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Conserved domains on  [gi|1897214338|pdb|6S95|A]
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Chain A, Genome polyprotein

Protein Classification

Flavi_E_C domain-containing protein( domain architecture ID 10187330)

Flavi_E_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Flavi_E_C cd12149
Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E; The ...
 10-101 2.41e-51

Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E; The C-terminal domain (domain III) of Flavivirus glycoprotein E appears to be involved in low-affinity interactions with negatively charged glycoaminoglycans on the host cell surface. Domain III may also play a role in interactions with alpha-v-beta-3 integrins in West Nile virus, Japanese encephalitis virus, and Dengue virus. The interface between domain I and domain III appears to be destabilized by the low-pH environment of the endosome, and domain III may play a vital role in the conformational changes of envelope glycoprotein E that follow the clathrin-mediated endocytosis of viral particles and are a prerequisite to membrane fusion.


:

Pssm-ID: 213392  Cd Length: 91  Bit Score: 156.31  E-value: 2.41e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6S95_A       10 KFSFAKNPADTGHGTVVLELQYTGVDGPCKIPISIVASLSDLTPIGRMVTANPYVasSEANSKVLVEMEPPFGDSFIVVG 89
Cdd:cd12149   1 KFSWKKEPADTGHGTVVMEVKYSGTDAPCRIPVRVVDSGSGGENVGRLITVNPII--TNANSKVFIEVEPPFGDSYIVVG 78

                        90
                ....*....|..
6S95_A       90 RGDKQINHHWHK 101
Cdd:cd12149  79 VGDTRLKHQWFQ 90
 
Name Accession Description Interval E-value
Flavi_E_C cd12149
Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E; The ...
 10-101 2.41e-51

Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E; The C-terminal domain (domain III) of Flavivirus glycoprotein E appears to be involved in low-affinity interactions with negatively charged glycoaminoglycans on the host cell surface. Domain III may also play a role in interactions with alpha-v-beta-3 integrins in West Nile virus, Japanese encephalitis virus, and Dengue virus. The interface between domain I and domain III appears to be destabilized by the low-pH environment of the endosome, and domain III may play a vital role in the conformational changes of envelope glycoprotein E that follow the clathrin-mediated endocytosis of viral particles and are a prerequisite to membrane fusion.


Pssm-ID: 213392  Cd Length: 91  Bit Score: 156.31  E-value: 2.41e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6S95_A       10 KFSFAKNPADTGHGTVVLELQYTGVDGPCKIPISIVASLSDLTPIGRMVTANPYVasSEANSKVLVEMEPPFGDSFIVVG 89
Cdd:cd12149   1 KFSWKKEPADTGHGTVVMEVKYSGTDAPCRIPVRVVDSGSGGENVGRLITVNPII--TNANSKVFIEVEPPFGDSYIVVG 78

                        90
                ....*....|..
6S95_A       90 RGDKQINHHWHK 101
Cdd:cd12149  79 VGDTRLKHQWFQ 90
Flavi_glycop_C pfam02832
Flavivirus glycoprotein, immunoglobulin-like domain;
3-101 1.17e-36

Flavivirus glycoprotein, immunoglobulin-like domain;


Pssm-ID: 280922  Cd Length: 97  Bit Score: 119.37  E-value: 1.17e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6S95_A          3 TYGMCTKKFSFAKNPADTGHGTVVLELQYTGVDGPCKIPISIVASLSDLTPIGRMVTANPYVASSEanSKVLVEMEPPFG 82
Cdd:pfam02832   1 SYKICTDKFFFEKEPADTGHGTVLMQVKVEGKDAPCKIPVFSADDEKAAINKGILITANPIASDKD--DEVLIEAEPPFG 78

                          90
                  ....*....|....*....
6S95_A         83 DSFIVVGRGDKQINHHWHK 101
Cdd:pfam02832  79 DSYIIVGAGDKALKLQWFK 97
 
Name Accession Description Interval E-value
Flavi_E_C cd12149
Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E; The ...
 10-101 2.41e-51

Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E; The C-terminal domain (domain III) of Flavivirus glycoprotein E appears to be involved in low-affinity interactions with negatively charged glycoaminoglycans on the host cell surface. Domain III may also play a role in interactions with alpha-v-beta-3 integrins in West Nile virus, Japanese encephalitis virus, and Dengue virus. The interface between domain I and domain III appears to be destabilized by the low-pH environment of the endosome, and domain III may play a vital role in the conformational changes of envelope glycoprotein E that follow the clathrin-mediated endocytosis of viral particles and are a prerequisite to membrane fusion.


Pssm-ID: 213392  Cd Length: 91  Bit Score: 156.31  E-value: 2.41e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6S95_A       10 KFSFAKNPADTGHGTVVLELQYTGVDGPCKIPISIVASLSDLTPIGRMVTANPYVasSEANSKVLVEMEPPFGDSFIVVG 89
Cdd:cd12149   1 KFSWKKEPADTGHGTVVMEVKYSGTDAPCRIPVRVVDSGSGGENVGRLITVNPII--TNANSKVFIEVEPPFGDSYIVVG 78

                        90
                ....*....|..
6S95_A       90 RGDKQINHHWHK 101
Cdd:cd12149  79 VGDTRLKHQWFQ 90
Flavi_glycop_C pfam02832
Flavivirus glycoprotein, immunoglobulin-like domain;
3-101 1.17e-36

Flavivirus glycoprotein, immunoglobulin-like domain;


Pssm-ID: 280922  Cd Length: 97  Bit Score: 119.37  E-value: 1.17e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6S95_A          3 TYGMCTKKFSFAKNPADTGHGTVVLELQYTGVDGPCKIPISIVASLSDLTPIGRMVTANPYVASSEanSKVLVEMEPPFG 82
Cdd:pfam02832   1 SYKICTDKFFFEKEPADTGHGTVLMQVKVEGKDAPCKIPVFSADDEKAAINKGILITANPIASDKD--DEVLIEAEPPFG 78

                          90
                  ....*....|....*....
6S95_A         83 DSFIVVGRGDKQINHHWHK 101
Cdd:pfam02832  79 DSYIIVGAGDKALKLQWFK 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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