NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|380765142|pdb|4DL1|J]
View 

Chain J, Myeloperoxidase light chain

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
An_peroxidase super family cl38107
Animal haem peroxidase;
7-103 9.69e-39

Animal haem peroxidase;


The actual alignment was detected with superfamily member pfam03098:

Pssm-ID: 460804 [Multi-domain]  Cd Length: 531  Bit Score: 134.99  E-value: 9.69e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4DL1_J          7 YRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTpgvkrNGFPVALARAVSNEIvrFPTDQLTPDQERSLMF 86
Cdd:pfam03098   1 YRTIDGSCNNLKNPSWGAAGTPFARLLPPAYEDGVSAPRGSS-----SGSPLPSPRLVSNKL--FAGDSGIPDPNLTLLL 73

                          90
                  ....*....|....*..
4DL1_J         87 MQWGQLLDHDLDFTPEP 103
Cdd:pfam03098  74 MQWGQFIDHDLTLTPES 90
 
Name Accession Description Interval E-value
An_peroxidase pfam03098
Animal haem peroxidase;
7-103 9.69e-39

Animal haem peroxidase;


Pssm-ID: 460804 [Multi-domain]  Cd Length: 531  Bit Score: 134.99  E-value: 9.69e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4DL1_J          7 YRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTpgvkrNGFPVALARAVSNEIvrFPTDQLTPDQERSLMF 86
Cdd:pfam03098   1 YRTIDGSCNNLKNPSWGAAGTPFARLLPPAYEDGVSAPRGSS-----SGSPLPSPRLVSNKL--FAGDSGIPDPNLTLLL 73

                          90
                  ....*....|....*..
4DL1_J         87 MQWGQLLDHDLDFTPEP 103
Cdd:pfam03098  74 MQWGQFIDHDLTLTPES 90
thyroid_peroxidase cd09825
Thyroid peroxidase (TPO); TPO is a member of the animal heme peroxidase family, which is ...
 23-101 1.56e-27

Thyroid peroxidase (TPO); TPO is a member of the animal heme peroxidase family, which is expressed in the thyroid and involved in the processing of iodine and iodine compounds. Specifically, TPO oxidizes iodide via hydrogen peroxide to form active iodine, which is then, for example, incorporated into the tyrosine residues of thyroglobulin to yield mono- and di-iodotyrosines.


Pssm-ID: 188657 [Multi-domain]  Cd Length: 565  Bit Score: 104.44  E-value: 1.56e-27
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
4DL1_J       23 GASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTP 101
Cdd:cd09825   1 GASNTPLARWLPPIYEDGFSEPVGWNKERLYNGFTLPSVREVSNKIMRTSSTAVTPDDLYSHMLTVWGQYIDHDIDFTP 79
 
Name Accession Description Interval E-value
An_peroxidase pfam03098
Animal haem peroxidase;
7-103 9.69e-39

Animal haem peroxidase;


Pssm-ID: 460804 [Multi-domain]  Cd Length: 531  Bit Score: 134.99  E-value: 9.69e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4DL1_J          7 YRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTpgvkrNGFPVALARAVSNEIvrFPTDQLTPDQERSLMF 86
Cdd:pfam03098   1 YRTIDGSCNNLKNPSWGAAGTPFARLLPPAYEDGVSAPRGSS-----SGSPLPSPRLVSNKL--FAGDSGIPDPNLTLLL 73

                          90
                  ....*....|....*..
4DL1_J         87 MQWGQLLDHDLDFTPEP 103
Cdd:pfam03098  74 MQWGQFIDHDLTLTPES 90
thyroid_peroxidase cd09825
Thyroid peroxidase (TPO); TPO is a member of the animal heme peroxidase family, which is ...
 23-101 1.56e-27

Thyroid peroxidase (TPO); TPO is a member of the animal heme peroxidase family, which is expressed in the thyroid and involved in the processing of iodine and iodine compounds. Specifically, TPO oxidizes iodide via hydrogen peroxide to form active iodine, which is then, for example, incorporated into the tyrosine residues of thyroglobulin to yield mono- and di-iodotyrosines.


Pssm-ID: 188657 [Multi-domain]  Cd Length: 565  Bit Score: 104.44  E-value: 1.56e-27
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
4DL1_J       23 GASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTP 101
Cdd:cd09825   1 GASNTPLARWLPPIYEDGFSEPVGWNKERLYNGFTLPSVREVSNKIMRTSSTAVTPDDLYSHMLTVWGQYIDHDIDFTP 79
peroxinectin_like_bacterial cd09822
Uncharacterized family of heme peroxidases, mostly bacterial; Animal heme peroxidases are ...
 61-101 7.91e-06

Uncharacterized family of heme peroxidases, mostly bacterial; Animal heme peroxidases are diverse family of enzymes which are not restricted to animals. Members are also found in metazoans, fungi, and plants, and also in bacteria - like most members of this family of uncharacterized proteins.


Pssm-ID: 188654 [Multi-domain]  Cd Length: 420  Bit Score: 42.68  E-value: 7.91e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
4DL1_J       61 ARAVSNEIVRFPTDQLTPdQERSLMFMQWGQLLDHDLDFTP 101
Cdd:cd09822   5 PREISNAVADQTESIPNS-RGLSDWFWVWGQFLDHDIDLTP 44
thyroid_peroxidase cd09825
Thyroid peroxidase (TPO); TPO is a member of the animal heme peroxidase family, which is ...
 4-101 3.35e-05

Thyroid peroxidase (TPO); TPO is a member of the animal heme peroxidase family, which is expressed in the thyroid and involved in the processing of iodine and iodine compounds. Specifically, TPO oxidizes iodide via hydrogen peroxide to form active iodine, which is then, for example, incorporated into the tyrosine residues of thyroglobulin to yield mono- and di-iodotyrosines.


Pssm-ID: 188657 [Multi-domain]  Cd Length: 565  Bit Score: 40.88  E-value: 3.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4DL1_J        4 QDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEY-EDGFSLPYGWTPGVKRNGFPVALARAVS-----NEIVRFPTdQLT 77
Cdd:cd09825 145 ANPREQINGLTSFIDASTVYGSTLALARSLRDLSsDDGLLRVNSKFDDSGRDYLPFQPEEVSScnpdpNGGERVPC-FLA 223

                        90       100
                ....*....|....*....|....
4DL1_J       78 PDQERSLMFMQWGQLLDHDLDFTP 101
Cdd:cd09825 224 GDGRASEVLTLTASHTLWLREHNR 247
dual_peroxidase_like cd09820
Dual oxidase and related animal heme peroxidases; Animal heme peroxidases of the dual-oxidase ...
 15-47 5.18e-03

Dual oxidase and related animal heme peroxidases; Animal heme peroxidases of the dual-oxidase like subfamily play vital roles in the innate mucosal immunity of gut epithelia. They provide reactive oxygen species which help control infection.


Pssm-ID: 188652 [Multi-domain]  Cd Length: 558  Bit Score: 34.58  E-value: 5.18e-03
                        10        20        30
                ....*....|....*....|....*....|...
4DL1_J       15 NNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGW 47
Cdd:cd09820   6 NNLAHPEWGAADSRLTRRLPAHYSDGVYAPSGE 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH