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Conserved domains on  [gi|343197565|pdb|3S1R|B]
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Chain B, DNA-directed RNA polymerase II subunit RPB2

Protein Classification

DNA-directed RNA polymerase subunit B family protein( domain architecture ID 1000145)

DNA-directed RNA polymerase subunit B family protein similar to fungal DNA-directed RNA polymerase II subunit RPB2

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ricin_B_lectin super family cl47023
Ricin-type beta-trefoil lectin domain;
31-1216 0e+00

Ricin-type beta-trefoil lectin domain;


The actual alignment was detected with superfamily member PRK08565:

Pssm-ID: 481363 [Multi-domain]  Cd Length: 1103  Bit Score: 1273.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         31 WAVISAFFREKGLVSQQLDSFNQFVDYTLQDIICEdstlileqlaqhTTESDNISRKYEISFGKIYVTKPMVNESDGVTH 110
Cdd:PRK08565    2 WTVVEAYFKEKGLVRQHLDSYNDFIERGLQEIVDE------------FGEIKTEIPGLKIVLGKIRVGEPEIKEADGSER 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        111 ALYPQEARLRNLTYSSGLFVDVKkrtyeaIDVPGRELKYEliaeeseddsesgKVFIGRLPIMLRSKNCYLSEATESDLY 190
Cdd:PRK08565   70 PITPMEARLRNLTYAAPLYLTMI------PVENGIEYEPE-------------EVKIGDLPIMVKSKICPLSGLSPDELI 130
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        191 KLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEIRSAlEKGSRfiSTLQVKlYGREGssarTIK 270
Cdd:PRK08565  131 EIGEDPKDPGGYFIINGSERVIVSQEDLAPNRVLVDKGEAGSSITHTAKVISS-RAGYR--AQVTVE-RRKDG----TIY 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        271 ATLPYIKQDIPIVIIFRALGIIPDGEILEHIcydVNDWQMLEMLKPCVEDGF-VIQDRETALDFIGRRgTALGIKKEKRI 349
Cdd:PRK08565  203 VSFPAVPGKIPFVILMRALGLETDRDIVYAV---SLDPEIQQELLPSLEQASsIAATVEDALDYIGKR-VAIGQPREYRI 278
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        350 QYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIF 429
Cdd:PRK08565  279 ERAEQILDKYLLPHLGTSPEDRIKKAYFLGQMASKLLELYLGRREPDDKDHYANKRLRLAGDLLAELFRVAFKQLVKDLK 358
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        430 RYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWGeqkkamSSRAGVSQVLNRYTYSSTLSHLRRTNTPIGRDGKLA 509
Cdd:PRK08565  359 YQLEKSYARGRKLDLRAIVRPDIITERIRHALATGNWV------GGRTGVSQLLDRTNYLSTLSHLRRVVSPLSRGQPHF 432
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        510 KPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMSCISVGTDPMPIITFLSEWGMEPLEDYVPHQSPDATRVFVNGVWHGV 589
Cdd:PRK08565  433 EARDLHGTQWGRICPFETPEGPNCGLVKNLALMAQISVGVDEEEVEEILYELGVVPVEEAREEEYISWSRVYLNGRLIGY 512
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        590 HRNPARLMETLRTLRRKGDINPEVSM--IRDIREKELKIFTDAGRVYRPLFIVEDDEslghkeLKVRKGHIAKLmateyq 667
Cdd:PRK08565  513 HPDGEELAEKIRELRRSGKISDEVNVayIETGEINEVYVNCDSGRVRRPLIVVENGK------PKLTREHVEKL------ 580
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        668 dieggfeDVEEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPaeaneendldvdpakrirvSHhattfTHCEIHPSM 747
Cdd:PRK08565  581 -------KKGELTFDDLVKMGVIEYLDAEEEENAYVALDPEDLTP-------------------EH-----THLEIWPPA 629
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        748 ILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAI 827
Cdd:PRK08565  630 ILGITASIIPYPEHNQSPRNTYQAAMAKQSLGLYAANFRIRTDTRGHLLHYPQRPLVQTRALEIIGYNDRPAGQNAVVAV 709
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        828 ACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPqrTNTLRMKHG--TYDKLDDDGLIAPGVRV 905
Cdd:PRK08565  710 LSYTGYNIEDAIIMNKASIERGLARSTFFRTYETEERKYPGGQEDKIEIP--EPNVRGYRGeeYYRKLDEDGIVSPEVEV 787
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        906 SGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDGLKFVKVRVRTTKIPQIGDKFASRHG 985
Cdd:PRK08565  788 KGGDVLIGKTSPPRFLEELEELSLGLQERRDTSVTVRHGEKGIVDTVLITESPEGNKLVKVRVRDLRIPELGDKFASRHG 867
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        986 QKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQ 1065
Cdd:PRK08565  868 QKGVIGMLVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLESIAGKVAALEGRFVDATPFYGEPEEELRKELLKLGYK 947
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       1066 SRGFEVMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAAS 1145
Cdd:PRK08565  948 PDGTEVMYDGRTGEKIKAPIFIGVVYYQKLHHMVADKIHARARGPVQILTRQPTEGRAREGGLRFGEMERDCLIGHGAAM 1027
                        1130      1140      1150      1160      1170      1180      1190
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
3S1R_B       1146 FLKERLMEASDAFRVHICGICGLMTVIAKlNHNQFECKGCDNKIDIYQIHIPYAAKLLFQELMAMNITPRL 1216
Cdd:PRK08565 1028 LLKERLLDSSDKTTIYVCELCGHIAWYDR-RKNKYVCPIHGDKGNISPVEVSYAFKLLLQELMSMGISPRL 1097
 
Name Accession Description Interval E-value
PRK08565 PRK08565
DNA-directed RNA polymerase subunit B; Provisional
31-1216 0e+00

DNA-directed RNA polymerase subunit B; Provisional


Pssm-ID: 236291 [Multi-domain]  Cd Length: 1103  Bit Score: 1273.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         31 WAVISAFFREKGLVSQQLDSFNQFVDYTLQDIICEdstlileqlaqhTTESDNISRKYEISFGKIYVTKPMVNESDGVTH 110
Cdd:PRK08565    2 WTVVEAYFKEKGLVRQHLDSYNDFIERGLQEIVDE------------FGEIKTEIPGLKIVLGKIRVGEPEIKEADGSER 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        111 ALYPQEARLRNLTYSSGLFVDVKkrtyeaIDVPGRELKYEliaeeseddsesgKVFIGRLPIMLRSKNCYLSEATESDLY 190
Cdd:PRK08565   70 PITPMEARLRNLTYAAPLYLTMI------PVENGIEYEPE-------------EVKIGDLPIMVKSKICPLSGLSPDELI 130
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        191 KLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEIRSAlEKGSRfiSTLQVKlYGREGssarTIK 270
Cdd:PRK08565  131 EIGEDPKDPGGYFIINGSERVIVSQEDLAPNRVLVDKGEAGSSITHTAKVISS-RAGYR--AQVTVE-RRKDG----TIY 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        271 ATLPYIKQDIPIVIIFRALGIIPDGEILEHIcydVNDWQMLEMLKPCVEDGF-VIQDRETALDFIGRRgTALGIKKEKRI 349
Cdd:PRK08565  203 VSFPAVPGKIPFVILMRALGLETDRDIVYAV---SLDPEIQQELLPSLEQASsIAATVEDALDYIGKR-VAIGQPREYRI 278
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        350 QYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIF 429
Cdd:PRK08565  279 ERAEQILDKYLLPHLGTSPEDRIKKAYFLGQMASKLLELYLGRREPDDKDHYANKRLRLAGDLLAELFRVAFKQLVKDLK 358
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        430 RYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWGeqkkamSSRAGVSQVLNRYTYSSTLSHLRRTNTPIGRDGKLA 509
Cdd:PRK08565  359 YQLEKSYARGRKLDLRAIVRPDIITERIRHALATGNWV------GGRTGVSQLLDRTNYLSTLSHLRRVVSPLSRGQPHF 432
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        510 KPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMSCISVGTDPMPIITFLSEWGMEPLEDYVPHQSPDATRVFVNGVWHGV 589
Cdd:PRK08565  433 EARDLHGTQWGRICPFETPEGPNCGLVKNLALMAQISVGVDEEEVEEILYELGVVPVEEAREEEYISWSRVYLNGRLIGY 512
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        590 HRNPARLMETLRTLRRKGDINPEVSM--IRDIREKELKIFTDAGRVYRPLFIVEDDEslghkeLKVRKGHIAKLmateyq 667
Cdd:PRK08565  513 HPDGEELAEKIRELRRSGKISDEVNVayIETGEINEVYVNCDSGRVRRPLIVVENGK------PKLTREHVEKL------ 580
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        668 dieggfeDVEEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPaeaneendldvdpakrirvSHhattfTHCEIHPSM 747
Cdd:PRK08565  581 -------KKGELTFDDLVKMGVIEYLDAEEEENAYVALDPEDLTP-------------------EH-----THLEIWPPA 629
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        748 ILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAI 827
Cdd:PRK08565  630 ILGITASIIPYPEHNQSPRNTYQAAMAKQSLGLYAANFRIRTDTRGHLLHYPQRPLVQTRALEIIGYNDRPAGQNAVVAV 709
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        828 ACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPqrTNTLRMKHG--TYDKLDDDGLIAPGVRV 905
Cdd:PRK08565  710 LSYTGYNIEDAIIMNKASIERGLARSTFFRTYETEERKYPGGQEDKIEIP--EPNVRGYRGeeYYRKLDEDGIVSPEVEV 787
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        906 SGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDGLKFVKVRVRTTKIPQIGDKFASRHG 985
Cdd:PRK08565  788 KGGDVLIGKTSPPRFLEELEELSLGLQERRDTSVTVRHGEKGIVDTVLITESPEGNKLVKVRVRDLRIPELGDKFASRHG 867
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        986 QKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQ 1065
Cdd:PRK08565  868 QKGVIGMLVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLESIAGKVAALEGRFVDATPFYGEPEEELRKELLKLGYK 947
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       1066 SRGFEVMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAAS 1145
Cdd:PRK08565  948 PDGTEVMYDGRTGEKIKAPIFIGVVYYQKLHHMVADKIHARARGPVQILTRQPTEGRAREGGLRFGEMERDCLIGHGAAM 1027
                        1130      1140      1150      1160      1170      1180      1190
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
3S1R_B       1146 FLKERLMEASDAFRVHICGICGLMTVIAKlNHNQFECKGCDNKIDIYQIHIPYAAKLLFQELMAMNITPRL 1216
Cdd:PRK08565 1028 LLKERLLDSSDKTTIYVCELCGHIAWYDR-RKNKYVCPIHGDKGNISPVEVSYAFKLLLQELMSMGISPRL 1097
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
43-1217 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 1173.12  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        43 LVSQQLDSFNQFVDYTLQDIICEDSTLileqlaqhttESDNISRKYEISFGKIYVTKPMVNEsDGVTHALYPQEARLRNL 122
Cdd:cd00653    1 LVKQQIDSFNYFLNVGLQEIVKSIPPI----------TDTDDDGRLKLKFGDIYLGKPKVEE-GGVTRKLTPNECRLRDL 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       123 TYSSGLFVDVKKRTYEaidvpgrelkyeliaeesEDDSESGKVFIGRLPIMLRSKNCYLSEATESDLYKLKECPFDMGGY 202
Cdd:cd00653   70 TYSAPLYVDIRLTVND------------------KGKIKEQEVFIGEIPIMLRSKLCNLNGLTPEELIKLGECPLDPGGY 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       203 FIINGSEKVLIAQERSAGNIVQVFkkaaPSPISHVAEIRSALEKGSRFISTLQVKLYGREGssarTIKATLPYIKQdipi 282
Cdd:cd00653  132 FIINGTEKVIINQEQRSPNVIIVE----DSKGKRIYTKTSIPSYSPYRGSWLEVKSDKKKD----RIYVRIDLKRQ---- 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       283 viifralgiipdgeilehicydvndwqmlemlkpcvedgfviqdrETALDFIGRRGtalgikkekriqyakdilqkeflp 362
Cdd:cd00653  200 ---------------------------------------------EEALKYIGKRF------------------------ 210
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       363 hitqlegfesrkaFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTVEEAHDF 442
Cdd:cd00653  211 -------------EDLIYMIRKLILLVLGKGKLDDIDHLGNKRVRLAGELLQNLFRSGLKRLEREVKEKLQKQLSKKKDL 277
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       443 NMKLAINAKTITSGLKYALATGNWGeQKKAMSSRAGVSQVLNRYTYSSTLSHLRRTNT-PIGRDGKLAKPRQLHNTHWGL 521
Cdd:cd00653  278 TPQLLINSKPITSGIKEFLATGNWG-SKRFLMQRSGLSQVLDRLNPLSELSHKRRISSlGLFRERKGFEVRDLHPSHWGR 356
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       522 VCPAETPEGQACGLVKNLSLMSCISvgtdpmpiitflsewgmepledyvphqspdatrvfvngvwhgvhrnparlmetlr 601
Cdd:cd00653  357 ICPIETPEGENCGLVKNLALMARIS------------------------------------------------------- 381
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       602 tlrrkgdinpevsmirdirekelkiftdaGRVYRPLFIVEDDeslghkelkvrkghiaklmateyqdieggfedveeytw 681
Cdd:cd00653  382 -----------------------------GRIERPYRIVEKE-------------------------------------- 394
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       682 ssllneglveyidaeeeesiliamqpedlepaeaneendldvdpakrirvshhattFTHCEIHPSMILGVAASIIPFPDH 761
Cdd:cd00653  395 --------------------------------------------------------VTHIEISPSQILSVAASLIPFPEH 418
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       762 NQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIM 841
Cdd:cd00653  419 NQSPRNLYQSNMQKQAVGTPALNQQYRMDTKLYLLLYPQKPLVGTGIEEYIAFGELPLGQNAIVAVMSYSGYNFEDAIII 498
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       842 NQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFekpqRTNTLRMKHGTYDKLDDDGLIAPGVRVSGEDVIIGKTTPISPD 921
Cdd:cd00653  499 NKSSVDRGFFRSIHYKKYEIELRKTKNGPEEIT----RGDIPNVSEEKLKNLDEDGIIRPGARVEPGDILVGKITPKGET 574
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       922 EEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTT---NQDGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRRED 998
Cdd:cd00653  575 ESTPIFGEKARDVRDTSLKYPGGEKGIVDDVKIFSrelNDGGNKLVKVYIRQKRKPQIGDKFASRHGQKGVISKILPQED 654
                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       999 MPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFEVMYNGHTG 1078
Cdd:cd00653  655 MPFTEDGIPPDIILNPHGFPSRMTIGQLLESLLGKAGALLGKFGDATPFDGAEEEDISELLGEAGLNYYGKEVLYDGRTG 734
                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B      1079 KKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAASFLKERLMEASDAF 1158
Cdd:cd00653  735 EPLEAPIFVGPVYYQRLKHMVDDKIHARSTGPYSLLTRQPLKGRSRGGGQRFGEMERDALIAHGAAYLLQERLTIKSDDV 814
                       1130      1140      1150      1160      1170
                 ....*....|....*....|....*....|....*....|....*....|....*....
3S1R_B      1159 RVHICGICGLMTVIaklnhnqFECKGCDNKIDIYQIHIPYAAKLLFQELMAMNITPRLY 1217
Cdd:cd00653  815 VARVCVKCGIILSA-------NLCRLCKKGTNISKVGIPYAFKLLFQELQSMNIDPRLK 866
rpoB_arch TIGR03670
DNA-directed RNA polymerase subunit B; This model represents the archaeal version of ...
580-1216 0e+00

DNA-directed RNA polymerase subunit B; This model represents the archaeal version of DNA-directed RNA polymerase subunit B (rpoB) and is observed in all archaeal genomes.


Pssm-ID: 274713 [Multi-domain]  Cd Length: 599  Bit Score: 774.20  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         580 VFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDEslghkeLKVRKGHIA 659
Cdd:TIGR03670    1 VYLNGRLIGYHDDPEELVEEVRKLRRSGKLSQEVNVAYYEETNEVYINCDAGRIRRPLIVVENGK------PKLTREHVE 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         660 KLMateyqdiEGgfedveEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPaeaneendldvdpakrirvSHhattfT 739
Cdd:TIGR03670   75 KLK-------EG------ELTWDDLVKQGVIEYLDAEEEENAYIALDPEELTP-------------------EH-----T 117
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         740 HCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPA 819
Cdd:TIGR03670  118 HLEIDPSAILGIIASTIPYPEHNQSPRNTMGAAMAKQSLGLYAANYRIRLDTRGHLLHYPQKPLVKTRVLELIGYDDRPA 197
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         820 GQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPqrTNTLRMKHG--TYDKLDDDG 897
Cdd:TIGR03670  198 GQNFVVAVMSYEGYNIEDALIMNKASIERGLARSTFFRTYEAEERRYPGGQEDRFEIP--EPDVRGYRGeeAYKHLDEDG 275
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         898 LIAPGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDGLKFVKVRVRTTKIPQIG 977
Cdd:TIGR03670  276 IVYPEVEVKGGDVLIGKTSPPRFLEELREFGLVTERRRDTSVTVRHGEKGIVDKVIITETEEGNKLVKVRVRDLRIPELG 355
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         978 DKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISK 1057
Cdd:TIGR03670  356 DKFASRHGQKGVIGMIVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLEMIAGKVAALEGRRVDGTPFEGEPEEELRK 435
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        1058 LLREHGYQSRGFEVMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDC 1137
Cdd:TIGR03670  436 ELLKLGFKPDGKEVMYDGITGEKLEAEIFIGVIYYQKLHHMVADKIHARSRGPVQVLTRQPTEGRAREGGLRFGEMERDV 515
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
3S1R_B        1138 MIAHGAASFLKERLMEASDAFRVHICGICGLMTVIAKlNHNQFECKGCDNKIDIYQIHIPYAAKLLFQELMAMNITPRL 1216
Cdd:TIGR03670  516 LIGHGAAMLLKERLLDESDKYVVYVCENCGHIAWEDK-RKGTAYCPVCGETGDISPVEMSYAFKLLLDELKSLGISPRL 593
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
30-1217 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 725.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        30 SWAVISAFFREKGLVSQQLDSFNQFVDYTLQDIICEDStlileqlaqhttESDNISRKYEISFGKIYVTKPMVnesdgvt 109
Cdd:COG0085    3 SFAKIKEPLELPNLLEIQLDSFNWFLEEGLQEIFDEIS------------PIEDFTGNLSLEFGDYRLGEPKY------- 63
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       110 halYPQEARLRNLTYSSGLFVDVkkrtyeaidvpgrelkyELIAEESEDdSESGKVFIGRLPIMLRSkncylseatesdl 189
Cdd:COG0085   64 ---TPEECKERDLTYAAPLYVKV-----------------RLVNKETGE-IKEQEVFMGDFPLMTDS------------- 109
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       190 yklkecpfdmgGYFIINGSEKVLIAQE-RSAGNIVqVFKKAAPSPISHVAEIRSA------LEKGSRfiSTLQVKLYGre 262
Cdd:COG0085  110 -----------GTFIINGTERVIVSQLvRSPGVYF-VEEEDKSGKDLYSAKVIPSrgawleFETDKD--GTIYVRIDR-- 173
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       263 gssartikatlpyiKQDIPIVIIFRALGIIPDGEILEHIcydvNDWQMLEMLKPCVEDGfVIQDRETALDFIGRRgtaLG 342
Cdd:COG0085  174 --------------KRKIPVTVLLRALGLETDEEILEAF----GDDPIQEYILATLEKD-NTKTQEEALLEIYRK---LR 231
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       343 IKKEKRIQYAKDILQKEF-------LPHI---------TQLEGFESR--KAFFLGYMINRLLLCALDRKDQDDRDHFGKK 404
Cdd:COG0085  232 PGEPPTIERAEQLLDNLFfdpkrydLAHVgrykinkklGLDVPPEDRvlTAEDIVATIKYLLELHLGEREPDDIDHLGNR 311
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       405 RLDLAGPLLAQLFKTLFKKLTKDIfRYmQRTVEEAHDFNMKLAINAKTITSGLKYALATGnwgeqkkamssraGVSQVLN 484
Cdd:COG0085  312 RVRLVGELLQNQFRVGLSRMERVV-RE-RMTTQDVEAITPQSLINIRPVVAAIKEFFGSS-------------QLSQFMD 376
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       485 RYTYSSTLSHLRRTNT----PIGRDgklaKP----RQLHNTHWGLVCPAETPEGQACGLVKNLSLMscisvgtdpmpiit 556
Cdd:COG0085  377 QTNPLSELTHKRRLSAlgpgGLSRE----RAgfevRDVHPSHYGRMCPIETPEGPNIGLIGSLALY-------------- 438
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       557 flsewgmepledyvphqspdatrvfvngvwhgvhrnparlmetlrtlrrkGDINPEvsmirdirekelkiftdaGRVYRP 636
Cdd:COG0085  439 --------------------------------------------------ARVNEY------------------GFIETP 450
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       637 LFIVEDdeslGhkelKVRKGhiaklmateyqdieggfedveeytwssllneglVEYIDAEEEESILIAMQPEDLePAEAN 716
Cdd:COG0085  451 YRKVEN----G----KVTDE---------------------------------IEYLTADEEENYYIAQANAPL-DEDGN 488
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       717 EENDLDVDPAKRIRVSHHATTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNynvrmdtmANIL 796
Cdd:COG0085  489 FLEERVLVRYRGEEVLVPPEEVDYMDVSPKQIVSVATSLIPFLEHDDANRALMGANMQRQAVPLLRPE--------APLL 560
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       797 YYP--------------QKPLgtTRAMEYLK------------FRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGL 850
Cdd:COG0085  561 HYPlqkfqrsnqgtcinQRPI--VRVGDRVEkgdvladgpatdNGELALGQNLLVAFMPWEGYNYEDAIIISERLVKDDV 638
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       851 FRSLFFRSYMDQEKKY--GMSITeTFEKPqrtntlrmKHG--TYDKLDDDGLIAPGVRVSGEDVIIGKTTP-----ISPD 921
Cdd:COG0085  639 LTSIHIEEYEIEARDTklGPEEI-TRDIP--------NVSeeALRNLDEDGIIRIGAEVKGGDILVGKVTPkgeteLTPE 709
                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       922 EEELgqRTAYHSK----RDASTPLRSTENGIVDQVLVTTNQDG-------LKFVKVRVRTTKIPQIGDKFASRHGQKGTI 990
Cdd:COG0085  710 ERLL--RAIFGEKarevRDTSLRVPHGEKGKVIDVKVFSREEGdelppgvNKLVRVYVAQKRKIEVGDKLAGRHGNKGVI 787
                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       991 GITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFE 1070
Cdd:COG0085  788 SRILPQEDMPFLEDGTPVDIVLNPLGVPSRMNVGQVLETHLGWAAALLGRRVATPVFDGAPEEEIRELLEKAGLPPDGKE 867
                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B      1071 VMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAASFLKER 1150
Cdd:COG0085  868 VLYDGRTGEPFDNPVTVGYMYYLKLHHMVDDKIHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQER 947
                       1210      1220      1230      1240      1250      1260      1270
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B      1151 LMEASDafrvhicGICGLMTV---IAKlnhnqfeckgcdnKIDIYQIHIPYAAKLLFQELMAMNITPRLY 1217
Cdd:COG0085  948 LTIKSD-------DVCGRVKVyeaIVK-------------GENIPEPGIPESFKVLLKELQSLGLDVEVL 997
RNA_pol_Rpb2_1 pfam04563
RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. ...
42-455 0e+00

RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the protrusion domain. The other lobe (pfam04561) is nested within this domain.


Pssm-ID: 367994 [Multi-domain]  Cd Length: 396  Bit Score: 555.07  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B          42 GLVSQQLDSFNQFVDYTLQDIICEDSTLILEQLAQHTTESDNisrKYEISFGKIYVTKPMVNESDGVTHALYPQEARLRN 121
Cdd:pfam04563    1 GLVRQQLDSFNEFVDNDLQKIIDENALIESEFEIQHPGENGD---KLSLKFGQIRLGKPMFDETDGSTREIYPQECRLRN 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         122 LTYSSGLFVDVKKRTYeaidvpgrelkyeliaeeSEDDSESGKVFIGRLPIMLRSKNCYLSEATESDLYKLKECPFDMGG 201
Cdd:pfam04563   78 LTYSAPLYVDLELSVY------------------NGEDIKPIEVFIGRLPIMLRSNACILSGATESELVKLGECPLDPGG 139
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         202 YFIINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEIRSALEKGSRFISTLQVKLYgrEGSSARTIKATLPYIKQDIP 281
Cdd:pfam04563  140 YFIINGSEKVIVAQEHRSRNHPIVFKKADPKKRGSVASVRSSAEISVRPDSTSWVNVL--EYLSNGTIYFKFPYIKKEIP 217
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         282 IVIIFRALGIIPDGEILEHICYDVNDWQMLEMLKPCVEDGFVI--QDRETALDFIGRRGTA---LGIKKEKRIQYAKDIL 356
Cdd:pfam04563  218 IVIILRALGFTSDREIFELICYDVNDQQLQEELLPSLEEGFKIriQTQEQALDYIGGRGRAifrMGRPREPRIKYAEEIL 297
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         357 QKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTV 436
Cdd:pfam04563  298 QKEVLPHLGTYELDETKKAYFIGYMIRRLLLLALGRREVDDRDHLGNKRLRLAGPLLASLFRVLFKKLVRDVRERLQKVL 377
                          410
                   ....*....|....*....
3S1R_B         437 EEAHDFNMKLAINAKTITS 455
Cdd:pfam04563  378 GSPDDLMLQLLVNAKPITS 396
 
Name Accession Description Interval E-value
PRK08565 PRK08565
DNA-directed RNA polymerase subunit B; Provisional
31-1216 0e+00

DNA-directed RNA polymerase subunit B; Provisional


Pssm-ID: 236291 [Multi-domain]  Cd Length: 1103  Bit Score: 1273.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         31 WAVISAFFREKGLVSQQLDSFNQFVDYTLQDIICEdstlileqlaqhTTESDNISRKYEISFGKIYVTKPMVNESDGVTH 110
Cdd:PRK08565    2 WTVVEAYFKEKGLVRQHLDSYNDFIERGLQEIVDE------------FGEIKTEIPGLKIVLGKIRVGEPEIKEADGSER 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        111 ALYPQEARLRNLTYSSGLFVDVKkrtyeaIDVPGRELKYEliaeeseddsesgKVFIGRLPIMLRSKNCYLSEATESDLY 190
Cdd:PRK08565   70 PITPMEARLRNLTYAAPLYLTMI------PVENGIEYEPE-------------EVKIGDLPIMVKSKICPLSGLSPDELI 130
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        191 KLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEIRSAlEKGSRfiSTLQVKlYGREGssarTIK 270
Cdd:PRK08565  131 EIGEDPKDPGGYFIINGSERVIVSQEDLAPNRVLVDKGEAGSSITHTAKVISS-RAGYR--AQVTVE-RRKDG----TIY 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        271 ATLPYIKQDIPIVIIFRALGIIPDGEILEHIcydVNDWQMLEMLKPCVEDGF-VIQDRETALDFIGRRgTALGIKKEKRI 349
Cdd:PRK08565  203 VSFPAVPGKIPFVILMRALGLETDRDIVYAV---SLDPEIQQELLPSLEQASsIAATVEDALDYIGKR-VAIGQPREYRI 278
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        350 QYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIF 429
Cdd:PRK08565  279 ERAEQILDKYLLPHLGTSPEDRIKKAYFLGQMASKLLELYLGRREPDDKDHYANKRLRLAGDLLAELFRVAFKQLVKDLK 358
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        430 RYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWGeqkkamSSRAGVSQVLNRYTYSSTLSHLRRTNTPIGRDGKLA 509
Cdd:PRK08565  359 YQLEKSYARGRKLDLRAIVRPDIITERIRHALATGNWV------GGRTGVSQLLDRTNYLSTLSHLRRVVSPLSRGQPHF 432
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        510 KPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMSCISVGTDPMPIITFLSEWGMEPLEDYVPHQSPDATRVFVNGVWHGV 589
Cdd:PRK08565  433 EARDLHGTQWGRICPFETPEGPNCGLVKNLALMAQISVGVDEEEVEEILYELGVVPVEEAREEEYISWSRVYLNGRLIGY 512
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        590 HRNPARLMETLRTLRRKGDINPEVSM--IRDIREKELKIFTDAGRVYRPLFIVEDDEslghkeLKVRKGHIAKLmateyq 667
Cdd:PRK08565  513 HPDGEELAEKIRELRRSGKISDEVNVayIETGEINEVYVNCDSGRVRRPLIVVENGK------PKLTREHVEKL------ 580
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        668 dieggfeDVEEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPaeaneendldvdpakrirvSHhattfTHCEIHPSM 747
Cdd:PRK08565  581 -------KKGELTFDDLVKMGVIEYLDAEEEENAYVALDPEDLTP-------------------EH-----THLEIWPPA 629
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        748 ILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAI 827
Cdd:PRK08565  630 ILGITASIIPYPEHNQSPRNTYQAAMAKQSLGLYAANFRIRTDTRGHLLHYPQRPLVQTRALEIIGYNDRPAGQNAVVAV 709
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        828 ACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPqrTNTLRMKHG--TYDKLDDDGLIAPGVRV 905
Cdd:PRK08565  710 LSYTGYNIEDAIIMNKASIERGLARSTFFRTYETEERKYPGGQEDKIEIP--EPNVRGYRGeeYYRKLDEDGIVSPEVEV 787
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        906 SGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDGLKFVKVRVRTTKIPQIGDKFASRHG 985
Cdd:PRK08565  788 KGGDVLIGKTSPPRFLEELEELSLGLQERRDTSVTVRHGEKGIVDTVLITESPEGNKLVKVRVRDLRIPELGDKFASRHG 867
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        986 QKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQ 1065
Cdd:PRK08565  868 QKGVIGMLVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLESIAGKVAALEGRFVDATPFYGEPEEELRKELLKLGYK 947
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       1066 SRGFEVMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAAS 1145
Cdd:PRK08565  948 PDGTEVMYDGRTGEKIKAPIFIGVVYYQKLHHMVADKIHARARGPVQILTRQPTEGRAREGGLRFGEMERDCLIGHGAAM 1027
                        1130      1140      1150      1160      1170      1180      1190
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
3S1R_B       1146 FLKERLMEASDAFRVHICGICGLMTVIAKlNHNQFECKGCDNKIDIYQIHIPYAAKLLFQELMAMNITPRL 1216
Cdd:PRK08565 1028 LLKERLLDSSDKTTIYVCELCGHIAWYDR-RKNKYVCPIHGDKGNISPVEVSYAFKLLLQELMSMGISPRL 1097
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
43-1217 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 1173.12  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        43 LVSQQLDSFNQFVDYTLQDIICEDSTLileqlaqhttESDNISRKYEISFGKIYVTKPMVNEsDGVTHALYPQEARLRNL 122
Cdd:cd00653    1 LVKQQIDSFNYFLNVGLQEIVKSIPPI----------TDTDDDGRLKLKFGDIYLGKPKVEE-GGVTRKLTPNECRLRDL 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       123 TYSSGLFVDVKKRTYEaidvpgrelkyeliaeesEDDSESGKVFIGRLPIMLRSKNCYLSEATESDLYKLKECPFDMGGY 202
Cdd:cd00653   70 TYSAPLYVDIRLTVND------------------KGKIKEQEVFIGEIPIMLRSKLCNLNGLTPEELIKLGECPLDPGGY 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       203 FIINGSEKVLIAQERSAGNIVQVFkkaaPSPISHVAEIRSALEKGSRFISTLQVKLYGREGssarTIKATLPYIKQdipi 282
Cdd:cd00653  132 FIINGTEKVIINQEQRSPNVIIVE----DSKGKRIYTKTSIPSYSPYRGSWLEVKSDKKKD----RIYVRIDLKRQ---- 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       283 viifralgiipdgeilehicydvndwqmlemlkpcvedgfviqdrETALDFIGRRGtalgikkekriqyakdilqkeflp 362
Cdd:cd00653  200 ---------------------------------------------EEALKYIGKRF------------------------ 210
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       363 hitqlegfesrkaFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTVEEAHDF 442
Cdd:cd00653  211 -------------EDLIYMIRKLILLVLGKGKLDDIDHLGNKRVRLAGELLQNLFRSGLKRLEREVKEKLQKQLSKKKDL 277
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       443 NMKLAINAKTITSGLKYALATGNWGeQKKAMSSRAGVSQVLNRYTYSSTLSHLRRTNT-PIGRDGKLAKPRQLHNTHWGL 521
Cdd:cd00653  278 TPQLLINSKPITSGIKEFLATGNWG-SKRFLMQRSGLSQVLDRLNPLSELSHKRRISSlGLFRERKGFEVRDLHPSHWGR 356
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       522 VCPAETPEGQACGLVKNLSLMSCISvgtdpmpiitflsewgmepledyvphqspdatrvfvngvwhgvhrnparlmetlr 601
Cdd:cd00653  357 ICPIETPEGENCGLVKNLALMARIS------------------------------------------------------- 381
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       602 tlrrkgdinpevsmirdirekelkiftdaGRVYRPLFIVEDDeslghkelkvrkghiaklmateyqdieggfedveeytw 681
Cdd:cd00653  382 -----------------------------GRIERPYRIVEKE-------------------------------------- 394
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       682 ssllneglveyidaeeeesiliamqpedlepaeaneendldvdpakrirvshhattFTHCEIHPSMILGVAASIIPFPDH 761
Cdd:cd00653  395 --------------------------------------------------------VTHIEISPSQILSVAASLIPFPEH 418
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       762 NQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIM 841
Cdd:cd00653  419 NQSPRNLYQSNMQKQAVGTPALNQQYRMDTKLYLLLYPQKPLVGTGIEEYIAFGELPLGQNAIVAVMSYSGYNFEDAIII 498
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       842 NQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFekpqRTNTLRMKHGTYDKLDDDGLIAPGVRVSGEDVIIGKTTPISPD 921
Cdd:cd00653  499 NKSSVDRGFFRSIHYKKYEIELRKTKNGPEEIT----RGDIPNVSEEKLKNLDEDGIIRPGARVEPGDILVGKITPKGET 574
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       922 EEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTT---NQDGLKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRRED 998
Cdd:cd00653  575 ESTPIFGEKARDVRDTSLKYPGGEKGIVDDVKIFSrelNDGGNKLVKVYIRQKRKPQIGDKFASRHGQKGVISKILPQED 654
                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       999 MPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFEVMYNGHTG 1078
Cdd:cd00653  655 MPFTEDGIPPDIILNPHGFPSRMTIGQLLESLLGKAGALLGKFGDATPFDGAEEEDISELLGEAGLNYYGKEVLYDGRTG 734
                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B      1079 KKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAASFLKERLMEASDAF 1158
Cdd:cd00653  735 EPLEAPIFVGPVYYQRLKHMVDDKIHARSTGPYSLLTRQPLKGRSRGGGQRFGEMERDALIAHGAAYLLQERLTIKSDDV 814
                       1130      1140      1150      1160      1170
                 ....*....|....*....|....*....|....*....|....*....|....*....
3S1R_B      1159 RVHICGICGLMTVIaklnhnqFECKGCDNKIDIYQIHIPYAAKLLFQELMAMNITPRLY 1217
Cdd:cd00653  815 VARVCVKCGIILSA-------NLCRLCKKGTNISKVGIPYAFKLLFQELQSMNIDPRLK 866
rpoB_arch TIGR03670
DNA-directed RNA polymerase subunit B; This model represents the archaeal version of ...
580-1216 0e+00

