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Conserved domains on  [gi|305677642|pdb|2XNH|A]
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Chain A, DNA TOPOISOMERASE 2-BINDING PROTEIN 1

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BRCT_TopBP1_rpt1 cd17737
first BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 108-179 1.02e-46

first BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the first BRCT domain.


:

Pssm-ID: 349369 [Multi-domain]  Cd Length: 72  Bit Score: 151.02  E-value: 1.02e-46
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
2XNH_A      108 DVTISCTSLEKEKREEVHKYVQ**GGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKS 179
Cdd:cd17737   1 DVTISCTSLEKEEREEVHKYVQLMGGRVSRDLTVSVTHLIAGEVGSKKYLVAASLKKPIMLPSWVKTLWEKS 72
BRCT_TopBP1_rpt2_like cd17731
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 198-274 8.66e-35

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.


:

Pssm-ID: 349363 [Multi-domain]  Cd Length: 77  Bit Score: 120.34  E-value: 8.66e-35
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
2XNH_A      198 PIFLGCIICVTGLCGLDRKEVQQLTVKHGGQY*GQLK*NeCTHLIVQEPKGQKYECAKRWN-VHCVTTQWFFDSIEKG 274
Cdd:cd17731   1 PPFKGLVICVTGFDSEERKEIQQLVEQNGGSYSPDLSKN-CTHLIAGSPSGQKYEFARKWNsIHIVTPEWLYDSIEAG 77
 
Name Accession Description Interval E-value
BRCT_TopBP1_rpt1 cd17737
first BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 108-179 1.02e-46

first BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the first BRCT domain.


Pssm-ID: 349369 [Multi-domain]  Cd Length: 72  Bit Score: 151.02  E-value: 1.02e-46
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
2XNH_A      108 DVTISCTSLEKEKREEVHKYVQ**GGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKS 179
Cdd:cd17737   1 DVTISCTSLEKEEREEVHKYVQLMGGRVSRDLTVSVTHLIAGEVGSKKYLVAASLKKPIMLPSWVKTLWEKS 72
BRCT_TopBP1_rpt2_like cd17731
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 198-274 8.66e-35

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.


Pssm-ID: 349363 [Multi-domain]  Cd Length: 77  Bit Score: 120.34  E-value: 8.66e-35
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
2XNH_A      198 PIFLGCIICVTGLCGLDRKEVQQLTVKHGGQY*GQLK*NeCTHLIVQEPKGQKYECAKRWN-VHCVTTQWFFDSIEKG 274
Cdd:cd17731   1 PPFKGLVICVTGFDSEERKEIQQLVEQNGGSYSPDLSKN-CTHLIAGSPSGQKYEFARKWNsIHIVTPEWLYDSIEAG 77
PTCB-BRCT pfam12738
twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ...
 203-266 1.87e-15

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair.


Pssm-ID: 463687 [Multi-domain]  Cd Length: 63  Bit Score: 69.15  E-value: 1.87e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
2XNH_A        203 CIICVTGLCGLDRKEVQQLTVKHGGQY*GQLK*NECTHLIVQEPKGQKYECAKRWNVHCVTTQW 266
Cdd:pfam12738   1 LVICVTGFDGDDREGLQKLIEAMGAEYTKDLT-KSVTHLICKSGEGEKYEKAKEWGIPVVSPLW 63
BRCT smart00292
breast cancer carboxy-terminal domain;
198-271 3.58e-13

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 63.55  E-value: 3.58e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
2XNH_A         198 PIFLGCIICVTG-LCGLDRKEVQQLTVKHGGQY*GQLK*NECTHLIVQEPKGQKYEC--AKRWNVHCVTTQWFFDSI 271
Cdd:smart00292   2 KLFKGKTFYITGsFDKEERDELKELIEALGGKVTSSLSSKTTTHVIVGSPEGGKLELlkAIALGIPIVKEEWLLDCL 78
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 107-176 9.37e-11

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 56.92  E-value: 9.37e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XNH_A        107 SDVTISCTSLEKEKREEVHKYVQ**GGRVYRDLNVSVTHLIAGEvGSKKYLVAANLKKPILLPSWIKTLW 176
Cdd:pfam00533   7 SGKTFVITGLDGLERDELKELIEKLGGKVTDSLSKKTTHVIVEA-RTKKYLKAKELGIPIVTEEWLLDCI 75
BRCT smart00292
breast cancer carboxy-terminal domain;
107-176 5.41e-08

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 49.30  E-value: 5.41e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
2XNH_A         107 SDVTISCTS-LEKEKREEVHKYVQ**GGRVYRDLN-VSVTHLIAG--EVGSKKYLVAANLKKPILLPSWIKTLW 176
Cdd:smart00292   5 KGKTFYITGsFDKEERDELKELIEALGGKVTSSLSsKTTTHVIVGspEGGKLELLKAIALGIPIVKEEWLLDCL 78
 
Name Accession Description Interval E-value
BRCT_TopBP1_rpt1 cd17737
first BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 108-179 1.02e-46

first BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the first BRCT domain.


Pssm-ID: 349369 [Multi-domain]  Cd Length: 72  Bit Score: 151.02  E-value: 1.02e-46
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
2XNH_A      108 DVTISCTSLEKEKREEVHKYVQ**GGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKS 179
Cdd:cd17737   1 DVTISCTSLEKEEREEVHKYVQLMGGRVSRDLTVSVTHLIAGEVGSKKYLVAASLKKPIMLPSWVKTLWEKS 72
BRCT_TopBP1_rpt2_like cd17731
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 198-274 8.66e-35

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.


Pssm-ID: 349363 [Multi-domain]  Cd Length: 77  Bit Score: 120.34  E-value: 8.66e-35
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
2XNH_A      198 PIFLGCIICVTGLCGLDRKEVQQLTVKHGGQY*GQLK*NeCTHLIVQEPKGQKYECAKRWN-VHCVTTQWFFDSIEKG 274
Cdd:cd17731   1 PPFKGLVICVTGFDSEERKEIQQLVEQNGGSYSPDLSKN-CTHLIAGSPSGQKYEFARKWNsIHIVTPEWLYDSIEAG 77
BRCT_PAXIP1_rpt2 cd17710
second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 199-279 6.51e-16

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the second BRCT domain.


Pssm-ID: 349342 [Multi-domain]  Cd Length: 81  Bit Score: 71.11  E-value: 6.51e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XNH_A      199 IFLGCIICVTGLCGLDRKEVQQLTVKHGGQY*GQLk*NECTHLIVQEPKGQKYECA-KRWNVHCVTTQWFFDSIEKGFCQ 277
Cdd:cd17710   1 LFSGVVVCPSQISAEDRLKLWAMVTFHGGKCQLNL-DKKCTHLVTGKASGAKYECAlKHEGIKIVTPDWVTDCIKAKTLL 79


                ..
2XNH_A      278 DE 279
Cdd:cd17710  80 DE 81
PTCB-BRCT pfam12738
twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ...
 203-266 1.87e-15

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair.


Pssm-ID: 463687 [Multi-domain]  Cd Length: 63  Bit Score: 69.15  E-value: 1.87e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
2XNH_A        203 CIICVTGLCGLDRKEVQQLTVKHGGQY*GQLK*NECTHLIVQEPKGQKYECAKRWNVHCVTTQW 266
Cdd:pfam12738   1 LVICVTGFDGDDREGLQKLIEAMGAEYTKDLT-KSVTHLICKSGEGEKYEKAKEWGIPVVSPLW 63
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 195-271 1.96e-15

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 69.63  E-value: 1.96e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
2XNH_A        195 FKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQY*GQLK*NeCTHLIVqEPKGQKYECAKRWNVHCVTTQWFFDSI 271
Cdd:pfam00533   1 PKEKLFSGKTFVITGLDGLERDELKELIEKLGGKVTDSLSKK-TTHVIV-EARTKKYLKAKELGIPIVTEEWLLDCI 75
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 203-270 1.02e-14

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 67.39  E-value: 1.02e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
2XNH_A      203 CIICVTGLCGLDRKEVQQLTVKHGGQY*GQLK*NECTHLIVQEPKGQKY-ECAKRWNVHCVTTQWFFDS 270
Cdd:cd00027   1 LVICFSGLDDEEREELKKLIEALGGKVSESLS-SKVTHLIAKSPSGEKYyLAALAWGIPIVSPEWLLDC 68
BRCT_PAXIP1_rpt4 cd17730
fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 204-275 1.21e-14

fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fourth BRCT domain.


