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Conserved domains on  [gi|340780526|pdb|3PIW|A]
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Chain A, Type I interferon 2

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IFab super family cl00092
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon ...
 19-150 6.42e-24

Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. All function as regulators of cellular activty by interacting with cell-surface receptors and activating various signalling pathways. Interferons produce antiviral and antiproliferative responses in cells. Receptor specificity determines function of the various members of the family.


The actual alignment was detected with superfamily member pfam00143:

Pssm-ID: 469611  Cd Length: 160  Bit Score: 91.10  E-value: 6.42e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PIW_A         19 LLESMGGIFPRECLKENVRITFPKYALQSNNsNQKTGVAKAVYKIMDHIDVLFANDSYPEAWNKRKVDNFQNIVYRLTKE 98
Cdd:pfam00143  15 LLNQMRRSSPQSCLKDRKDFKFPQEILSGSQ-LQKEQAALVLHEMLQQIFNLFSTNHSSAAWNETLLEQLLNGLHQQLED 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
3PIW_A         99 -NKCIMrmrAQGTVDDFPARDD----ALKSYFNKLATLLRNKDNSFCAWEVVRHELL 150
Cdd:pfam00143  94 lETCLG---EEMEEEESPLGNEdsrlALKKYFQRIHLYLKEKEYSSCAWEVVRVEIR 147
 
Name Accession Description Interval E-value
Interferon pfam00143
Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical ...
 19-150 6.42e-24

Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical cytokine superfamily,which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules.


Pssm-ID: 459689  Cd Length: 160  Bit Score: 91.10  E-value: 6.42e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PIW_A         19 LLESMGGIFPRECLKENVRITFPKYALQSNNsNQKTGVAKAVYKIMDHIDVLFANDSYPEAWNKRKVDNFQNIVYRLTKE 98
Cdd:pfam00143  15 LLNQMRRSSPQSCLKDRKDFKFPQEILSGSQ-LQKEQAALVLHEMLQQIFNLFSTNHSSAAWNETLLEQLLNGLHQQLED 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
3PIW_A         99 -NKCIMrmrAQGTVDDFPARDD----ALKSYFNKLATLLRNKDNSFCAWEVVRHELL 150
Cdd:pfam00143  94 lETCLG---EEMEEEESPLGNEdsrlALKKYFQRIHLYLKEKEYSSCAWEVVRVEIR 147
IFab cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon ...
 19-150 1.35e-18

Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. All function as regulators of cellular activty by interacting with cell-surface receptors and activating various signalling pathways. Interferons produce antiviral and antiproliferative responses in cells. Receptor specificity determines function of the various members of the family.


Pssm-ID: 238047  Cd Length: 152  Bit Score: 77.38  E-value: 1.35e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PIW_A       19 LLESMGGIFPRECLKENVRITFPKYALQSNnSNQKTGVAKAVYKIMDHIDVLFANDSYPEAWNKRKVDNFQNIVYR-LTK 97
Cdd:cd00095  15 LLRQMRRLPPQSCLKDRADFGFPQELLQGD-QFQKAQAASVLHEMLQQIFNIFSTPSSSAAWNETLLESLLNELHQqLNH 93

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
3PIW_A       98 ENKCIMrmrAQGTVDDFPARDD---ALKSYFNKLATLLRNKDNSFCAWEVVRHELL 150
Cdd:cd00095  94 LETCLE---QEMGEEETPGPRNthlHLRKYFQRIQLYLKEKKYSPCAWEVVRAEIM 146
IFabd smart00076
Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative ...
 40-150 1.80e-14

Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon.


Pssm-ID: 197503  Cd Length: 117  Bit Score: 65.41  E-value: 1.80e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PIW_A          40 FPKYALQSNNSnQKTGVAKAVYKIMDHIDVLFANDSYPEAWNKRKVDNFQNIVYR-LTKENKCIMrmrAQGTVDDFPARD 118
Cdd:smart00076   4 FPEEILDGSQF-QKAQAASVIHEMLQQIFNIFSSPSSSAAWNETLLESLLNELHQqLNHLEACLK---QQMGEEETPLTR 79

                           90       100       110
                   ....*....|....*....|....*....|....*
3PIW_A         119 D---ALKSYFNKLATLLRNKDNSFCAWEVVRHELL 150
Cdd:smart00076  80 NthlALKKYFQRIQLYLKEKKYSPCAWEVVRVEIR 114
 
Name Accession Description Interval E-value
Interferon pfam00143
Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical ...
 19-150 6.42e-24

Interferon alpha/beta domain; Type I interferons (alpha, beta) belong to the larger helical cytokine superfamily,which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules.


Pssm-ID: 459689  Cd Length: 160  Bit Score: 91.10  E-value: 6.42e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PIW_A         19 LLESMGGIFPRECLKENVRITFPKYALQSNNsNQKTGVAKAVYKIMDHIDVLFANDSYPEAWNKRKVDNFQNIVYRLTKE 98
Cdd:pfam00143  15 LLNQMRRSSPQSCLKDRKDFKFPQEILSGSQ-LQKEQAALVLHEMLQQIFNLFSTNHSSAAWNETLLEQLLNGLHQQLED 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
3PIW_A         99 -NKCIMrmrAQGTVDDFPARDD----ALKSYFNKLATLLRNKDNSFCAWEVVRHELL 150
Cdd:pfam00143  94 lETCLG---EEMEEEESPLGNEdsrlALKKYFQRIHLYLKEKEYSSCAWEVVRVEIR 147
IFab cd00095
Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon ...
 19-150 1.35e-18

Interferon alpha, beta. Includes also interferon omega and tau. Different from interferon gamma family. Type I interferons(alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. All function as regulators of cellular activty by interacting with cell-surface receptors and activating various signalling pathways. Interferons produce antiviral and antiproliferative responses in cells. Receptor specificity determines function of the various members of the family.


Pssm-ID: 238047  Cd Length: 152  Bit Score: 77.38  E-value: 1.35e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PIW_A       19 LLESMGGIFPRECLKENVRITFPKYALQSNnSNQKTGVAKAVYKIMDHIDVLFANDSYPEAWNKRKVDNFQNIVYR-LTK 97
Cdd:cd00095  15 LLRQMRRLPPQSCLKDRADFGFPQELLQGD-QFQKAQAASVLHEMLQQIFNIFSTPSSSAAWNETLLESLLNELHQqLNH 93

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
3PIW_A       98 ENKCIMrmrAQGTVDDFPARDD---ALKSYFNKLATLLRNKDNSFCAWEVVRHELL 150
Cdd:cd00095  94 LETCLE---QEMGEEETPGPRNthlHLRKYFQRIQLYLKEKKYSPCAWEVVRAEIM 146
IFabd smart00076
Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative ...
 40-150 1.80e-14

Interferon alpha, beta and delta; Interferons produce antiviral and antiproliferative responses in cells. They are classified into five groups, all of them related but gamma-interferon.


Pssm-ID: 197503  Cd Length: 117  Bit Score: 65.41  E-value: 1.80e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PIW_A          40 FPKYALQSNNSnQKTGVAKAVYKIMDHIDVLFANDSYPEAWNKRKVDNFQNIVYR-LTKENKCIMrmrAQGTVDDFPARD 118
Cdd:smart00076   4 FPEEILDGSQF-QKAQAASVIHEMLQQIFNIFSSPSSSAAWNETLLESLLNELHQqLNHLEACLK---QQMGEEETPLTR 79

                           90       100       110
                   ....*....|....*....|....*....|....*
3PIW_A         119 D---ALKSYFNKLATLLRNKDNSFCAWEVVRHELL 150
Cdd:smart00076  80 NthlALKKYFQRIQLYLKEKKYSPCAWEVVRVEIR 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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