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Conserved domains on  [gi|230160|pdb|1MCP|H]
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Chain H, IGA-KAPPA MCPC603 FAB (HEAVY CHAIN)

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 3-121 7.84e-57

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


:

Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 175.96  E-value: 7.84e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H        3 KLVESGGGLVQPGGSLRLSCATSGFTFSDFYMEWVRQPPGKRLEWIAASRNKGNkyTTEYSASVKGRFIVSRDTSQSILY 82
Cdd:cd04981   1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYPGGG--DTYYADSFKGRFTITRDTSKSTAY 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
1MCP_H       83 LQMNALRAEDTAIYYCAR-NYYGSTWYFDVWGAGTTVTVS 121
Cdd:cd04981  79 LQLNSLTSEDTAVYYCARgLGGYGYSYFDYWGQGTTVTVS 118
IgC1_CH1_IgA cd21818
CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy alpha chain; ...
 127-222 6.91e-50

CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy alpha chain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin constant-1 set domain of alpha chains. It belongs to a family composed of the first immunoglobulin constant-1 set domain of alpha, epsilon, gamma, and mu heavy chains. This domain is found on the Fab antigen-binding fragment. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each is composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) with three (alpha, delta and gamma) or four (epsilon and mu) constant domains (CH1 to CH4). Ig molecules are modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. This group belongs to the C1-set of IgSF domains, which are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules, and in various T-cell receptors.


:

Pssm-ID: 409623  Cd Length: 94  Bit Score: 157.67  E-value: 6.91e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H      127 NPTIYPLTLPPALSSDPVIIGCLIHDYFPSgTMNVTWGKSGKDITTVNFPPALASGGRYTMSNQLTLPAVECPEGESVKC 206
Cdd:cd21818   1 SPTVFPLSLCPSLSSDPVVIGCLVQGFFPE-PVNVTWNYSGKGGTARNFPAMLASGGRYTQSSQLTLPADQCPEGEAYKC 79

                        90
                ....*....|....*.
1MCP_H      207 SVQHDsNPVQELDVNC 222
Cdd:cd21818  80 SVQHY-SPSQDLNVPC 94
 
Name Accession Description Interval E-value
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 3-121 7.84e-57

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 175.96  E-value: 7.84e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H        3 KLVESGGGLVQPGGSLRLSCATSGFTFSDFYMEWVRQPPGKRLEWIAASRNKGNkyTTEYSASVKGRFIVSRDTSQSILY 82
Cdd:cd04981   1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYPGGG--DTYYADSFKGRFTITRDTSKSTAY 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
1MCP_H       83 LQMNALRAEDTAIYYCAR-NYYGSTWYFDVWGAGTTVTVS 121
Cdd:cd04981  79 LQLNSLTSEDTAVYYCARgLGGYGYSYFDYWGQGTTVTVS 118
IgC1_CH1_IgA cd21818
CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy alpha chain; ...
 127-222 6.91e-50

CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy alpha chain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin constant-1 set domain of alpha chains. It belongs to a family composed of the first immunoglobulin constant-1 set domain of alpha, epsilon, gamma, and mu heavy chains. This domain is found on the Fab antigen-binding fragment. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each is composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) with three (alpha, delta and gamma) or four (epsilon and mu) constant domains (CH1 to CH4). Ig molecules are modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. This group belongs to the C1-set of IgSF domains, which are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules, and in various T-cell receptors.


Pssm-ID: 409623  Cd Length: 94  Bit Score: 157.67  E-value: 6.91e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H      127 NPTIYPLTLPPALSSDPVIIGCLIHDYFPSgTMNVTWGKSGKDITTVNFPPALASGGRYTMSNQLTLPAVECPEGESVKC 206
Cdd:cd21818   1 SPTVFPLSLCPSLSSDPVVIGCLVQGFFPE-PVNVTWNYSGKGGTARNFPAMLASGGRYTQSSQLTLPADQCPEGEAYKC 79

                        90
                ....*....|....*.
1MCP_H      207 SVQHDsNPVQELDVNC 222
Cdd:cd21818  80 SVQHY-SPSQDLNVPC 94
IGv smart00406
Immunoglobulin V-Type;
17-100 2.31e-32

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 112.48  E-value: 2.31e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H          17 SLRLSCATSGFTFSDFYMEWVRQPPGKRLEWIAASRNKGNKYtteYSASVKGRFIVSRDTSQSILYLQMNALRAEDTAIY 96
Cdd:smart00406   1 SVTLSCKFSGSTFSSYYVSWVRQPPGKGLEWLGYIGSNGSSY---YQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTY 77


                   ....
1MCP_H          97 YCAR 100
Cdd:smart00406  78 YCAV 81
C1-set pfam07654
Immunoglobulin C1-set domain;
130-213 5.20e-21

Immunoglobulin C1-set domain;


Pssm-ID: 462221  Cd Length: 85  Bit Score: 83.45  E-value: 5.20e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H        130 IYPLTLPPALSSDPVIIGCLIHDYFPsGTMNVTWGKSGKDITT--VNFPPALASGGRYTMSNQLTLPAVECPEGESVKCS 207
Cdd:pfam07654   1 VYVFPPSPEELGKPNTLTCLVTGFYP-PDITVTWLKNGQEVTEgvKTTPPSPNSDWTYQLSSYLTVTPSDWESGDEYTCR 79


                  ....*.
1MCP_H        208 VQHDSN 213
Cdd:pfam07654  80 VEHEGL 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 11-120 5.42e-14

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 65.56  E-value: 5.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H         11 LVQPGGSLRLSCATSGFTFSD-FYMEWVRQPPGKRLEW-IAASRNKGNKYTTeysasvKGRFIVSRDTSQSILYLQMNAL 88
Cdd:pfam07686   7 TVALGGSVTLPCTYSSSMSEAsTSVYWYRQPPGKGPTFlIAYYSNGSEEGVK------KGRFSGRGDPSNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|..
1MCP_H         89 RAEDTAIYYCARNYYGStwyfDVWGAGTTVTV 120
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGE----GVFGKGTRLTV 108
IGc1 smart00407
Immunoglobulin C-Type;
143-216 1.45e-08

Immunoglobulin C-Type;


Pssm-ID: 214651  Cd Length: 75  Bit Score: 50.00  E-value: 1.45e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
1MCP_H         143 PVIIGCLIHDYFPSgTMNVTWGKSGKDIT--TVNFPPALASGGRYTMSNQLTLPAVECPEGESVKCSVQHDSNPVQ 216
Cdd:smart00407   1 KATLVCLVSGFYPP-DITVTWLRNGQEVTegVSTTDPLKNSDGTYFLSSYLTVPASTWESGDVYTCQVTHEGLKEP 75
PHA03273 PHA03273
envelope glycoprotein C; Provisional
 116-215 9.42e-04

envelope glycoprotein C; Provisional


Pssm-ID: 223031  Cd Length: 486  Bit Score: 39.60  E-value: 9.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H       116 TTVTVSsesARNPTIYPLTLPPALSSDPVIIGCLIHDYFPSGTMNVTWGKSGKDITTVNFPPALAS---GGRYTMSNQLT 192
Cdd:PHA03273 228 TSVTVS---TYNAPLVDLSVHPSLKGENYRAVCVVASYFPHSSVKLRWYKNAKEVDFTKYVTNASSvwvDGLITRISTLS 304

                         90       100
                 ....*....|....*....|....
1MCP_H       193 LPAVECPEGE-SVKCSVQHDSNPV 215
Cdd:PHA03273 305 IPVDPDEEYTpSLRCSIEWYRDEV 328
 
Name Accession Description Interval E-value
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 3-121 7.84e-57

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 175.96  E-value: 7.84e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H        3 KLVESGGGLVQPGGSLRLSCATSGFTFSDFYMEWVRQPPGKRLEWIAASRNKGNkyTTEYSASVKGRFIVSRDTSQSILY 82
Cdd:cd04981   1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYPGGG--DTYYADSFKGRFTITRDTSKSTAY 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
1MCP_H       83 LQMNALRAEDTAIYYCAR-NYYGSTWYFDVWGAGTTVTVS 121
Cdd:cd04981  79 LQLNSLTSEDTAVYYCARgLGGYGYSYFDYWGQGTTVTVS 118
IgC1_CH1_IgA cd21818
CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy alpha chain; ...
 127-222 6.91e-50

CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy alpha chain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin constant-1 set domain of alpha chains. It belongs to a family composed of the first immunoglobulin constant-1 set domain of alpha, epsilon, gamma, and mu heavy chains. This domain is found on the Fab antigen-binding fragment. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each is composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) with three (alpha, delta and gamma) or four (epsilon and mu) constant domains (CH1 to CH4). Ig molecules are modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. This group belongs to the C1-set of IgSF domains, which are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules, and in various T-cell receptors.


Pssm-ID: 409623  Cd Length: 94  Bit Score: 157.67  E-value: 6.91e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H      127 NPTIYPLTLPPALSSDPVIIGCLIHDYFPSgTMNVTWGKSGKDITTVNFPPALASGGRYTMSNQLTLPAVECPEGESVKC 206
Cdd:cd21818   1 SPTVFPLSLCPSLSSDPVVIGCLVQGFFPE-PVNVTWNYSGKGGTARNFPAMLASGGRYTQSSQLTLPADQCPEGEAYKC 79

                        90
                ....*....|....*.
1MCP_H      207 SVQHDsNPVQELDVNC 222
Cdd:cd21818  80 SVQHY-SPSQDLNVPC 94
IgC1_CH1_IgADEGM cd04985
CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy alpha, delta, ...
 127-220 1.66e-39

CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy alpha, delta, epsilon, gamma, and mu chains; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin constant-1 set domain of alpha, delta, epsilon, gamma, and mu heavy chains. This domain is found on the Fab antigen-binding fragment. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each is composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) with three (alpha, delta and gamma) or four (epsilon and mu) constant domains (CH1 to CH4). Ig molecules are modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. This group belongs to the C1-set of IgSF domains, which are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules, and in various T-cell receptors.


Pssm-ID: 409374  Cd Length: 98  Bit Score: 131.17  E-value: 1.66e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H      127 NPTIYPLTLPPAL-SSDPVIIGCLIHDYFPSgTMNVTWGK---SGKDITTVNFPPALASGGRYTMSNQLTLPAVECPEGE 202
Cdd:cd04985   1 APTVFPLQSATKSqSNGPVALGCLISDYFPE-SITVSWQKntnSITSGFTRTFPVVLRSGGDYSCSSQLTVPLQEWNSGE 79

                        90
                ....*....|....*....
1MCP_H      203 SVKCSVQHD-SNPVQELDV 220
Cdd:cd04985  80 VYKCQVQHSaSNSKQEKDV 98
IGv smart00406
Immunoglobulin V-Type;
17-100 2.31e-32

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 112.48  E-value: 2.31e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H          17 SLRLSCATSGFTFSDFYMEWVRQPPGKRLEWIAASRNKGNKYtteYSASVKGRFIVSRDTSQSILYLQMNALRAEDTAIY 96
Cdd:smart00406   1 SVTLSCKFSGSTFSSYYVSWVRQPPGKGLEWLGYIGSNGSSY---YQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTY 77


                   ....
1MCP_H          97 YCAR 100
Cdd:smart00406  78 YCAV 81
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 11-120 2.41e-21

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 85.08  E-value: 2.41e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H       11 LVQPGGSLRLSCATSGFtFSDFYMEWVRQPPGKRLEWIAASRNKGNKYTTEysasVKGRFIVSRDTSQSIlYLQMNALRA 90
Cdd:cd00099   9 SVQEGESVTLSCEVSSS-FSSTYIYWYRQKPGQGPEFLIYLSSSKGKTKGG----VPGRFSGSRDGTSSF-SLTISNLQP 82

                        90       100       110
                ....*....|....*....|....*....|
1MCP_H       91 EDTAIYYCARNYYGSTWYFdVWGAGTTVTV 120
Cdd:cd00099  83 EDSGTYYCAVSESGGTDKL-TFGSGTRLTV 111
C1-set pfam07654
Immunoglobulin C1-set domain;
130-213 5.20e-21

Immunoglobulin C1-set domain;


