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Conserved domains on  [gi|1732261856|pdb|6QNN|B]
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Chain B, G2 and S phase-expressed protein 1

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GTSE1_CTD cd21864
C-terminal domain of G2 and S phase-expressed protein 1; G2 and S phase-expressed protein 1 ...
 3-59 6.35e-17

C-terminal domain of G2 and S phase-expressed protein 1; G2 and S phase-expressed protein 1 (GTSE-1), also called protein B99 homolog, is a cell cycle-regulated protein mainly localized in the cytoplasm and apparently associated with microtubules. It may be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression of GTSE-1 delays G2/M phase progression. GTSE-1 is a clathrin adaptor protein; it is recruited to the spindle by clathrin, which stabilizes microtubules by inhibiting the microtubule depolymerase MCAK. This model corresponds to a conserved domain at the C-terminus of GTSE-1, which is required for clathrin binding and is only conserved in vertebrates.


:

Pssm-ID: 412061 [Multi-domain]  Cd Length: 56  Bit Score: 66.68  E-value: 6.35e-17
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|....*..
6QNN_B       3 PLIDLPLIDFCDTPEAHVAVGSESRPLIDLmTNTPDMNKNVAKPSPVVGQLIDLSSP 59
Cdd:cd21864  1 QLKENLLVDFEANPEAHPAVQSEDRPLIDL-SNTPDLNKVIPLKPSVVGQLIDLSSP 56
 
Name Accession Description Interval E-value
GTSE1_CTD cd21864
C-terminal domain of G2 and S phase-expressed protein 1; G2 and S phase-expressed protein 1 ...
 3-59 6.35e-17

C-terminal domain of G2 and S phase-expressed protein 1; G2 and S phase-expressed protein 1 (GTSE-1), also called protein B99 homolog, is a cell cycle-regulated protein mainly localized in the cytoplasm and apparently associated with microtubules. It may be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression of GTSE-1 delays G2/M phase progression. GTSE-1 is a clathrin adaptor protein; it is recruited to the spindle by clathrin, which stabilizes microtubules by inhibiting the microtubule depolymerase MCAK. This model corresponds to a conserved domain at the C-terminus of GTSE-1, which is required for clathrin binding and is only conserved in vertebrates.


Pssm-ID: 412061 [Multi-domain]  Cd Length: 56  Bit Score: 66.68  E-value: 6.35e-17
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|....*..
6QNN_B       3 PLIDLPLIDFCDTPEAHVAVGSESRPLIDLmTNTPDMNKNVAKPSPVVGQLIDLSSP 59
Cdd:cd21864  1 QLKENLLVDFEANPEAHPAVQSEDRPLIDL-SNTPDLNKVIPLKPSVVGQLIDLSSP 56
 
Name Accession Description Interval E-value
GTSE1_CTD cd21864
C-terminal domain of G2 and S phase-expressed protein 1; G2 and S phase-expressed protein 1 ...
 3-59 6.35e-17

C-terminal domain of G2 and S phase-expressed protein 1; G2 and S phase-expressed protein 1 (GTSE-1), also called protein B99 homolog, is a cell cycle-regulated protein mainly localized in the cytoplasm and apparently associated with microtubules. It may be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression of GTSE-1 delays G2/M phase progression. GTSE-1 is a clathrin adaptor protein; it is recruited to the spindle by clathrin, which stabilizes microtubules by inhibiting the microtubule depolymerase MCAK. This model corresponds to a conserved domain at the C-terminus of GTSE-1, which is required for clathrin binding and is only conserved in vertebrates.


Pssm-ID: 412061 [Multi-domain]  Cd Length: 56  Bit Score: 66.68  E-value: 6.35e-17
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|....*..
6QNN_B       3 PLIDLPLIDFCDTPEAHVAVGSESRPLIDLmTNTPDMNKNVAKPSPVVGQLIDLSSP 59
Cdd:cd21864  1 QLKENLLVDFEANPEAHPAVQSEDRPLIDL-SNTPDLNKVIPLKPSVVGQLIDLSSP 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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