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Conserved domains on  [gi|112491206|pdb|2H9N|A]
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Chain A, WD-repeat protein 5

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-309 2.88e-112

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 330.72  E-value: 2.88e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       15 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 94
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       95 VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 174
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A      175 RIWDTASGQCLKTLiDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIfaNFSvTGGKWIV 254
Cdd:COG2319 271 RLWDLATGELLRTL-TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS-PDGKTLA 346

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
2H9N_A      255 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLW 309
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-309 2.88e-112

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 330.72  E-value: 2.88e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       15 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 94
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       95 VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 174
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A      175 RIWDTASGQCLKTLiDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIfaNFSvTGGKWIV 254
Cdd:COG2319 271 RLWDLATGELLRTL-TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS-PDGKTLA 346

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
2H9N_A      255 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLW 309
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-310 2.85e-104

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 306.57  E-value: 2.85e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       16 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 95
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       96 SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 175
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A      176 IWDTASGQCLKTLIDDDNpPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNekYCIFANFSvTGGKWIVS 255
Cdd:cd00200 161 LWDLRTGKCVATLTGHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN--GVNSVAFS-PDGYLLAS 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
2H9N_A      256 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALenDKTIKLWK 310
Cdd:cd00200 237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA--DGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 20-266 4.35e-19

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 87.83  E-value: 4.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A        20 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA----YDGK---FEKTISGHKLGISDVAWSSDSNLLVSASD-DKTLK 91
Cdd:PLN00181 479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECesiiKDGRdihYPVVELASRSKLSGICWNSYIKSQVASSNfEGVVQ 558

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A        92 IWDVSSGKCLKTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDpVSAVHFNRD-GSLIVSSS 169
Cdd:PLN00181 559 VWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAFGS 637

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       170 YDGLCRIWDTASGQC-LKTLIDDdNPPVSFVKFSPNGKYILAATlDNTLKLWDYSKGKC------LKTYTGHKNEKYciF 242
Cdd:PLN00181 638 ADHKVYYYDLRNPKLpLCTMIGH-SKTVSYVRFVDSSTLVSSST-DNTLKLWDLSMSISginetpLHSFMGHTNVKN--F 713

                        250       260
                 ....*....|....*....|....
2H9N_A       243 ANFSVTGGkWIVSGSEDNLVYIWN 266
Cdd:PLN00181 714 VGLSVSDG-YIATGSETNEVFVYH 736
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 97-136 6.54e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 6.54e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
2H9N_A          97 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 136
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
98-136 5.79e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.81  E-value: 5.79e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
2H9N_A         98 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 136
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 82-208 3.44e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 38.48  E-value: 3.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A         82 VSASDDKTLKIWDVSSGKCLKTLK------GhsnyvfcCNFNPQSNLI-VSGSFDESVRIWDVKTGKCLKTLPAHSDP-V 153
Cdd:TIGR03866  15 VSNEKDNTISVIDTATLKVTRTFPvgqrprG-------ITFSKDGKLLyVCASDSDTIQVIDPATGEVLHTLPSGPDPeQ 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
2H9N_A        154 SAVHFNrDGSLIVSSSYDGLCRIWDTASGQCLKTLidddnpPVSF----VKFSPNGKYI 208
Cdd:TIGR03866  88 FALHPN-GKILYIANEDDALVTVIDIETRKVLAQI------DVGVepegMAVSPDGKIV 139
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-309 2.88e-112

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 330.72  E-value: 2.88e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       15 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 94
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       95 VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 174
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A      175 RIWDTASGQCLKTLiDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIfaNFSvTGGKWIV 254
Cdd:COG2319 271 RLWDLATGELLRTL-TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS-PDGKTLA 346

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
2H9N_A      255 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLW 309
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-310 2.85e-104

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 306.57  E-value: 2.85e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       16 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 95
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       96 SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 175
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A      176 IWDTASGQCLKTLIDDDNpPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNekYCIFANFSvTGGKWIVS 255
Cdd:cd00200 161 LWDLRTGKCVATLTGHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN--GVNSVAFS-PDGYLLAS 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
2H9N_A      256 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALenDKTIKLWK 310
Cdd:cd00200 237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA--DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
15-309 5.67e-100

