|
Name |
Accession |
Description |
Interval |
E-value |
| prot_deacyl_CobB |
NF040867 |
NAD-dependent protein deacetylase; |
6-246 |
6.36e-156 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 468804 Cd Length: 242 Bit Score: 432.77 E-value: 6.36e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 6 RKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLF-AEPNPAHYA 84
Cdd:NF040867 1 EKAAELLASSRHAIAFTGAGISTESGIPTFRGPDGLWRRYDPEELATIEAFERDPKLVWEFYRWRMEKLFdAKPNPAHYA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 85 IAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEI-PRCRKCGSYYvKPRVV 163
Cdd:NF040867 81 LAELERMGILKAVITQNVDGLHQRAGSRNVIELHGNMRRVRCTSCGRTYDLEEVLRKIDKGELpPRCPECGGLL-RPDVV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 164 LFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIV 243
Cdd:NF040867 160 LFGEPLPDDALEEAFELAERSDVVLVVGSSLTVYPAAYLPYIAKENGGKLIIINPEETPLDPIADIVLRGRAGEVLPKLV 239
|
...
1S7G_B 244 EEV 246
Cdd:NF040867 240 EEV 242
|
|
| SIR2_Af2 |
cd01413 |
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, ... |
12-234 |
6.78e-141 |
|
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The Sir2 homolog from the archaea Sulfolobus solftaricus deacetylates the non-specific DNA protein Alba to mediate transcription repression.
Pssm-ID: 238704 Cd Length: 222 Bit Score: 394.04 E-value: 6.78e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 12 LAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLF-AEPNPAHYAIAELER 90
Cdd:cd01413 1 LTKSRKTVVLTGAGISTESGIPDFRSPDGLWKKYDPEEVASIDYFYRNPEEFWRFYKEIILGLLeAQPNKAHYFLAELEK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 91 MGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEfVEDFNKGEIPRCRKCGSYyVKPRVVLFGEPLP 170
Cdd:cd01413 81 QGIIKAIITQNIDGLHQRAGSKNVIELHGTLQTAYCVNCGSKYDLEE-VKYAKKHEVPRCPKCGGI-IRPDVVLFGEPLP 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
1S7G_B 171 QRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGK 234
Cdd:cd01413 159 QALLREAIEAAKEADLFIVLGSSLVVYPANLLPLIAKENGAKLVIVNADETPFDYIADLVIQDK 222
|
|
| SIR2 |
COG0846 |
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ... |
3-244 |
5.09e-136 |
|
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440607 Cd Length: 243 Bit Score: 382.59 E-value: 5.09e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 3 DEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLF-AEPNPA 81
Cdd:COG0846 2 TKIERLAELLREAKRIVVLTGAGISAESGIPDFRGPDGLWEKYDPEEVASPEAFRRDPELVWAFYNERRRLLRdAEPNAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 82 HYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSyYVKPR 161
Cdd:COG0846 82 HRALAELEKAGKLVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGKRYDLEDVLEDLEGELPPRCPKCGG-LLRPD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 162 VVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPK 241
Cdd:COG0846 161 VVWFGEMLPEEALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKRAGAPLVEINPEPTPLDSLADLVIRGDAGEVLPA 240
|
...
1S7G_B 242 IVE 244
Cdd:COG0846 241 LVE 243
|
|
| PRK00481 |
PRK00481 |
NAD-dependent deacetylase; Provisional |
3-248 |
6.05e-131 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 234777 Cd Length: 242 Bit Score: 369.51 E-value: 6.05e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 3 DEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEF-SMEMKDKLFAEPNPA 81
Cdd:PRK00481 1 MRIEELAEILDKAKRIVVLTGAGISAESGIPDFRSANGLWEEHRPEDVASPEGFARDPELVWKFyNERRRQLLDAKPNAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 82 HYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVedfnKGEIPRCRKCGSYyVKPR 161
Cdd:PRK00481 81 HRALAELEKLGKLVTVITQNIDGLHERAGSKNVIELHGSLLRARCTKCGQTYDLDEYL----KPEPPRCPKCGGI-LRPD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 162 VVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPK 241
Cdd:PRK00481 156 VVLFGEMLPELAIDEAYEALEEADLFIVIGTSLVVYPAAGLPYEAREHGAKTVEINLEPTPLDSLFDLVIHGKAGEVVPE 235
|
....*..
