NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|326634627|pdb|3R0P|F]
View 

Chain F, L-PSP putative endoribonuclease

Protein Classification

RidA family protein( domain architecture ID 10794411)

RidA (reactive intermediate/imine deaminase A) family protein similar to 2-iminobutanoate/2-iminopropanoate deaminase, which catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia

CATH:  3.30.1330.40
PubMed:  14624641

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 4-126 9.99e-62

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


:

Pssm-ID: 129116  Cd Length: 124  Bit Score: 184.81  E-value: 9.99e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3R0P_F          4 KAIIHSDNAPAAIGTYSQAVKVNNTVYLSGQIPLDPVTMQLVEGDFAVQAHQVFKNLRAVCEAAGGGLRDIVKLNVYLTD 83
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
3R0P_F         84 LANFPIVNEVMGQYFQAPYPARAAIGINQLPRASLIEADGIMV 126
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIAV 123
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 4-126 9.99e-62

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 184.81  E-value: 9.99e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3R0P_F          4 KAIIHSDNAPAAIGTYSQAVKVNNTVYLSGQIPLDPVTMQLVEGDFAVQAHQVFKNLRAVCEAAGGGLRDIVKLNVYLTD 83
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
3R0P_F         84 LANFPIVNEVMGQYFQAPYPARAAIGINQLPRASLIEADGIMV 126
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIAV 123
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 1-127 3.23e-51

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 158.03  E-value: 3.23e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3R0P_F        1 MTNKAIihSDNAPAAIGTYSQAVKVNNTVYLSGQIPLDPVTMQlVEGDFAVQAHQVFKNLRAVCEAAGGGLRDIVKLNVY 80
Cdd:COG0251   1 MTRELI--NPPAPAPIGPYSQAVRVGNLVFVSGQVPLDPDTGE-LGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVY 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
3R0P_F       81 LTDLANFPIVNEVMGQYFQAPYPARAAIGINQLPRASLIEADGIMVI 127
Cdd:COG0251  78 LTDMADFAAVNEVYAEYFGEGRPARTAVGVAALPKGALVEIEAIAAL 124
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 11-126 4.00e-43

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 137.43  E-value: 4.00e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3R0P_F         11 NAPAAIGTYSQAVKVNNTVYLSGQIPLDPVTMQLVEGDFAVQAHQVFKNLRAVCEAAGGGLRDIVKLNVYLTDLANFPIV 90
Cdd:pfam01042   1 NAPAAAGPYSQAVKAGNLVYVSGQIPLDPDTGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEV 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
3R0P_F         91 NEVMGQYFQAP-YPARAAIGINQLPRASLIEADGIMV 126
Cdd:pfam01042  81 NEVYAEYFDADkAPARSAVGVAALPLGALVEIEAIAV 117
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 19-124 2.06e-41

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 132.68  E-value: 2.06e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3R0P_F       19 YSQAVKVNNTVYLSGQIPLDPVTMqLVEGDFAVQAHQVFKNLRAVCEAAGGGLRDIVKLNVYLTDLANFPIVNEVMGQYF 98
Cdd:cd00448   1 YSQAVRVGNLVFVSGQIPLDPDGE-LVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFF 79

                        90       100
                ....*....|....*....|....*..
3R0P_F       99 -QAPYPARAAIGINQLPRASLIEADGI 124
Cdd:cd00448  80 gEGPPPARTAVGVAALPPGALVEIEAI 106
PRK11401 PRK11401
enamine/imine deaminase;
4-126 2.85e-26

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 95.13  E-value: 2.85e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3R0P_F         4 KAIIHSDNAPAAIGTYSQAVKVNNTVYLSGQIPLDPVTMQLVEgDFAVQAHQVFKNLRAVCEAAGGGLRDIVKLNVYLTD 83
Cdd:PRK11401   2 KKIIETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGEIPA-DVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
3R0P_F        84 LANFPIVNEVMGQYF---QAPYPARAAIGINQLPRASLIEADGIMV 126
Cdd:PRK11401  81 LNDFATINEVYKQFFdehQATYPTRSCVQVARLPKDVKLEIEAIAV 126
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 4-126 9.99e-62

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 184.81  E-value: 9.99e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3R0P_F          4 KAIIHSDNAPAAIGTYSQAVKVNNTVYLSGQIPLDPVTMQLVEGDFAVQAHQVFKNLRAVCEAAGGGLRDIVKLNVYLTD 83
Cdd:TIGR00004   1 KKIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
3R0P_F         84 LANFPIVNEVMGQYFQAPYPARAAIGINQLPRASLIEADGIMV 126
Cdd:TIGR00004  81 LNDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIAV 123
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 1-127 3.23e-51