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 299.52  E-value: 5.67e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       15 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 94
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       95 VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 174
Cdd:COG2319 149 LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A      175 RIWDTASGQCLKTLiDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIfaNFSvTGGKWIV 254
Cdd:COG2319 229 RLWDLATGKLLRTL-TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV--AFS-PDGKLLA 304

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
2H9N_A      255 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLW 309
Cdd:COG2319 305 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS--DDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
15-309 3.45e-86

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 264.47  E-value: 3.45e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       15 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 94
Cdd:COG2319  27 ALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWD 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       95 VSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 174
Cdd:COG2319 107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A      175 RIWDTASGQCLKTLIDDDNpPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIfaNFSvTGGKWIV 254
Cdd:COG2319 187 RLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV--AFS-PDGRLLA 262

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
2H9N_A      255 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLW 309
Cdd:COG2319 263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS--DDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
19-221 3.97e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 238.66  E-value: 3.97e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       19 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG 98
Cdd:COG2319 199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       99 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 178
Cdd:COG2319 279 ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
2H9N_A      179 TASGQCLKTLIDDDNPpVSFVKFSPNGKYILAATLDNTLKLWD 221
Cdd:COG2319 359 LATGELLRTLTGHTGA-VTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
32-309 1.01e-68

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 219.40  E-value: 1.01e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       32 FSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV 111
Cdd:COG2319   2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A      112 FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 191
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A      192 DNPPVSfVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIfaNFSvTGGKWIVSGSEDNLVYIWNLQTKE 271
Cdd:COG2319 162 SGAVTS-VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS-PDGKLLASGSADGTVRLWDLATGK 237

                       250       260       270
                ....*....|....*....|....*....|....*...
2H9N_A      272 IVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLW 309
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPDGRLLASGS--ADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
16-181 1.15e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 198.60  E-value: 1.15e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       16 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 95
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       96 SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 175
Cdd:COG2319 318 ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVR 397


                ....*.
2H9N_A      176 IWDTAS 181
Cdd:COG2319 398 LWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-178 8.77e-55

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 179.84  E-value: 8.77e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       12 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLK 91
Cdd:cd00200 123 ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIK 202

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       92 IWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 171
Cdd:cd00200 203 LWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                ....*..
2H9N_A      172 GLCRIWD 178
Cdd:cd00200 283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
73-309 2.22e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 169.32  E-value: 2.22e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       73 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDP 152
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A      153 VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSfVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT 232
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRS-VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
2H9N_A      233 GHKNEKYCIfaNFSvTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLW 309
Cdd:COG2319 160 GHSGAVTSV--AFS-PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS--ADGTVRLW 231
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 20-266 4.35e-19

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 87.83  E-value: 4.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A        20 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA----YDGK---FEKTISGHKLGISDVAWSSDSNLLVSASD-DKTLK 91
Cdd:PLN00181 479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECesiiKDGRdihYPVVELASRSKLSGICWNSYIKSQVASSNfEGVVQ 558

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A        92 IWDVSSGKCLKTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDpVSAVHFNRD-GSLIVSSS 169
Cdd:PLN00181 559 VWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAFGS 637

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       170 YDGLCRIWDTASGQC-LKTLIDDdNPPVSFVKFSPNGKYILAATlDNTLKLWDYSKGKC------LKTYTGHKNEKYciF 242
Cdd:PLN00181 638 ADHKVYYYDLRNPKLpLCTMIGH-SKTVSYVRFVDSSTLVSSST-DNTLKLWDLSMSISginetpLHSFMGHTNVKN--F 713

                        250       260
                 ....*....|....*....|....
2H9N_A       243 ANFSVTGGkWIVSGSEDNLVYIWN 266
Cdd:PLN00181 714 VGLSVSDG-YIATGSETNEVFVYH 736
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 72-303 1.32e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 62.03  E-value: 1.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A        72 VAWSSDSNLLVSASDDKTLKIWDVSS----GKCLK----TLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL 143
Cdd:PLN00181 489 IGFDRDGEFFATAGVNKKIKIFECESiikdGRDIHypvvELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLV 568

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       144 KTLPAHSDPVSAVHFNR-DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNppVSFVKF-SPNGKYILAATLDNTLKLWD 221
Cdd:PLN00181 569 TEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN--ICCVQFpSESGRSLAFGSADHKVYYYD 646

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       222 YSKGKC-LKTYTGH-KNEKYCIFANFSVtggkwIVSGSEDNLVYIWNLQ------TKEIVQKLQGHTDVVISTACHPTEN 293
Cdd:PLN00181 647 LRNPKLpLCTMIGHsKTVSYVRFVDSST-----LVSSSTDNTLKLWDLSmsisgiNETPLHSFMGHTNVKNFVGLSVSDG 721

                        250
                 ....*....|
2H9N_A       294 IIASAALEND 303
Cdd:PLN00181 722 YIATGSETNE 731
PTZ00421 PTZ00421
coronin; Provisional
 20-201 4.49e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 60.29  E-value: 4.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A        20 LAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTIS-------GH--KLGISDVAWSSdSNLLVSASDDKT 89
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNISdpivhlqGHtkKVGIVSFHPSA-MNVLASAGADMV 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A        90 LKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVS--AVHFNRDGSLI-- 165
Cdd:PTZ00421 150 VNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCLWAKRKDLIItl 229

                        170       180       190
                 ....*....|....*....|....*....|....*..
2H9N_A       166 -VSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF 201
Cdd:PTZ00421 230 gCSKSQQRQIMLWDTRKMASPYSTVDLDQSSALFIPF 266
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 97-136 6.54e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 6.54e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
2H9N_A          97 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 136
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
52-225 1.02e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 57.78  E-value: 1.02e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       52 GAYDGKFEKTISGHKLGISDVAWSSDSNLL-VSASDDKTLKIWDVSSGKCLKTLK--GHSNYVFccnFNPQ-SNLIVSGS 127
Cdd:COG3391  53 GVALLAGLGLGAAAVADADGADAGADGRRLyVANSGSGRVSVIDLATGKVVATIPvgGGPRGLA---VDPDgGRLYVADS 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A      128 FDESVRIWDVKTGKCLKTLPAHSDPVSAVhFNRDGS-LIVSSSYDGlcRIW------DTASGQCLKTLIDDDNPpvSFVK 200
Cdd:COG3391 130 GNGRVSVIDTATGKVVATIPVGAGPHGIA-VDPDGKrLYVANSGSN--TVSvivsviDTATGKVVATIPVGGGP--VGVA 204

                       170       180       190
                ....*....|....*....|....*....|...
2H9N_A      201 FSPNGKYILAA--------TLDNTLKLWDYSKG 225
Cdd:COG3391 205 VSPDGRRLYVAnrgsntsnGGSNTVSVIDLATL 237
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 139-178 1.69e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 1.69e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
2H9N_A         139 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 178
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
98-136 5.79e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.81  E-value: 5.79e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
2H9N_A         98 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 136
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 55-94 6.47e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 6.47e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
2H9N_A          55 DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 94
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
140-178 7.12e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.81  E-value: 7.12e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
2H9N_A        140 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 178
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
56-94 1.66e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 1.66e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
2H9N_A         56 GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 94
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 94-309 2.82e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.09  E-value: 2.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A        94 DVSSGKCLKTlkghSNYVFCCNFNPQSNLIVSGSFDESVRIWD----VKTGKCLKtLP----AHSDPVSAVHFNRD-GSL 164
Cdd:PLN00181 473 DLKQGDLLNS----SNLVCAIGFDRDGEFFATAGVNKKIKIFEcesiIKDGRDIH-YPvvelASRSKLSGICWNSYiKSQ 547

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       165 IVSSSYDGLCRIWDTASGQcLKTLIDDDNPPVSFVKFSPNGKYILAA-TLDNTLKLWDYSKGKCLKTYTGHKNeKYCIfa 243
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQ-LVTEMKEHEKRVWSIDYSSADPTLLASgSDDGSVKLWSINQGVSIGTIKTKAN-ICCV-- 623

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
2H9N_A       244 NFSVTGGKWIVSGSEDNLVYIWNLQTKEI-VQKLQGHTDVVISTACHPTENIIASAaleNDKTIKLW 309
Cdd:PLN00181 624 QFPSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTLVSSS---TDNTLKLW 687
WD40 pfam00400
WD domain, G-beta repeat;
16-51 5.31e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 5.31e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
2H9N_A         16 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 51
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 16-51 8.89e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 8.89e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
2H9N_A          16 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 51
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 55-296 3.04e-07

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 51.23  E-value: 3.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A         55 DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFccnfnPQSNLIVSGSfdeSVRI 134
Cdd:pfam20426 113 DGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEKRSRNTQTEF-----PRKDHVIAET---PFHI 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A        135 wdvktgkclktLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAtlD 214
Cdd:pfam20426 185 -----------LCGHDDIITCLYVSVELDIVISGSKDGTCIFHTLREGRYVRSIRHPSGCPLSKLVASRHGRIVLYA--D 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A        215 NTLKLWDYS-KGKCLKTYT--GHKNekyCIfaNFSvTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 291
Cdd:pfam20426 252 DDLSLHLYSiNGKHIASSEsnGRLN---CI--ELS-SCGEFLVCAGDQGQIVVRSMNSLEVVRRYNGIGKIITSLTVTPE 325


                  ....*
2H9N_A        292 ENIIA 296
Cdd:pfam20426 326 ECFLA 330
PTZ00420 PTZ00420
coronin; Provisional
 62-141 2.14e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.71  E-value: 2.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A        62 ISGHKLGISDVAWSS-DSNLLVSASDDKTLKIWDV----SSGKCLK----TLKGHSNYVFCCNFNPQSNLIV-SGSFDES 131
Cdd:PTZ00420  70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIphndESVKEIKdpqcILKGHKKKISIIDWNPMNYYIMcSSGFDSF 149

                         90
                 ....*....|
2H9N_A       132 VRIWDVKTGK 141
Cdd:PTZ00420 150 VNIWDIENEK 159
PTZ00420 PTZ00420
coronin; Provisional
 104-178 3.67e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.33  E-value: 3.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       104 LKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIWD----------VKTGKCLktLPAHSDPVSAVHFNRDGSLIV-SSSYD 171
Cdd:PTZ00420  70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEiphndesvkeIKDPQCI--LKGHKKKISIIDWNPMNYYIMcSSGFD 147


                 ....*..
2H9N_A       172 GLCRIWD 178
Cdd:PTZ00420 148 SFVNIWD 154
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 72-159 4.84e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.49  E-value: 4.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A         72 VAWSSDSNLLVSASDDKTL--------KIWDVSsgkclktLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL 143
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELllhrlnwqRVWTLS-------PDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73

                          90
                  ....*....|....*.
2H9N_A        144 KTLPAHSDPVSAVHFN 159
Cdd:pfam12894  74 HHFSAGSDLITCLGWG 89
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
196-260 5.10e-05

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 44.63  E-value: 5.10e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
2H9N_A      196 VSFVKFSPNGKYILAATLdNTLKLWDYSKGK-CLKTYTGHKN---------EKYCIFANFSVT---GGKWIVSGSEDN 260
Cdd:COG5170 283 ISDFKFSDNGRYILSRDY-LTVKIWDVNMAKnPIKTIPMHCDlmdelndvyENDAIFDKFEISfsgDDKHVLSGSYSN 359
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 116-205 1.14e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 42.96  E-value: 1.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A      116 FNPQSNLIVSGSFDESVRIWDVKTGKcLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRiWDTASGQcLKTLIDDDNPP 195
Cdd:COG3386  15 WDPDGRLYWVDIPGGRIHRYDPDGGA-VEVFAEPSGRPNGLAFDPDGRLLVADHGRGLVR-FDPADGE-VTVLADEYGKP 91

