NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|83754266|pdb|2B6P|A]
View 

Chain A, Lens fiber major intrinsic protein

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 3-219 7.69e-99

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 288.06  E-value: 7.69e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A          3 ELRSASFWRAICAEFFASLFYVFFGLGASLRWAP-----GPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLV 77
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKlvsslAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A         78 GSQMSLLRAICYMVAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRL 157
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
2B6P_A        158 GSVA-LAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLY 219
Cdd:pfam00230 161 GTVApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 3-219 7.69e-99

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 288.06  E-value: 7.69e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A          3 ELRSASFWRAICAEFFASLFYVFFGLGASLRWAP-----GPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLV 77
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKlvsslAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A         78 GSQMSLLRAICYMVAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRL 157
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
2B6P_A        158 GSVA-LAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLY 219
Cdd:pfam00230 161 GTVApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 11-222 3.00e-75

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 228.29  E-value: 3.00e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A       11 RAICAEFFASLFYVFFGLGASLRWAPG---PLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAI 87
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAggaSGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A       88 CYMVAQLLGAVAGAAVLYSVTPPAVRGNLALN---------TLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRLG 158
Cdd:cd00333  81 PYIIAQLLGAILGAALLYGLYYGLYLEFLGANnivagifgtYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPPG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
2B6P_A      159 SVA-LAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFT---NHWVYWVGPVIGAGLGSLLYDFL 222
Cdd:cd00333 161 GLApLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARhwhYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 15-219 1.74e-74

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 226.03  E-value: 1.74e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A         15 AEFFASLFYVFFGLGASL-------RWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAI 87
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnvagaYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A         88 CYMVAQLLGAVAGAAVLYSVTPPAVRGNLALNTLH-PGVSVGQATIVEIFLTLQFVLCIFATYDERRNG-RLGSVALAVG 165
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSAsAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVpRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
2B6P_A        166 FSLTLGHLFGMYYTGAGMNPARSFAPAILTR--NFTNHWVYWVGPVIGAGLGSLLY 219
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGlaGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 8-223 6.13e-53

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 171.46  E-value: 6.13e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A        8 SFWRAICAEFFASLFYVFFGLG--ASLRWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLR 85
Cdd:COG0580   1 SLMKRLLAEFLGTFILVLLGCGvvAVLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A       86 AICYMVAQLLGAVAGAAVLYSVTPPAVRG-NLALNTLH-------PGVSVGQATIVEIFLTLQFVLCIFATYDERR-NGR 156
Cdd:COG0580  81 VLPYIIAQLLGAFLGAALVYLIYGGHFDAtEDGGAKLGvfatspaIGYSLGAAFLTEIIGTFVLVFVILGITDKRAaPGG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
2B6P_A      157 LGsvALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAIL------TRNFTNHWVYWVGPVIGAGLGSLLYDFLL 223
Cdd:COG0580 161 LA--PLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFhalgkgGSDWGYLWVPIVAPILGAALAALLYRALF 231
PLN00027 PLN00027
aquaporin TIP; Provisional
 11-222 2.77e-44

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 149.94  E-value: 2.77e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A        11 RAICAEFFASLFYVFFGLGASLRW-------APGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSL 83
Cdd:PLN00027  21 KAALAEFISTLIFVFAGEGSGMAFnkltdngSTTPAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNITL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A        84 LRAICYMVAQLLGAVAGAAVLYSVTPPAVRGNLALNtlhPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRLGSVA-L 162
Cdd:PLN00027 101 LRGILYWIAQLLGSVVACLLLKFSTGGLETSAFSLS---SGVGVWNAFVFEIVMTFGLVYTVYATAVDPKKGDLGIIApI 177

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A       163 AVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLYDFL 222
Cdd:PLN00027 178 AIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELI 237
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 3-219 7.69e-99

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 288.06  E-value: 7.69e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A          3 ELRSASFWRAICAEFFASLFYVFFGLGASLRWAP-----GPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLV 77
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKlvsslAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A         78 GSQMSLLRAICYMVAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRL 157
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
2B6P_A        158 GSVA-LAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLY 219
Cdd:pfam00230 161 GTVApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 11-222 3.00e-75

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 228.29  E-value: 3.00e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A       11 RAICAEFFASLFYVFFGLGASLRWAPG---PLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAI 87
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAggaSGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A       88 CYMVAQLLGAVAGAAVLYSVTPPAVRGNLALN---------TLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRLG 158
Cdd:cd00333  81 PYIIAQLLGAILGAALLYGLYYGLYLEFLGANnivagifgtYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPPG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
2B6P_A      159 SVA-LAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFT---NHWVYWVGPVIGAGLGSLLYDFL 222
Cdd:cd00333 161 GLApLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARhwhYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 15-219 1.74e-74