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 158.03  E-value: 3.23e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3R0P_F        1 MTNKAIihSDNAPAAIGTYSQAVKVNNTVYLSGQIPLDPVTMQlVEGDFAVQAHQVFKNLRAVCEAAGGGLRDIVKLNVY 80
Cdd:COG0251   1 MTRELI--NPPAPAPIGPYSQAVRVGNLVFVSGQVPLDPDTGE-LGGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVY 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
3R0P_F       81 LTDLANFPIVNEVMGQYFQAPYPARAAIGINQLPRASLIEADGIMVI 127
Cdd:COG0251  78 LTDMADFAAVNEVYAEYFGEGRPARTAVGVAALPKGALVEIEAIAAL 124
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 11-126 4.00e-43

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 137.43  E-value: 4.00e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3R0P_F         11 NAPAAIGTYSQAVKVNNTVYLSGQIPLDPVTMQLVEGDFAVQAHQVFKNLRAVCEAAGGGLRDIVKLNVYLTDLANFPIV 90
Cdd:pfam01042   1 NAPAAAGPYSQAVKAGNLVYVSGQIPLDPDTGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEV 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
3R0P_F         91 NEVMGQYFQAP-YPARAAIGINQLPRASLIEADGIMV 126
Cdd:pfam01042  81 NEVYAEYFDADkAPARSAVGVAALPLGALVEIEAIAV 117
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 19-124 2.06e-41

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 132.68  E-value: 2.06e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3R0P_F       19 YSQAVKVNNTVYLSGQIPLDPVTMqLVEGDFAVQAHQVFKNLRAVCEAAGGGLRDIVKLNVYLTDLANFPIVNEVMGQYF 98
Cdd:cd00448   1 YSQAVRVGNLVFVSGQIPLDPDGE-LVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFF 79

                        90       100
                ....*....|....*....|....*..
3R0P_F       99 -QAPYPARAAIGINQLPRASLIEADGI 124
Cdd:cd00448  80 gEGPPPARTAVGVAALPPGALVEIEAI 106
PRK11401 PRK11401
enamine/imine deaminase;
4-126 2.85e-26

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 95.13  E-value: 2.85e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3R0P_F         4 KAIIHSDNAPAAIGTYSQAVKVNNTVYLSGQIPLDPVTMQLVEgDFAVQAHQVFKNLRAVCEAAGGGLRDIVKLNVYLTD 83
Cdd:PRK11401   2 KKIIETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGEIPA-DVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
3R0P_F        84 LANFPIVNEVMGQYF---QAPYPARAAIGINQLPRASLIEADGIMV 126
Cdd:PRK11401  81 LNDFATINEVYKQFFdehQATYPTRSCVQVARLPKDVKLEIEAIAV 126
YjgH_like cd02198
YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, ...
 19-119 3.87e-23

YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100005  Cd Length: 111  Bit Score: 86.55  E-value: 3.87e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3R0P_F       19 YSQAVKVNNTVYLSGQIPLDPVTMqlVEGDFAVQAHQVFKNLRAVCEAAGGGLRDIVKLNVYLTDLAN-FPIVNEVMGQY 97
Cdd:cd02198   3 YSPAVRVGDTLFVSGQVGSDADGS--VAEDFEAQFRLAFQNLGAVLEAAGCSFDDVVELTTFHVDMAAhLPAFAAVKDEY 80

                        90       100
                ....*....|....*....|..
3R0P_F       98 FQAPYPARAAIGINQLPRASLI 119
Cdd:cd02198  81 FKEPYPAWTAVGVAWLARPGLL 102
YjgF_YER057c_UK114_like_6 cd06154
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 14-122 4.25e-21

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100011  Cd Length: 119  Bit Score: 81.45  E-value: 4.25e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3R0P_F       14 AAIGtYSQAVKVNNTVYLSGQIPLDPVTMQlVEGDFAVQAHQVFKNLRAVCEAAGGGLRDIVKLNVYLTDLANFPIVNEV 93
Cdd:cd06154   9 EQAG-YSRAVRVGNWVFVSGTTGYDYDGMV-MPGDAYEQTRQCLEIIEAALAEAGASLEDVVRTRMYVTDIADFEAVGRA 86

                        90       100       110
                ....*....|....*....|....*....|..
3R0P_F       94 MGQYFQAPYPARAAIGINQLPRASL---IEAD 122
Cdd:cd06154  87 HGEVFGDIRPAATMVVVSLLVDPEMlveIEVT 118
YjgF_YER057c_UK114_like_2 cd06150
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 19-127 1.21e-15

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100007  Cd Length: 105  Bit Score: 67.18  E-value: 1.21e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3R0P_F       19 YSQAVKVNNTVYLSGQIPLDPvtmqlvEGDFAVQAHQVFKNLRAVCEAAGGGLRDIVKLNVYLTDLANFPIVNEVMGQYF 98
Cdd:cd06150   3 MSQAVVHNGTVYLAGQVADDT------SADITGQTRQVLAKIDALLAEAGSDKSRILSATIWLADMADFAAMNAVWDAWV 76

                        90       100       110
                ....*....|....*....|....*....|
3R0P_F       99 QAPY-PARAAIGINQLPRASLIEadgIMVI 127
Cdd:cd06150  77 PPGHaPARACVEAKLADPGYLVE---IVVT 103
eu_AANH_C_2 cd06156
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 19-98 6.99e-14

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100013  Cd Length: 118  Bit Score: 63.12  E-value: 6.99e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3R0P_F       19 YSQAVKVNNTVYLSGQIPLDPVTMQLVEGDFAVQAHQVFKNLRAVCEAAggGLRDIVKLNVYLTDLANFPIVNEVMGQYF 98
Cdd:cd06156   1 YSQAIVVPKVAYISGQIGLIPATMTLLEGGITLQAVLSLQHLERVAKAM--NVQWVLAAVCYVTDESSVPIARSAWSKYC 78
YjgF_YER057c_UK114_like_4 cd06152
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 19-114 1.67e-11

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100009  Cd Length: 114  Bit Score: 56.93  E-value: 1.67e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3R0P_F       19 YSQAVKVNNTVYLSGQIPLDPVTMQLVEgDFAVQAHQVFKNLRAVCEAAGG-GLRDIVKLNVYLTDLANfPIVNEVMGQY 97
Cdd:cd06152   3 YSQAVRIGDRIEISGQGGWDPDTGKIPE-DLEEEIDQAFDNVELALKAAGGkGWEQVYKVNSYHVDIKN-EEAFGLMVEN 80

                        90       100
                ....*....|....*....|.
3R0P_F       98 FQAPYPARA----AIGINQLP 114
Cdd:cd06152  81 FKKWMPNHQpiwtCVGVTALG 101
YjgF_YER057c_UK114_like_1 cd02199
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 12-124 5.13e-09

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100006  Cd Length: 142  Bit Score: 50.92  E-value: 5.13e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3R0P_F       12 APAAIGTYSQAVKVNNTVYLSGQIPLDPVTMQL---VEGDFAVQ-----AHQVFKNLRAVCEAAGGGL---RDIVKLNVY 80
Cdd:cd02199   9 APAPVGNYVPAVRTGNLLYVSGQLPRVDGKLVYtgkVGADLSVEegqeaARLCALNALAALKAALGDLdrvKRVVRLTGF 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
3R0P_F       81 LTDLANF---PIV----NEVMGQYFQ-APYPARAAIGINQLPRASLIEADGI 124
Cdd:cd02199  89 VNSAPDFteqPKVangaSDLLVEVFGeAGRHARSAVGVASLPLNAAVEVEAI 140
eu_AANH_C_1 cd06155
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 52-122 3.66e-08

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100012  Cd Length: 101  Bit Score: 47.64  E-value: 3.66e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
3R0P_F       52 QAHQVFKNLRAVCEAAGGGLRDIVKLNVYLTDLANFPIVNEVMGQYFQAPYP-ARAAIGINqLPRASLIEAD 122
Cdd:cd06155  27 QMESIFSKLREILQSNGLSLSDILYVTLYLRDMSDFAEVNSVYGTFFDKPNPpSRVCVECG-LPEGCDVQLS 97
YjgF_YER057c_UK114_like_3 cd06151
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 20-120 8.76e-07

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100008  Cd Length: 126  Bit Score: 44.62  E-value: 8.76e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3R0P_F       20 SQAVKV---NNTVYLSGQIPlDPVTMQLVE------GDFAVQAHQVFKNLRAVCEAAGGGLRDIVKLNVYL------TDL 84
Cdd:cd06151   2 AQAVEVpagAATIYLSGTVP-AVVNASAPKgsparyGDTETQTISVLKRIETILQSQGLTMGDVVKMRVFLvadpalDGK 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
3R0P_F       85 ANFPIVNEVMGQYF----QAPYPARAAIGINQLPRAS-LIE 120
Cdd:cd06151  81 MDFAGFMKAYRQFFgtaeQPNKPARSTLQVAGLVNPGwLVE 121
YjgF_YER057c_UK114_like_5 cd06153
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 44-104 4.88e-05

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100010  Cd Length: 114  Bit Score: 39.93  E-value: 4.88e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
3R0P_F       44 LVEGDFAVQAHQVFKNLRAVCEAAGGG-----LRDIVKLNVYLTDLANFPIVNEVMGQYFQAPYPA 104
Cdd:cd06153  29 VHPGDVEAQTRETLENIEALLEAAGRGggaqfLADLLRLKVYLRDREDLPAVRAILAARLGPAVPA 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH