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Conserved domains on  [gi|2046389443|pdb|7ENA|n]
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Chain n, Mediator of RNA polymerase II transcription subunit 14

Protein Classification

mediator of RNA polymerase II transcription subunit 14( domain architecture ID 10554477)

mediator of RNA polymerase II transcription subunit 14 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes

Gene Ontology:  GO:0003712|GO:0016592|GO:0006357|GO:0051123
PubMed:  29209056

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med14 pfam08638
Mediator complex subunit MED14; Saccharomyces cerevisiae RGR1 mediator complex subunit affects ...
 51-238 5.49e-73

Mediator complex subunit MED14; Saccharomyces cerevisiae RGR1 mediator complex subunit affects chromatin structure, transcriptional regulation of diverse genes and sporulation, required for glucose repression, HO repression, RME1 repression and sporulation. This subunit is also found in higher eukaryotes and Med14 is the agreed unified nomenclature for this subunit. Med14 is found in the tail region of Mediator.


:

Pssm-ID: 462543  Cd Length: 192  Bit Score: 241.25  E-value: 5.49e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n          51 LSTLIEFLLHRAYSELMVLTDLLP--RKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAIL 128
Cdd:pfam08638    4 LSLLVDRLVQRSYNELSELIETLPntSESDVEKKRRLLDFAQRTRQQFIKLLVLVKWSRKAEDVSKLIDLLAFLRQQNMA 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n         129 FVDTLDRLASLARDaLVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDkIIPPDPITKIEKQATLHQLNQILRHRLVTTD- 207
Cdd:pfam08638   84 FEDAADALKNMKRS-LVNARLPNPDLPTALEVLSTGRYPRLPTLIYD-IIPPPPLTPKEILKTLRDLNTLLSIRLNLHEk 161

                          170       180       190
                   ....*....|....*....|....*....|.
7ENA_n         208 LPPQLANLTVANGRVKFRVEGEFEATLTVMG 238
Cdd:pfam08638  162 IPPQFRNYTIADGRVTFTVPGEFEVDLTIAG 192
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1015-1189 1.01e-10

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 66.48  E-value: 1.01e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        1015 TSGAYPLT-SPPTSYHSTVNQSPSMmhtqspgnlhaaSSPSGALRAPSPASFVPTPPPSShgisigPGASFASPhgTLDP 1093
Cdd:pfam05109  482 TSGASPVTpSPSPRDNGTESKAPDM------------TSPTSAVTTPTPNATSPTPAVTT------PTPNATSP--TLGK 541

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        1094 SSPYTMVSPSGRAGNWPgSPQVSGPSPAARMPGMSPANPS--LHSPVPDASH------SPRAGTSSQTM-PTNMPPPRKL 1164
Cdd:pfam05109  542 TSPTSAVTTPTPNATSP-TPAVTTPTPNATIPTLGKTSPTsaVTTPTPNATSptvgetSPQANTTNHTLgGTSSTPVVTS 620

                          170       180
                   ....*....|....*....|....*....
7ENA_n        1165 PQRSWAASIPT----ILTHSALNILLLPS 1189
Cdd:pfam05109  621 PPKNATSAVTTgqhnITSSSTSSMSLRPS 649
 
Name Accession Description Interval E-value
Med14 pfam08638
Mediator complex subunit MED14; Saccharomyces cerevisiae RGR1 mediator complex subunit affects ...
 51-238 5.49e-73

Mediator complex subunit MED14; Saccharomyces cerevisiae RGR1 mediator complex subunit affects chromatin structure, transcriptional regulation of diverse genes and sporulation, required for glucose repression, HO repression, RME1 repression and sporulation. This subunit is also found in higher eukaryotes and Med14 is the agreed unified nomenclature for this subunit. Med14 is found in the tail region of Mediator.


Pssm-ID: 462543  Cd Length: 192  Bit Score: 241.25  E-value: 5.49e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n          51 LSTLIEFLLHRAYSELMVLTDLLP--RKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAIL 128
Cdd:pfam08638    4 LSLLVDRLVQRSYNELSELIETLPntSESDVEKKRRLLDFAQRTRQQFIKLLVLVKWSRKAEDVSKLIDLLAFLRQQNMA 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n         129 FVDTLDRLASLARDaLVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDkIIPPDPITKIEKQATLHQLNQILRHRLVTTD- 207
Cdd:pfam08638   84 FEDAADALKNMKRS-LVNARLPNPDLPTALEVLSTGRYPRLPTLIYD-IIPPPPLTPKEILKTLRDLNTLLSIRLNLHEk 161

                          170       180       190
                   ....*....|....*....|....*....|.
7ENA_n         208 LPPQLANLTVANGRVKFRVEGEFEATLTVMG 238
Cdd:pfam08638  162 IPPQFRNYTIADGRVTFTVPGEFEVDLTIAG 192
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1015-1189 1.01e-10