Pssm-ID: 462221  Cd Length: 85  Bit Score: 83.45  E-value: 5.20e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H        130 IYPLTLPPALSSDPVIIGCLIHDYFPsGTMNVTWGKSGKDITT--VNFPPALASGGRYTMSNQLTLPAVECPEGESVKCS 207
Cdd:pfam07654   1 VYVFPPSPEELGKPNTLTCLVTGFYP-PDITVTWLKNGQEVTEgvKTTPPSPNSDWTYQLSSYLTVTPSDWESGDEYTCR 79


                  ....*.
1MCP_H        208 VQHDSN 213
Cdd:pfam07654  80 VEHEGL 85
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 13-121 3.24e-17

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 74.32  E-value: 3.24e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H       13 QPGGSLRLSCATSGFTFSDFYMEWVRQPPGKRLEWIA-ASRNKGNKYTteySASVKGRFIVSRDTSQSILYLQMNALRAE 91
Cdd:cd04982  11 EESKSVTISCKVSGIDFSTTYIHWYRQKPGQALERLLyVSSTSAVRKD---SGKTKNKFEARKDVGKSTSTLTITNLEKE 87

                        90       100       110
                ....*....|....*....|....*....|
1MCP_H       92 DTAIYYCARNYYGSTWYFDVWGAGTTVTVS 121
Cdd:cd04982  88 DSATYYCAYWESGSGYYIKVFGSGTKLIVT 117
IgC1_CH1_IgM cd21819
CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy mu chain; ...
 128-216 6.59e-17

CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy mu chain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin constant-1 set domain of mu chains. It belongs to a family composed of the first immunoglobulin constant-1 set domain of alpha, delta, epsilon, gamma, and mu heavy chains. This domain is found on the Fab antigen-binding fragment. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each is composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) with three (alpha, delta and gamma) or four (epsilon and mu) constant domains (CH1 to CH4). Ig molecules are modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. This group belongs to the C1-set of IgSF domains, which are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules, and in various T-cell receptors.


Pssm-ID: 409624  Cd Length: 95  Bit Score: 72.75  E-value: 6.59e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H      128 PTIYPLTLPPALSSDPVIIGCLIHDYFPSgTMNVTWGKSGKDITT--VNFPPALaSGGRYTMSNQLTLPAVECPEGESVK 205
Cdd:cd21819   2 PTLFPLVSCGSSTSDPVTVGCLATDFLPD-SITFSWTDDNNSLTTgvKTYPSVL-TGGTYTASSQLQVPESEWKSKENFY 79

                        90
                ....*....|.
1MCP_H      206 CSVQHDSNPVQ 216
Cdd:cd21819  80 CKVEHPGGNKE 90
IgV_H_TCR_mu cd16095
T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the ...
 1-120 1.37e-14

T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain of the T-cell receptor Mu. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409514  Cd Length: 115  Bit Score: 67.59  E-value: 1.37e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H        1 EVKLVESGGGLVQPGGSLRLSCATSGFTFSDFYMEWVRQPPGKRLEWIAASRNKGNKYTteysasvKGRFIVSRDTSQSI 80
Cdd:cd16095   1 ETQLEESGGGSHPAGKTLSLKCQTSGFQFNTSQLSWYLWVPGHAPLWLTSLDHISTKVS-------EDRITSSREDTNSQ 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
1MCP_H       81 LYLQMNALRAEDTAIYYCARNY-YGSTWYFDVWGAGTTVTV 120
Cdd:cd16095  74 IFLQIKGLGLRDSGQYHCARRVgYGDDTDKLIFGPGTDVIV 114
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 11-120 5.42e-14

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 65.56  E-value: 5.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H         11 LVQPGGSLRLSCATSGFTFSD-FYMEWVRQPPGKRLEW-IAASRNKGNKYTTeysasvKGRFIVSRDTSQSILYLQMNAL 88
Cdd:pfam07686   7 TVALGGSVTLPCTYSSSMSEAsTSVYWYRQPPGKGPTFlIAYYSNGSEEGVK------KGRFSGRGDPSNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|..
1MCP_H         89 RAEDTAIYYCARNYYGStwyfDVWGAGTTVTV 120
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGE----GVFGKGTRLTV 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 7-120 6.12e-13

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 62.14  E-value: 6.12e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H           7 SGGGLVQPGGSLRLSCATSGFtfSDFYMEWVRQPPgkrlEWIAASrnkgnkytteysasvkGRFIVSRDTSQSilYLQMN 86
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGS--PPPEVTWYKQGG----KLLAES----------------GRFSVSRSGSTS--TLTIS 56

