCCAAAATTTATTCTCATCCTCCAACAGAAAGCAGTAAAACACCAACTGCAG
CAACCATTTTCTTTGGGGCTGACAATGCTATTCCCAAATCAGAAACAACTATTACTTCAGAAGGAGACCA
CGTCACTTCAGTAAATGAATATATGCTAGAAAGCGATTTTTCAACAACTACAGACAACAAACTGACAGCT
AAAAAGGAAAAACTCAAATCAGAAGATGATATGGGGACCGACTTTATTAAGTCAACAACTCACCTACAGA
AAGAAATTACCTCTCTGACTGGCACTACAAACTCCATAACAAGAGACTCTATTACCGAACATTTCATGCC
AGTGAAAATTGGGAATATTTCATCACCAGTTACTACTGTTTCTTTAATAGATTTTTCCACTGACATAGCA
AAAGAAGATATCCTCTTAGCTACCATTGACACAGGAGATGCAGAGATCTCAATAACCTCTGAAGTCTCTG
GCACACTAAAGGACAGCAGTGCTGGTGTTGCTGACGCTCCTGCCTTTCCACGTAAAAAGGATGAAGCTGA
TATGAGCAATTATAATTCCTCCATCAAATCCAATGTCCCTGCTGATGAGGCTGTCCAGGTCACTGATTCC
ACTATTCCTGAGGCTGAAATCCCTCCTGCTCCTGAAGAAAGCTTCACTACTATTCCAGACATAACTGCCC
TTGAAGAAGAGAAAATAACCGAAATTGACCTAAGTGTTTTAGAAGATGACACCAGTGCTGTGGCTACATT
AACTGACTCTGATGAGAAGTTTATCACTGTGTTTGAACTCACTACCTCTGCTGAAAAAGACAAAGATAAA
CGGGAAGATACTCTGCTAACTGATGAAGAAACTACCGAGGGAGCCAGTATTTGGATGGAGAGAGATACTG
CAAATGAAGCAGAGACCCATTCTGTTTTGCTTACTGCTGTTGAATCCAGATATGACTTCGTTGTCCCTGC
ATCAATAGCTACAAACCTAGTGGAAGAATCATCTACAGAAGAAGATTTGTCTGAAACTGATAATACAGAG
ACTGTACCTAAGATCACTGAGCCATTTTCTGGAACTACCTCTGTATTAGATACCCCAGACTATAAGGAAG
ACACCTCCACAACTGAAACGGATATCTTTGAACTACTGAAAGAAGAACCCGATGAGTTCATGATTTAA

Translation (395 aa):
MAEDGLPKIYSHPPTESSKTPTAATIFFGADNAIPKSETTITSEGDHVTSVNEYMLESDFSTTTDNKLTA
KKEKLKSEDDMGTDFIKSTTHLQKEITSLTGTTNSITRDSITEHFMPVKIGNISSPVTTVSLIDFSTDIA
KEDILLATIDTGDAEISITSEVSGTLKDSSAGVADAPAFPRKKDEADMSNYNSSIKSNVPADEAVQVTDS
TIPEAEIPPAPEESFTTIPDITALEEEKITEIDLSVLEDDTSAVATLTDSDEKFITVFELTTSAEKDKDK
REDTLLTDEETTEGASIWMERDTANEAETHSVLLTAVESRYDFVVPASIATNLVEESSTEEDLSETDNTE
TVPKITEPFSGTTSVLDTPDYKEDTSTTETDIFELLKEEPDEFMI


Links Key
 Links to:   History report
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  Nucleotide report
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 Re-query CCDS DB by:   CCDS ID
  Gene ID
  Nucleotide ID
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 Genome Browser Links:   Ensembl Genome Browser
  NCBI Sequence Viewer
  UCSC Genome Browser
  VEGA Genome Browser

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