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 66.48  E-value: 1.01e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        1015 TSGAYPLT-SPPTSYHSTVNQSPSMmhtqspgnlhaaSSPSGALRAPSPASFVPTPPPSShgisigPGASFASPhgTLDP 1093
Cdd:pfam05109  482 TSGASPVTpSPSPRDNGTESKAPDM------------TSPTSAVTTPTPNATSPTPAVTT------PTPNATSP--TLGK 541

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        1094 SSPYTMVSPSGRAGNWPgSPQVSGPSPAARMPGMSPANPS--LHSPVPDASH------SPRAGTSSQTM-PTNMPPPRKL 1164
Cdd:pfam05109  542 TSPTSAVTTPTPNATSP-TPAVTTPTPNATIPTLGKTSPTsaVTTPTPNATSptvgetSPQANTTNHTLgGTSSTPVVTS 620

                          170       180
                   ....*....|....*....|....*....
7ENA_n        1165 PQRSWAASIPT----ILTHSALNILLLPS 1189
Cdd:pfam05109  621 PPKNATSAVTTgqhnITSSSTSSMSLRPS 649
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 972-1196 1.01e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 57.10  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        972 DARRRSVNEDDNP-PSPIGGDMM-DSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHA 1049
Cdd:PHA03307  206 PPRRSSPISASASsPAPAPGRSAaDDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPA 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1050 ASSPSGALRAPSPASFVP----TPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQvSGPSPAArmP 1125
Cdd:PHA03307  286 SSSSSPRERSPSPSPSSPgsgpAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPS-RPPPPAD--P 362

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
7ENA_n       1126 GMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPP--PRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVP 1196
Cdd:PHA03307  363 SSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRarRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLTP 435
 
Name Accession Description Interval E-value
Med14 pfam08638
Mediator complex subunit MED14; Saccharomyces cerevisiae RGR1 mediator complex subunit affects ...
 51-238 5.49e-73

Mediator complex subunit MED14; Saccharomyces cerevisiae RGR1 mediator complex subunit affects chromatin structure, transcriptional regulation of diverse genes and sporulation, required for glucose repression, HO repression, RME1 repression and sporulation. This subunit is also found in higher eukaryotes and Med14 is the agreed unified nomenclature for this subunit. Med14 is found in the tail region of Mediator.


Pssm-ID: 462543  Cd Length: 192  Bit Score: 241.25  E-value: 5.49e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n          51 LSTLIEFLLHRAYSELMVLTDLLP--RKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAIL 128
Cdd:pfam08638    4 LSLLVDRLVQRSYNELSELIETLPntSESDVEKKRRLLDFAQRTRQQFIKLLVLVKWSRKAEDVSKLIDLLAFLRQQNMA 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n         129 FVDTLDRLASLARDaLVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDkIIPPDPITKIEKQATLHQLNQILRHRLVTTD- 207
Cdd:pfam08638   84 FEDAADALKNMKRS-LVNARLPNPDLPTALEVLSTGRYPRLPTLIYD-IIPPPPLTPKEILKTLRDLNTLLSIRLNLHEk 161

                          170       180       190
                   ....*....|....*....|....*....|.
7ENA_n         208 LPPQLANLTVANGRVKFRVEGEFEATLTVMG 238
Cdd:pfam08638  162 IPPQFRNYTIADGRVTFTVPGEFEVDLTIAG 192
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1015-1189 1.01e-10

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 66.48  E-value: 1.01e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        1015 TSGAYPLT-SPPTSYHSTVNQSPSMmhtqspgnlhaaSSPSGALRAPSPASFVPTPPPSShgisigPGASFASPhgTLDP 1093
Cdd:pfam05109  482 TSGASPVTpSPSPRDNGTESKAPDM------------TSPTSAVTTPTPNATSPTPAVTT------PTPNATSP--TLGK 541

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        1094 SSPYTMVSPSGRAGNWPgSPQVSGPSPAARMPGMSPANPS--LHSPVPDASH------SPRAGTSSQTM-PTNMPPPRKL 1164
Cdd:pfam05109  542 TSPTSAVTTPTPNATSP-TPAVTTPTPNATIPTLGKTSPTsaVTTPTPNATSptvgetSPQANTTNHTLgGTSSTPVVTS 620

