|
Name |
Accession |
Description |
Interval |
E-value |
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
2-319 |
0e+00 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 596.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 2 IKKIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDEN 81
Cdd:PRK03202 1 MKRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 82 IRAVAIENLKKRGIDALVVIGGDGSYMGAMRLTEMGFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLRDTSSSH 161
Cdd:PRK03202 81 GRAKAIENLKKLGIDALVVIGGDGSYMGAKRLTEHGIPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDTASSH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 162 QRISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSREDLVNEIKAGIAKGKKHAIVAITEHMCDVDELAHFIEKETGR 241
Cdd:PRK03202 161 ERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEELCAKIKKGRERGKKHAIIVVAEGVMPAEELAKEIEERTGL 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
2PFK_A 242 ETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLAGYGGRCVGIQNEQLVHHDIIDAIENMKRPFKGDWLDCAKKL 319
Cdd:PRK03202 241 ETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGRMVGIQNNKIVHVPIEEAVENMKHPFDKDLYELAKKL 318
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
3-320 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 579.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 3 KKIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENI 82
Cdd:cd00763 1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSARFPEFKDEEG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 83 RAVAIENLKKRGIDALVVIGGDGSYMGAMRLTEMGFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLRDTSSSHQ 162
Cdd:cd00763 81 QAKAIEQLKKHGIDALVVIGGDGSYMGAMRLTEHGFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRDTSSSHQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 163 RISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSREDLVNEIKAGIAKGKKHAIVAITEHMCDVDELAHFIEKETGRE 242
Cdd:cd00763 161 RISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGKKHAIVVVAEGVYDVDELAKEIEEATGFE 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
2PFK_A 243 TRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLAGYGGRCVGIQNEQLVHHDIIDAIENMKrPFKGDWLDCAKKLY 320
Cdd:cd00763 241 TRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAGKGGLAVGIQNEQLVHHDIIDAIENMK-PFKKDWLALAKKLS 317
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
2-319 |
5.36e-165 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 462.62 E-value: 5.36e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 2 IKKIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDEN 81
Cdd:COG0205 1 MKRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKTEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 82 IRAVAIENLKKRGIDALVVIGGDGSYMGAMRLTE-MGFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLRDTSSS 160
Cdd:COG0205 81 GREKALENLKKLGIDALVVIGGDGSLDGAAKLAEeYGIPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRDTAAS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 161 HQRISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSREDLVNEIKAGIAKGKKHAIVAITEHMCDVD----------- 229
Cdd:COG0205 161 HERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKLLEKLKERRKRGKGYSIIVVAEGAGDEDgeavleadtda 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 230 -----------ELAHFIEKETGRETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLAGYGGRCVGIQNEQLVHHDII 298
Cdd:COG0205 241 fghvrlggigeYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLEGKTGVMVGIRRGEIVLVPLE 320
|
330 340
....*....|....*....|..
2PFK_A 299 DAIENMKR-PFKGDWLDCAKKL 319
Cdd:COG0205 321 EVANKEKPvDPDSPLIQLAREL 342
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
4-274 |
1.73e-154 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 433.30 E-value: 1.73e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 4 KIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENIR 83
Cdd:pfam00365 1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKTEEGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 84 AVAIENLKKRGIDALVVIGGDGSYMGAMRLT-EMGFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLRDTSSSHQ 162
Cdd:pfam00365 81 EKIAENLKKLGIDALVVIGGDGSLTGANKLSeERGIPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDTASSHN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 163 RISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSREDLVNEIKAGIaKGKKHAIVAITEHMCDVDELAHFIEKETGRE 242
Cdd:pfam00365 161 RVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELR-KGKRFSIIVVAEGASDGEFLAKLIEEGTGIE 239
|
250 260 270
....*....|....*....|....*....|..
2PFK_A 243 TRATVLGHIQRGGSPVPYDRILASRMGAYAID 274
Cdd:pfam00365 240 TRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| PFKA_ATP |
TIGR02482 |
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ... |
4-301 |
7.51e-142 |
|
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 213713 [Multi-domain] Cd Length: 301 Bit Score: 402.50 E-value: 7.51e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 4 KIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENIR 83
Cdd:TIGR02482 1 KIGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLINGKIEPLESKNVSGIIHRGGTILGTARCPEFKTEEVR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 84 AVAIENLKKRGIDALVVIGGDGSYMGAMRLTEMG-FPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLRDTSSSHQ 162
Cdd:TIGR02482 81 EKAVENLKKLGIEGLVVIGGDGSYTGAQKLYEEGgIPVIGLPGTIDNDIPGTDYTIGFDTALNTIIDAVDKIRDTATSHE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 163 RISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSREDLVNEIKAGIAKGKKHAIVAITEHMC--DVDELAHFIEKETG 240
Cdd:TIGR02482 161 RAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYDIDELIQRLKEQHEAGKKHSIIIVAEGNIvgSAKEVAKKIEEKTG 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
2PFK_A 241 RETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLAGYGGRCVGIQNEQLVHHDIIDAI 301
Cdd:TIGR02482 241 IETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGKGGVMIGIQNNKIVTHPIEEAL 301
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
2-319 |
0e+00 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 596.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 2 IKKIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDEN 81
Cdd:PRK03202 1 MKRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 82 IRAVAIENLKKRGIDALVVIGGDGSYMGAMRLTEMGFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLRDTSSSH 161
Cdd:PRK03202 81 GRAKAIENLKKLGIDALVVIGGDGSYMGAKRLTEHGIPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDTASSH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 162 QRISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSREDLVNEIKAGIAKGKKHAIVAITEHMCDVDELAHFIEKETGR 241
Cdd:PRK03202 161 ERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEELCAKIKKGRERGKKHAIIVVAEGVMPAEELAKEIEERTGL 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
2PFK_A 242 ETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLAGYGGRCVGIQNEQLVHHDIIDAIENMKRPFKGDWLDCAKKL 319
Cdd:PRK03202 241 ETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGRMVGIQNNKIVHVPIEEAVENMKHPFDKDLYELAKKL 318
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
3-320 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 579.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 3 KKIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENI 82
Cdd:cd00763 1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSARFPEFKDEEG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 83 RAVAIENLKKRGIDALVVIGGDGSYMGAMRLTEMGFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLRDTSSSHQ 162
Cdd:cd00763 81 QAKAIEQLKKHGIDALVVIGGDGSYMGAMRLTEHGFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRDTSSSHQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 163 RISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSREDLVNEIKAGIAKGKKHAIVAITEHMCDVDELAHFIEKETGRE 242
Cdd:cd00763 161 RISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGKKHAIVVVAEGVYDVDELAKEIEEATGFE 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
2PFK_A 243 TRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLAGYGGRCVGIQNEQLVHHDIIDAIENMKrPFKGDWLDCAKKLY 320
Cdd:cd00763 241 TRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAGKGGLAVGIQNEQLVHHDIIDAIENMK-PFKKDWLALAKKLS 317
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
3-318 |
1.36e-170 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 476.79 E-value: 1.36e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 3 KKIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENI 82
Cdd:cd00363 1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSARCKEFRTEEG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 83 RAVAIENLKKRGIDALVVIGGDGSYMGAMRLTEM------GFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLRD 156
Cdd:cd00363 81 RAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEwpskyqGFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDRIRD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 157 TSSSHQRISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEF---SREDLVNEIKAGIAKGKKHAIVAITEHMCD------ 227
Cdd:cd00363 161 TASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAadeWEEEMVDVIKKRRERGKRHGIVIVAEGAIDfipkpi 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 228 -VDELAHFIEKETGRETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLAGYGGRCVGIQNE---QLVHHDIIDAIEN 303
Cdd:cd00363 241 tEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPVGIQNLnenQVVRHPLTEAVNM 320
|
330
....*....|....*...
2PFK_A 304 MKR---PFKGDWLDCAKK 318
Cdd:cd00363 321 TKRvgvDLEGRPFKKFAK 338
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
2-319 |
5.36e-165 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 462.62 E-value: 5.36e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 2 IKKIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDEN 81
Cdd:COG0205 1 MKRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKTEE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 82 IRAVAIENLKKRGIDALVVIGGDGSYMGAMRLTE-MGFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLRDTSSS 160
Cdd:COG0205 81 GREKALENLKKLGIDALVVIGGDGSLDGAAKLAEeYGIPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRDTAAS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 161 HQRISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSREDLVNEIKAGIAKGKKHAIVAITEHMCDVD----------- 229
Cdd:COG0205 161 HERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKLLEKLKERRKRGKGYSIIVVAEGAGDEDgeavleadtda 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 230 -----------ELAHFIEKETGRETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLAGYGGRCVGIQNEQLVHHDII 298
Cdd:COG0205 241 fghvrlggigeYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLEGKTGVMVGIRRGEIVLVPLE 320
|
330 340
....*....|....*....|..