                        90
                ....*....|...
2H9N_A      196 VSF---VKFSPNG 205
Cdd:COG3386  92 LNRpndGVVDPDG 104
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 49-117 1.83e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 1.83e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
2H9N_A         49 KIWGAYDGKfektisgHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFN 117
Cdd:pfam12894  28 RVWTLSPDK-------EDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 181-221 2.68e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 2.68e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
2H9N_A         181 SGQCLKTLIDDDNPpVSFVKFSPNGKYILAATLDNTLKLWD 221
Cdd:smart00320   1 SGELLKTLKGHTGP-VTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
225-266 3.80e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 3.80e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
2H9N_A        225 GKCLKTYTGHKNEKYCIFANFSvtgGKWIVSGSEDNLVYIWN 266
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD---GKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
182-221 3.84e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 3.84e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
2H9N_A        182 GQCLKTLIDDDNPpVSFVKFSPNGKYILAATLDNTLKLWD 221
Cdd:pfam00400   1 GKLLKTLEGHTGS-VTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 269-310 4.13e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 4.13e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
2H9N_A         269 TKEIVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLWK 310
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGS--DDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 97-182 4.85e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 41.21  E-value: 4.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A         97 SGKCLKTLKGHSNyvfccNFnpqsnLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 176
Cdd:pfam20426  81 GAQCFATLQTPSE-----NF-----LISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMV 150


                  ....*.
2H9N_A        177 WDTASG 182
Cdd:pfam20426 151 WEVLRG 156
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 29-209 5.46e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.56  E-value: 5.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A        29 SVKFSPNGEWLASSS-ADKLIKIW--GAYDGKFEKTISghKLGISDV---AWSSDSNLLVSASDDKTLKIWDVSSGKC-- 100
Cdd:COG4946  347 LPAWSPDGKSIAYFSdASGEYELYiaPADGSGEPKQLT--LGDLGRVfnpVWSPDGKKIAFTDNRGRLWVVDLASGKVrk 424

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       101 -LKTLKGHSNYVFccNFNPQSNLIV----SGSFDESVRIWDVKTGkclKTLPAhSDPVSavhfnrdgslivsssydglcr 175
Cdd:COG4946  425 vDTDGYGDGISDL--AWSPDSKWLAyskpGPNQLSQIFLYDVETG---KTVQL-TDGRY--------------------- 477

                        170       180       190
                 ....*....|....*....|....*....|....
2H9N_A       176 iwdtasgqclktliDDDNPpvsfvKFSPNGKYIL 209
Cdd:COG4946  478 --------------DDGSP-----AFSPDGKYLY 492
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 80-212 5.64e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 39.66  E-value: 5.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       80 LLVSASDDKTLKIW--DVSSGKcLKTLKGHSNYVFCCNFNPQSNLIV-----SGSFDesVRIWDVKTGKcLKTLPAHSDP 152
Cdd:COG0823   1 LAFTLSRDGNSDIYvvDLDGGE-PRRLTNSPGIDTSPAWSPDGRRIAftsdrGGGPQ--IYVVDADGGE-PRRLTFGGGY 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
2H9N_A      153 VSAVHFNRDGSLIVSSSY-DGLCRIW--DTASGQcLKTLIDDDNPPVsfvkFSPNGKYILAAT 212
Cdd:COG0823  77 NASPSWSPDGKRLAFVSRsDGRFDIYvlDLDGGA-PRRLTDGPGSPS----WSPDGRRIVFSS 134
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 224-266 1.06e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.06e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
2H9N_A         224 KGKCLKTYTGHKNEKYCIFANFSvtgGKWIVSGSEDNLVYIWN 266
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD---GKYLASGSDDGTIKLWD 40
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 122-220 1.29e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 38.88  E-value: 1.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A      122 LIVSGSFDESVRIW--DVKTGKcLKTLPAHSDPVSAVHFNRDGSLIV-SSSYDGLCRIW--DTASGQclKTLIDDDNPPV 196
Cdd:COG0823   1 LAFTLSRDGNSDIYvvDLDGGE-PRRLTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYvvDADGGE--PRRLTFGGGYN 77

                        90       100
                ....*....|....*....|....*
2H9N_A      197 SFVKFSPNGKYIL-AATLDNTLKLW 220
Cdd:COG0823  78 ASPSWSPDGKRLAfVSRSDGRFDIY 102
COG5354 COG5354
Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];
187-273 1.78e-03

Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];


Pssm-ID: 227657 [Multi-domain]  Cd Length: 561  Bit Score: 39.86  E-value: 1.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A      187 TLIDDDNPPVSFVKFSPNGKYILAATLDNtLKLWDY-SKGKCLKTYtgHKNEKYCIFAnfsvTGGKWIVSGS-------- 257
Cdd:COG5354  26 TRFESENWPVAYVSESPLGTYLFSEHAAG-VECWGGpSKAKLVRFR--HPDVKYLDFS----PNEKYLVTWSrepiiepe 98

                        90       100
                ....*....|....*....|...
2H9N_A      258 -------EDNLVYIWNLQTKEIV 273
Cdd:COG5354  99 ieispftSKNNVFVWDIASGMIV 121
Nup160 pfam11715
Nucleoporin Nup120/160; Nup120 is conserved from fungi to plants to humans, and is homologous ...
 69-103 1.80e-03

Nucleoporin Nup120/160; Nup120 is conserved from fungi to plants to humans, and is homologous with the Nup160 of vertebrates. The nuclear core complex, or NPC, mediates macromolecular transport across the nuclear envelope. Deletion of the NUP120 gene causes clustering of NPCs at one side of the nuclear envelope, moderate nucleolar fragmentation and slower cell growth. The vertebrate NPC is estimated to contain between 30 and 60 different proteins. most of which are not known. Two important ones in creating the nucleoporin basket are Nup98 and Nup153, and Nup120, in conjunction with Nup 133, interacts with these two and itself plays a role in mRNA export. Nup160, Nup133, Nup96, and Nup107 are all targets of phosphorylation. The phosphorylation sites are clustered mainly at the N-terminal regions of these proteins, which are predicted to be natively disordered. The entire Nup107-160 sub-complex is stable throughout the cell cycle, thus it seems unlikely that phosphorylation affects interactions within the Nup107-160 sub-complex, but rather that it regulates the association of the sub-complex with the NPC and other proteins.


Pssm-ID: 432020 [Multi-domain]  Cd Length: 540  Bit Score: 39.75  E-value: 1.80e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
2H9N_A         69 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKT 103
Cdd:pfam11715 225 APAVTTVGGQNFLFTLSLDHTLRVWDLLTGKCLAT 259
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 17-77 2.96e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.49  E-value: 2.96e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
2H9N_A         17 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 77
Cdd:pfam12894  31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 82-208 3.44e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 38.48  E-value: 3.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A         82 VSASDDKTLKIWDVSSGKCLKTLK------GhsnyvfcCNFNPQSNLI-VSGSFDESVRIWDVKTGKCLKTLPAHSDP-V 153
Cdd:TIGR03866  15 VSNEKDNTISVIDTATLKVTRTFPvgqrprG-------ITFSKDGKLLyVCASDSDTIQVIDPATGEVLHTLPSGPDPeQ 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
2H9N_A        154 SAVHFNrDGSLIVSSSYDGLCRIWDTASGQCLKTLidddnpPVSF----VKFSPNGKYI 208
Cdd:TIGR03866  88 FALHPN-GKILYIANEDDALVTVIDIETRKVLAQI------DVGVepegMAVSPDGKIV 139
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 72-223 3.63e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 38.33  E-value: 3.63e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A       72 VAWSSDSNLLVSASDDKTLKIWDVSSGKcLKTLKGHSNYVFCCNFNPQSNLIVsGSFDESVRIWDVKTGKcLKTLPAHSD 151
Cdd:COG3386  13 PVWDPDGRLYWVDIPGGRIHRYDPDGGA-VEVFAEPSGRPNGLAFDPDGRLLV-ADHGRGLVRFDPADGE-VTVLADEYG 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A      152 PvSAVHFN-----RDGSLIVSSSYD-----GLCRIwdTASGQcLKTLIDDdnppVSF---VKFSPNGKY-ILAATLDNTL 217
Cdd:COG3386  90 K-PLNRPNdgvvdPDGRLYFTDMGEylptgALYRV--DPDGS-LRVLADG----LTFpngIAFSPDGRTlYVADTGAGRI 161


