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Conserved domains on  [gi|756142355|pdb|2MXZ|A]
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Chain A, L-alanyl-D-glutamate peptidase

Protein Classification

M15 family metallopeptidase( domain architecture ID 13000805)

M15 family metallopeptidase of the zinc-binding metallopeptidase family, which contains mostly carboxypeptidases and dipeptidases, is involved in bacterial cell wall biosynthesis and metabolism

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
L-Ala-D-Glu_peptidase_like cd14845
L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase; This L-Ala-D-Glu ...
 9-136 2.39e-26

L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase; This L-Ala-D-Glu peptidase family includes L-alanyl-D-glutamate peptidase (bacteriophage T5) (also known as L-alanoyl-D-glutamate endopeptidase), and Ply118 and Ply500 L-Ala-D-Glu peptidase. Bacteriophage endolysin degrades the peptidoglycan of the bacterial host from within, leading to cell lysis and release of progeny virions. The bacteriophage endolysin Ply118 cleaves between L-Ala and D-Glu residues of Listeria cell wall peptidoglycan. This family belongs to the MEROPS peptidase M15 subfamily C.


:

Pssm-ID: 350620 [Multi-domain]  Cd Length: 126  Bit Score: 95.51  E-value: 2.39e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2MXZ_A        9 SEKQLATVKPELQKVARRALELSP---YDFTIVQGIRTVAQSAQNIANGTSFL------KDPSKSKHITGDAIDFAPYIN 79
Cdd:cd14845   1 SERRIAGLHPEVRAVVKELIELAEeegIDFRITEGYRSPARQAALYAQGRTKPglivtnARGGQSYHNYGLAVDIVPLVN 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
2MXZ_A       80 GKIDWNDleAFWAVKKAFEQAGKE-LGIKLRFGADWnasgdyhdeikRGTYDGGHVEL 136
Cdd:cd14845  81 GKLSTGG--ADPWVSKAYQKLGEIaKSLGLEWGGDW-----------KSFKDYPHFQL 125
 
Name Accession Description Interval E-value
L-Ala-D-Glu_peptidase_like cd14845
L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase; This L-Ala-D-Glu ...
 9-136 2.39e-26

L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase; This L-Ala-D-Glu peptidase family includes L-alanyl-D-glutamate peptidase (bacteriophage T5) (also known as L-alanoyl-D-glutamate endopeptidase), and Ply118 and Ply500 L-Ala-D-Glu peptidase. Bacteriophage endolysin degrades the peptidoglycan of the bacterial host from within, leading to cell lysis and release of progeny virions. The bacteriophage endolysin Ply118 cleaves between L-Ala and D-Glu residues of Listeria cell wall peptidoglycan. This family belongs to the MEROPS peptidase M15 subfamily C.


Pssm-ID: 350620 [Multi-domain]  Cd Length: 126  Bit Score: 95.51  E-value: 2.39e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2MXZ_A        9 SEKQLATVKPELQKVARRALELSP---YDFTIVQGIRTVAQSAQNIANGTSFL------KDPSKSKHITGDAIDFAPYIN 79
Cdd:cd14845   1 SERRIAGLHPEVRAVVKELIELAEeegIDFRITEGYRSPARQAALYAQGRTKPglivtnARGGQSYHNYGLAVDIVPLVN 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
2MXZ_A       80 GKIDWNDleAFWAVKKAFEQAGKE-LGIKLRFGADWnasgdyhdeikRGTYDGGHVEL 136
Cdd:cd14845  81 GKLSTGG--ADPWVSKAYQKLGEIaKSLGLEWGGDW-----------KSFKDYPHFQL 125
Peptidase_M15_4 pfam13539
D-alanyl-D-alanine carboxypeptidase; This family resembles VanY, pfam02557, which is part of ...
 64-120 5.41e-07

D-alanyl-D-alanine carboxypeptidase; This family resembles VanY, pfam02557, which is part of the peptidase M15 family.


Pssm-ID: 433291 [Multi-domain]  Cd Length: 67  Bit Score: 44.24  E-value: 5.41e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
2MXZ_A         64 SKHITGDAIDFAPYINGKID----WNDLEAFWAVKKAFEQAGkelgikLRFGADWNASGDY 120
Cdd:pfam13539   8 SNHSYGLAIDINPLVNPYWGavlpENGIPYADEVVEAFEKLG------FEWGGDWKSFKDY 62
 
Name Accession Description Interval E-value
L-Ala-D-Glu_peptidase_like cd14845
L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase; This L-Ala-D-Glu ...
 9-136 2.39e-26

L-Ala-D-Glu peptidase, also known as L-alanyl-D-glutamate endopeptidase; This L-Ala-D-Glu peptidase family includes L-alanyl-D-glutamate peptidase (bacteriophage T5) (also known as L-alanoyl-D-glutamate endopeptidase), and Ply118 and Ply500 L-Ala-D-Glu peptidase. Bacteriophage endolysin degrades the peptidoglycan of the bacterial host from within, leading to cell lysis and release of progeny virions. The bacteriophage endolysin Ply118 cleaves between L-Ala and D-Glu residues of Listeria cell wall peptidoglycan. This family belongs to the MEROPS peptidase M15 subfamily C.


Pssm-ID: 350620 [Multi-domain]  Cd Length: 126  Bit Score: 95.51  E-value: 2.39e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2MXZ_A        9 SEKQLATVKPELQKVARRALELSP---YDFTIVQGIRTVAQSAQNIANGTSFL------KDPSKSKHITGDAIDFAPYIN 79
Cdd:cd14845   1 SERRIAGLHPEVRAVVKELIELAEeegIDFRITEGYRSPARQAALYAQGRTKPglivtnARGGQSYHNYGLAVDIVPLVN 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
2MXZ_A       80 GKIDWNDleAFWAVKKAFEQAGKE-LGIKLRFGADWnasgdyhdeikRGTYDGGHVEL 136
Cdd:cd14845  81 GKLSTGG--ADPWVSKAYQKLGEIaKSLGLEWGGDW-----------KSFKDYPHFQL 125
Peptidase_M15 cd14814
Metalloproteases including zinc D-Ala-D-Ala carboxypeptidase, L-Ala-D-Glu peptidase, L, ...
 18-137 1.62e-10

Metalloproteases including zinc D-Ala-D-Ala carboxypeptidase, L-Ala-D-Glu peptidase, L,D-carboxypeptidase, bacteriophage endolysins, and related proteins; This family summarizes zinc-binding metallopeptidases which are mostly carboxypeptidases and dipeptidases, and includes zinc-dependent D-Ala-D-Ala carboxypeptidases, VanX, L-Ala-D-Glu peptidase, L,D-carboxypeptidase and bacteriophage endolysins, amongst other family members. These peptidases belong to MEROPS family M15 which are involved in bacterial cell wall biosynthesis and metabolism.


Pssm-ID: 350615 [Multi-domain]  Cd Length: 111  Bit Score: 54.37  E-value: 1.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2MXZ_A       18 PELQKVARRALELSP---YDFTIVQGIRTVAQSAQNIAN------GTSFLKDPSKSKHITGDAIDFAPYINgkidWNDLE 88
Cdd:cd14814   1 PDAAEALARMIAAAGaegRTLTINSGYRTYAQQLRLFAAkgkgsgGRRWAAPPGTSNHQWGLAIDLGDGGG----WRETQ 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
2MXZ_A       89 AFWAVKKAFEQAGkelgikLRFGADWNASGdyhdeikrGTYDGGHVELV 137
Cdd:cd14814  77 GYRWLKANAPRYG------FDNPGGARRGG--------AFQEPWHWEYV 111
Peptidase_M15_4 pfam13539
D-alanyl-D-alanine carboxypeptidase; This family resembles VanY, pfam02557, which is part of ...
 64-120 5.41e-07

D-alanyl-D-alanine carboxypeptidase; This family resembles VanY, pfam02557, which is part of the peptidase M15 family.


Pssm-ID: 433291 [Multi-domain]  Cd Length: 67  Bit Score: 44.24  E-value: 5.41e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
2MXZ_A         64 SKHITGDAIDFAPYINGKID----WNDLEAFWAVKKAFEQAGkelgikLRFGADWNASGDY 120
Cdd:pfam13539   8 SNHSYGLAIDINPLVNPYWGavlpENGIPYADEVVEAFEKLG------FEWGGDWKSFKDY 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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