2PFK_A 299 DAIENMKR-PFKGDWLDCAKKL 319
Cdd:COG0205 321 EVANKEKPvDPDSPLIQLAREL 342
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
4-274 |
1.73e-154 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 433.30 E-value: 1.73e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 4 KIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENIR 83
Cdd:pfam00365 1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKTEEGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 84 AVAIENLKKRGIDALVVIGGDGSYMGAMRLT-EMGFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLRDTSSSHQ 162
Cdd:pfam00365 81 EKIAENLKKLGIDALVVIGGDGSLTGANKLSeERGIPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDTASSHN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 163 RISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSREDLVNEIKAGIaKGKKHAIVAITEHMCDVDELAHFIEKETGRE 242
Cdd:pfam00365 161 RVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELR-KGKRFSIIVVAEGASDGEFLAKLIEEGTGIE 239
|
250 260 270
....*....|....*....|....*....|..
2PFK_A 243 TRATVLGHIQRGGSPVPYDRILASRMGAYAID 274
Cdd:pfam00365 240 TRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| PFKA_ATP |
TIGR02482 |
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ... |
4-301 |
7.51e-142 |
|
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 213713 [Multi-domain] Cd Length: 301 Bit Score: 402.50 E-value: 7.51e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 4 KIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDENIR 83
Cdd:TIGR02482 1 KIGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLINGKIEPLESKNVSGIIHRGGTILGTARCPEFKTEEVR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 84 AVAIENLKKRGIDALVVIGGDGSYMGAMRLTEMG-FPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLRDTSSSHQ 162
Cdd:TIGR02482 81 EKAVENLKKLGIEGLVVIGGDGSYTGAQKLYEEGgIPVIGLPGTIDNDIPGTDYTIGFDTALNTIIDAVDKIRDTATSHE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 163 RISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSREDLVNEIKAGIAKGKKHAIVAITEHMC--DVDELAHFIEKETG 240
Cdd:TIGR02482 161 RAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYDIDELIQRLKEQHEAGKKHSIIIVAEGNIvgSAKEVAKKIEEKTG 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
2PFK_A 241 RETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLAGYGGRCVGIQNEQLVHHDIIDAI 301
Cdd:TIGR02482 241 IETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGKGGVMIGIQNNKIVTHPIEEAL 301
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
3-279 |
3.34e-87 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 276.53 E-value: 3.34e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 3 KKIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYE--DRMVQLDRYSVSDMINRGGTFLGSARFPEFRDE 80
Cdd:TIGR02478 1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDggDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 81 NIRAVAIENLKKRGIDALVVIGGDGSYMGAmRLTEMGFP------------------------CIGLPGTIDNDIKGTDY 136
Cdd:TIGR02478 81 PGRLKAARNLVSNGIDALVVIGGDGSLTGA-DLFREEWPslleelvdtgkitaeqaeehrhltIVGLVGSIDNDMCGTDM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 137 TIGFFTALSTVVEAIDRLRDTSSSHQRISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEV---EFSREDLVNEIKAGIAKG 213
Cdd:TIGR02478 160 TIGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERppeEGWEDQLCHKLKRNRKAG 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
2PFK_A 214 KKHAIVAITE-------HMCDVDELAHFIEKETGRETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLAG 279
Cdd:TIGR02478 240 KRKTIVIVAEgaidrdlNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLES 312
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
2-302 |
9.74e-85 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 259.23 E-value: 9.74e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 2 IKKIGVLTSGGDAPGMNAAIRGVVRSAL-TEGLEVMGIYDGYLGLYED--RMVQLDRYSVSDMINRGGTFLGSAR----- 73
Cdd:PRK14071 4 KKRIGILTSGGDCAGLNAVIRAVVHRARgTYGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILGTTNkgdpf 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 74 -FP------EFRDENIravaIENLKKRGIDALVVIGGDGSYMGAMRLTEMG-FPCIGLPGTIDNDIKGTDYTIGFFTALS 145
Cdd:PRK14071 84 aFPmpdgslRDRSQEI----IDGYHSLGLDALIGIGGDGSLAILRRLAQQGgINLVGIPKTIDNDVGATEVSIGFDTAVN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 146 TVVEAIDRLRDTSSSHQRISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSREDLVNEIKAGIAKGKKHAIVAITEHM 225
Cdd:PRK14071 160 IATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTLENVCKKIRERQEEGKNFCLVVVSEAV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 226 CDVD--------------------ELAHFIEKETGRETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLAGYGGRCV 285
Cdd:PRK14071 240 RTEEgeqvtktqalgedryggigqYLAEQIAERTGAETRVTVLGHIQRGGIPSPRDRLLASAFGVAAVDLIAQGKFDRMV 319
|
330
....*....|....*..