DNA-directed RNA polymerase subunit B; This model represents the archaeal version of DNA-directed RNA polymerase subunit B (rpoB) and is observed in all archaeal genomes.


Pssm-ID: 274713 [Multi-domain]  Cd Length: 599  Bit Score: 774.20  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         580 VFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDEslghkeLKVRKGHIA 659
Cdd:TIGR03670    1 VYLNGRLIGYHDDPEELVEEVRKLRRSGKLSQEVNVAYYEETNEVYINCDAGRIRRPLIVVENGK------PKLTREHVE 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         660 KLMateyqdiEGgfedveEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPaeaneendldvdpakrirvSHhattfT 739
Cdd:TIGR03670   75 KLK-------EG------ELTWDDLVKQGVIEYLDAEEEENAYIALDPEELTP-------------------EH-----T 117
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         740 HCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPA 819
Cdd:TIGR03670  118 HLEIDPSAILGIIASTIPYPEHNQSPRNTMGAAMAKQSLGLYAANYRIRLDTRGHLLHYPQKPLVKTRVLELIGYDDRPA 197
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         820 GQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPqrTNTLRMKHG--TYDKLDDDG 897
Cdd:TIGR03670  198 GQNFVVAVMSYEGYNIEDALIMNKASIERGLARSTFFRTYEAEERRYPGGQEDRFEIP--EPDVRGYRGeeAYKHLDEDG 275
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         898 LIAPGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDGLKFVKVRVRTTKIPQIG 977
Cdd:TIGR03670  276 IVYPEVEVKGGDVLIGKTSPPRFLEELREFGLVTERRRDTSVTVRHGEKGIVDKVIITETEEGNKLVKVRVRDLRIPELG 355
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         978 DKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISK 1057
Cdd:TIGR03670  356 DKFASRHGQKGVIGMIVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLEMIAGKVAALEGRRVDGTPFEGEPEEELRK 435
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        1058 LLREHGYQSRGFEVMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDC 1137
Cdd:TIGR03670  436 ELLKLGFKPDGKEVMYDGITGEKLEAEIFIGVIYYQKLHHMVADKIHARSRGPVQVLTRQPTEGRAREGGLRFGEMERDV 515
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
3S1R_B        1138 MIAHGAASFLKERLMEASDAFRVHICGICGLMTVIAKlNHNQFECKGCDNKIDIYQIHIPYAAKLLFQELMAMNITPRL 1216
Cdd:TIGR03670  516 LIGHGAAMLLKERLLDESDKYVVYVCENCGHIAWEDK-RKGTAYCPVCGETGDISPVEMSYAFKLLLDELKSLGISPRL 593
PRK07225 PRK07225
DNA-directed RNA polymerase subunit B'; Validated
578-1216 0e+00

DNA-directed RNA polymerase subunit B'; Validated


Pssm-ID: 235972 [Multi-domain]  Cd Length: 605  Bit Score: 742.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        578 TRVFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVEDDESlghkelKVRKGH 657
Cdd:PRK07225    5 AKVYVNGKLIGTHDDPEELVEEIREARRSGEISEEVNVSYKEETNEVIINTDAGRARRPLIVVENGEP------LLTEEH 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        658 IAKLmateyqdiEGGfedveEYTWSSLLNEGLVEYIDAEEEESILIAMQPEDLEPAeaneendldvdpakrirvshHatt 737
Cdd:PRK07225   79 IEKL--------KNG-----ELTFDDLVKQGVIEYLDAEEEENAYIAVYEEDLTEE--------------------H--- 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        738 fTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFREL 817
Cdd:PRK07225  123 -THLEIDPSLILGIGAGMIPYPEHNASPRITMGAGMIKQSLGLPAANYKLRPDTRGHLLHYPQVPLVKTQTQEIIGFDER 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        818 PAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMSITETFEKPQRTntLRMKHG--TYDKLDD 895
Cdd:PRK07225  202 PAGQNFVVAVMSYEGYNIEDALIMNKASIERGLGRSHFFRTYEGEERRYPGGQEDRFEIPDKD--VRGYRGeeAYRHLDE 279
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        896 DGLIAPGVRVSGEDVIIGKTTPISPDEEELGQRTAYHSKRDASTPLRSTENGIVDQVLVTTNQDGLKFVKVRVRTTKIPQ 975
Cdd:PRK07225  280 DGLVNPETEVKEGDVLIGKTSPPRFLEEPDDFGISPEKRRETSVTMRSGEEGIVDTVILTETEEGSRLVKVRVRDLRIPE 359
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        976 IGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGI 1055
Cdd:PRK07225  360 LGDKFASRHGQKGVIGLIVPQEDMPFTESGVVPDLIINPHAIPSRMTVGHVLEMIGGKVGSLEGRRVDGTAFSGEDEEDL 439
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       1056 SKLLREHGYQSRGFEVMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMER 1135
Cdd:PRK07225  440 REALEKLGFEHTGKEVMYDGITGEKIEAEIFVGVIYYQKLHHMVANKLHARSRGPVQVLTRQPTEGRAREGGLRFGEMER 519
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       1136 DCMIAHGAASFLKERLMEASDAFRVHICGICGlMTVIAKLNHNQFECKGCDNKIDIYQIHIPYAAKLLFQELMAMNITPR 1215
Cdd:PRK07225  520 DVLIGHGAAMLLKERLLDESDKVEIYVCAKCG-MIAIYDKKRNRKYCPICGEETDIYPVEMSYAFKLLLDELKSLGIAPR 598

                  .
3S1R_B       1216 L 1216
Cdd:PRK07225  599 L 599
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
30-1217 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 725.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        30 SWAVISAFFREKGLVSQQLDSFNQFVDYTLQDIICEDStlileqlaqhttESDNISRKYEISFGKIYVTKPMVnesdgvt 109
Cdd:COG0085    3 SFAKIKEPLELPNLLEIQLDSFNWFLEEGLQEIFDEIS------------PIEDFTGNLSLEFGDYRLGEPKY------- 63
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       110 halYPQEARLRNLTYSSGLFVDVkkrtyeaidvpgrelkyELIAEESEDdSESGKVFIGRLPIMLRSkncylseatesdl 189
Cdd:COG0085   64 ---TPEECKERDLTYAAPLYVKV-----------------RLVNKETGE-IKEQEVFMGDFPLMTDS------------- 109
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       190 yklkecpfdmgGYFIINGSEKVLIAQE-RSAGNIVqVFKKAAPSPISHVAEIRSA------LEKGSRfiSTLQVKLYGre 262
Cdd:COG0085  110 -----------GTFIINGTERVIVSQLvRSPGVYF-VEEEDKSGKDLYSAKVIPSrgawleFETDKD--GTIYVRIDR-- 173
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       263 gssartikatlpyiKQDIPIVIIFRALGIIPDGEILEHIcydvNDWQMLEMLKPCVEDGfVIQDRETALDFIGRRgtaLG 342
Cdd:COG0085  174 --------------KRKIPVTVLLRALGLETDEEILEAF----GDDPIQEYILATLEKD-NTKTQEEALLEIYRK---LR 231
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       343 IKKEKRIQYAKDILQKEF-------LPHI---------TQLEGFESR--KAFFLGYMINRLLLCALDRKDQDDRDHFGKK 404
Cdd:COG0085  232 PGEPPTIERAEQLLDNLFfdpkrydLAHVgrykinkklGLDVPPEDRvlTAEDIVATIKYLLELHLGEREPDDIDHLGNR 311
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       405 RLDLAGPLLAQLFKTLFKKLTKDIfRYmQRTVEEAHDFNMKLAINAKTITSGLKYALATGnwgeqkkamssraGVSQVLN 484
Cdd:COG0085  312 RVRLVGELLQNQFRVGLSRMERVV-RE-RMTTQDVEAITPQSLINIRPVVAAIKEFFGSS-------------QLSQFMD 376
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       485 RYTYSSTLSHLRRTNT----PIGRDgklaKP----RQLHNTHWGLVCPAETPEGQACGLVKNLSLMscisvgtdpmpiit 556
Cdd:COG0085  377 QTNPLSELTHKRRLSAlgpgGLSRE----RAgfevRDVHPSHYGRMCPIETPEGPNIGLIGSLALY-------------- 438
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       557 flsewgmepledyvphqspdatrvfvngvwhgvhrnparlmetlrtlrrkGDINPEvsmirdirekelkiftdaGRVYRP 636
Cdd:COG0085  439 --------------------------------------------------ARVNEY------------------GFIETP 450
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       637 LFIVEDdeslGhkelKVRKGhiaklmateyqdieggfedveeytwssllneglVEYIDAEEEESILIAMQPEDLePAEAN 716
Cdd:COG0085  451 YRKVEN----G----KVTDE---------------------------------IEYLTADEEENYYIAQANAPL-DEDGN 488
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       717 EENDLDVDPAKRIRVSHHATTFTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNynvrmdtmANIL 796
Cdd:COG0085  489 FLEERVLVRYRGEEVLVPPEEVDYMDVSPKQIVSVATSLIPFLEHDDANRALMGANMQRQAVPLLRPE--------APLL 560
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       797 YYP--------------QKPLgtTRAMEYLK------------FRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGL 850
Cdd:COG0085  561 HYPlqkfqrsnqgtcinQRPI--VRVGDRVEkgdvladgpatdNGELALGQNLLVAFMPWEGYNYEDAIIISERLVKDDV 638
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       851 FRSLFFRSYMDQEKKY--GMSITeTFEKPqrtntlrmKHG--TYDKLDDDGLIAPGVRVSGEDVIIGKTTP-----ISPD 921
Cdd:COG0085  639 LTSIHIEEYEIEARDTklGPEEI-TRDIP--------NVSeeALRNLDEDGIIRIGAEVKGGDILVGKVTPkgeteLTPE 709
                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       922 EEELgqRTAYHSK----RDASTPLRSTENGIVDQVLVTTNQDG-------LKFVKVRVRTTKIPQIGDKFASRHGQKGTI 990
Cdd:COG0085  710 ERLL--RAIFGEKarevRDTSLRVPHGEKGKVIDVKVFSREEGdelppgvNKLVRVYVAQKRKIEVGDKLAGRHGNKGVI 787
                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       991 GITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGISKLLREHGYQSRGFE 1070
Cdd:COG0085  788 SRILPQEDMPFLEDGTPVDIVLNPLGVPSRMNVGQVLETHLGWAAALLGRRVATPVFDGAPEEEIRELLEKAGLPPDGKE 867
                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B      1071 VMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAASFLKER 1150
Cdd:COG0085  868 VLYDGRTGEPFDNPVTVGYMYYLKLHHMVDDKIHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQER 947
                       1210      1220      1230      1240      1250      1260      1270
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B      1151 LMEASDafrvhicGICGLMTV---IAKlnhnqfeckgcdnKIDIYQIHIPYAAKLLFQELMAMNITPRLY 1217
Cdd:COG0085  948 LTIKSD-------DVCGRVKVyeaIVK-------------GENIPEPGIPESFKVLLKELQSLGLDVEVL 997
RNA_pol_Rpb2_1 pfam04563
RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. ...
42-455 0e+00

RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the protrusion domain. The other lobe (pfam04561) is nested within this domain.


Pssm-ID: 367994 [Multi-domain]  Cd Length: 396  Bit Score: 555.07  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B          42 GLVSQQLDSFNQFVDYTLQDIICEDSTLILEQLAQHTTESDNisrKYEISFGKIYVTKPMVNESDGVTHALYPQEARLRN 121
Cdd:pfam04563    1 GLVRQQLDSFNEFVDNDLQKIIDENALIESEFEIQHPGENGD---KLSLKFGQIRLGKPMFDETDGSTREIYPQECRLRN 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         122 LTYSSGLFVDVKKRTYeaidvpgrelkyeliaeeSEDDSESGKVFIGRLPIMLRSKNCYLSEATESDLYKLKECPFDMGG 201
Cdd:pfam04563   78 LTYSAPLYVDLELSVY------------------NGEDIKPIEVFIGRLPIMLRSNACILSGATESELVKLGECPLDPGG 139
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         202 YFIINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEIRSALEKGSRFISTLQVKLYgrEGSSARTIKATLPYIKQDIP 281
Cdd:pfam04563  140 YFIINGSEKVIVAQEHRSRNHPIVFKKADPKKRGSVASVRSSAEISVRPDSTSWVNVL--EYLSNGTIYFKFPYIKKEIP 217
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         282 IVIIFRALGIIPDGEILEHICYDVNDWQMLEMLKPCVEDGFVI--QDRETALDFIGRRGTA---LGIKKEKRIQYAKDIL 356
Cdd:pfam04563  218 IVIILRALGFTSDREIFELICYDVNDQQLQEELLPSLEEGFKIriQTQEQALDYIGGRGRAifrMGRPREPRIKYAEEIL 297
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         357 QKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTV 436
Cdd:pfam04563  298 QKEVLPHLGTYELDETKKAYFIGYMIRRLLLLALGRREVDDRDHLGNKRLRLAGPLLASLFRVLFKKLVRDVRERLQKVL 377
                          410
                   ....*....|....*....
3S1R_B         437 EEAHDFNMKLAINAKTITS 455
Cdd:pfam04563  378 GSPDDLMLQLLVNAKPITS 396
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
753-1124 0e+00

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 541.74  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         753 ASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLGTTRAMEYLKFRELPAGQNAIVAIACYSG 832
Cdd:pfam00562    2 ASLIPFVDHNQSPRNTYQCAMGKQAMGIYTLNKFYRSDQNTYVLCYPQKPLVKTGAVEAGGFGELPLGQNAIVAVMSYTG 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         833 YNQEDSMIMNQSSIDRGLFRSLFFRSYMDQEKKYGMsITETFEKPqrtntLRMKHGTYDKLDDDGLIAPGVRVSGEDVII 912
Cdd:pfam00562   82 YNQEDAIIINKSSVDRGFFTSIHIKEIEARKTKLGP-IEEITRDI-----PNVSEEALKKLDEDGIVRVGAEVKPGDILV 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         913 GKTTPISPDEE--ELGQRTAYHsKRDASTPLRSTENGIVDQVLV-TTNQDGLKFVKVRVRTTKIPQIGDKFASRHGQKGT 989
Cdd:pfam00562  156 GKVGPTELTKLlrAIFGEKARD-VKDTSLKVPPGEEGVVDDVIVfELPPGGIKMVKVYIRQKRKPEVGDKFASRHGQKGV 234
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         990 IGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFT--DITVEGISKLLREHGYQSR 1067
Cdd:pfam00562  235 VSRILPQEDMPFTEDGIPPDIILNPHGVPSRMTIGQLLETHLGKAAALLGVFVDATPFDgaSTEVEDIGELLEKAGYNYY 314
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
3S1R_B        1068 GFEVMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSR 1124
Cdd:pfam00562  315 GKEVLYDGRTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGPYSLLTRQPLGGRAR 371
PRK09606 PRK09606
DNA-directed RNA polymerase subunit B''; Validated
28-566 2.89e-128

DNA-directed RNA polymerase subunit B''; Validated


Pssm-ID: 236587 [Multi-domain]  Cd Length: 494  Bit Score: 402.79  E-value: 2.89e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         28 EDSWAVISAFFREKGLVSQQLDSFNQFVDYTLQDIICEdstlileqlaQHTTESDnISRKYEISFGKIYVTKPMVNESDG 107
Cdd:PRK09606    3 EDRRVLSDAYFKEHRLVRHHIDSYNDFVDNGLQKIIDE----------QGPIETE-IEDGVYVELGKIRVGKPVVKEADG 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        108 VTHALYPQEARLRNLTYSSGLFVdvkkrtyeaidvpgrelkyELIAEESEDDSESGKVFIGRLPIMLRSKNCYLSEATES 187
Cdd:PRK09606   72 SEREIYPMEARLRNLTYSAPLYL-------------------EMSPVEGGEEEEPEEVYIGELPVMVGSKICNLYGLSEE 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        188 DLYKLKECPFDMGGYFIINGSEKVLIAQERSAGNIVQVFKKAAPSPISHVAEIRSAlEKGSRFISTLQVKlygREGssar 267
Cdd:PRK09606  133 ELIEVGEDPLDPGGYFIVNGSERVLMTLEDLAPNKILVEKDERYGDRIEVAKVFSQ-RRGYRALVTVERN---RDG---- 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        268 TIKATLPYIKQDIPIVIIFRALGIIPDGEILEHICYDVNdwQMLEMLKPCVEDGfvIQDRETALDFIGRRGtALGIKKEK 347
Cdd:PRK09606  205 LLEVSFPSVPGSIPFVILMRALGLETDEEIVEAVSDDPE--IVKFMLENLEEAE--VDTQEEALEYIGKRV-APGQTKEY 279
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        348 RIQYAKDILQKEFLPHITQLEGFESRKAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKD 427
Cdd:PRK09606  280 RIKRAEYVIDRYLLPHLGVEPEVRRAKAHYLGRMAEACFELALGRREEDDKDHYANKRLKLAGDLMEDLFRVAFNRLARD 359
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        428 IFRYMQRTVEEAHDFNMKLAINAKTITSGLKYALATGNWgeqkkaMSSRAGVSQVLNRYTYSSTLSHLRRTNTPIGRDGK 507
Cdd:PRK09606  360 VKYQLERANMRNRELSIKTAVRSDVLTERLEHAMATGNW------VGGRTGVSQLLDRTDYMATLSHLRRVVSPLSRSQP 433
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*....
3S1R_B        508 LAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMSCISVGTDPMPIITFLSEWGMEPL 566
Cdd:PRK09606  434 HFEARDLHPTQWGRICPSETPEGPNCGLVKNFAQMVEISTGEDEEEVKEILKELGVEPE 492
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
30-1156 1.42e-74