1S7G_B 242 IVEEVKR 248
Cdd:PRK00481 236 LVEELLA 242
|
|
| SIR2 |
pfam02146 |
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ... |
23-198 |
8.65e-88 |
|
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i
Pssm-ID: 426621 Cd Length: 179 Bit Score: 257.95 E-value: 8.65e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 23 GAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWE---FSMEMKDKLF--AEPNPAHYAIAELERMGIVKAV 97
Cdd:pfam02146 1 GAGISTESGIPDFRSDDGLYAKLAPEELASPEAFFSNPELVWDpepFYNIARELLPgeAQPNPAHYFIAKLEDKGKLLRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 98 ITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSyYVKPRVVLFGEPLPqRTLFEA 177
Cdd:pfam02146 81 ITQNIDGLHERAGSKKVVELHGSFAKARCVSCHQKYTGETLYERIRPEKVPHCPQCGG-LLKPDIVFFGENLP-DKFHRA 158
|
170 180
....*....|....*....|.
1S7G_B 178 IEEAKHCDAFMVVGSSLVVYP 198
Cdd:pfam02146 159 YEDLEEADLLIVIGTSLKVYP 179
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| prot_deacyl_CobB |
NF040867 |
NAD-dependent protein deacetylase; |
6-246 |
6.36e-156 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 468804 Cd Length: 242 Bit Score: 432.77 E-value: 6.36e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 6 RKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLF-AEPNPAHYA 84
Cdd:NF040867 1 EKAAELLASSRHAIAFTGAGISTESGIPTFRGPDGLWRRYDPEELATIEAFERDPKLVWEFYRWRMEKLFdAKPNPAHYA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 85 IAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEI-PRCRKCGSYYvKPRVV 163
Cdd:NF040867 81 LAELERMGILKAVITQNVDGLHQRAGSRNVIELHGNMRRVRCTSCGRTYDLEEVLRKIDKGELpPRCPECGGLL-RPDVV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 164 LFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIV 243
Cdd:NF040867 160 LFGEPLPDDALEEAFELAERSDVVLVVGSSLTVYPAAYLPYIAKENGGKLIIINPEETPLDPIADIVLRGRAGEVLPKLV 239
|
...
1S7G_B 244 EEV 246
Cdd:NF040867 240 EEV 242
|
|
| SIR2_Af2 |
cd01413 |
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, ... |
12-234 |
6.78e-141 |
|
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The Sir2 homolog from the archaea Sulfolobus solftaricus deacetylates the non-specific DNA protein Alba to mediate transcription repression.
Pssm-ID: 238704 Cd Length: 222 Bit Score: 394.04 E-value: 6.78e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 12 LAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLF-AEPNPAHYAIAELER 90
Cdd:cd01413 1 LTKSRKTVVLTGAGISTESGIPDFRSPDGLWKKYDPEEVASIDYFYRNPEEFWRFYKEIILGLLeAQPNKAHYFLAELEK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 91 MGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEfVEDFNKGEIPRCRKCGSYyVKPRVVLFGEPLP 170
Cdd:cd01413 81 QGIIKAIITQNIDGLHQRAGSKNVIELHGTLQTAYCVNCGSKYDLEE-VKYAKKHEVPRCPKCGGI-IRPDVVLFGEPLP 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
1S7G_B 171 QRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGK 234
Cdd:cd01413 159 QALLREAIEAAKEADLFIVLGSSLVVYPANLLPLIAKENGAKLVIVNADETPFDYIADLVIQDK 222
|
|
| SIR2 |
COG0846 |
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ... |
3-244 |
5.09e-136 |
|
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440607 Cd Length: 243 Bit Score: 382.59 E-value: 5.09e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 3 DEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLF-AEPNPA 81
Cdd:COG0846 2 TKIERLAELLREAKRIVVLTGAGISAESGIPDFRGPDGLWEKYDPEEVASPEAFRRDPELVWAFYNERRRLLRdAEPNAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 82 HYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSyYVKPR 161
Cdd:COG0846 82 HRALAELEKAGKLVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGKRYDLEDVLEDLEGELPPRCPKCGG-LLRPD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 162 VVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPK 241
Cdd:COG0846 161 VVWFGEMLPEEALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKRAGAPLVEINPEPTPLDSLADLVIRGDAGEVLPA 240
|
...
1S7G_B 242 IVE 244
Cdd:COG0846 241 LVE 243
|
|
| PRK00481 |
PRK00481 |
NAD-dependent deacetylase; Provisional |
3-248 |
6.05e-131 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 234777 Cd Length: 242 Bit Score: 369.51 E-value: 6.05e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 3 DEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEF-SMEMKDKLFAEPNPA 81
Cdd:PRK00481 1 MRIEELAEILDKAKRIVVLTGAGISAESGIPDFRSANGLWEEHRPEDVASPEGFARDPELVWKFyNERRRQLLDAKPNAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 82 HYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVedfnKGEIPRCRKCGSYyVKPR 161
Cdd:PRK00481 81 HRALAELEKLGKLVTVITQNIDGLHERAGSKNVIELHGSLLRARCTKCGQTYDLDEYL----KPEPPRCPKCGGI-LRPD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 162 VVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPK 241
Cdd:PRK00481 156 VVLFGEMLPELAIDEAYEALEEADLFIVIGTSLVVYPAAGLPYEAREHGAKTVEINLEPTPLDSLFDLVIHGKAGEVVPE 235
|
....*..
1S7G_B 242 IVEEVKR 248
Cdd:PRK00481 236 LVEELLA 242
|
|
| SIR2-fam |
cd01407 |
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze ... |
16-234 |
1.54e-124 |
|
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer.
Pssm-ID: 238698 Cd Length: 218 Bit Score: 352.64 E-value: 1.54e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 16 KHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVA-SISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIV 94
Cdd:cd01407 1 KRIVVLTGAGISTESGIPDFRSPGGLWARLDPEELAfSPEAFRRDPELFWGFYRERRYPLNAQPNPAHRALAELERKGKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 95 KAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSyYVKPRVVLFGEPLPQRtL 174
Cdd:cd01407 81 KRVITQNVDGLHQRAGSPKVIELHGSLFRVRCTKCGKEYPRDELQADIDREEVPRCPKCGG-LLRPDVVFFGESLPEE-L 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 175 FEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGK 234
Cdd:cd01407 159 DEAAEALAKADLLLVIGTSLQVYPAAGLPLYAPERGAPVVIINLEPTPADRKADLVILGD 218
|
|
| SIRT5_Af1_CobB |
cd01412 |
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ... |
16-243 |
1.30e-104 |
|
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.
Pssm-ID: 238703 Cd Length: 224 Bit Score: 302.20 E-value: 1.30e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 16 KHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEF-SMEMKDKLFAEPNPAHYAIAELERMGIV 94
Cdd:cd01412 1 RRVVVLTGAGISAESGIPTFRDADGLWARFDPEELATPEAFARDPELVWEFyNWRRRKALRAQPNPAHLALAELERRLPN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 95 KAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWsefVEDFNKGEIPRCRKCGSyYVKPRVVLFGEPLPQrTL 174
Cdd:cd01412 81 VLLITQNVDGLHERAGSRNVIELHGSLFRVRCSSCGYVGEN---NEEIPEEELPRCPKCGG-LLRPGVVWFGESLPL-AL 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
1S7G_B 175 FEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIV 243
Cdd:cd01412 156 LEAVEALAKADLFLVIGTSGVVYPAAGLPEEAKERGARVIEINPEPTPLSPIADFAFRGKAGEVLPALL 224
|
|
| SIR2 |
cd00296 |
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ... |
16-234 |
4.03e-99 |
|
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.
