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Conserved domains on  [gi|159164276|pdb|2DOA|A]
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Chain A, RNA polymerase II elongation factor ELL

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ELL super family cl28770
RNA polymerase II elongation factor ELL; ELL is a family of RNA polymerase II elongation ...
 10-98 2.56e-55

RNA polymerase II elongation factor ELL; ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity. by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF. Some members carry an Occludin domain pfam07303 just downstream. There is no S. cerevisiae member.


The actual alignment was detected with superfamily member pfam10390:

Pssm-ID: 463068  Cd Length: 281  Bit Score: 172.85  E-value: 2.56e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DOA_A         10 QRPFRDRVLHLLALRPYRKAELLLRLQKDGLTQADKDALDGLLQQVANMSAKDGTCTLQDCMYKDVQKDWPGYSEGDQQL 89
Cdd:pfam10390 193 QRPLRERVIHLLALKPYKKPELLLRLQKDGLSQKDKNSLGSILQEVANLNPKDNTYTLKDHLYKEVQKDWPGYSEGDRQL 272


                  ....*....
2DOA_A         90 LKRVLVRKL 98
Cdd:pfam10390 273 LKRILVRKL 281
 
Name Accession Description Interval E-value
ELL pfam10390
RNA polymerase II elongation factor ELL; ELL is a family of RNA polymerase II elongation ...
 10-98 2.56e-55

RNA polymerase II elongation factor ELL; ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity. by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF. Some members carry an Occludin domain pfam07303 just downstream. There is no S. cerevisiae member.


Pssm-ID: 463068  Cd Length: 281  Bit Score: 172.85  E-value: 2.56e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DOA_A         10 QRPFRDRVLHLLALRPYRKAELLLRLQKDGLTQADKDALDGLLQQVANMSAKDGTCTLQDCMYKDVQKDWPGYSEGDQQL 89
Cdd:pfam10390 193 QRPLRERVIHLLALKPYKKPELLLRLQKDGLSQKDKNSLGSILQEVANLNPKDNTYTLKDHLYKEVQKDWPGYSEGDRQL 272


                  ....*....
2DOA_A         90 LKRVLVRKL 98
Cdd:pfam10390 273 LKRILVRKL 281
 
Name Accession Description Interval E-value
ELL pfam10390
RNA polymerase II elongation factor ELL; ELL is a family of RNA polymerase II elongation ...
 10-98 2.56e-55

RNA polymerase II elongation factor ELL; ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity. by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF. Some members carry an Occludin domain pfam07303 just downstream. There is no S. cerevisiae member.


Pssm-ID: 463068  Cd Length: 281  Bit Score: 172.85  E-value: 2.56e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2DOA_A         10 QRPFRDRVLHLLALRPYRKAELLLRLQKDGLTQADKDALDGLLQQVANMSAKDGTCTLQDCMYKDVQKDWPGYSEGDQQL 89
Cdd:pfam10390 193 QRPLRERVIHLLALKPYKKPELLLRLQKDGLSQKDKNSLGSILQEVANLNPKDNTYTLKDHLYKEVQKDWPGYSEGDRQL 272


                  ....*....
2DOA_A         90 LKRVLVRKL 98
Cdd:pfam10390 273 LKRILVRKL 281
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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