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 269.61  E-value: 1.42e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B          30 SWAVISAFFREKGLVSQQLDSFNQFVDYTLQDIICEDSTL--ILEQLAQHTTESDNISRKY-EISFGKIYVTkpmvnesd 106
Cdd:TIGR02013    7 DFGKIPEVLEVPNLLEIQLDSYDWFLQQDTPPEKRKEEGLeeVFKSIFPIEDYTGNIELEYlSYRLGEPKYS-------- 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         107 gvthalyPQEARLRNLTYSSGLFVDVKKRTYEAIDVpgrelkYELIAEEseddsesgkVFIGRLPIMlrskncylseaTE 186
Cdd:TIGR02013   79 -------VEECKERGLTYSAPLKVKLRLINKEEDGT------KEIKEQD---------VYMGDIPLM-----------TD 125
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         187 SdlyklkecpfdmgGYFIINGSEKVLIAQ-ERSAGnivQVFKKAAPSPIShvaeirsalekgsrfistlqvklyGREGSS 265
Cdd:TIGR02013  126 R-------------GTFIINGAERVVVSQlHRSPG---VFFSSEKDTTKS------------------------GKVLFS 165
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         266 ARTI------------KATLPYIKQD----IPIVIIFRALGIIPDGEILEHIcyDVNDWQMLEMLK-PCvedgfviQDRE 328
Cdd:TIGR02013  166 ARIIpyrgswlefetdKKDVLYVRIDrkrkLPATVLLRALGYTIDTLILNRL--GSGEYIRNTLRKdPT-------NSEE 236
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         329 TALDFIGRRgtaLGIKKEKRIQYAKDILQKEFLphitqlegfeSRKAFFLG----YMINRLLL-------CALDRKD--- 394
Cdd:TIGR02013  237 EALVEIYRK---LRPGEPPTVEAARSLLENLFF----------DPKRYDLGrvgrYKLNKKLGldvpesiGVLTKEDiia 303
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         395 --------------QDDRDHFGKKRLDLAGPLLAQLFKTLFKKltkdifryMQRTVEE---AHDFNmKLA----INAKTI 453
Cdd:TIGR02013  304 tikyliklrngkgeIDDIDHLGNRRIRSVGELLQNQFRVGLAR--------MERIVRErmsTQDTD-TLTpqdlINAKPI 374
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         454 TSGLKYALATGNwgeqkkamssragVSQVLNRYTYSSTLSHLRRTNT--PIG--RDGKLAKPRQLHNTHWGLVCPAETPE 529
Cdd:TIGR02013  375 SAAIKEFFGSSQ-------------LSQFMDQTNPLAELTHKRRLSAlgPGGltRERAGFEVRDVHPTHYGRICPIETPE 441
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         530 GQACGLVKNLSlmscisvgtdpmpiiTFlsewgmepledyvphqspdaTRVfvngvwhgvhrNPARLMETlrtlrrkgdi 609
Cdd:TIGR02013  442 GPNIGLINSLS---------------TY--------------------ARV-----------NEYGFIET---------- 465
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         610 nPevsmirdirekelkiftdagrvYRplfiveddeslghkelKVRKGhiaklmateyqdiEGGFEDVeeytwssllnegl 689
Cdd:TIGR02013  466 -P----------------------YR----------------KVKDG-------------KVVVTDE------------- 480
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         690 VEYIDAEEEESILIAmqpedlePAEAN-EENDLDVDPAKRIRVSHHATTF-----THCEIHPSMILGVAASIIPFPDHNQ 763
Cdd:TIGR02013  481 IDYLTADEEDNYVIA-------QANAPlDENGRFVEDLVVARYRGEITLVspdqvDYMDVSPKQVVSVAASLIPFLEHDD 553
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         764 SPRNTYQSAMGKQAM-------------------------------GV---------FLTNYNVRMDTMANILYYP---- 799
Cdd:TIGR02013  554 ANRALMGSNMQRQAVpllrseaplvgtgmeakvardsgavivakrgGVveyvdakriVIRYDEDEEEPDGGIDIYRllky 633
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         800 ----------QKPL---------GTTRAMEYLKFR-ELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRSY 859
Cdd:TIGR02013  634 qrsnqdtcinQRPIvsvgdrveaGDVLADGPSTDLgELALGRNVLVAFMPWNGYNYEDAILISERLVKDDVFTSIHIEEY 713
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         860 --MDQEKKYGMS-ITEtfEKPQrtntlrMKHGTYDKLDDDGLIAPGVRVSGEDVIIGKTTPIS----PDEEELgQRTAYH 932
Cdd:TIGR02013  714 evEARDTKLGPEeITR--DIPN------VSEEALRNLDENGIVRIGAEVKAGDILVGKVTPKGetelTPEEKL-LRAIFG 784
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         933 SK----RDASTPLRSTENGIVDQVLVTTNQDG-------LKFVKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPF 1001
Cdd:TIGR02013  785 EKardvRDTSLRVPPGVEGTVIDVKVFSREQGdelppgvNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSKILPIEDMPF 864
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        1002 TAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGD--ASP-FTDITVEGISKLLREHGYQSRGFEVMYNGHTG 1078
Cdd:TIGR02013  865 LEDGTPVDIVLNPLGVPSRMNIGQILETHLGWAGKRLGRKGVpiATPvFDGASEEEIKEYLEKAGLPRDGKVRLYDGRTG 944
                         1210      1220      1230      1240      1250      1260      1270
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
3S1R_B        1079 KKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAASFLKERLMEASD 1156
Cdd:TIGR02013  945 EQFDRPVTVGYMYMLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSD 1022
RNA_pol_Rpb2_2 pfam04561
RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of ...
219-407 1.38e-55

RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the lobe domain. DNA has been demonstrated to bind to the concave surface of the lobe domain, and plays a role in maintaining the transcription bubble. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 1 (DRI).


Pssm-ID: 398318 [Multi-domain]  Cd Length: 185  Bit Score: 191.02  E-value: 1.38e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         219 AGNIVQVFKKAAPSPIShvaeirsaleKGSRFISTLQVKLYGREGSSARTIKATLPYIKQDIPIVIIFRALGIIPDGEIL 298
Cdd:pfam04561    1 RSNGIYVEKELDKNGII----------ATYTSSLISNRGSWLKLEIDGKTLIWSRPSKKRKIPIVIFLKALGLVSDREIL 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         299 EHICYDVNDWQMLEMLKPCVEDGFVIQDRETALDFIGrRGTALGIKKEKRIQYAKDILQK-----EFLPHITQLEGFESR 373
Cdd:pfam04561   71 DRLCYDFNDPQMLELLKPELEEAENIYTQEEALDYIG-KGFALRRGEEPRLQRAREILYSrdpkyNLNKHLGLNEPFENE 149
                          170       180       190
                   ....*....|....*....|....*....|....*.
3S1R_B         374 --KAFFLGYMINRLLLCALDRKDQDDRDHFGKKRLD 407
Cdd:pfam04561  150 rlKAQDILYMIDRLLNLKLGRRKPDDIDHLGNKRVR 185
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
43-1156 9.72e-54

DNA-directed RNA polymerase subunit beta; Reviewed


Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 205.72  E-value: 9.72e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         43 LVSQQLDSFNQFVDytlQDIICEDSTLileqlaQHTTES----DNISRKYEISFGKIYVTKPMVNEsdgvthalypQEAR 118
Cdd:PRK00405   27 LLEIQLDSFDWFLQ---LDVPPEDEGL------EEVFRSifpiEDFNGNLSLEFVSYELGEPKYDV----------EECK 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        119 LRNLTYSSGLFVDVkkrtyeaidvpgrelkyELIAEESEDDSESgKVFIGRLPIMlrskncylseaTESdlyklkecpfd 198
Cdd:PRK00405   88 ERGLTYSAPLRVKL-----------------RLINKETGEIKEQ-EVYMGDIPLM-----------TEN----------- 127
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        199 mgGYFIINGSEKVLIAQ-ERSAGnivqVFkkaapspishvaeirsalekgsrFISTLQVKLYGREGSSARTI-------- 269
Cdd:PRK00405  128 --GTFIINGTERVIVSQlHRSPG----VY-----------------------FDHDKDKTSSGKLLYSARIIpyrgswle 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        270 -----KATLpYIKQD----IPIVIIFRALGIiPDGEILEHICYDVNDWQMLEMLKPCVEDGFVIQDRETALDFIGRRGTA 340
Cdd:PRK00405  179 fefdpKDIL-YVRIDrrrkLPVTVLLRALGY-SDEEILDLFYEKEEFGKEIEVPVEYLLGKVLAEDIVDEETGEVLAEAN 256
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        341 LGIKKEKRIQYAKDILQKEflPHITQLEGF---------------ESRKAFF-----------LG----YMINRLL---- 386
Cdd:PRK00405  257 DEITEELDGPYIRNTLEKD--PTSSREEALveiyrrlrpgepptvEAARSLLenlffdpkrydLSkvgrYKLNKKLglde 334
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        387 ------------------LCAL--DRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKltkdifryMQRTVEEahdfNMKL 446
Cdd:PRK00405  335 dedvrvltkediiatikyLINLrnGKGEVDDIDHLGNRRVRSVGELLQNQFRIGLSR--------MERAVRE----RMSL 402
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        447 A----------INAKTITSGLKYALATGnwgeQkkamssragVSQV------LnrytysSTLSHLRRTNT--PIG----- 503
Cdd:PRK00405  403 QdldtltpqdlINAKPVVAAIKEFFGSS----Q---------LSQFmdqtnpL------SELTHKRRLSAlgPGGltrer 463
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        504 -----RDgklakprqLHNTHWGLVCPAETPEGQACGLVKNLSlmscisvgtdpmpiiTFlsewgmepledyvphqspdaT 578
Cdd:PRK00405  464 agfevRD--------VHPTHYGRICPIETPEGPNIGLINSLA---------------TY--------------------A 500
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        579 RVfvngvwhgvhrNPARLMETlrtlrrkgdinPevsmirdirekelkiftdagrvYRplfiveddeslghkelKVRKGHI 658
Cdd:PRK00405  501 RV-----------NEYGFIET-----------P----------------------YR----------------KVVDGKV 520
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        659 aklmateyqdieggfedveeytwsslLNEglVEYIDAEEEESILIAmqpedlepaEANEEndldVDPAKRI-------RV 731
Cdd:PRK00405  521 --------------------------TDE--IVYLTADEEDNYVIA---------QANAP----LDEDGRFvdelvtaRY 559
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        732 SHHATTFTHCEIH-----PSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAmgVFLtnynVRmdtmanilyyPQKPL-GT 805
Cdd:PRK00405  560 KGEFVLVPPEEVDymdvsPKQVVSVAASLIPFLEHDDANRALMGSNMQRQA--VPL----LR----------PEAPLvGT 623
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        806 trAMEY---------------------------------------------LKFR------------------------- 815
Cdd:PRK00405  624 --GMERrvardsgavvvakrdgvveyvdasrivvrveeldpgedgvdiynlIKFQrsnqntcinqrpivkvgdrvekgdv 701
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        816 ----------ELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLffrsymdqekkygmSITEtFEKPQRtNTlrm 885
Cdd:PRK00405  702 ladgpstdngELALGQNVLVAFMPWNGYNFEDAILISERLVKEDVFTSI--------------HIEE-YEIEAR-DT--- 762
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        886 KHG----TYD----------KLDDDGLIAPGVRVSGEDVIIGKTTP-----ISPdEEEL-----GQRTAYHskRDAStpL 941
Cdd:PRK00405  763 KLGpeeiTRDipnvseealrNLDESGIVRIGAEVKPGDILVGKVTPkgeteLTP-EEKLlraifGEKARDV--KDTS--L 837
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        942 R--STENGIVDQVLV-TTNQDG-------LKFVKVRV---RttKIpQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVP 1008
Cdd:PRK00405  838 RvpHGEEGTVIDVKVfTRIEQGdelppgvNKLVKVYIaqkR--KI-QVGDKMAGRHGNKGVVSRILPVEDMPYLEDGTPV 914
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       1009 DLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGdASP-FTDITVEGISKLLREHGYQSRGFEVMYNGHTGKKLMAQIFF 1087
Cdd:PRK00405  915 DIVLNPLGVPSRMNIGQILETHLGWAAKGLGIKF-ATPvFDGAKEEEIKELLEEAGLPEDGKTTLYDGRTGEPFDRPVTV 993
                        1290      1300      1310      1320      1330      1340
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
3S1R_B       1088 GPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAASFLKERLMEASD 1156
Cdd:PRK00405  994 GYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSD 1062
rpoB CHL00207
RNA polymerase beta subunit; Provisional
201-1212 5.89e-53

RNA polymerase beta subunit; Provisional


Pssm-ID: 214397 [Multi-domain]  Cd Length: 1077  Bit Score: 203.01  E-value: 5.89e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        201 GYFIINGSEKVLIAQE-RSAGNIVQVFKKaapspishvaeirsalEKGSRFISTLQVKLYGR----EGSSARTIKATLPY 275
Cdd:CHL00207  106 GTFIINGLERVIVSQIiRSPGIYFKKEIK----------------KNSNKIYSATLIPNRGSwikfELDKNKEIWIRIDK 169
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        276 IKQdIPIVIIFRALGIiPDGEILEHICYDVN-------------------DWQMLEMLKPCVEDGFVIQDRETALDFIGR 336
Cdd:CHL00207  170 NRK-KPLIIFLKALGL-TDQDIYSRLTKSEFlkklkpillnsnsytneeiLLEIYKNLSPIEPATVNDANQNLFSRFFDP 247
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        337 RGTALGIKKEKRIQYAKDILQKEFLPHITQLEGFESrkafflgymINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQL 416
Cdd:CHL00207  248 KNYDLGKVGRYKINNKLNLNIPERVRNLTYEDILSI---------IDKLINLKINKGNFDDIDHLKNRRVRSVGELLQNQ 318
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        417 F----KTLFKKLTKDIFRYMQRTVEeahDFNMklaINAKTITSGLKYALAtgnwgeqkkamSSRagVSQVLNRYTYSSTL 492
Cdd:CHL00207  319 FriglKRLERILRNRMTICDIDSLS---KFNL---INPKPLIALIREFFG-----------SSQ--LSQYMDQTNPLSEL 379
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        493 SHLRRTNT--PIGRDgKLAKP---RQLHNTHWGLVCPAETPEGQACGLVKnlSLMSCISVGTDPMPIITFLsewgmeple 567
Cdd:CHL00207  380 THKRRISIlgPGGLD-KDRISfavRDIHPSHYGRICPIETPEGPNCGLIG--SLATNARINKFGFIETPFY--------- 447
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        568 dyvphqspdatRVFVNGVWhgVHRNPARLMETLRTLRRkgdINPEvsmirDIREKELKIFTDagrvyrplfiveddeslg 647
Cdd:CHL00207  448 -----------KVINGKVK--KFGNPIYLTADSEDLYR---IAPN-----DINLNKNNYFKK------------------ 488
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        648 hKELKVRKGHIAKLmateyqdieggfedveeytwssllneglveyIDAEEEESILIAmqpedlepaeaneendldvdpak 727
Cdd:CHL00207  489 -NIIPVRYKQEFKT-------------------------------VNPSKVDFIAIS----------------------- 513
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        728 rirvshhattfthceihPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMG---------------------------- 779
Cdd:CHL00207  514 -----------------PIQVFSIAESLIPFLEHNDANRALMGSNMQRQAVPllypekpivgtgyekqialdsgmtiisl 576
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        780 -----VFLTNYNVRMDTMAN--ILYYPQK-------------PL---------GTTRAM-EYLKFRELPAGQNAIVAIAC 829
Cdd:CHL00207  577 tegivVSVSAYKIIIQDDNNryIHYYLQKyqrsnqntcinyrPIvwvgekiniGQILADgSDIDNSELALGQNVLVAYMP 656
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        830 YSGYNQEDSMIMNQSSIDRGLFRSLFFrsymdqeKKYGMSITETFEKPQRTNTLRMKHGTYD--KLDDDGLIAPGVRVSG 907
Cdd:CHL00207  657 WEGYNFEDAILINKRLVYEDLFTSIHI-------EKYEIELRQTKLGSEEITRNIPNVSEYSlkNLDENGIISIGSKVLA 729
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        908 EDVIIGKTTPIS----PDEEELGQRTAYHSKRDA-STPLRSTENG---IVDQVLVTTNQ-DGLKF---VKVRVRTTKIP- 974
Cdd:CHL00207  730 GDILVGKITPKGesdqLPEGKLLRAIFGEKAKDVkDTSLRMPNGGygrVIKVEIFSRSKgDELKFgyyLKIRVFIAQIRk 809
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        975 -QIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVE 1053
Cdd:CHL00207  810 iQVGDKLAGRHGNKGIISRILPRQDMPYLPDGTPPDIILNPLGVPSRMNVGQLFECLLGLAGDNLNKRFKILPFDEMYGS 889
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       1054 GISKLLREHGYQSRGFE---------------VMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQP 1118
Cdd:CHL00207  890 EYSRILINNKLNQASIKnneywlfnsyhpgkmVLRDGRTGYKFKNPVTVGIAYMLKLIHLVDDKIHARTTGPYSLVTQQP 969
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       1119 VEGRSRDGGLRFGEMERDCMIAHGAASFLKERLMEASDAFRVhicgicglmtviaklnhNQFECKGCDNKIDIYQIHIPY 1198
Cdd:CHL00207  970 LGGKAQHGGQRFGEMEVWALEAFGAAYTLKELLTIKSDDMQG-----------------RNETLNAIVKGQPIPKPGTPE 1032
                        1130
                  ....*....|....
3S1R_B       1199 AAKLLFQELMAMNI 1212
Cdd:CHL00207 1033 SFKVLMRELQSLGL 1046
RNA_pol_Rpb2_7 pfam04560
RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of ...
1126-1219 1.01e-42

RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain comprised of the structural domains anchor and clamp. The clamp region (C-terminal) contains a zinc-binding motif. The clamp region is named due to its interaction with the clamp domain found in Rpb1. The domain also contains a region termed "switch 4". The switches within the polymerase are thought to signal different stages of transcription.


Pssm-ID: 461355 [Multi-domain]  Cd Length: 87  Bit Score: 150.43  E-value: 1.01e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        1126 GGLRFGEMERDCMIAHGAASFLKERLMEASDAFRVHICGICGLMTVIAKlnhnqfeCKGCDNKIDIYQIHIPYAAKLLFQ 1205
Cdd:pfam04560    1 GGLRFGEMERWALIAYGAAHTLQERLTIKSDAYEVDVCGRCGLYAAYNK-------CPICKGETDISPGYIPESFKLLFQ 73
                           90
                   ....*....|....
3S1R_B        1206 ELMAMNITPRLYTD 1219
Cdd:pfam04560   74 ELQSLGIDPRLLLE 87
rpoB CHL00001
RNA polymerase beta subunit
42-1162 1.52e-37

RNA polymerase beta subunit


Pssm-ID: 214330 [Multi-domain]  Cd Length: 1070  Bit Score: 153.52  E-value: 1.52e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B         42 GLVSQQLDSFNQFVDytlqdiicedsTLILEQLAQHTTESDnISRKYEIS-FGKIY-VTKPMVNEsdgvthalypQEARL 119
Cdd:CHL00001   14 GFNQIQFEGFCRFID-----------QGLTEELSKFPKIED-TDQEIEFQlFVETYqLVEPLIKE----------RDAVY 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        120 RNLTYSSGLFVDVkkrtyeaidvpgrelkyELIAEESEDDSESgKVFIGRLPIMlrskncylseatesdlyklkecpfDM 199
Cdd:CHL00001   72 ESLTYSSELYVPA-----------------GLIWKKSRDMQEQ-TVFIGNIPLM------------------------NS 109
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        200 GGYFIINGSEKVLIAQersagnIVQvfkkaapSP-ISHVAEIRSaleKGSR-----FIST----LQVKLYGREGSSARTI 269
Cdd:CHL00001  110 LGTFIINGIYRVVINQ------ILR-------SPgIYYRSELDH---NGISvytgtIISDwggrLELEIDRKARIWARVS 173
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        270 KatlpyiKQDIPIVIIFRALGIIPDgEILEHICYdvndwqmLEMLKPCVEDgfviqdretaldfigrrgtalgiKKEKRI 349
Cdd:CHL00001  174 R------KQKISILVLLSAMGLNLR-EILDNVCY-------PEIFLSFLND-----------------------KEKKKI 216
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        350 QYAKD-ILqkEFLPHITQLEGF---------ESRKAFF-----LGYM----INRLL----------------LCALDRKD 394
Cdd:CHL00001  217 GSKENaIL--EFYQQFACVGGDpvfseslckELQKKFFqqrceLGRIgrrnMNRKLnldipenntfllpqdvLAAADYLI 294
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        395 Q--------DDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTVEEAHDFNMKLAINAKTITSGLK-----YAL 461
Cdd:CHL00001  295 GmkfgmgtlDDIDHLKNKRIRSVADLLQDQFGLALNRLENAVRGTICGAIRRKLIPTPQNLVTSTPLTTTYEsffgsHPL 374
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        462 atgnwgeqkkamssragvSQVLNRYTYSSTLSHLRRTNT--PIGRDGKLA--KPRQLHNTHWGLVCPAETPEGQACGLVK 537
Cdd:CHL00001  375 ------------------SQFLDQTNPLTEIVHGRKLSSlgPGGLTGRTAsfRVRDIHPSHYGRICPIDTSEGINAGLIG 436
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        538 nlSLMSCISVGTdpmpiitflseWGMepLEdyvphqSPdatrvfvngvwhgvhrnparlmetlrtlrrkgdinpevsmir 617
Cdd:CHL00001  437 --SLAIHARIGH-----------WGS--LE------SP------------------------------------------ 453
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        618 direkelkiftdagrvyrplfiveddeslghkelkvrkghiaklmateyqdieggFedveeYTWSSLLNEGLVEYIDAEE 697
Cdd:CHL00001  454 -------------------------------------------------------F-----YEISERSKEERMVYLSPSE 473
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        698 EESILIAMQpEDLepAEANEENDLDVDPAkRIRVSHHATTFTHCE---IHPSMILGVAASIIPFPDHNQSPRNTYQSAMG 774
Cdd:CHL00001  474 DEYYMIAAG-NSL--ALNQGIQEEQVVPA-RYRQEFLTIAWEQIHlrsIFPFQYFSIGASLIPFLEHNDANRALMGSNMQ 549
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        775 KQAM-----------------------GVFLTNYNVRMD----------TMANILYYP--------------QKPlgTTR 807
Cdd:CHL00001  550 RQAVplsrsekcivgtglerqvaldsgVVAIAEHEGKIIytdtdkiilsGNGDTLSIPlvmyqrsnkntcmhQKP--QVR 627
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        808 AMEYLKFRELPA------------GQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRsymdqekKYGMSITETFE 875
Cdd:CHL00001  628 RGKCVKKGQILAdgaatvggelalGKNVLVAYMPWEGYNFEDAVLISERLVYEDIYTSFHIR-------KYEIQTHVTSQ 700
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        876 KPQR-TN--------TLRmkhgtydKLDDDGLIAPGVRVSGEDVIIGKTTPISPDEEE-----------LGQRTAyhSKR 935
Cdd:CHL00001  701 GPERiTKeiphleahLLR-------NLDKNGIVMLGSWVETGDILVGKLTPQEAEESSyapegrllraiFGIQVS--TSK 771
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        936 DasTPLRSTENG---IVDQVLVTTNQDGLKFVK-VRV---RTTKIpQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVP 1008
Cdd:CHL00001  772 E--TCLKLPIGGrgrVIDVRWIQKKGGSSYNPEtIHVyilQKREI-QVGDKVAGRHGNKGIISKILPRQDMPYLQDGTPV 848
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       1009 DLIINPHAIPSRMTVAHLIECLLSKVAALSGNEGDASPFTDITVEGIS-KLLREHGYQSRG-------FEVMY------- 1073
Cdd:CHL00001  849 DMVLNPLGVPSRMNVGQIFECLLGLAGDLLNRHYRIAPFDERYEQEASrKLVFSELYEASKqtanpwvFEPEYpgksrlf 928
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       1074 NGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAASFLKERLME 1153
Cdd:CHL00001  929 DGRTGDPFEQPVTIGKAYILKLIHQVDDKIHARSSGPYALVTQQPLRGRSKQGGQRVGEMEVWALEGFGVAYILQEMLTY 1008

                  ....*....
3S1R_B       1154 ASDafrvHI 1162
Cdd:CHL00001 1009 KSD----HI 1013
PRK09603 PRK09603
DNA-directed RNA polymerase subunit beta/beta';
396-1156 5.05e-37

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 181983 [Multi-domain]  Cd Length: 2890  Bit Score: 152.77  E-value: 5.05e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        396 DDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIfRYMQRTVEEAHDFNMKL-AINAKTITSGLKYALATGNwgeqkkams 474
Cdd:PRK09603  455 DDRDHLGNRRIRAVGELLANELHSGLVKMQKTI-KDKLTTMSGAFDSLMPHdLVNSKMITSTIMEFFMGGQ--------- 524
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        475 sragVSQVLNRYTYSSTLSHLRRTNTpIGrDGKLAK------PRQLHNTHWGLVCPAETPEGQACGLVKNLSlmscisvg 548
Cdd:PRK09603  525 ----LSQFMDQTNPLSEVTHKRRLSA-LG-EGGLVKdrvgfeARDVHPTHYGRICPIETPEGQNIGLINTLS-------- 590
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        549 tdpmpiiTFlsewgmepledyvphqspdaTRVfvngvwhgvhrnparlmetlrtlrrkgdinpevsmirdirekelkifT 628
Cdd:PRK09603  591 -------TF--------------------TRV-----------------------------------------------N 596
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        629 DAGRVYRPLfiveddeslghkeLKVRKGHIAklmateyqdieggfedveeytwssllneGLVEYIDAEEEESILIAMQPE 708
Cdd:PRK09603  597 DLGFIEAPY-------------KKVVDGKVV----------------------------GETIYLTAIQEDSHIIAPAST 635
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        709 DLEPAEANEENDLDVDPAKRIRVSHHATTfTHCEIHPSMILGVAASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNV- 787
Cdd:PRK09603  636 PIDEEGNILGDLIETRVEGEIVLNEKSKV-TLMDLSSSMLVGVAASLIPFLEHDDANRALMGTNMQRQAVPLLRSDAPIv 714
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        788 -------------------------RMDTM-----------ANILYYP-QKPLGTTRAMEY------------------- 811
Cdd:PRK09603  715 gtgiekiiardswgaikanragvveKIDSKniyilgegkeeAYIDAYSlQKNLRTNQNTSFnqvpivkvgdkveagqiia 794
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        812 ----LKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRS--LFFRSYMDQEKKYGmsITETFEKPQRTNTLRM 885
Cdd:PRK09603  795 dgpsMDRGELALGKNVRVAFMPWNGYNFEDAIVVSERITKDDIFTSthIYEKEVDARELKHG--VEEFTADIPDVKEEAL 872
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        886 KHgtydkLDDDGLIAPGVRVSGEDVIIGKTTP---ISPDEEELGQRTAYHSK---------------------------- 934
Cdd:PRK09603  873 AH-----LDESGIVKVGTYVSAGMILVGKTSPkgeIKSTPEERLLRAIFGDKaghvvnkslycppslegtvidvkvftkk 947
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        935 ---RDAST-------------------------------------PLRS------------------------------- 943
Cdd:PRK09603  948 gyeKDARVlsayeeekakldmehfdrltmlnreellrvssllsqaILEEpfshngkdykegdqipkeeiasinrftlasl 1027
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        944 --------------TENGIVDQ--VLVTTNQDGL--------------KFVKVRVRTTKIPQIGDKFASRHGQKGTIGIT 993
Cdd:PRK09603 1028 vkkyskevqnhyeiTKNNFLEQkkVLGEEHEEKLsilekddilpngviKKVKLYIATKRKLKVGDKMAGRHGNKGIVSNI 1107
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        994 YRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIECLLSKVAALSG-----------------------------NEGD- 1043
Cdd:PRK09603 1108 VPVADMPYTADGEPVDIVLNPLGVPSRMNIGQILEMHLGLVGKEFGkqiasmledktkdfakelrakmleianaiNEKDp 1187
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       1044 ---------------------------ASP-FTDITVEGISKLLREHGYQSRGFEVMYNGHTGKKLMAQIFFGPTYYQRL 1095
Cdd:PRK09603 1188 ltihalencsdeelleyakdwskgvkmAIPvFEGISQEKFYKLFELAKIAMDGKMDLYDGRTGEKMRERVNVGYMYMIKL 1267
                         970       980       990      1000      1010      1020
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
3S1R_B       1096 RHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAASFLKERLMEASD 1156
Cdd:PRK09603 1268 HHLVDEKVHARSTGPYSLVTHQPVGGKALFGGQRFGEMEVWALEAYGAAHTLKEMLTIKSD 1328
RNA_pol_Rpb2_4 pfam04566
RNA polymerase Rpb2, domain 4; RNA polymerases catalyze the DNA dependent polymerization of ...
580-641 7.05e-32

RNA polymerase Rpb2, domain 4; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 4, is also known as the external 2 domain.


Pssm-ID: 428012 [Multi-domain]  Cd Length: 62  Bit Score: 118.62  E-value: 7.05e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
3S1R_B         580 VFVNGVWHGVHRNPARLMETLRTLRRKGDINPEVSMIRDIREKELKIFTDAGRVYRPLFIVE 641
Cdd:pfam04566    1 VFLNGNLIGVHRDPEELVETLRKLRRSGKISEEVSIVRDIREKEVRINTDGGRVCRPLIIVE 62
RNA_pol_Rpb2_3 pfam04565
RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of ...
481-543 2.18e-29

RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 3, s also known as the fork domain and is proximal to catalytic site.


Pssm-ID: 428011 [Multi-domain]  Cd Length: 67  Bit Score: 111.46  E-value: 2.18e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
3S1R_B         481 QVLNRYTYSSTLSHLRRTNTPIG---RDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMS 543
Cdd:pfam04565    1 QVLDRTNYLSTLSHLRRVNSPRGglfREMKTTEVRDLHPSHWGRICPVETPEGPNCGLVKHLALYA 66
PRK14844 PRK14844
DNA-directed RNA polymerase subunit beta/beta';
381-1182 7.09e-26

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 173305 [Multi-domain]  Cd Length: 2836  Bit Score: 116.65  E-value: 7.09e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        381 MINRLLLCALDRKDQDDRDHFGKKRLDLAGPLLAQLFKTLFKKLTKDIFRYMQRTVEE---AHDFnmklaINAKTITSGL 457
Cdd:PRK14844  449 IVRKIVLLRDGQGSVDDIDHLGNRRVRSVGEFIENQFRTGLLKLERAVVDSMSTSSLDkvsPSDF-----INPKVLTNVL 523
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        458 KyalatgnwgeqkkAMSSRAGVSQVLNRYTYSSTLSHLRRTNT--PIG--RDGKLAKPRQLHNTHWGLVCPAETPEGQAC 533
Cdd:PRK14844  524 R-------------DFFNSSQLSQFMDQTNPLSEITHKRRLSAlgPGGltRERAGFEVRDVHPTHYGRICPIETPEGQNI 590
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        534 GLVKNLSLMSCISvgtdpmpiitflsEWGM--EPLEDYVPHQSPDATRvFVNGVWHGVHR---------NPARLMETLRT 602
Cdd:PRK14844  591 GLINSLAIYARIN-------------KYGFieSPYRKVVNRVVTDQIE-YLSAIDEGLYYiadtsakldENNCFVDDMLY 656
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        603 LRRKGDI----NPEVSMIrDIREKELkIFTDAGRVyrPlFIVEDDESLGHKELKVRKGHIAKLMATEYQDIEGGFEDVEE 678
Cdd:PRK14844  657 CRYAGSFvmvsSDQVSYI-DVSPKQV-ISVAASLI--P-FLENDDANRALMGSNMQRQAVPLLKPTAPLVATGMESFVAS 731
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        679 YTWSSLL--NEGLVeyiDAEEEESILI-AMQPEDLepaeaneeNDLDVD--PAKRIRVSHHATTFthceihpsmilgvaa 753
Cdd:PRK14844  732 GSGAVVLakRDGIV---DSSDSNSIVIrAFDKERV--------NYLDVDiyHLRKFQRSNHNTCI--------------- 785
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        754 siipfpdhNQSPRntyqsamgkqamgVFLTNYNVRMDTMANilyYPQKPLGttrameylkfrELPAGQNAIVAIACYSGY 833
Cdd:PRK14844  786 --------NQKPL-------------VCVGDYVKEGDVIAD---GPAINSG-----------ELALGQNLLVAFMSWQGY 830
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        834 NQEDSMIMNQSSIDRGLFRSLFFRSY--------MDQEKkygmsITETFEKPQRTNtlrMKHgtydkLDDDGLIAPGVRV 905
Cdd:PRK14844  831 NFEDSIIISSEVVKKDLFTSIHIEEFecvvhdtpLGSEK-----ITRAIPGVNEEN---LYH-----LDDSGIVKIGTRV 897
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        906 SGEDVIIGKTTP------------------------------ISPDEE--------------ELGQRtAYHSKRDASTPL 941
Cdd:PRK14844  898 GPGYILVGKVTPkpslslppetkllmtifgeksfdcadsslyTSPDVEgtvidvqvftrrgvEENER-ALLIKQKEINDF 976
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        942 RSTENGIVD-----------QVLVTT-NQDGLKF---------------------------------------------- 963
Cdd:PRK14844  977 EKERDYIINvtseyfydelkKLLINSgSQDREKFdsiereqwwgiglknqsiseqvkslkkdfdekvshaiaqfkrkvek 1056
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B        964 --------------VKVRVRTTKIPQIGDKFASRHGQKGTIGITYRREDMPFTAEGIVPDLIINPHAIPSRMTVAHLIEC 1029
Cdd:PRK14844 1057 lhegydlpqgvsmsVKVFIAVKHSLQPGDKMAGRHGNKGVISRVVPVEDMPYLEDGTPVDIILNPLGVPSRMNVGQILET 1136
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       1030 LL-------------------------------------SKVAAL---------------------SGNEG--------- 1042
Cdd:PRK14844 1137 HVgwackklgekvgnildeinkiksafckgirslnddnfTKFAAAyldnkkienidddeitasvlnTPNKNalndelnel 1216
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       1043 ---------------------------------------------------DASPFTDITVEG-----ISKLLREHGYQS 1066
Cdd:PRK14844 1217 venylnscksaysnlrnflievyscgsnvsicnnirdisdnnliefarklrDGIPVAAPVFEGpkdeqIAKLFELAGLDN 1296
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3S1R_B       1067 RGFEVMYNGHTGKKLMAQIFFGPTYYQRLRHMVDDKIHARARGPMQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAASF 1146
Cdd:PRK14844 1297 SGQAVLYDGCSGEKFDRKVTVGYMYMLKLHHLVDGKIHARSVGPYSLVTQQPLGGKSHFGGQRFGEMECWALQAYGAAYT 1376
                        1050      1060      1070
                  ....*....|....*....|....*....|....*.
3S1R_B       1147 LKERLMEASDafrvHICGICGLMTVIAKLNHNqFEC 1182
Cdd:PRK14844 1377 LQEMLTVKSD----DINGRVKIYESIIKGDSN-FEC 1407
RNA_pol_Rpb2_5 pfam04567
RNA polymerase Rpb2, domain 5; RNA polymerases catalyze the DNA dependent polymerization of ...
681-745 7.62e-22

RNA polymerase Rpb2, domain 5; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 5, is also known as the external 2 domain.


Pssm-ID: 428013 [Multi-domain]  Cd Length: 53  Bit Score: 89.52  E-value: 7.62e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
3S1R_B         681 WSSLLNEGLVEYIDAEEEESILIAMQPEDLEPAEaneendldvdpaKRIRVSHHATTFTHCEIHP 745
Cdd:pfam04567    1 WSDLLREGVIEYLDAEEEETSMIAMTPEDLEESS------------REEREGPYAHTYTHCEIHP 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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