Pssm-ID: 349362 [Multi-domain]  Cd Length: 73  Bit Score: 67.27  E-value: 1.21e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
2XNH_A      204 IICVTGLCGLDRKEVQQLTVKHGGQY*GQLk*NECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGF 275
Cdd:cd17730   2 VISVTGFDGSEREDIKRMIELMGAKYTGYL-TRSNTHLICKRPEGEKYEKAKEWRIPVVNAQWLEDILLGGR 72
BRCT_Rad4_rpt2 cd17746
second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...
 198-283 1.91e-14

second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the second one.


Pssm-ID: 349377 [Multi-domain]  Cd Length: 91  Bit Score: 67.65  E-value: 1.91e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XNH_A      198 PIFLGCIICVTGLCGLDRKEVQQLTVKHGGQY*GQLk*NECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQ 277
Cdd:cd17746   5 PTLFKCRVCLTNIGQPERSRIENYVLKHGGTFCPDL-TRDVTHLIAGTSSGRKYEYALKWKINVVCVEWLWQSIQRNAVL 83


                ....*.
2XNH_A      278 DESIYK 283
Cdd:cd17746  84 EPQYFQ 89
BRCT_TopBP1_rpt5 cd18434
fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 202-274 4.57e-14

fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the fifth BRCT domain.


Pssm-ID: 349387  Cd Length: 89  Bit Score: 66.17  E-value: 4.57e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XNH_A      202 GCIICVTGLCGLDRK-----------EVQQLTVKHGGQY*GQLK*neCTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDS 270
Cdd:cd18434   4 GCVISVSQFTGTERDclthlaellgaKVQDYFVRKANPSKGLLA---STHLVLKEPEGSKYEAAKKWNLPAVTKSWLFEC 80


                ....
2XNH_A      271 IEKG 274
Cdd:cd18434  81 ARTG 84
BRCT_TopBP1_rpt2_like cd17731
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 109-179 2.79e-13

second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain.


Pssm-ID: 349363 [Multi-domain]  Cd Length: 77  Bit Score: 63.71  E-value: 2.79e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
2XNH_A      109 VTISCTSLEKEKREEVHKYVQ**GGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKK-PILLPSWIKTLWEKS 179
Cdd:cd17731   6 LVICVTGFDSEERKEIQQLVEQNGGSYSPDLSKNCTHLIAGSPSGQKYEFARKWNSiHIVTPEWLYDSIEAG 77
BRCT smart00292
breast cancer carboxy-terminal domain;
198-271 3.58e-13

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 63.55  E-value: 3.58e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
2XNH_A         198 PIFLGCIICVTG-LCGLDRKEVQQLTVKHGGQY*GQLK*NECTHLIVQEPKGQKYEC--AKRWNVHCVTTQWFFDSI 271
Cdd:smart00292   2 KLFKGKTFYITGsFDKEERDELKELIEALGGKVTSSLSSKTTTHVIVGSPEGGKLELlkAIALGIPIVKEEWLLDCL 78
BRCT_Rad4_rpt1 cd17740
first BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar ...
 107-180 4.76e-13

first BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples the S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the first one.