2PFK_A 286 GIQNEQLVHHDIIDAIE 302
Cdd:PRK14071 320 AWQNRQVVSVPIAEAIA 336
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
3-279 |
1.06e-76 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 249.35 E-value: 1.06e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 3 KKIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYE--DRMVQLDRYSVSDMINRGGTFLGSARFPEFRDE 80
Cdd:cd00764 4 KAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKggDYIKQAEWESVSNWLQEGGTIIGSARCKEFRER 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 81 NIRAVAIENLKKRGIDALVVIGGDGSYMGA-----------------MRLTEMGFP------CIGLPGTIDNDIKGTDYT 137
Cdd:cd00764 84 EGRLQAAYNLIQRGITNLCVIGGDGSLTGAdlfrsewpslleelvkdGKITEEEVAkyqhlnIVGMVGSIDNDFCGTDMT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 138 IGFFTALSTVVEAIDRLRDTSSSHQRISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSR---EDLVNEIKAGIAKGK 214
Cdd:cd00764 164 IGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDgweDQMCRRLSEHRSRGK 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
2PFK_A 215 KHAIVAITEHMCDVD-------ELAHFIEKETGRETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLAG 279
Cdd:cd00764 244 RLNIIIVAEGAIDDQlkpitseDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEA 315
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
3-296 |
1.14e-56 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 195.25 E-value: 1.14e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 3 KKIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARfpEFRDENI 82
Cdd:TIGR02478 390 LRIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNR--SLPGDDL 467
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 83 RAVAiENLKKRGIDALVVIGGDGSYMGAMRL-------TEMGFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLR 155
Cdd:TIGR02478 468 GTIA-YYFQQHKIDGLIIIGGFEAFEALYQLdaarekyPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIK 546
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 156 DTSS-SHQRISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSREDL---VNEIKAGIAKGKKHAIVAITEHMCDV--- 228
Cdd:TIGR02478 547 QSASaSKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLqedIEHLKETFAEGRAGKLILRNEKASKVytt 626
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 229 DELAHFIEKET-GR-ETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLLLAGYGGrcVGIQNEQLVHHD 296
Cdd:TIGR02478 627 DFIARIISEEGkGRfDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKA--NKHADKLSADDT 694
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
4-276 |
3.55e-45 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 163.46 E-value: 3.55e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 4 KIGVLTSGGDAPGMNAAIRGVVRSALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSAR-FPEFRDENI 82
Cdd:cd00764 391 NIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRtLPKKDLETI 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 83 ravaIENLKKRGIDALVVIGGDGSYMGAMRL-------TEMGFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLR 155
Cdd:cd00764 471 ----AYNFQKYGIDGLIIVGGFEAYKGLLQLreareqyEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIK 546
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 156 DT-SSSHQRISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSRED-------LVNEIKAGIAKGKKHAIVAITEHMCD 227
Cdd:cd00764 547 QSaSGTKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDlqenvehLTEKMKTTIGRGLVLRNEKCNENYTT 626
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
2PFK_A 228 VDELAHFIEKETGR-ETRATVLGHIQRGGSPVPYDRILASRMGAYAIDLL 276
Cdd:cd00764 627 VFTYELYSEEGKGVfDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWI 676
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
4-293 |
3.81e-39 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 143.26 E-value: 3.81e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 4 KIGVLTSGGDAPGMNAAIRGVVRSALTE-GLE-VMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSARFPEFRDen 81
Cdd:PTZ00286 89 KAGIVTCGGLCPGLNVVIRELVMNLINNyGVKtIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTILGSSRGGFDPK-- 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 82 iraVAIENLKKRGIDALVVIGGDGSYMGAMRLTE----MGFPC--IGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDRLR 155
Cdd:PTZ00286 167 ---VMVDTLIRHGINILFTLGGDGTHRGALAIYKelrrRKLNIsvVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAY 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 156 DTSSSHQR-ISVVEVMGRYCGDLTLAAAIAGGCEFVV-VPEVEFSREDLVNEIKAGIAKgKKHAIVAITEHMC------- 226
Cdd:PTZ00286 244 VEAKSAKNgVGIVKLMGRDSGFIALHASVASADVNVClIPEFDIPLEGVLEYIEQRLQK-KGHCVIVVAEGAGqslkdad 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 227 --------------DV-----DELAHFIEKETGRETratvLGHIQ-----RGGSPVPYDRILASRMGAYAIDLLLAGYGG 282
Cdd:PTZ00286 323 ldlgtdasgnkklwDIgvylkDEITKYLKKKKPEHT----VKYIDpsymiRAVPANAADAKFCTQLAQNAVHGAMAGFTG 398
|
330
....*....|.
2PFK_A 283 RCVGIQNEQLV 293
Cdd:PTZ00286 399 FIIGHVHNNYV 409
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
4-306 |
1.94e-28 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 113.37 E-value: 1.94e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 4 KIGVLTSGGDAPGMNAAIRGVVRSALTEGLE-VMGIYDGYLGLYEDRM--VQLDRYSVSDMINRGGTFLGSARF-PEFRD 79
Cdd:PLN02884 55 KAAIVTCGGLCPGLNDVIRQIVFTLEIYGVKnIVGIPFGYRGFFEKGLseMPLSRKVVQNIHLSGGSLLGVSRGgAKTSD 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 80 eniravAIENLKKRGIDALVVIGGDGSYMGAM------RLTEMGFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDR 153
Cdd:PLN02884 135 ------IVDSIEARGINMLFVLGGNGTHAGANaihnecRKRKMKVSVVGVPKTIDNDILLMDKTFGFDTAVEEAQRAINS 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 154 LR-DTSSSHQRISVVEVMGRYCGDLTLAAAIAGG-CEFVVVPEVEFS---REDLVNEIKAGIAKgKKHAIVAITE----- 223
Cdd:PLN02884 209 AYiEAHSAYHGIGLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTldgPNGVLRHLEHLIET-KGSAVVCVAEgagqd 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 224 ---HMCDVDELAHFIEKETGRETRATVLGHIQRGGSP--VPY---------------DRILASRMGAYAIDLLLAGYGGR 283
Cdd:PLN02884 288 llqKTNATDASGNPVLGDIGVHLQQEIKKHFKDIGVPadVKYidptymiracranasDAILCTVLGQNAVHGAFAGFSGI 367
|
330 340
....*....|....*....|...
2PFK_A 284 CVGIQNEQLVHHDIIDAIENMKR 306
Cdd:PLN02884 368 TVGICNTHYVYLPIPEVIAYPRR 390
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
1-288 |
2.24e-28 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 113.42 E-value: 2.24e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 1 MIKKIGVLTSGGDAPGMNAAIRGVVRSAL--TEGLEVMGIYDGYLGLYEDRMVQLDRYSVSD---MINRGGTFLGSARFP 75
Cdd:PRK14072 2 MKGNALYAQSGGPTAVINASAAGVIEEARkhKKIGKVYGARNGIIGILDEDLIDLSKESDEAlaaLAHTPSGALGSCRYK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 76 EFRDENIRA---VAIENLKKRGIDALVVIGGDGSYMGAMRLTE----MGFP--CIGLPGTIDNDIKGTDYTIGF-----F 141
Cdd:PRK14072 82 LKSLEEDRAeyeRLLEVFKAHDIGYFFYNGGNDSMDTALKVSQlakkMGYPirCIGIPKTIDNDLPGTDHCPGFgsaakY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 142 TALStVVEAIdrlRDTSSSHQ--RISVVEVMGRYCGDLTLAAAIA-----GGCEFVVVPEVEFSREDLVNEIKAGIAKGK 214
Cdd:PRK14072 162 IATS-VLEAA---LDVAAMANtsKVFILEVMGRHAGWLAAAAALAkqnpdDAPHLIYLPERPFDEEKFLADVRAIVKRYG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 215 KHAIVA-----------ITEHMCDVDE------------LAHFIEKETGRETRATVLGHIQRGG----SPVpyDRILASR 267
Cdd:PRK14072 238 YCVVVVsegirdadgkfIAEAGLAEDAfghaqlggvapvLANLIKEKLGKKVHWAVLDYLQRAArhiaSKT--DVEEAYA 315
|
330 340
....*....|....*....|.
