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Conserved domains on  [gi|299856873|pdb|3N4T|A]
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Chain A, APH(2'')-Id

Protein Classification

phosphotransferase family protein( domain architecture ID 10007008)

phosphotransferase family protein may catalyze the phosphorylation of aminoglycosides and confer aminoglycoside antibiotic resistance; similar to viomycin phosphotransferase, 4-hydroxytryptamine kinase, and hygromycin B phosphotransferase

CATH:  1.10.510.10
EC:  2.7.-.-
Gene Ontology:  GO:0016301|GO:0005524|GO:0016310
PubMed:  16244704
SCOP:  3000066

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YcbJ COG3173
Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction ...
 7-234 2.99e-22

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];


:

Pssm-ID: 442406 [Multi-domain]  Cd Length: 284  Bit Score: 93.64  E-value: 2.99e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3N4T_A        7 DQVEKAIEQLYPDFT-INTIEISGEGNDCIAYEI--NRDFIFKF-PKHSRGSTNLFNEVNILKRIHNKLPLPIPEVVFTG 82
Cdd:COG3173   6 AALRALLAAQLPGLAgLPEVEPLSGGWSNLTYRLdtGDRLVLRRpPRGLASAHDVRREARVLRALAPRLGVPVPRPLALG 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3N4T_A       83 MPSETYQMSFAGFTKIKGVPLTPLLLNNLPKQsQNQAAKDLARFLSELHSINIS--GFKSNLVLDFREKINEDNKKIKKL 160
Cdd:COG3173  86 EDGEVIGAPFYVMEWVEGETLEDALPDLSPAE-RRALARALGEFLAALHAVDPAaaGLADGRPEGLERQLARWRAQLRRA 164

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
3N4T_A      161 LSRELKGPQMkkvDDFYRDILENEIYFKYYPCLIHNDFSSDHILFDTEKNTICGIIDFGDAAISDPDNDFISLM 234
Cdd:COG3173 165 LARTDDLPAL---RERLAAWLAANLPEWGPPVLVHGDLRPGNLLVDPDDGRLTAVIDWELATLGDPAADLAYLL 235
 
Name Accession Description Interval E-value
YcbJ COG3173
Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction ...
 7-234 2.99e-22

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];


Pssm-ID: 442406 [Multi-domain]  Cd Length: 284  Bit Score: 93.64  E-value: 2.99e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3N4T_A        7 DQVEKAIEQLYPDFT-INTIEISGEGNDCIAYEI--NRDFIFKF-PKHSRGSTNLFNEVNILKRIHNKLPLPIPEVVFTG 82
Cdd:COG3173   6 AALRALLAAQLPGLAgLPEVEPLSGGWSNLTYRLdtGDRLVLRRpPRGLASAHDVRREARVLRALAPRLGVPVPRPLALG 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3N4T_A       83 MPSETYQMSFAGFTKIKGVPLTPLLLNNLPKQsQNQAAKDLARFLSELHSINIS--GFKSNLVLDFREKINEDNKKIKKL 160
Cdd:COG3173  86 EDGEVIGAPFYVMEWVEGETLEDALPDLSPAE-RRALARALGEFLAALHAVDPAaaGLADGRPEGLERQLARWRAQLRRA 164

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
3N4T_A      161 LSRELKGPQMkkvDDFYRDILENEIYFKYYPCLIHNDFSSDHILFDTEKNTICGIIDFGDAAISDPDNDFISLM 234
Cdd:COG3173 165 LARTDDLPAL---RERLAAWLAANLPEWGPPVLVHGDLRPGNLLVDPDDGRLTAVIDWELATLGDPAADLAYLL 235
APH pfam01636
Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance ...
 40-252 5.78e-22

Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.


Pssm-ID: 426359 [Multi-domain]  Cd Length: 239  Bit Score: 92.18  E-value: 5.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3N4T_A         40 NRDFIFKFPKHSRGSTNLFNEVNILKRIHNKLPLPIPEVVFTGMPSETYQMSFAGFTKIKGvpltPLLLNNLPKQSQNQA 119
Cdd:pfam01636  20 DGRYVLRLPPPGRAAEELRRELALLRHLAAAGVPPVPRVLAGCTDAELLGLPFLLMEYLPG----EVLARPLLPEERGAL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3N4T_A        120 AKDLARFLSELHSINISGFKSNLVLDFREKINEDNKKIKKLLSRELKGPQMKKVDDFYRDILENEIYFKYYPCLIHNDFS 199
Cdd:pfam01636  96 LEALGRALARLHAVDPAALPLAGRLARLLELLRQLEAALARLLAAELLDRLEELEERLLAALLALLPAELPPVLVHGDLH 175

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
3N4T_A        200 SDHILFDtEKNTICGIIDFGDAAISDPDNDFISLMED-DEEYGMEFVSKILNHY 252
Cdd:pfam01636 176 PGNLLVD-PGGRVSGVIDFEDAGLGDPAYDLAILLNSwGRELGAELLAAYLAAY 228
APH_ChoK_like_1 cd05155
Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase and ...
 42-226 1.76e-14

Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase and Choline kinase; This subfamily is composed of uncharacterized bacterial proteins with similarity to APH and ChoK. Other APH/ChoK-like proteins include ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). These proteins catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates, such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides, and macrolides leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270704 [Multi-domain]  Cd Length: 234  Bit Score: 71.11  E-value: 1.76e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3N4T_A       42 DFIFKFPKHSRGSTNLFNEVNILKRIHNKLPLPIPEVVFTGMPSETYQMSFAGFTKIKGVPLTPLLLnnlpkQSQNQAAK 121
Cdd:cd05155  20 DLAVRLPRRAWAAELLEKEQRWLPRLAPRLPLPVPVPLALGKPGAGYPWPWSVYRWLEGETAADAPL-----ADPAAAAE 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3N4T_A      122 DLARFLSELHSINISG----FKSN----LVLDFREKINEDNKkikklLSRELKGPQMKKVddfYRDILENEIYFKyYPCL 193
Cdd:cd05155  95 DLARFLAALHAIDPAGppnpGRGNplrgRDLAVRDAEEALAA-----LAGLLDVAAARAL---WERALAAPAWAG-PPVW 165

                       170       180       190
                ....*....|....*....|....*....|...
3N4T_A      194 IHNDFSSDHILFDTEKntICGIIDFGDAAISDP 226
Cdd:cd05155 166 LHGDLHPGNLLVRDGR--LSAVIDFGDLGVGDP 196
 
Name Accession Description Interval E-value
YcbJ COG3173
Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction ...
 7-234 2.99e-22

Predicted kinase, aminoglycoside phosphotransferase (APT) family [General function prediction only];


Pssm-ID: 442406 [Multi-domain]  Cd Length: 284  Bit Score: 93.64  E-value: 2.99e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3N4T_A        7 DQVEKAIEQLYPDFT-INTIEISGEGNDCIAYEI--NRDFIFKF-PKHSRGSTNLFNEVNILKRIHNKLPLPIPEVVFTG 82
Cdd:COG3173   6 AALRALLAAQLPGLAgLPEVEPLSGGWSNLTYRLdtGDRLVLRRpPRGLASAHDVRREARVLRALAPRLGVPVPRPLALG 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3N4T_A       83 MPSETYQMSFAGFTKIKGVPLTPLLLNNLPKQsQNQAAKDLARFLSELHSINIS--GFKSNLVLDFREKINEDNKKIKKL 160
Cdd:COG3173  86 EDGEVIGAPFYVMEWVEGETLEDALPDLSPAE-RRALARALGEFLAALHAVDPAaaGLADGRPEGLERQLARWRAQLRRA 164

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
3N4T_A      161 LSRELKGPQMkkvDDFYRDILENEIYFKYYPCLIHNDFSSDHILFDTEKNTICGIIDFGDAAISDPDNDFISLM 234
Cdd:COG3173 165 LARTDDLPAL---RERLAAWLAANLPEWGPPVLVHGDLRPGNLLVDPDDGRLTAVIDWELATLGDPAADLAYLL 235
APH pfam01636
Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance ...
 40-252 5.78e-22

Phosphotransferase enzyme family; This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.


Pssm-ID: 426359 [Multi-domain]  Cd Length: 239  Bit Score: 92.18  E-value: 5.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3N4T_A         40 NRDFIFKFPKHSRGSTNLFNEVNILKRIHNKLPLPIPEVVFTGMPSETYQMSFAGFTKIKGvpltPLLLNNLPKQSQNQA 119
Cdd:pfam01636  20 DGRYVLRLPPPGRAAEELRRELALLRHLAAAGVPPVPRVLAGCTDAELLGLPFLLMEYLPG----EVLARPLLPEERGAL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3N4T_A        120 AKDLARFLSELHSINISGFKSNLVLDFREKINEDNKKIKKLLSRELKGPQMKKVDDFYRDILENEIYFKYYPCLIHNDFS 199
Cdd:pfam01636  96 LEALGRALARLHAVDPAALPLAGRLARLLELLRQLEAALARLLAAELLDRLEELEERLLAALLALLPAELPPVLVHGDLH 175