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 226.03  E-value: 1.74e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A         15 AEFFASLFYVFFGLGASL-------RWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAI 87
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnvagaYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A         88 CYMVAQLLGAVAGAAVLYSVTPPAVRGNLALNTLH-PGVSVGQATIVEIFLTLQFVLCIFATYDERRNG-RLGSVALAVG 165
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSAsAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVpRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
2B6P_A        166 FSLTLGHLFGMYYTGAGMNPARSFAPAILTR--NFTNHWVYWVGPVIGAGLGSLLY 219
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGlaGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 8-223 6.13e-53

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 171.46  E-value: 6.13e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A        8 SFWRAICAEFFASLFYVFFGLG--ASLRWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLR 85
Cdd:COG0580   1 SLMKRLLAEFLGTFILVLLGCGvvAVLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A       86 AICYMVAQLLGAVAGAAVLYSVTPPAVRG-NLALNTLH-------PGVSVGQATIVEIFLTLQFVLCIFATYDERR-NGR 156
Cdd:COG0580  81 VLPYIIAQLLGAFLGAALVYLIYGGHFDAtEDGGAKLGvfatspaIGYSLGAAFLTEIIGTFVLVFVILGITDKRAaPGG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
2B6P_A      157 LGsvALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAIL------TRNFTNHWVYWVGPVIGAGLGSLLYDFLL 223
Cdd:COG0580 161 LA--PLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFhalgkgGSDWGYLWVPIVAPILGAALAALLYRALF 231
PLN00027 PLN00027
aquaporin TIP; Provisional
 11-222 2.77e-44

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 149.94  E-value: 2.77e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A        11 RAICAEFFASLFYVFFGLGASLRW-------APGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSL 83
Cdd:PLN00027  21 KAALAEFISTLIFVFAGEGSGMAFnkltdngSTTPAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNITL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A        84 LRAICYMVAQLLGAVAGAAVLYSVTPPAVRGNLALNtlhPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRLGSVA-L 162
Cdd:PLN00027 101 LRGILYWIAQLLGSVVACLLLKFSTGGLETSAFSLS---SGVGVWNAFVFEIVMTFGLVYTVYATAVDPKKGDLGIIApI 177

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A       163 AVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLYDFL 222
Cdd:PLN00027 178 AIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELI 237
PLN00166 PLN00166
aquaporin TIP2; Provisional
 6-219 3.54e-36

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 128.90  E-value: 3.54e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A         6 SASFWRAICAEFFASLFYVFFGLGASLRWAP-------GPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVG 78
Cdd:PLN00166  14 SVASLKAYLSEFIATLLFVFAGVGSAIAFAKltsdaalDPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A        79 SQMSLLRAICYMVAQLLGAVAGAAVLYSVTPPAvrgNLALNTLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRLG 158
Cdd:PLN00166  94 GNITIITGFFYWIAQCLGSIVACLLLVFVTNGE---SVPTHGVAAGLGAIEGVVMEIVVTFALVYTVYATAADPKKGSLG 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
2B6P_A       159 SVA-LAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLY 219
Cdd:PLN00166 171 TIApIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIY 232
PRK05420 PRK05420
aquaporin Z; Provisional
 11-223 2.16e-34

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 123.54  E-value: 2.16e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A        11 RAICAEFFASLFYVFFGLGASLRWAPGP---LHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAI 87
Cdd:PRK05420   3 KKLAAEFFGTFWLVFGGCGSAVLAAAFPelgIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKELV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A        88 CYMVAQLLGAVAGAAVLYSVTP-----PAVRGNLALN--TLHP--GVSVGQATIVEIFLTLQFVLCIFATYDERRNGrlG 158
Cdd:PRK05420  83 PYIIAQVVGGIAAAAVLYLIASgkagfDLAGSGFASNgyGEHSpgGYSLLAALVCEVVLTAFFLLVILGATDKRAPA--G 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
2B6P_A       159 SVALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNF--TNHWVYWVGPVIGAGLGSLLYDFLL 223
Cdd:PRK05420 161 FAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWalEQLWLFWVAPIVGAIIGGLIYRLLL 227
PLN00167 PLN00167
aquaporin TIP5; Provisional
 11-225 1.21e-32

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 120.01  E-value: 1.21e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A        11 RAICAEFFASLFYVFFGLGASLR-------WAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSL 83
Cdd:PLN00167  23 RSYLAEFISTFFFVFAAVGSAMSsrklmpdAASDPSSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGGHISV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A        84 LRAICYMVAQLLGAVAgAAVLYSVTppAVRGNLALNTLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRnGRLGSVA-L 162
Cdd:PLN00167 103 PTAMFYWISQMLASVM-ACLFLKVT--TVGQHVPTYKIAEEMTGFGASVLEGVLTFGLVYTVYAAGDPRR-GLLGAIGpL 178

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
2B6P_A       163 AVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLYDFLLFP 225
Cdd:PLN00167 179 AIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYDNVVFP 241
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 15-245 6.28e-28