Pssm-ID: 349371  Cd Length: 82  Bit Score: 63.26  E-value: 4.76e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
2XNH_A      107 SDVTISCTSLEKEKREEVHKYVQ**GGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKK--PILLPSWIKTLWEKSQ 180
Cdd:cd17740   4 SGIVLCCTSIPAEQRTEIATKASKMGAAYTADLTSDVTHLVAGQVNTTKYKFAARSRPdiKVMTVEWVEHLYESWQ 79
BRCT cd00027
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 109-172 1.22e-12

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


Pssm-ID: 349339 [Multi-domain]  Cd Length: 68  Bit Score: 61.61  E-value: 1.22e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
2XNH_A      109 VTISCTSLEKEKREEVHKYVQ**GGRVYRDLNVSVTHLIAGEV-GSKKYLVAANLKKPILLPSWI 172
Cdd:cd00027   1 LVICFSGLDDEEREELKKLIEALGGKVSESLSSKVTHLIAKSPsGEKYYLAALAWGIPIVSPEWL 65
BRCT pfam00533
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ...
 107-176 9.37e-11

BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.


Pssm-ID: 425736 [Multi-domain]  Cd Length: 75  Bit Score: 56.92  E-value: 9.37e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XNH_A        107 SDVTISCTSLEKEKREEVHKYVQ**GGRVYRDLNVSVTHLIAGEvGSKKYLVAANLKKPILLPSWIKTLW 176
Cdd:pfam00533   7 SGKTFVITGLDGLERDELKELIEKLGGKVTDSLSKKTTHVIVEA-RTKKYLKAKELGIPIVTEEWLLDCI 75
BRCT_BRC1_like_rpt4 cd18438
fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 204-270 1.04e-10

fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. Members in this family contains six BRCT domains. This family corresponds to the fourth repeat.


Pssm-ID: 349391 [Multi-domain]  Cd Length: 68  Bit Score: 56.62  E-value: 1.04e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
2XNH_A      204 IICVTGLCGLDRKEVQQLTVKHGGQY*GQLK*NEcTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDS 270
Cdd:cd18438   2 KITITNYTGAARQYLEKLILALGATYTKNLKPDN-THLITASPEGEKYEAAKEWNIPIVNHLWLYDS 67
BRCT_Ect2_rpt1 cd17733
first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar ...
 120-178 1.31e-10

first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins; ECT2 is a guanine nucleotide exchange factor (GEF) for Rho GTPases, phosphorylated in G2/M phases, and is involved in the regulation of cytokinesis. It contains two tandem BRCT domains. The family corresponds to the first BRCT domain.


Pssm-ID: 349365 [Multi-domain]  Cd Length: 76  Bit Score: 56.57  E-value: 1.31e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
2XNH_A      120 KREEVHKYVQ**---GGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEK 178
Cdd:cd17733  13 KKEELSRLVNLVhhmGGSIRKDFSSKVTHLVANSTQGEKYRVAVSLGTPIMTEDWIYKAWEK 74
BRCT_Ect2_rpt2 cd17732
second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar ...
 199-279 6.79e-10

second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins; ECT2 is a guanine nucleotide exchange factor (GEF) for Rho GTPases, phosphorylated in G2/M phases, and is involved in the regulation of cytokinesis. It contains two tandem BRCT domains. The family corresponds to the second BRCT domain.


Pssm-ID: 349364  Cd Length: 80  Bit Score: 54.58  E-value: 6.79e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XNH_A      199 IFLGCIICVTGLCGLDRKEVQQLTVKHGGQY*gQLK*NECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQD 278
Cdd:cd17732   1 PFEGCTLSFLGFSDEEKTHMEELTEENGGKVT-PLGDPSCTHLVVDESTVKELPFEPSSKLHVVKQEWFWASIQMDACAD 79


                .
2XNH_A      279 E 279
Cdd:cd17732  80 E 80
BRCT_Rev1 cd17719
BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha ...
 199-282 5.03e-09

BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha integrin-binding protein 80, or AIBP80, or Rev1-like terminal deoxycytidyl transferase, is a DNA template-dependent dCMP transferase required for mutagenesis induced by UV light.