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
3N4T_A        200 SDHILFDtEKNTICGIIDFGDAAISDPDNDFISLMED-DEEYGMEFVSKILNHY 252
Cdd:pfam01636 176 PGNLLVD-PGGRVSGVIDFEDAGLGDPAYDLAILLNSwGRELGAELLAAYLAAY 228
APH_ChoK_like_1 cd05155
Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase and ...
 42-226 1.76e-14

Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase and Choline kinase; This subfamily is composed of uncharacterized bacterial proteins with similarity to APH and ChoK. Other APH/ChoK-like proteins include ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). These proteins catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates, such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides, and macrolides leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270704 [Multi-domain]  Cd Length: 234  Bit Score: 71.11  E-value: 1.76e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3N4T_A       42 DFIFKFPKHSRGSTNLFNEVNILKRIHNKLPLPIPEVVFTGMPSETYQMSFAGFTKIKGVPLTPLLLnnlpkQSQNQAAK 121
Cdd:cd05155  20 DLAVRLPRRAWAAELLEKEQRWLPRLAPRLPLPVPVPLALGKPGAGYPWPWSVYRWLEGETAADAPL-----ADPAAAAE 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3N4T_A      122 DLARFLSELHSINISG----FKSN----LVLDFREKINEDNKkikklLSRELKGPQMKKVddfYRDILENEIYFKyYPCL 193
Cdd:cd05155  95 DLARFLAALHAIDPAGppnpGRGNplrgRDLAVRDAEEALAA-----LAGLLDVAAARAL---WERALAAPAWAG-PPVW 165

                       170       180       190
                ....*....|....*....|....*....|...
3N4T_A      194 IHNDFSSDHILFDTEKntICGIIDFGDAAISDP 226
Cdd:cd05155 166 LHGDLHPGNLLVRDGR--LSAVIDFGDLGVGDP 196
MPH2' cd05152
Macrolide 2'-Phosphotransferase; MPH2' catalyzes the transfer of the gamma-phosphoryl group ...
 40-254 2.38e-13

Macrolide 2'-Phosphotransferase; MPH2' catalyzes the transfer of the gamma-phosphoryl group from ATP to the 2'-hydroxyl of macrolide antibiotics such as erythromycin, clarithromycin, and azithromycin, among others. Macrolides penetrate the bacterial cell and bind to ribosomes, where it interrupts protein elongation, leading ultimately to the demise of the bacterium. Phosphorylation of macrolides leads to their inactivation. Based on substrate specificity and amino acid sequence, MPH2' is divided into types I and II, encoded by mphA and mphB genes, respectively. MPH2'I inactivates 14-membered ring macrolides while MPH2'II inactivates both 14- and 16-membered ring macrolides. Enzymatic inactivation of macrolides has been reported as a mechanism for bacterial resistance in clinical samples. MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270701 [Multi-domain]  Cd Length: 276  Bit Score: 68.81  E-value: 2.38e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3N4T_A       40 NRDFIFKFPKHSRGSTNLFNEVNILKRIHNKLPLPIPEV-VFTGmpsetyqmSFAGFTKIKGV-------PLTPLLLNNL 111
Cdd:cd05152  35 GRRWVLRIPRRPDVSERLEAEKKVLDLVTPHLPFAVPDWrIHTP--------ELIAYPLLPGVpaatidpEIQNYVWNWD 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3N4T_A      112 PKQSQNQAAKDLARFLSELHSINI-----SGFKSNLVLDFREKINEDNKKIK-------KLLSRelkgpqmkkvddfYRD 179
Cdd:cd05152 107 PLAPPPVFARSLGKALAALHSIPAdlaaaAGLPVYTAEEVRARMAARMDRVKetfgvppALLAR-------------WQA 173

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
3N4T_A      180 ILENEIYFKYYPCLIHNDFSSDHILFDtEKNTICGIIDFGDAAISDPDNDFISLMeddEEYGMEFVSKILNHYKH 254
Cdd:cd05152 174 WLADDSLWPFHTVLVHGDLHPGHILVD-EDGRVTGLIDWTEAKVGDPADDFAWHY---AAFGEEALERLLDAYEK 244
APH_ChoK_like cd05120
Aminoglycoside 3'-phosphotransferase and Choline Kinase family; This family is composed of APH, ...
 40-239 3.37e-12