Pssm-ID: 238184 [Multi-domain] Cd Length: 222 Bit Score: 288.47 E-value: 4.03e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 16 KHAVVFTGAGISAESGIPTFRGED-GLWRKYDPEEVA-SISGFKRNPRAFWEFSMEMKDKLF-AEPNPAHYAIAELERMG 92
Cdd:cd00296 1 KRVVVFTGAGISTESGIPDFRGLGtGLWTRLDPEELAfSPEAFRRDPELFWLFYKERRYTPLdAKPNPAHRALAELERKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 93 IVKAVITQNIDMLHQRAGSR--RVLELHGSMDKLDCLDCHETYDWSEFVEDFnkgEIPRCRKCGSYyVKPRVVLFGEPLP 170
Cdd:cd00296 81 KLKRIITQNVDGLHERAGSRrnRVIELHGSLDRVRCTSCGKEYPRDEVLERE---KPPRCPKCGGL-LRPDVVDFGEALP 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
1S7G_B 171 QRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMAD--PIFDVKIIGK 234
Cdd:cd00296 157 KEWFDRALEALLEADLVLVIGTSLTVYPAARLLLRAPERGAPVVIINREPTPADalKKADLVILGD 222
|
|
| SIR2 |
pfam02146 |
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ... |
23-198 |
8.65e-88 |
|
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i
Pssm-ID: 426621 Cd Length: 179 Bit Score: 257.95 E-value: 8.65e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 23 GAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWE---FSMEMKDKLF--AEPNPAHYAIAELERMGIVKAV 97
Cdd:pfam02146 1 GAGISTESGIPDFRSDDGLYAKLAPEELASPEAFFSNPELVWDpepFYNIARELLPgeAQPNPAHYFIAKLEDKGKLLRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 98 ITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSyYVKPRVVLFGEPLPqRTLFEA 177
Cdd:pfam02146 81 ITQNIDGLHERAGSKKVVELHGSFAKARCVSCHQKYTGETLYERIRPEKVPHCPQCGG-LLKPDIVFFGENLP-DKFHRA 158
|
170 180
....*....|....*....|.
1S7G_B 178 IEEAKHCDAFMVVGSSLVVYP 198
Cdd:pfam02146 159 YEDLEEADLLIVIGTSLKVYP 179
|
|
| PRK14138 |
PRK14138 |
NAD-dependent deacetylase; Provisional |
10-231 |
1.34e-73 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 172627 [Multi-domain] Cd Length: 244 Bit Score: 224.32 E-value: 1.34e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 10 EILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYdPEEVASISGFKRNPRAFWEFSMEMKDKLF-AEPNPAHYAIAEL 88
Cdd:PRK14138 6 ELLNESRLTVTLTGAGISTPSGIPDFRGPQGIYKKY-PQNVFDIDFFYSHPEEFYRFAKEGIFPMLeAKPNLAHVLLAKL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 89 ERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSyYVKPRVVLFGEP 168
Cdd:PRK14138 85 EEKGLIEAVITQNIDRLHQKAGSKKVIELHGNVEEYYCVRCGKRYTVEDVIEKLEKSDVPRCDDCSG-LIRPNIVFFGEA 163
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
1S7G_B 169 LPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKI 231
Cdd:PRK14138 164 LPQDALREAIRLSSKASLMIVMGSSLVVYPAAELPLITVRSGGKLVIVNLGETPLDDIATLKY 226
|
|
| SIRT7 |
cd01410 |
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ... |
16-234 |
5.25e-70 |
|