                           90       100       110
                   ....*....|....*....|....*....|....*
1MCP_H          87 ALRAEDTAIYYC-ARNYYGSTWyfdvwgAGTTVTV 120
Cdd:smart00410  57 NVTPEDSGTYTCaATNSSGSAS------SGTTLTV 85
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 12-120 1.30e-12

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 61.71  E-value: 1.30e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H       12 VQPGGSLRLSCATSGFTFSDFYMEWVRQPPGKRLEWIAasrnkgnKYTTEYSASVKGRFivSRDTSQSILYLQMNALRAE 91
Cdd:cd04984  10 VSPGETVTITCTGSSGNISGNYVNWYQQKPGSAPRYLI-------YEDKHRPSGIPDRF--SGSKSGNTASLTISGAQTE 80

                        90       100
                ....*....|....*....|....*....
1MCP_H       92 DTAIYYCArNYYGSTWYFdvwGAGTTVTV 120
Cdd:cd04984  81 DEADYYCQ-VWDSNSYVF---GGGTKLTV 105
IgC1_CH1_IgEG cd21817
CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy epsilon and ...
 128-210 1.85e-12

CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy epsilon and gamma chain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin constant-1 set domain of epsilon and gamma chains. It belongs to a family composed of the first immunoglobulin constant-1 set domain of alpha, delta, epsilon, gamma, and mu heavy chains. This domain is found on the Fab antigen-binding fragment. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each is composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) with three (alpha, delta and gamma) or four (epsilon and mu) constant domains (CH1 to CH4). Ig molecules are modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. This group belongs to the C1-set of IgSF domains, which are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules, and in various T-cell receptors.


Pssm-ID: 409622  Cd Length: 94  Bit Score: 61.31  E-value: 1.85e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H      128 PTIYPLTlpPALSSDP---VIIGCLIHDYFPSGTMnVTWGKSGKDITTVNFPPALASGGRYTMSNQLTLPAVECPeGESV 204
Cdd:cd21817   2 PSVFPLA--PCCKSTNgssVTLGCLVTGYFPEPVT-VTWNSGSLTSGVKTFPAVLQSSGLYTTSSQVTVPSSSWG-SQTF 77


                ....*.
1MCP_H      205 KCSVQH 210
Cdd:cd21817  78 TCNVEH 83
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 11-120 4.77e-12

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 60.37  E-value: 4.77e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H       11 LVQPGGSLRLSCA-TSGFTfsdfYMEWVRQPPGKRLEWIAASRNKGNKYTTEYSASvkgRFIVSRdTSQSILYLQMNALR 89
Cdd:cd05899   9 IKRRGQSVTLRCSqKSGHD----NMYWYRQDPGKGLQLLFYSYGGGLNEEGDLPGD---RFSASR-PSLTRSSLTIKSAE 80

                        90       100       110
                ....*....|....*....|....*....|....*
1MCP_H       90 AEDTAIYYCA----RNYYgsTWYFdvwGAGTTVTV 120
Cdd:cd05899  81 PEDSAVYLCAsslgGGAD--EAYF---GPGTRLTV 110
IgC1 cd00098
Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, ...
 136-214 1.93e-11

Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, classical Ig-like domains resembling the antibody constant domain. Members of the IgC1 family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, while the IgC domain is involved in oligomerization and molecular interactions. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other strands by G, F, C, and C'.


Pssm-ID: 409354  Cd Length: 95  Bit Score: 58.63  E-value: 1.93e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H      136 PPALSSDPVIIGCLIHDYFPSGtMNVTWGKSGKDIT--TVNFPPALASGGRYTMSNQLTLPAVECPEGESVKCSVQHDSN 213
Cdd:cd00098   9 PEEKGGGKVTLVCLVSGFYPKD-ITVTWLKNGVPLTsgVSTSSPVEPNDGTYSVTSSLTVPPSDWDEGATYTCVVTHESL 87


                .
1MCP_H      214 P 214
Cdd:cd00098  88 K 88
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 12-120 1.95e-10

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 56.12  E-value: 1.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H       12 VQPGGSLRLSCATSGFTFSDFYmeWVRQPPGKRLEW-IAASRNKGNKytteysasVKGRFIVSRDTSQSILYLQMNALRA 90
Cdd:cd04983  10 VQEGENVTLNCNYSTSTFYYLF--WYRQYPGQGPQFlIYISSDSGNK--------KKGRFSATLDKSRKSSSLHISAAQL 79

                        90       100       110
                ....*....|....*....|....*....|..
1MCP_H       91 EDTAIYYCARNYYGSTW--YFdvwGAGTTVTV 120
Cdd:cd04983  80 SDSAVYFCALSESGGTGklTF---GKGTRLTV 108
IGc1 smart00407
Immunoglobulin C-Type;
143-216 1.45e-08

Immunoglobulin C-Type;


Pssm-ID: 214651  Cd Length: 75  Bit Score: 50.00  E-value: 1.45e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
1MCP_H         143 PVIIGCLIHDYFPSgTMNVTWGKSGKDIT--TVNFPPALASGGRYTMSNQLTLPAVECPEGESVKCSVQHDSNPVQ 216
Cdd:smart00407   1 KATLVCLVSGFYPP-DITVTWLRNGQEVTegVSTTDPLKNSDGTYFLSSYLTVPASTWESGDVYTCQVTHEGLKEP 75
IgV_TCR_gammadelta cd20988
Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the ...
 12-120 2.30e-07

Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409580  Cd Length: 114  Bit Score: 47.94  E-value: 2.30e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H       12 VQPGGSLRLSCATSGFTFSDFYMEWVRQPPGKRLEWIaaSRNKGnkyttEYSASVKGRFIVSRDTSQSILYLQMNALRAE 91
Cdd:cd20988  10 VSVGKPVTLKCSMKGEAISNYYINWYRKTQGNTMTFI--YREGG-----IYGPGFKDNFRGDIDSSNNLAVLKILEASER 82

                        90       100       110
                ....*....|....*....|....*....|.
1MCP_H       92 DTAIYYCARNYYGSTWYFD--VWGAGTTVTV 120
Cdd:cd20988  83 DEGSYYCASDTPGGGREYDplIFGKGTYLTV 113
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 2-120 1.33e-06

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 45.46  E-value: 1.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H        2 VKLVESGGGL-VQPGGSLRLSCATSGfTFSDFYMEWVRQPPG---KRLEWIAASRNKGnkytteysasVKGRFivSRDTS 77
Cdd:cd04980   1 IVMTQSPASLsVSPGERVTISCKASQ-SISSNYLAWYQQKPGqapKLLIYYASTLHSG----------VPSRF--SGSGS 67

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
1MCP_H       78 QSILYLQMNALRAEDTAIYYCaRNYYGSTWYFdvwGAGTTVTV 120
Cdd:cd04980  68 GTDFTLTISSVEPEDAAVYYC-QQGYTFPYTF---GGGTKLEI 106
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 12-120 1.93e-06

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 45.20  E-value: 1.93e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H       12 VQPGGSLRLSCaTSGFTFSDFYMEWVRQPPGKRLEWIAasrnkgnKYTTEYSASVKGRFIVSRDTSQSILYLQMNALRAE 91
Cdd:cd07706  11 VQVGEEVTLNC-RYETSWTNYYLFWYKQLPSGEMTFLI-------RQDSSEQNAKSGRYSVNFQKAQKSISLTISALQLE 82

                        90       100       110
                ....*....|....*....|....*....|.
1MCP_H       92 DTAIYYCARNYYGSTwyfD--VWGAGTTVTV 120
Cdd:cd07706  83 DSAKYFCALSLPYDT---DklIFGKGTRLTV 110
IgC1_CH1_IgD cd16092
CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin delta chain; member ...
 128-213 7.41e-06

CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin delta chain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin constant-1 set domain of delta chains. It belongs to a family composed of the first immunoglobulin constant-1 set domain of alpha, delta, epsilon, gamma, and mu heavy chains. This domain is found on the Fab antigen-binding fragment. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each is composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) with three (alpha, delta and gamma) or four (epsilon and mu) constant domains (CH1 to CH4). Ig molecules are modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. This group belongs to the C1-set of IgSF domains, which are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules, and in various T-cell receptors.