2PFK_A 268 MGAYAIDLLLAGYGGRCVGIQ 288
Cdd:PRK14072 316 VGKAAVEYALAGKNGVMPAIR 336
|
|
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
4-294 |
5.65e-28 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 112.65 E-value: 5.65e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 4 KIGVLTSGGDAPGMNAAIRGVVRSALTE-GL-EVMGIYDGYLGL---YEDRMVQLDRYSVSDMINRGGTFLGSARFPEFR 78
Cdd:PRK06830 82 KAAIVTCGGLCPGLNDVIRAIVLELHHHyGVrRILGIRYGYQGLiprYGHDPVELTPEVVADIHEFGGTILGSSRGPQDP 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 79 DEniravAIENLKKRGIDALVVIGGDGSYMGAMRLTE------MGFPCIGLPGTIDNDIKGTDYTIGFFTALSTVVEAID 152
Cdd:PRK06830 162 EE-----IVDTLERMNINILFVIGGDGTLRGASAIAEeierrgLKISVIGIPKTIDNDINFIQKSFGFETAVEKATEAIR 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 153 rlrdtsSSHQR-------ISVVEVMGRYCGDLTLAAAIAGG-CEFVVVPEVEFSRED---LVNEIKAGIAKgKKHAIVAI 221
Cdd:PRK06830 237 ------CAHVEangapngIGLVKLMGRHSGFIAAYAALASKdVNFVLIPEVPFDLEGpngLLAALEKRLAE-RGHAVIVV 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 222 TE----HMCDVDEL----AHFIEKETGRETRATVLGHIQRGGSPV-----------------PYDRILASRMGAYAIDLL 276
Cdd:PRK06830 310 AEgagqELFDDTGEtdasGNPKLGDIGLFLKDRIKEYFKARGIPInlkyidpsyiirsvpanANDSVYCGFLGQNAVHAA 389
|
330
....*....|....*...
2PFK_A 277 LAGYGGRCVGIQNEQLVH 294
Cdd:PRK06830 390 MAGKTGMVVGRWNNRFVH 407
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
7-197 |
5.88e-25 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 104.44 E-value: 5.88e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 7 VLTSGGDAPGMNAAIRGVVRsalteGL-------EVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGGTFLGSArfpefRD 79
Cdd:PLN02564 92 IVTCGGLCPGLNTVIREIVC-----GLsymygvtRILGIDGGYRGFYSRNTIPLTPKVVNDIHKRGGTILGTS-----RG 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 80 ENIRAVAIENLKKRGIDALVVIGGDGSYMGAMRLTE----MGFPC--IGLPGTIDNDIKGTDYTIGFFTALSTVVEAIDR 153
Cdd:PLN02564 162 GHDTSKIVDSIQDRGINQVYIIGGDGTQKGASVIYEeirrRGLKVavAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINA 241
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
2PFK_A 154 LR-DTSSSHQRISVVEVMGRYCGDLTLAAAIAG-GCEFVVVPEVEF 197
Cdd:PLN02564 242 AHvEAESVENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPESPF 287
|
|
| PRK07085 |
PRK07085 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional |
3-223 |
8.84e-21 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
Pssm-ID: 235930 Cd Length: 555 Bit Score: 92.68 E-value: 8.84e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 3 KKIGVLTSGGDAPGMNAAIRGvvrsaLTEGLEVM-------GIYDGYLGLYEDRMVQLDRYSVSDMINRGG-TFLGSARf 74
Cdd:PRK07085 71 LKVGVILSGGQAPGGHNVIAG-----LFDGLKKLnpdsklfGFIGGPLGLLNGKYIEITEEVIDEYRNTGGfDMIGSGR- 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 75 pefrdENIR-----AVAIENLKKRGIDALVVIGGDGSYMGAMRLTE------MGFPCIGLPGTIDNDIKGT--DYTIGFF 141
Cdd:PRK07085 145 -----TKIEteeqkEACLETVKKLKLDGLVIIGGDDSNTNAAILAEyfakhgCKTQVIGVPKTIDGDLKNEfiETSFGFD 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 142 TALSTVVEAIDRL-RDTSSSHQRISVVEVMGRYcgdltlAAAIAGGCEFVVVP-------EVE---FSREDLVNEIKAGI 210
Cdd:PRK07085 220 TATKTYSEMIGNIsRDALSAKKYWHFIKLMGRS------ASHIALECALQTHPnicliseEVAekkMSLQDIVHYIASVI 293
|
250
....*....|....*..