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238701 Cd Length: 206 Bit Score: 213.70 E-value: 5.25e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 16 KHAVVFTGAGISAESGIPTFRGEDGLWRKyDPEEvasisgfKRNPRAFWEFSmemkdklFAEPNPAHYAIAELERMGIVK 95
Cdd:cd01410 1 KHLVVFTGAGISTSAGIPDFRGPNGVWTL-LPED-------KGRRRFSWRFR-------RAEPTLTHMALVELERAGLLK 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 96 AVITQNIDMLHQRAGSRR--VLELHGSMDKLDCLDCHETYD-WSEFVEDFNKGEIPRCRKCGSYyVKPRVVLFGEPLPQR 172
Cdd:cd01410 66 FVISQNVDGLHLRSGLPRekLSELHGNMFIEVCKSCGPEYVrDDVVETRGDKETGRRCHACGGI-LKDTIVDFGERLPPE 144
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
1S7G_B 173 TLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGK 234
Cdd:cd01410 145 NWMGAAAAACRADLFLCLGTSLQVTPAANLPLKAARAGGRLVIVNLQPTPKDKLADLVIHGD 206
|
|
| SIR2H |
cd01411 |
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species ... |
10-239 |
1.38e-68 |
|
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238702 Cd Length: 225 Bit Score: 211.07 E-value: 1.38e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 10 EILAKSKHAVVFTGAGISAESGIPTFRGEDGLW---RKYDPEEVASISGFKRNPRAFWEFsmeMKDKLF---AEPNPAHY 83
Cdd:cd01411 3 HILKNAKRIVFFTGAGVSTASGIPDYRSKNGLYneiYKYSPEYLLSHDFLEREPEKFYQF---VKENLYfpdAKPNIIHQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 84 AIAELERMGIvKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDfnkgeiPRCRKCGSyYVKPRVV 163
Cdd:cd01411 80 KMAELEKMGL-KAVITQNIDGLHQKAGSKNVVEFHGSLYRIYCTVCGKTVDWEEYLKS------PYHAKCGG-VIRPDIV 151
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
1S7G_B 164 LFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELpyIA-KKAGAKMIIVNAEPTMADPIFDVkIIGKAGEVL 239
Cdd:cd01411 152 LYEEMLNESVIEEAIQAIEKADLLVIVGTSFVVYPFAGL--IDyRQAGANLIAINKEPTQLDSPATL-VIKDAVKVF 225
|
|
| SIRT4 |
cd01409 |
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and ... |
12-239 |
1.51e-65 |
|
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238700 Cd Length: 260 Bit Score: 204.45 E-value: 1.51e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 12 LAKSKHAVVFTGAGISAESGIPTFRGEDGLW-RKYDPeevASISGFKRNPRA---FWEFSM----EMKDklfAEPNPAHY 83
Cdd:cd01409 5 VARSRRLLVLTGAGISTESGIPDYRSEGGLYsRTFRP---MTHQEFMRSPAArqrYWARSFvgwpRFSA---AQPNAAHR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 84 AIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEF------------------------- 138
Cdd:cd01409 79 ALAALEAAGRLHGLITQNVDGLHTKAGSRNVVELHGSLHRVVCLSCGFRTPRAELqdrlealnpgfaeqaagqapdgdvd 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 139 --VEDFNKGEIPRCRKCGSYyVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIV 216
Cdd:cd01409 159 leDEQVAGFRVPECERCGGV-LKPDVVFFGENVPRDRVVTAAARLAEADALLVLGSSLMVYSGYRFVLAAAEAGLPIAIV 237
|
250 260
....*....|....*....|...
1S7G_B 217 NAEPTMADPIFDVKIIGKAGEVL 239
Cdd:cd01409 238 NIGPTRADHLATLKVDARCGEVL 260
|
|
| PTZ00409 |
PTZ00409 |
Sir2 (Silent Information Regulator) protein; Provisional |
9-253 |
2.78e-64 |
|
Sir2 (Silent Information Regulator) protein; Provisional
Pssm-ID: 173599 [Multi-domain] Cd Length: 271 Bit Score: 201.69 E-value: 2.78e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 9 AEILAKSKHAVVFTGAGISAESGIPTFRGE-DGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAE 87
Cdd:PTZ00409 22 ADMIRKCKYVVALTGSGTSAESNIPSFRGPsSSIWSKYDPKIYGTIWGFWKYPEKIWEVIRDISSDYEIELNPGHVALST 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 88 LERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFV----EDFNKGEIPRCrKCGSYYvKPRVV 163
Cdd:PTZ00409 102 LESLGYLKFVVTQNVDGLHEESGNTKVIPLHGSVFEARCCTCRKTIQLNKIMlqktSHFMHQLPPEC-PCGGIF-KPNVI 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 164 LFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPT-MADPIFDVKIIGKAGEvLPKI 242
Cdd:PTZ00409 180 LFGEVIPKSLLKQAEKEIDKCDLLLVVGTSSSVSTATNLCYRAHRKKKKIVEVNISKTyITNRISDYHVRAKFSE-LAQI 258
|
250
....*....|.
1S7G_B 243 VEEVKRlRSEK 253
Cdd:PTZ00409 259 SDILKG-RSEK 268
|
|
| PTZ00408 |
PTZ00408 |
NAD-dependent deacetylase; Provisional |
19-251 |
1.30e-62 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 240405 Cd Length: 242 Bit Score: 196.20 E-value: 1.30e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 19 VVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFA---EPNPAHYAIAELER--MGI 93
Cdd:PTZ00408 8 TILTGAGISAESGISTFRDGNGLWENHRVEDVATPDAFLRNPALVQRFYNERRRALLSssvKPNKAHFALAKLEReyRGG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 94 VKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDfnkgEIPRCRKCGSY-YVKPRVVLFGE-PLPQ 171
Cdd:PTZ00408 88 KVVVVTQNVDNLHERAGSTHVLHMHGELLKVRCTATGHVFDWTEDVVH----GSSRCKCCGCVgTLRPHIVWFGEmPLYM 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 172 RTLFEAIEEAkhcDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLRS 251
Cdd:PTZ00408 164 DEIESVMSKT---DLFVAVGTSGNVYPAAGFVGRAQFYGATTLELNLEEGTNYSQFDESIYGKASVIVPAWVDRVLKLSN 240
|
|
| SIRT1 |
cd01408 |
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and ... |
16-233 |
3.67e-53 |
|
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The nuclear SIRT1 has been shown to target the p53 tumor suppressor protein for deacetylation to suppress DNA damage, and the cytoplasmic SIRT2 homolog has been shown to target alpha-tubulin for deacetylation for the maintenance of cell integrity.
Pssm-ID: 238699 Cd Length: 235 Bit Score: 172.05 E-value: 3.67e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 16 KHAVVFTGAGISAESGIPTFRGED-GLW---RKY---DPEEVASISGFKRNPRAFWEFSMEMKDKLFaEPNPAHYAIAEL 88
Cdd:cd01408 1 KKIVVLVGAGISTSAGIPDFRSPGtGLYanlARYnlpYPEAMFDISYFRKNPRPFYALAKELYPGQF-KPSVAHYFIKLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 89 ERMGIVKAVITQNIDMLHQRAG--SRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYyVKPRVVLFG 166
Cdd:cd01408 80 EDKGLLLRNYTQNIDTLERVAGvpDDRIIEAHGSFATAHCIKCKHKYPGDWMREDIFNQEVPKCPRCGGL-VKPDIVFFG 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 167 EPLPQRtLFEAIEEAKH-CDAFMVVGSSLVVYPAAELPYIAkKAGAKMIIVNAEPT--MADPIFDVKIIG 233
Cdd:cd01408 159 ESLPSR-FFSHMEEDKEeADLLIVIGTSLKVAPFASLPSRV-PSEVPRVLINREPVghLGKRPFDVALLG 226
|
|
| PRK05333 |
PRK05333 |
NAD-dependent protein deacetylase; |
19-244 |
6.10e-50 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 235415 Cd Length: 285 Bit Score: 165.24 E-value: 6.10e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 19 VVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMeMKDKLF--AEPNPAHYAIAELERMGIVKA 96
Cdd:PRK05333 23 FVLTGAGISTDSGIPDYRDRNGQWKRSPPITYQAFMGSDAARRRYWARSM-VGWPVFgrAQPNAAHHALARLGAAGRIER 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 97 VITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVE---------------------------DFNKGEIPR 149
Cdd:PRK05333 102 LVTQNVDGLHQRAGSRDVIELHGRLDGVRCMGCGARHPRAEIQHvleaanpewlaleaapapdgdadlewaAFDHFRVPA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 150 CRKCGSYyVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDV 229
Cdd:PRK05333 182 CPACGGI-LKPDVVFFGENVPRERVAAARAALDAADAVLVVGSSLMVYSGYRFCVWAAQQGKPIAALNLGRTRADPLLTL 260
|
250
....*....|....*
1S7G_B 230 KIIGKAGEVLPKIVE 244
Cdd:PRK05333 261 KVEASCAQALAALVA 275
|
|
| PTZ00410 |
PTZ00410 |
NAD-dependent SIR2; Provisional |
20-208 |
2.86e-28 |
|
NAD-dependent SIR2; Provisional
Pssm-ID: 185600 Cd Length: 349 Bit Score: 109.96 E-value: 2.86e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 20 VFTGAGISAESGIPTFRGED-GLWRKY------DPEEVASISGFKRNPRAFWEFSMEMKdkLFA---EPNPAHYAIAELE 89
Cdd:PTZ00410 34 VMVGAGISVAAGIPDFRSPHtGIYAKLgkynlnSPTDAFSLTLLREKPEVFYSIAREMD--LWPghfQPTAVHHFIRLLA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 90 RMGIVKAVITQNIDMLHQRAG--SRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSyYVKPRVVLFGE 167
Cdd:PTZ00410 112 DEGRLLRCCTQNIDGLERAAGvpPSLLVEAHGSFSAASCIECHTPYDIEQAYLEARSGKVPHCSTCGG-IVKPDVVFFGE 190
|
170 180 190 200
....*....|....*....|....*....|....*....|.
1S7G_B 168 PLPQrTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKK 208
Cdd:PTZ00410 191 NLPD-AFFNVHHDIPEAELLLIIGTSLQVHPFALLACVVPK 230
|
|
| SIR2-like |
cd01406 |
Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key ... |
16-123 |
6.53e-04 |
|
Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation.
Pssm-ID: 238697 [Multi-domain] Cd Length: 242 Bit Score: 40.08 E-value: 6.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1S7G_B 16 KHAVVFTGAGISAESGIPTFRG------------EDGLWR-KYDPEEVASISG--FKRNPRAFW-----EFSMEMKDKlf 75
Cdd:cd01406 1 GRVVIFVGAGVSVSSGLPDWKTlldeiaselgleIDGYSVeAKDENDYLELAEllEKEFGTIGIkinavLEEKTRPDF-- 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
1S7G_B 76 aEPNPAHYAIAEL-----------------------ERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDK 123
Cdd:cd01406 79 -EPSPLHELLLRLfinnegdviiittnydrlletalKEINKVVKVIVSVQLALSASARFNGVYKIHGDVDD 148
|
|
| |