                ....*.
2H9N_A      218 KLWDYS 223
Cdd:COG3386 162 YRFDLD 167
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 200-274 3.95e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 38.87  E-value: 3.95e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
2H9N_A       200 KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYcIFANFSvTGGKWIV-SGSEDNL---VYIWNLQTKEIVQ 274
Cdd:COG4946  395 VWSPDGKKIAFTDNRGRLWVVDLASGKVRKVDTDGYGDGI-SDLAWS-PDSKWLAySKPGPNQlsqIFLYDVETGKTVQ 471
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 55-223 4.72e-03

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 37.64  E-value: 4.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A         55 DGKFEKTISGHKLG-ISDVAWSSDSN--LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFccnFNPQSNLIVSGSFDE- 130
Cdd:pfam08662  47 TGGPDCVVELDKEGpIHDVAWSPNGKefAVIYGYMPAKVSFFDLKGNVIHSFGEQPRNTIF---WSPFGRLVLLAGFGNl 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A        131 --SVRIWDVKTGKCLKTlpahsdpvsAVHFNrdgslivsssydglcriwdtasgqclktlidddnppVSFVKFSPNGKYI 208
Cdd:pfam08662 124 agDIEFWDVVNKKKIAT---------AEASN------------------------------------ATLCEWSPDGRYF 158

                         170       180
                  ....*....|....*....|.
2H9N_A        209 LAATL------DNTLKLWDYS 223
Cdd:pfam08662 159 LTATTaprlrvDNGFKIWHYN 179
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 161-226 5.37e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 38.48  E-value: 5.37e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
2H9N_A       161 DGSLIVSSSYDGlcRIW--DTASGQClkTLIDDD--NPPVSFVKFSPNGKYIL-AATLDNTL---KLWDYSKGK 226
Cdd:COG4946  399 DGKKIAFTDNRG--RLWvvDLASGKV--RKVDTDgyGDGISDLAWSPDSKWLAySKPGPNQLsqiFLYDVETGK 468
COG3292 COG3292
Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];
108-272 7.07e-03

Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];


Pssm-ID: 442521 [Multi-domain]  Cd Length: 924  Bit Score: 38.05  E-value: 7.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A      108 SNYVFCCNFNPQSNLIVS---GSFDESVRIWDVKTGKcLKTLPAHS---DPVSAVHFNRDGSLIVSSSYDGLCRiWDTAS 181
Cdd:COG3292 266 GNSVRSIAEDSDGNLWIRlwiGTYGGGLFRLDPKTGK-FKRYNPNGlpsNSVYSILEDSDGNLWIGTSGGGLYR-YDPKT 343

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2H9N_A      182 GQCLKTLIDD--DNPPVSFVKFSPNGKyILAATlDNTLKLWDYSKGKcLKTYTGHKNEK-------YCIFANFSvtGGKW 252
Cdd:COG3292 344 GKFTKFSEDNglSNNFIRSILEDSDGN-LWVGT-NGGLYRLDPKTGK-FTNFTHDPDKNglssnyiNSIFEDSD--GRLW 418

                       170       180
                ....*....|....*....|
2H9N_A      253 IvsGSEDNLVYIWNLQTKEI 272
Cdd:COG3292 419 I--GTDGGGLYRYDPKTGKF 436
WD40 pfam00400
WD domain, G-beta repeat;
270-309 8.22e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.47  E-value: 8.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
2H9N_A        270 KEIVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLW 309
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGS--DDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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