2PFK_A 211 ----AKGKKHAIVAITE 223
Cdd:PRK07085 294 adraAKGKNYGVILIPE 310
|
|
| PTZ00287 |
PTZ00287 |
6-phosphofructokinase; Provisional |
2-223 |
9.10e-21 |
|
6-phosphofructokinase; Provisional
Pssm-ID: 240345 [Multi-domain] Cd Length: 1419 Bit Score: 93.18 E-value: 9.10e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 2 IKKIGVLTSGGDAPGMNAAIRGVVRSA--LTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGG-TFLGSARFPEFR 78
Cdd:PTZ00287 177 VLKIGIILSGGPAPGGHNVISGIYDYAkrYNEQSQVIGFLGGIDGLYSKNYVTITDSLMNRFRNLGGfNMLWSGRGKVRN 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 79 DENIraVAIENL-KKRGIDALVVIGGDGSYMGAMRLTE------MGFPCIGLPGTIDNDIK--GTDYTIGFFTALSTVVE 149
Cdd:PTZ00287 257 KDDL--IAIENIvAKLKLNGLVIIGGDGSNSNAALISEyfaerqIPISIIGIPKTIDGDLKseAIEISFGFDTATKTYSE 334
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 150 AIDRL-RDTSSSHQRISVVEVMGRYCGDLTLAAAIAGGCEFVVV-PEVE---FSREDLVNEIKAGIAK----GKKHAIVA 220
Cdd:PTZ00287 335 VIGNLcTDVKTGHNVYHVVRVMGRSASHVVLECALQTRPNIVLIgEEVEkenLSLKDIVSNIVNTILKrrslNKNYGVIL 414
|
...
2PFK_A 221 ITE 223
Cdd:PTZ00287 415 IPE 417
|
|
| PRK06555 |
PRK06555 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated |
1-200 |
1.97e-16 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
Pssm-ID: 180620 [Multi-domain] Cd Length: 403 Bit Score: 79.28 E-value: 1.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 1 MIKKIGVLTSGGDAPGMNAAIRGVVR--SALTEGLEVMGIYDGYLGLYEDRMVQLD---RYSVSDMINRGGTFLGSAR-- 73
Cdd:PRK06555 2 AVKKVALLTAGGLAPCLSSAVGGLIEryTEIAPEVEIIAYRSGYQGLLLGDSIEITpavRANAGLLHRYGGSPIGNSRvk 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 74 FPEFRD----------ENIRAVAIENLKKRGIDALVVIGGDGSYMGAMRLT----EMGFP--CIGLPGTIDNDIKGTDYT 137
Cdd:PRK06555 82 LTNVADcvkrglvkegENPLKVAAERLAADGVDILHTIGGDDTNTTAADLAaylaENGYDltVVGLPKTIDNDVVPIRQS 161
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
2PFK_A 138 IGFFTALSTVVEAIDRLRDTSSSHQRISVV-EVMGRYCGDLTLAAAIA-----GGCEFvvVPEVEFSRE 200
Cdd:PRK06555 162 LGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWLTAATARAyrewlDRQEY--VPGFGLSAE 228
|
|
| PTZ00468 |
PTZ00468 |
phosphofructokinase family protein; Provisional |
3-223 |
3.35e-16 |
|
phosphofructokinase family protein; Provisional
Pssm-ID: 185647 [Multi-domain] Cd Length: 1328 Bit Score: 79.63 E-value: 3.35e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 3 KKIGVLTSGGDAPGMNAAIRGVVR--SALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGG-TFLGSARFPEFRD 79
Cdd:PTZ00468 103 RRIGVVLSGGQASGGHNVIAGLMSyiKLCNQSSQLFGFLGGPEGVYSERYRELTEDDINGILNQGGfNIICSGRHKIETE 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 80 ENIRAvAIENLKKRGIDALVVIGGDGSYMGAMRLTEM------GFPCIGLPGTIDNDIKG--TDYTIGFFTALSTVVEAI 151
Cdd:PTZ00468 183 EQMRA-SLEICEKLKLHGLVVIGGDDSNTNAAVLAEYfkrnssSTVVVGCPKTIDGDLKNevIETSFGYDTAVKTYSEQI 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 152 DRLRDT-SSSHQRISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEvEFSRED-----LVNEIKAGIAK----GKKHAIVAI 221
Cdd:PTZ00468 262 GSIMDAiKTEGYGYYFVRLMGRSASHITLECGLQTRANMILIGE-EIKEENrslmsIVDEIVEMILKrdslGKKHGIVLL 340
|
..
2PFK_A 222 TE 223
Cdd:PTZ00468 341 PE 342
|
|
| Pyrophosphate_PFK |
cd00765 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
4-228 |
5.18e-16 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent phosphofructokinases. These are found in bacteria as well as plants. These may be dimeric nonallosteric enzymes as in bacteria or allosteric heterotetramers as in plants.