Pssm-ID: 319341  Cd Length: 96  Bit Score: 43.29  E-value: 7.41e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H      128 PTIYPLTLPPALSSD--PVIIGCLIHDYFPSgTMNVTWGKSGKDITTVNFPPALASGGRYTMSNQLTLPAVECPEGEsVK 205
Cdd:cd16092   2 PDVFPIISGCRHPKDnsPVVLACLITGYHPT-SVTVTWYMGTQSQPQRTFPEIQRRDSYYMTSSQLSTPLQQWRQGE-YK 79


                ....*...
1MCP_H      206 CSVQHDSN 213
Cdd:cd16092  80 CVVQHTAS 87
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 11-99 8.25e-05

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 40.89  E-value: 8.25e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H       11 LVQPGGSLRLSCATSGFTFSD--FYMEWvRQPPGKR--LEWIAA-SRNKGNKYTTEYSasvKGRFIVSRDTSQSILYLQM 85
Cdd:cd07700   9 LVQTNQTVKMSCEAKTSPKNTriYWLRQ-RQAPSKDshFEFLASwDPSKGIVYGEGVD---QEKLIILSDSDSSRYILSL 84

                        90
                ....*....|....
1MCP_H       86 NALRAEDTAIYYCA 99
Cdd:cd07700  85 MSVKPEDSGTYFCM 98
IgC1_L cd07699
Immunoglobulin light chain Constant domain; member of the C1-set of Ig superfamily (IgSF) ...
 128-212 5.68e-04

Immunoglobulin light chain Constant domain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin (Ig) light chain constant (C) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determine the type of immunoglobulin: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409496  Cd Length: 99  Bit Score: 38.21  E-value: 5.68e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H      128 PTIypLTLPP---ALSSDPVIIGCLIHDYFPSGtMNVTWGKSGKDITT--VNFPPALASGGRYTMSNQLTLPAVECPEGE 202
Cdd:cd07699   2 PSV--TIFPPsseELSSGKATLVCLINKFYPGF-ATVTWKVDGSTVSSgvTTSKTEQQSDNTYSMSSYLTLSSSDWNKHK 78

                        90
                ....*....|
1MCP_H      203 SVKCSVQHDS 212
Cdd:cd07699  79 VYTCEVTHEG 88
PHA03273 PHA03273
envelope glycoprotein C; Provisional
 116-215 9.42e-04

envelope glycoprotein C; Provisional


Pssm-ID: 223031  Cd Length: 486  Bit Score: 39.60  E-value: 9.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1MCP_H       116 TTVTVSsesARNPTIYPLTLPPALSSDPVIIGCLIHDYFPSGTMNVTWGKSGKDITTVNFPPALAS---GGRYTMSNQLT 192
Cdd:PHA03273 228 TSVTVS---TYNAPLVDLSVHPSLKGENYRAVCVVASYFPHSSVKLRWYKNAKEVDFTKYVTNASSvwvDGLITRISTLS 304

                         90       100
                 ....*....|....*....|....
1MCP_H       193 LPAVECPEGE-SVKCSVQHDSNPV 215
Cdd:PHA03273 305 IPVDPDEEYTpSLRCSIEWYRDEV 328
IgC_TCR_delta cd07687
Immunoglobulin (Ig) constant domain of the delta chain of delta/gamma T-cell antigen receptors ...
 146-219 6.53e-03

Immunoglobulin (Ig) constant domain of the delta chain of delta/gamma T-cell antigen receptors (TCRs); The members here are composed of the constant domain of the delta chain of delta/gamma T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. The majority of T cells contain alpha-beta TCRs, but a small subset contain gamma-delta TCRs. Alpha-beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma-delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing and MHC independently of the bound peptide. Gamma-delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds.


Pssm-ID: 409484  Cd Length: 80  Bit Score: 34.78  E-value: 6.53e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
1MCP_H      146 IGCLIHDYFPSgTMNVTWGKSGKdITTVNFPPALASGGRYTmsnqlTLPAVECPEGESVKCSVQHDSNPVQELD 219
Cdd:cd07687  13 VACLVKNFYPK-EVTISLSSSKK-IIEFDPAIVISPNGKYS-----AVKLGKYGDSDSVTCSVQHSNKTVHSTD 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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