Pssm-ID: 349351 [Multi-domain]  Cd Length: 87  Bit Score: 52.19  E-value: 5.03e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XNH_A      199 IFLGCIICVTGLCGLDRKEVQQLTVKHGGQY*GQLK*NECTHLIVQEPKGQKY-ECAKRWNVHCVTTQWFFDSIEKGFCQ 277
Cdd:cd17719   1 IFKGVVIYVNGYTDPSADELKRLILLHGGQYEHYYSRSRVTHIIATNLPGSKIkKLKKARNYKVVRPEWIVDSIKAGRLL 80


                ....*
2XNH_A      278 DESIY 282
Cdd:cd17719  81 PEAPY 85
BRCT smart00292
breast cancer carboxy-terminal domain;
107-176 5.41e-08

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 49.30  E-value: 5.41e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
2XNH_A         107 SDVTISCTS-LEKEKREEVHKYVQ**GGRVYRDLN-VSVTHLIAG--EVGSKKYLVAANLKKPILLPSWIKTLW 176
Cdd:smart00292   5 KGKTFYITGsFDKEERDELKELIEALGGKVTSSLSsKTTTHVIVGspEGGKLELLKAIALGIPIVKEEWLLDCL 78
BRCT_Rad4_rpt4 cd17723
fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...
 205-274 4.46e-07

fourth BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system, which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the fourth one.


Pssm-ID: 349355 [Multi-domain]  Cd Length: 74  Bit Score: 46.48  E-value: 4.46e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
2XNH_A      205 ICVTGLCGLDRKEVQQLTVKHGGQY*GQLK*NECTHLIVQ--EPKGQKYECAKRWNVHCVTTQWFFDSIEKG 274
Cdd:cd17723   4 ISLTGFSGVDLLHISKLIKLLGAKYHESLT-KDRSLLIVNstEKKSDKINFAKKWGIPVVSVEWLWDCLKEG 74
BRCT_Rad4_rpt2 cd17746
second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ...
 111-180 3.27e-06

second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the second one.


Pssm-ID: 349377 [Multi-domain]  Cd Length: 91  Bit Score: 44.53  E-value: 3.27e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XNH_A      111 ISCTSLEKEKREEVHKYVQ**GGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWiktLWEKSQ 180
Cdd:cd17746  12 VCLTNIGQPERSRIENYVLKHGGTFCPDLTRDVTHLIAGTSSGRKYEYALKWKINVVCVEW---LWQSIQ 78
PTCB-BRCT pfam12738
twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ...
 109-171 2.32e-05

twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair.


Pssm-ID: 463687 [Multi-domain]  Cd Length: 63  Bit Score: 41.42  E-value: 2.32e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
2XNH_A        109 VTISCTSLEKEKREEVHKYVQ**GGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSW 171
Cdd:pfam12738   1 LVICVTGFDGDDREGLQKLIEAMGAEYTKDLTKSVTHLICKSGEGEKYEKAKEWGIPVVSPLW 63
BRCT_BRC1_like_rpt2 cd18436
second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 200-270 5.09e-05

second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the second repeat.


Pssm-ID: 349389 [Multi-domain]  Cd Length: 75  Bit Score: 40.68  E-value: 5.09e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
2XNH_A      200 FLGCIICVTGLCGLDRKEVQQLTVKHGGQY*GQLk*NECTHLIVQEPKGQKYECA---KRWNVHCVTTQWFFDS 270
Cdd:cd18436   1 FSGVVITCSDLPSGDKEAIYGGVLALGGQYSDEL-TRDVTHLIALSPDGDKYKTAlkrPELNIKIVLPHWFDDC 73
BRCT_BRC1_like_rpt2 cd18436
second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ...
 107-172 6.02e-05

second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the second repeat.


Pssm-ID: 349389 [Multi-domain]  Cd Length: 75  Bit Score: 40.68  E-value: 6.02e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
2XNH_A      107 SDVTISCTSLEKEKREEVHKYVQ**GGRVYRDLNVSVTHLIAGEVGSKKYLVA---ANLKKPILLPSWI 172
Cdd:cd18436   2 SGVVITCSDLPSGDKEAIYGGVLALGGQYSDELTRDVTHLIALSPDGDKYKTAlkrPELNIKIVLPHWF 70
BRCT_PARP4_like cd17726
BRCT domain of poly [ADP-ribose] polymerase 4 (PARP-4) and similar proteins; PARP-4, also ...
 199-275 1.56e-04

BRCT domain of poly [ADP-ribose] polymerase 4 (PARP-4) and similar proteins; PARP-4, also termed 193 kDa vault protein, or ADP-ribosyltransferase diphtheria toxin-like 4 (ARTD4), or PARP-related/IalphaI-related H5/proline-rich (PH5P), or vault poly(ADP-ribose) polymerase (VPARP), shows poly(ADP-ribosyl)ation activity that catalyzes the formation of ADP-ribose polymers in response to DNA damage. PARP-4 is a component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this group.


Pssm-ID: 349358 [Multi-domain]  Cd Length: 85  Bit Score: 39.58  E-value: 1.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XNH_A      199 IFLGCIIC--VTGLCGLD-RKEVQQLTVKHGGQY*GQLK*NECTHLIVQEPKGQ-KYEC--AKRWNVHCVTTQWFFDSIE 272
Cdd:cd17726   1 VFSGCQIVldLKTLPGFKeKKKLKKKITENGGIISYIIN-KKCTHVVVNNAKALsSYKCrmAQKYGIPVVSLDYIWKCVE 79


                ...
2XNH_A      273 KGF 275
Cdd:cd17726  80 AGK 82
BRCT_PAXIP1_rpt2 cd17710
second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 132-172 2.44e-04

second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the second BRCT domain.


Pssm-ID: 349342 [Multi-domain]  Cd Length: 81  Bit Score: 39.14  E-value: 2.44e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
2XNH_A      132 GGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKP-ILLPSWI 172
Cdd:cd17710  28 GGKCQLNLDKKCTHLVTGKASGAKYECALKHEGIkIVTPDWV 69
BRCT_microcephalin_rpt2 cd17736
second BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage ...
 110-150 3.60e-04

second BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the second repeat.


Pssm-ID: 349368 [Multi-domain]  Cd Length: 76  Bit Score: 38.34  E-value: 3.60e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
2XNH_A      110 TISCTSLEKEKREEVHKYVQ**GG-RVYRDLNVSVTHLIAGE 150
Cdd:cd17736   2 TLVMTSVHSEEQELLESVVKKLGGfRVEDSVTEKTTHVVVGS 43
BRCT_CHS5_like cd17742
BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed ...
 214-268 5.84e-04

BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed protein CAL3, is a component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. It is also involved in targeting FUS1 to sites of polarized growth.


Pssm-ID: 349373 [Multi-domain]  Cd Length: 77  Bit Score: 37.70  E-value: 5.84e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
2XNH_A      214 DRKEVQQLTVKHGGQY*GQLK*nECTHLIVQEPKGQKYECAKRWNVHCVTTQWFF 268
Cdd:cd17742  15 SVDELEQCLERIGAKPTDRVAI-DTTHFVCTVPSGPEYEKAKEMNIPIVRPEWLR 68
BRCT_TopBP1_rpt7 cd17738
seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA ...
 114-172 3.36e-03

seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the seventh BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is missing in this group.


Pssm-ID: 349370 [Multi-domain]  Cd Length: 75  Bit Score: 35.62  E-value: 3.36e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
2XNH_A      114 TSLEKEKREEVHKYVQ**GGRVYRDL--NVSVTHLIAGEVG-SKKYLVAANLKKPILLPSWI 172
Cdd:cd17738   7 SGFSEDEKKELISIIEKLGGKVLDSDefDPKCTHLICGKPSrSEKFLAACAAGKWILHPSYI 68
BRCT_Bard1_rpt1 cd17734
first BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins; ...
 109-174 3.52e-03

first BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins; Bard1, also termed BARD-1, or RING-type E3 ubiquitin transferase BARD1, is a critical factor in BRCA1-mediated tumor suppression and may also serve as a target for tumorigenic lesions in some human cancers. It associates with BRCA1 (breast cancer-1) to form a heterodimeric BRCA1/BARD1 complex that is responsible for maintaining genomic stability through nuclear functions involving DNA damage signaling and repair, transcriptional regulation, and cell cycle control. The BRCA1/BARD1 complex catalyzes autoubiquitination of BRCA1 and trans ubiquitination of other protein substrates. Its E3 ligase activity is dramatically reduced in the presence of UBX domain protein 1 (UBXN1). BARD-1 contains an N-terminal C3HC4-type RING-HC finger that binds BRCA1, and a C-terminal region with three ankyrin repeats and tandem BRCT domains that bind CstF-50 (cleavage stimulation factor) to modulate mRNA processing and RNAP II stability in response to DNA damage. The family corresponds to the first BRCT domain.


Pssm-ID: 349366  Cd Length: 80  Bit Score: 35.65  E-value: 3.52e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
2XNH_A      109 VTISCTSLEKEKREEVHKYVQ**GGRVYRDLNVSVTHLIAGEVGSK------KYLVAANLKKPILLPSWIKT 174
Cdd:cd17734   1 LVLLGSGLSSEQKKLLEKLAQLLKAKVVTEFSPEVTHVVVPADERGvcprtmKYLMGILAGKWIVSFEWVEA 72
BRCT_CTDP1 cd17729
BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar ...
 199-279 3.87e-03

BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins; CTDP1 (EC 3.1.3.16), also termed TFIIF-associating CTD phosphatase, or TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1), promotes the activity of RNA polymerase II through processively dephosphorylating 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. It plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.


Pssm-ID: 349361 [Multi-domain]  Cd Length: 97  Bit Score: 35.97  E-value: 3.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2XNH_A      199 IFLGCIICVTGL----CGLDRKEVQQLTVKHGGQY*GQLk*NECTHLIVQEPKGQKYECAKRW-NVHCVTTQWFFDSIEK 273
Cdd:cd17729  13 VLKGCVIVFSGViptgIDPERSRLWKLAESLGAKVVTDL-SPRTTHLVAAKLGTEKVKQALKMpGIHVVHPDWLWACAER 91


                ....*.
2XNH_A      274 GFCQDE 279
Cdd:cd17729  92 WERVDE 97
BRCT_TopBP1_rpt6 cd17727
sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ...
 202-269 6.48e-03

sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the sixth BRCT domain.


Pssm-ID: 349359 [Multi-domain]  Cd Length: 75  Bit Score: 34.88  E-value: 6.48e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
2XNH_A      202 GCIICVTGLCGLDRKEVQQLTVKHGGQY*GQLk*NECTHLIVQ---EPKGQKYECAKRWNVHCVTTQWFFD 269
Cdd:cd17727   3 GVVICVSKKLSKRQGELNKIAASLGAEYRWTY-DESCTHFIYQgkaNDTNREYKSAKEQGKFIVSPHWLYA 72
BRCT_PAXIP1_rpt3 cd17711
third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ...
 202-274 7.19e-03

third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the third BRCT domain.


Pssm-ID: 349343  Cd Length: 81  Bit Score: 34.93  E-value: 7.19e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
2XNH_A      202 GCIICVTG----LCGLDRKEVQQLTVKHGGQY*GQLk*NECTHLIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKG 274
Cdd:cd17711   1 GCVFFIADypeqMGDQEIATWKKVIEEHGGEVVDEY-SPRVTHVICESQDSPEYQQALRDGKRVVTAYWLNDVLKRG 76
BRCT_2 pfam16589
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ...
 199-274 7.80e-03

BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.


Pssm-ID: 465186 [Multi-domain]  Cd Length: 84  Bit Score: 34.65  E-value: 7.80e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
2XNH_A        199 IFLGCIICVTGLCGLDRKEVQQLTVKHGGqY*GQLK*NECTHLIVqePKGQKYECAKRWNVHCVTTQWFFDSIEKG 274
Cdd:pfam16589   4 LFEPLRFYINAIPSPSRSKLKRLIEANGG-TVVDNINPAVYIVIA--PYNKTDKLAENTKLGVVSPQWIFDCVKKG 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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