Pssm-ID: 238390 Cd Length: 550 Bit Score: 78.37 E-value: 5.18e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 4 KIGVLTSGGDAPGMNAAIRGVVrSALTE---GLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGG-TFLGSARfPEFRD 79
Cdd:cd00765 74 KIGIVLSGGQAPGGHNVISGLF-DYLKErakGSTLYGFKGGPAGILKCDYIELNAEYIQPYRNTGGfDMICSGR-TKIET 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 80 ENIRAVAIENLKKRGIDALVVIGGDGSYMGAMRLTE------MGFPCIGLPGTIDNDIKG--TDYTIGFFTALSTVVEAI 151
Cdd:cd00765 152 EDQFKQAEETAKKLDLDALVVIGGDDSNTNAALLAEnfrskgLKTRVIGVPKTIDGDLKNkeIETSFGFDTATKIYSELI 231
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
2PFK_A 152 DRL-RDTSSSHQRISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEvefsredlvnEIKAgiakgKKHAIVAITEHMCDV 228
Cdd:cd00765 232 GNVmRDARSTGKYWHFVKLMGRSASHIALECALKTHPNICIISE----------EVSA-----QKQTLKNITDYMVDV 294
|
|
| PLN02251 |
PLN02251 |
pyrophosphate-dependent phosphofructokinase |
4-235 |
2.13e-12 |
|
pyrophosphate-dependent phosphofructokinase
Pssm-ID: 215140 Cd Length: 568 Bit Score: 67.51 E-value: 2.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 4 KIGVLTSGGDAPGMNAAIRGVVR--SALTEGLEVMGIYDGYLGLYEDRMVQLDRYSVSDMINRGG-TFLGSAR----FPE 76
Cdd:PLN02251 98 KIGVVLSGGQAPGGHNVISGIFDylQEHAKGSVLYGFKGGPAGIMKCKYVELTAEFIYPYRNQGGfDMICSGRdkieTPE 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 77 -FRDeniravAIENLKKRGIDALVVIGGDGSYMGAMRLTE------MGFPCIGLPGTIDNDIKGTDYTI--GFFTALSTV 147
Cdd:PLN02251 178 qFKQ------AEETATKLDLDGLVVIGGDDSNTNACLLAEyfraknLKTRVIGCPKTIDGDLKSKEVPTsfGFDTACKIY 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 148 VEAI-DRLRDTSSSHQRISVVEVMGRYCGDLTLAAAIAGGCEFVVVPEVEFSRE----DLVNEIKAGIAK----GKKHAI 218
Cdd:PLN02251 252 SEMIgNVMIDARSTGKYYHFVRLMGRAASHITLECALQTHPNITIIGEEVAAKKltlkNVTDYIVDVICKraelGYNYGV 331
|
250
....*....|....*...
2PFK_A 219 VAITEHMCD-VDELAHFI 235
Cdd:PLN02251 332 ILIPEGLIDfIPEVQHLI 349
|
|
| PLN03028 |
PLN03028 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Provisional |
4-223 |
2.01e-07 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
Pssm-ID: 215543 Cd Length: 610 Bit Score: 52.47 E-value: 2.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 4 KIGVLTSGGDAPGMNAAIRGvvrsaLTEGLEV-------MGIYDGYLGLYEDRMVQLDRYSVSDMINRGG-TFLGSARFP 75
Cdd:PLN03028 81 RVGVVFCGRQSPGGHNVIWG-----LHDALKAhnpnsvlLGFLGGTEGLFAQKTLEITDDVLSTYKNQGGyDLLGRTKDQ 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 76 EFRDENIRAV--AIENLKkrgIDALVVIGGDGSYMGAMRLTE--MGFPC----IGLPGTIDNDIKG--TDYTIGFFTALS 145
Cdd:PLN03028 156 IRTTEQVNAAlaACEALK---LDGLVIIGGVTSNTDAAQLAEtfAEAKCktkvVGVPVTLNGDLKNqfVETNVGFDTICK 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2PFK_A 146 TVVEAIDRL-RDTSSSHQRISVVEVMGRYCGDLTLAAAIAGGCEFVVV-PEVEFSR---EDLVNEI----KAGIAKGKKH 216
Cdd:PLN03028 233 VNSQLISNVcTDALSAEKYYYFIRLMGRKASHVALECALQSHPNMVILgEEVAASKltlFDITKQIcdavQARAEQDKNH 312
|
....*..
2PFK_A 217 AIVAITE 223
Cdd:PLN03028 313 GVILIPE 319
|
|
| |
