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Conserved domains on  [gi|185177854|pdb|3BRV|A]
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Chain A, Inhibitor of nuclear factor kappa-B kinase subunit beta

Protein Classification

IKBKB_SDD and IKKbetaNEMObind domain-containing protein( domain architecture ID 10573526)

IKBKB_SDD and IKKbetaNEMObind domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IKKbetaNEMObind pfam12179
I-kappa-kinase-beta NEMO binding domain; This domain family is found in eukaryotes, and is ...
 9-45 4.05e-12

I-kappa-kinase-beta NEMO binding domain; This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with pfam00069. These proteins are involved in inflammatory reactions. They cause release of NF-kappa-B into the nucleus of inflammatory cells and upregulation of transcription of proinflammatory cytokines. They perform this function by phosphorylating I-kappa-B proteins which are targeted for degradation to release NF-kappa-B. This kinase (I-kappa-kinase-beta) is found in association with IKK-alpha and NEMO (NF-kappa-B essential modulator). This domain is the binding site of IKK-beta for NEMO.


:

Pssm-ID: 463485  Cd Length: 37  Bit Score: 53.46  E-value: 4.05e-12
                         10        20        30
                 ....*....|....*....|....*....|....*..
3BRV_A         9 EELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWL 45
Cdd:pfam12179  1 AQLIEENLNYLSQLSSLMQEATKEQDQSLMSLDWSWL 37
 
Name Accession Description Interval E-value
IKKbetaNEMObind pfam12179
I-kappa-kinase-beta NEMO binding domain; This domain family is found in eukaryotes, and is ...
 9-45 4.05e-12

I-kappa-kinase-beta NEMO binding domain; This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with pfam00069. These proteins are involved in inflammatory reactions. They cause release of NF-kappa-B into the nucleus of inflammatory cells and upregulation of transcription of proinflammatory cytokines. They perform this function by phosphorylating I-kappa-B proteins which are targeted for degradation to release NF-kappa-B. This kinase (I-kappa-kinase-beta) is found in association with IKK-alpha and NEMO (NF-kappa-B essential modulator). This domain is the binding site of IKK-beta for NEMO.


Pssm-ID: 463485  Cd Length: 37  Bit Score: 53.46  E-value: 4.05e-12
                         10        20        30
                 ....*....|....*....|....*....|....*..
3BRV_A         9 EELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWL 45
Cdd:pfam12179  1 AQLIEENLNYLSQLSSLMQEATKEQDQSLMSLDWSWL 37
 
Name Accession Description Interval E-value
IKKbetaNEMObind pfam12179
I-kappa-kinase-beta NEMO binding domain; This domain family is found in eukaryotes, and is ...
 9-45 4.05e-12

I-kappa-kinase-beta NEMO binding domain; This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with pfam00069. These proteins are involved in inflammatory reactions. They cause release of NF-kappa-B into the nucleus of inflammatory cells and upregulation of transcription of proinflammatory cytokines. They perform this function by phosphorylating I-kappa-B proteins which are targeted for degradation to release NF-kappa-B. This kinase (I-kappa-kinase-beta) is found in association with IKK-alpha and NEMO (NF-kappa-B essential modulator). This domain is the binding site of IKK-beta for NEMO.


Pssm-ID: 463485  Cd Length: 37  Bit Score: 53.46  E-value: 4.05e-12
                         10        20        30
                 ....*....|....*....|....*....|....*..
3BRV_A         9 EELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWL 45
Cdd:pfam12179  1 AQLIEENLNYLSQLSSLMQEATKEQDQSLMSLDWSWL 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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