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Conserved domains on  [gi|673541977|pdb|4U5W|C]
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Chain C, Protein Nef

Protein Classification

protein Nef( domain architecture ID 10452613)

protein Nef accelerates virulent progression of AIDS by its interaction with cellular proteins involved in signal transduction and host cell activation; it binds specifically to a subset of the Src kinase family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-protein pfam00469
Negative factor, (F-Protein) or Nef; Nef protein accelerates virulent progression of AIDS by ...
 2-149 6.24e-105

Negative factor, (F-Protein) or Nef; Nef protein accelerates virulent progression of AIDS by its interaction with cellular proteins involved in signal transduction and host cell activation. Nef has been shown to bind specifically to a subset of the Src kinase family.


:

Pssm-ID: 425700  Cd Length: 220  Bit Score: 298.54  E-value: 6.24e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4U5W_C          2 LEAQEEEEVGFPVRPQVPLRPMTYKAALDISHFLKEKGGLEGLIWSQRRQEILDLWIYHTQGYFPDWQNYTPGPGIRYPL 81
Cdd:pfam00469  75 LDSDEEDEVGFPVRPQVPLRPMTYKLAVDMSHFIKEKGGLEGLYYSERRHRILDLYLEKEEGIIPDWQNYTPGPGIRYPL 154

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
4U5W_C         82 TFGWCFKLVPVEPEKVEEanEGENNSLLHPMSLHGMEDAEKEVLVWRFDSKLAFHHMARELHPEYYKD 149
Cdd:pfam00469 155 TFGWLFKLVPVDVEEEEE--EGENNCLLHPAQTHGMDDPHGEVLVWKFDSLLAYEYEAFELHPEEFGH 220
 
Name Accession Description Interval E-value
F-protein pfam00469
Negative factor, (F-Protein) or Nef; Nef protein accelerates virulent progression of AIDS by ...
 2-149 6.24e-105

Negative factor, (F-Protein) or Nef; Nef protein accelerates virulent progression of AIDS by its interaction with cellular proteins involved in signal transduction and host cell activation. Nef has been shown to bind specifically to a subset of the Src kinase family.


Pssm-ID: 425700  Cd Length: 220  Bit Score: 298.54  E-value: 6.24e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4U5W_C          2 LEAQEEEEVGFPVRPQVPLRPMTYKAALDISHFLKEKGGLEGLIWSQRRQEILDLWIYHTQGYFPDWQNYTPGPGIRYPL 81
Cdd:pfam00469  75 LDSDEEDEVGFPVRPQVPLRPMTYKLAVDMSHFIKEKGGLEGLYYSERRHRILDLYLEKEEGIIPDWQNYTPGPGIRYPL 154

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
4U5W_C         82 TFGWCFKLVPVEPEKVEEanEGENNSLLHPMSLHGMEDAEKEVLVWRFDSKLAFHHMARELHPEYYKD 149
Cdd:pfam00469 155 TFGWLFKLVPVDVEEEEE--EGENNCLLHPAQTHGMDDPHGEVLVWKFDSLLAYEYEAFELHPEEFGH 220
 
Name Accession Description Interval E-value
F-protein pfam00469
Negative factor, (F-Protein) or Nef; Nef protein accelerates virulent progression of AIDS by ...
 2-149 6.24e-105

Negative factor, (F-Protein) or Nef; Nef protein accelerates virulent progression of AIDS by its interaction with cellular proteins involved in signal transduction and host cell activation. Nef has been shown to bind specifically to a subset of the Src kinase family.


Pssm-ID: 425700  Cd Length: 220  Bit Score: 298.54  E-value: 6.24e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4U5W_C          2 LEAQEEEEVGFPVRPQVPLRPMTYKAALDISHFLKEKGGLEGLIWSQRRQEILDLWIYHTQGYFPDWQNYTPGPGIRYPL 81
Cdd:pfam00469  75 LDSDEEDEVGFPVRPQVPLRPMTYKLAVDMSHFIKEKGGLEGLYYSERRHRILDLYLEKEEGIIPDWQNYTPGPGIRYPL 154

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
4U5W_C         82 TFGWCFKLVPVEPEKVEEanEGENNSLLHPMSLHGMEDAEKEVLVWRFDSKLAFHHMARELHPEYYKD 149
Cdd:pfam00469 155 TFGWLFKLVPVDVEEEEE--EGENNCLLHPAQTHGMDDPHGEVLVWKFDSLLAYEYEAFELHPEEFGH 220
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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