Aminoglycoside 3'-phosphotransferase and Choline Kinase family; This family is composed of APH, ChoK, ethanolamine kinase (ETNK), macrolide 2'-phosphotransferase (MPH2'), an unusual homoserine kinase, and uncharacterized proteins with similarity to the N-terminal domain of acyl-CoA dehydrogenase 10 (ACAD10). The members of this family catalyze the transfer of the gamma-phosphoryl group from ATP (or CTP) to small molecule substrates such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine. Phosphorylation of the antibiotics, aminoglycosides and macrolides, leads to their inactivation and to bacterial antibiotic resistance. Phosphorylation of choline, ethanolamine, and homoserine serves as precursors to the synthesis of important biological compounds, such as the major phospholipids, phosphatidylcholine and phosphatidylethanolamine and the amino acids, threonine, methionine, and isoleucine. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270690 [Multi-domain]  Cd Length: 158  Bit Score: 63.09  E-value: 3.37e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3N4T_A       40 NRDFIFKFPKhSRGSTNLFNEVNILKRIHNKLPLPIPEVVFTGMPSETYqmsFAGFTKIKGVPLTPLLLNNLpKQSQNQA 119
Cdd:cd05120  20 PREYVLKIGP-PRLKKDLEKEAAMLQLLAGKLSLPVPKVYGFGESDGWE---YLLMERIEGETLSEVWPRLS-EEEKEKI 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3N4T_A      120 AKDLARFLSELHSINisgfksnlvldfrekinednkkikkllsrelkgpqmkkvddfyrdileneiyfkyYPCLIHNDFS 199
Cdd:cd05120  95 ADQLAEILAALHRID-------------------------------------------------------SSVLTHGDLH 119

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
3N4T_A      200 SDHILFDtEKNTICGIIDFGDAAISDPDNDFISLMEDDEE 239
Cdd:cd05120 120 PGNILVK-PDGKLSGIIDWEFAGYGPPAFDYAAALRDWTE 158
CotS COG0510
Thiamine kinase or a related kinase [Coenzyme transport and metabolism];
191-234 1.26e-03

Thiamine kinase or a related kinase [Coenzyme transport and metabolism];


Pssm-ID: 440276 [Multi-domain]  Cd Length: 156  Bit Score: 38.61  E-value: 1.26e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
3N4T_A      191 PCLIHNDFSSDHILFdTEKNTICgIIDFGDAAISDPDNDFISLM 234
Cdd:COG0510  49 LVLCHGDLHPGNFLV-TDDGRLY-LIDWEYAGLGDPAFDLAALL 90
HomoserineK_II cd05153
Type II Homoserine Kinase; This subfamily is composed of unusual homoserine kinases, from a ...
 120-221 1.28e-03

Type II Homoserine Kinase; This subfamily is composed of unusual homoserine kinases, from a subset of bacteria, which have a Protein Kinase fold. These proteins do not bear any similarity to the GHMP family homoserine kinases present in most bacteria and eukaryotes. Homoserine kinase catalyzes the transfer of the gamma-phosphoryl group from ATP to L-homoserine producing L-homoserine phosphate, an intermediate in the production of the amino acids threonine, methionine, and isoleucine. The Type II homoserine kinase subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270702 [Multi-domain]  Cd Length: 300  Bit Score: 39.93  E-value: 1.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3N4T_A      120 AKDLARFLSELHSInISGFK----SNLVLDFREKINEdnkKIKKLLSRELKGpqmkkvddfYRDILENEI-YFKYY---- 190
Cdd:cd05153 110 CRAIGAALARLHLA-LAGFPpprpNPRGLAWWKPLAE---RLKARLDLLAAD---------DRALLEDELaRLQALapsd 176

                        90       100       110
                ....*....|....*....|....*....|...
3N4T_A      191 -PC-LIHNDFSSDHILFDteKNTICGIIDFGDA 221
Cdd:cd05153 177 lPRgVIHADLFRDNVLFD--GDRLSGIIDFYDA 207
SrkA COG2334
Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist [Signal ...
 193-221 2.04e-03

Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist [Signal transduction mechanisms]; Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 441905 [Multi-domain]  Cd Length: 297  Bit Score: 39.14  E-value: 2.04e-03
                        10        20
                ....*....|....*....|....*....
3N4T_A      193 LIHNDFSSDHILFDTEKntICGIIDFGDA 221
Cdd:COG2334 181 VIHGDLHPDNVLFDGDG--VSGLIDFDDA 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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