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 108.07  E-value: 6.28e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A        15 AEFFASLFYVFFGLGASL--RWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAICYMVA 92
Cdd:PLN00182  47 AEMIGTYFIIFSGCGVVVvnVLYGGTITFPGICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVPLYIGA 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A        93 QLLGAVAGA---AVLYSVTPPAVRGNLalntlhPGVSVGQATIVEIFLT--LQFVLCIFATyDERRNGRLGSVAlaVGFS 167
Cdd:PLN00182 127 QLTGSLLASltlRLMFNVTPEAFFGTT------PTDSSGQALVAEIIISflLMFVISGVAT-DSRAVGELAGIA--VGMT 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A       168 LTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLYDFLLFPR--LKSVSERLSILKGSRPSES 245
Cdd:PLN00182 198 IILNVFVAGPISGASMNPARSLGPAIVMGRYKGIWVYIVGPFVGIIAGGFVYNLIRFTDkpLRELTKSASFLRSVSQKHN 277
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 2-225 2.05e-27

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 107.13  E-value: 2.05e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A         2 WELRS-ASFWRAICAEFFASLFYVFFGLG--ASLRWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVG 78
Cdd:PTZ00016  41 WAPREyRPNVREYVAEFLGTFVLLFFGEGvvATTHTVGNNGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVF 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A        79 SQMSLLRAICYMVAQLLGAVAGAAVLYSVTPPAVR--------------GNLALNTLHPGVSVGQATIVEIFLTLQFVLC 144
Cdd:PTZ00016 121 GKFPWKKLPGYFVAQLLGAFVGAACVYGLYYGFFKdhgipelpwetmanGFAGVFATYPREGNFYAIFSELILTAILLLV 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A       145 IFATYDERRNGRLGSVALAVGFS-LTLGHLFGmYYTGAGMNPARSFAPAILT------RNFTNH----WVYWVGPVIGAG 213
Cdd:PTZ00016 201 ILAITDPNNCPAFNYLPVAVGLLvFVIGISFG-GNTGYALNPARDLGPRLFSailwgsEVFTKDnyyfWVPLVAPFVGAV 279

                        250
                 ....*....|..
2B6P_A       214 LGSLLYDFLLFP 225
Cdd:PTZ00016 280 LGMFLYDKFIPP 291
PLN00026 PLN00026
aquaporin NIP; Provisional
 8-219 4.48e-26

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 103.40  E-value: 4.48e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A         8 SFWRAICAEFFASLFYVFFGLGASL--RWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLR 85
Cdd:PLN00026  69 SLTRKLGAEFVGTFILIFAATAGPIvnQKYDGAETLIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPWKH 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A        86 AICYMVAQLLGAVAGAAVLYSVTPPAVRGNLALntlhPGVSVGQATIVEIFLT--LQFVLCIFATyDERRNGRLGSVAla 163
Cdd:PLN00026 149 VPAYIAAQVSASICASFALKGVFHPFMSGGVTV----PSVSTGQAFALEFIITfnLLFVVTAVAT-DTRAVGELAGIA-- 221

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
2B6P_A       164 VGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLY 219
Cdd:PLN00026 222 VGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTY 277
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 11-222 2.69e-25

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 100.70  E-value: 2.69e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A        11 RAICAEFFASLFYVF--FGLGASLRWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAIC 88
Cdd:PLN00183  46 RMVLAEMVGTFILMFcvCGIIASTQLSGGEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVPL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A        89 YMVAQLLGAVAGAAVLYSVTPPavrgNLALNTLHPGVSVGQATIVEIFLTLQFV-LCIFATYDERRNGRLGsvALAVGFS 167
Cdd:PLN00183 126 YITAQTVGSVLATYVGVSVYGV----KADLMTTKPAQGCSSAFWVEFIATFIVMfLAASLTSQPQSLGHLS--GFVIGIA 199

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
2B6P_A       168 LTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLYDFL 222
Cdd:PLN00183 200 IGLAVLITGPVSGGSMNPARSLGPAIVSWDFKDIWIYITAPTIGAVAGALMFHLL 254
PLN00184 PLN00184
aquaporin NIP1; Provisional
 6-241 3.68e-25

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 100.87  E-value: 3.68e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A         6 SASFWRAICAEFFASLFYVFFGLGA--------SLRWAPGplhvlqVALAFGLALATLVQAVGHISGAHVNPAVTFAFLV 77
Cdd:PLN00184  50 SVPFLQKLIAEVLGTYFLVFTGCASvvvnmqndNVVTLPG------IAIVWGLTIMVLIYSLGHISGAHINPAVTIAFAS 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A        78 GSQMSLLRAICYMVAQLLGAVAGAA---VLYSVTPPAVRG--NLALNTLHPGVSVgQATIVEIFLT--LQFVLCIFATyD 150
Cdd:PLN00184 124 CGRFPLKQVPAYVISQVIGSTLAAAtlrLLFGLDHDVCSGkhDVFIGSSPVGSDL-QAFVMEFIVTfyLMFIISGVAT-D 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B6P_A       151 ERRNGRLGsvALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLYDFLLFPR--LK 228
Cdd:PLN00184 202 NRAIGELA--GLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVYNTVRYTDkpLR 279

                        250
                 ....*....|...
2B6P_A       229 SVSERLSILKGSR 241
Cdd:PLN00184 280 EITKSGSFLKTVR 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH