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Conserved domains on  [gi|261825096|pdb|3K4S|A]
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Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D

Protein Classification

3',5'-cyclic nucleotide phosphodiesterase( domain architecture ID 10446396)

3',5'-cyclic nucleotide phosphodiesterase catalyzes the hydrolysis of cAMP or cGMP to produce adenosine 5'-phosphate or guanosine 5'-phosphate, respectively

CATH:  1.10.1300.10
EC:  3.1.4.-
Gene Ontology:  GO:0046872|GO:0004114
PubMed:  11008484|9868367
SCOP:  4001423

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
95-335 2.65e-121

3'5'-cyclic nucleotide phosphodiesterase;


:

Pssm-ID: 459723  Cd Length: 238  Bit Score: 349.16  E-value: 2.65e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K4S_A         95 YHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGF 174
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K4S_A        175 KLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSgvllLDNYSDRIQVL-QNMVHCA 253
Cdd:pfam00233  81 QILQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESKKTLDF----LENEEDRRLLLlSMLIKAA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K4S_A        254 DLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCD-KHNASVEKSQVGFIDYIVHPLWETWADLVhPDAQDIL 332
Cdd:pfam00233 157 DISNPTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDrEKKTSLPKSQIGFIDFIVLPLFEALAKLF-PELQPLL 235

                  ...
3K4S_A        333 DTL 335
Cdd:pfam00233 236 DQL 238
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
95-335 2.65e-121

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 459723  Cd Length: 238  Bit Score: 349.16  E-value: 2.65e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K4S_A         95 YHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGF 174
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K4S_A        175 KLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSgvllLDNYSDRIQVL-QNMVHCA 253
Cdd:pfam00233  81 QILQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESKKTLDF----LENEEDRRLLLlSMLIKAA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K4S_A        254 DLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCD-KHNASVEKSQVGFIDYIVHPLWETWADLVhPDAQDIL 332
Cdd:pfam00233 157 DISNPTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDrEKKTSLPKSQIGFIDFIVLPLFEALAKLF-PELQPLL 235

                  ...
3K4S_A        333 DTL 335
Cdd:pfam00233 236 DQL 238
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
95-277 4.39e-10

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 57.35  E-value: 4.39e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K4S_A       95 YHNNIHAADVVQSTHVLlstpALEAVFTDLEILAAIFASAIHDVDHPGVSNQFlintnselalmYNDSSVLENHHLAVGF 174
Cdd:cd00077   1 EHRFEHSLRVAQLARRL----AEELGLSEEDIELLRLAALLHDIGKPGTPDAI-----------TEEESELEKDHAIVGA 65
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K4S_A      175 KLLQEEncdifqnltkkQRQSLRKMVIDIVLATDMSkHMNLLADLKTMVETKKvtssgvllldnysDRIQVLQNMVHCAD 254
Cdd:cd00077  66 EILREL-----------LLEEVIKLIDELILAVDAS-HHERLDGLGYPDGLKG-------------EEITLEARIVKLAD 120
                       170       180
                ....*....|....*....|....*
3K4S_A      255 LSNPTKPLQLY--RQWTDRIMEEFF 277
Cdd:cd00077 121 RLDALRRDSREkrRRIAEEDLEELL 145
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
94-268 6.85e-06

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 44.98  E-value: 6.85e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K4S_A          94 AYHNNIHAADVVQSTHVLLSTPALeavftdLEILAAIFASAIHDVDHPGVSNQFLINTnselalmyndsSVLENHHLAVG 173
Cdd:smart00471   2 DYHVFEHSLRVAQLAAALAEELGL------LDIELLLLAALLHDIGKPGTPDSFLVKT-----------SVLEDHHFIGA 64
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K4S_A         174 FKLLQEENCDIFQNLtkkqrqslrkmvidivLATDMSKHMNLLADLKTMVETkkvtssgvllldnysdriqVLQNMVHCA 253
Cdd:smart00471  65 EILLEEEEPRILEEI----------------LRTAILSHHERPDGLRGEPIT-------------------LEARIVKVA 109
                          170
                   ....*....|....*
3K4S_A         254 DLSNPTKPLQLYRQW 268
Cdd:smart00471 110 DRLDALRADRRYRRV 124
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
95-335 2.65e-121

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 459723  Cd Length: 238  Bit Score: 349.16  E-value: 2.65e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K4S_A         95 YHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGF 174
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K4S_A        175 KLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSgvllLDNYSDRIQVL-QNMVHCA 253
Cdd:pfam00233  81 QILQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESKKTLDF----LENEEDRRLLLlSMLIKAA 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K4S_A        254 DLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCD-KHNASVEKSQVGFIDYIVHPLWETWADLVhPDAQDIL 332
Cdd:pfam00233 157 DISNPTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDrEKKTSLPKSQIGFIDFIVLPLFEALAKLF-PELQPLL 235

                  ...
3K4S_A        333 DTL 335
Cdd:pfam00233 236 DQL 238
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
95-277 4.39e-10

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 57.35  E-value: 4.39e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K4S_A       95 YHNNIHAADVVQSTHVLlstpALEAVFTDLEILAAIFASAIHDVDHPGVSNQFlintnselalmYNDSSVLENHHLAVGF 174
Cdd:cd00077   1 EHRFEHSLRVAQLARRL----AEELGLSEEDIELLRLAALLHDIGKPGTPDAI-----------TEEESELEKDHAIVGA 65
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K4S_A      175 KLLQEEncdifqnltkkQRQSLRKMVIDIVLATDMSkHMNLLADLKTMVETKKvtssgvllldnysDRIQVLQNMVHCAD 254
Cdd:cd00077  66 EILREL-----------LLEEVIKLIDELILAVDAS-HHERLDGLGYPDGLKG-------------EEITLEARIVKLAD 120
                       170       180
                ....*....|....*....|....*
3K4S_A      255 LSNPTKPLQLY--RQWTDRIMEEFF 277
Cdd:cd00077 121 RLDALRRDSREkrRRIAEEDLEELL 145
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
94-268 6.85e-06

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 44.98  E-value: 6.85e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K4S_A          94 AYHNNIHAADVVQSTHVLLSTPALeavftdLEILAAIFASAIHDVDHPGVSNQFLINTnselalmyndsSVLENHHLAVG 173
Cdd:smart00471   2 DYHVFEHSLRVAQLAAALAEELGL------LDIELLLLAALLHDIGKPGTPDSFLVKT-----------SVLEDHHFIGA 64
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K4S_A         174 FKLLQEENCDIFQNLtkkqrqslrkmvidivLATDMSKHMNLLADLKTMVETkkvtssgvllldnysdriqVLQNMVHCA 253
Cdd:smart00471  65 EILLEEEEPRILEEI----------------LRTAILSHHERPDGLRGEPIT-------------------LEARIVKVA 109
                          170
                   ....*....|....*
3K4S_A         254 DLSNPTKPLQLYRQW 268
Cdd:smart00471 110 DRLDALRADRRYRRV 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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