                          170       180
                   ....*....|....*....|....*....
7ENA_n        1165 PQRSWAASIPT----ILTHSALNILLLPS 1189
Cdd:pfam05109  621 PPKNATSAVTTgqhnITSSSTSSMSLRPS 649
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1014-1190 5.03e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 57.85  E-value: 5.03e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        1014 GTSGAYPLTSPPTSY-----------HSTVNQSPSMmHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHG-ISIGPG 1081
Cdd:pfam03154  202 SAPSVPPQGSPATSQppnqtqstaapHTLIQQTPTL-HPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGqMPPMPH 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        1082 ASFASPHGTLDPSSPYTMVSPSGRA-GNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHS-PRAGTSsqtMPTNMP 1159
Cdd:pfam03154  281 SLQTGPSHMQHPVPPQPFPLTPQSSqSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPlPPAPLS---MPHIKP 357

                          170       180       190
                   ....*....|....*....|....*....|..
7ENA_n        1160 PPRK-LPQrswaasIPTILTHSALNILLLPSP 1190
Cdd:pfam03154  358 PPTTpIPQ------LPNPQSHKHPPHLSGPSP 383
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 972-1196 1.01e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 57.10  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        972 DARRRSVNEDDNP-PSPIGGDMM-DSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHA 1049
Cdd:PHA03307  206 PPRRSSPISASASsPAPAPGRSAaDDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPA 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1050 ASSPSGALRAPSPASFVP----TPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQvSGPSPAArmP 1125
Cdd:PHA03307  286 SSSSSPRERSPSPSPSSPgsgpAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPS-RPPPPAD--P 362

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
7ENA_n       1126 GMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPP--PRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVP 1196
Cdd:PHA03307  363 SSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRarRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLTP 435
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1014-1197 1.45e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.49  E-value: 1.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1014 GTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPS--PASFVPTPP---PSSHGISIGPGASFASPH 1088
Cdd:PHA03247 2774 APAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAasPAGPLPPPTsaqPTAPPPPPGPPPPSLPLG 2853

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1089 GTLDPSSPYTMVSPSGRAGNWPGS-----------PQVSGPSPAARMPGMSPANPslhsPVPDASHSPRAGTSSQTMPTN 1157
Cdd:PHA03247 2854 GSVAPGGDVRRRPPSRSPAAKPAAparppvrrlarPAVSRSTESFALPPDQPERP----PQPQAPPPPQPQPQPPPPPQP 2929

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
7ENA_n       1158 MPPPRKlPQRSWAASIPTILTHSALNIL-LLPSPTPG-LVPG 1197
Cdd:PHA03247 2930 QPPPPP-PPRPQPPLAPTTDPAGAGEPSgAVPQPWLGaLVPG 2970
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1022-1190 1.02e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 53.38  E-value: 1.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        1022 TSPPTSYHSTV-NQSPSMMHTQSPGNLHAASSPSGALRAPSpASFVPT--PPPSSHGISIGPG-ASFASPHGTLDPSSPY 1097
Cdd:pfam05109  410 TNATTTTHKVIfSKAPESTTTSPTLNTTGFAAPNTTTGLPS-STHVPTnlTAPASTGPTVSTAdVTSPTPAGTTSGASPV 488

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        1098 TmVSPSGR-AGNWPGSPQ-------VSGPSPAARMPgmspaNPSLHSPVPDAShSPRAGTSSQTMPTNMPPPR------K 1163
Cdd:pfam05109  489 T-PSPSPRdNGTESKAPDmtsptsaVTTPTPNATSP-----TPAVTTPTPNAT-SPTLGKTSPTSAVTTPTPNatsptpA 561

                          170       180
                   ....*....|....*....|....*..
7ENA_n        1164 LPQRSWAASIPTILTHSALNILLLPSP 1190
Cdd:pfam05109  562 VTTPTPNATIPTLGKTSPTSAVTTPTP 588
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1015-1199 4.74e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 51.33  E-value: 4.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1015 TSGAYPLTSPPTSY----HSTVNQSPSMMhtqSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGT 1090
Cdd:PHA03307   15 AEGGEFFPRPPATPgdaaDDLLSGSQGQL---VSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1091 LDPSSPYTMvsPSGRAGNWPGSPQVSGPSPAArmpgmSPANPsLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWA 1170
Cdd:PHA03307   92 LSTLAPASP--AREGSPTPPGPSSPDPPPPTP-----PPASP-PPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVA 163

                         170       180
                  ....*....|....*....|....*....
7ENA_n       1171 ASIPTILtHSALNILLLPSPTPGLVPGLA 1199
Cdd:PHA03307  164 SDAASSR-QAALPLSSPEETARAPSSPPA 191
PHA03378 PHA03378
EBNA-3B; Provisional
 1020-1201 5.77e-06

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 51.22  E-value: 5.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1020 PLTSPPTSYHSTVNQS------PSMMHTQSPGNLHAASSP---SGALRAPSPASFVPTPPPSSHGISIGPgASFASPHGT 1090
Cdd:PHA03378  576 PLTSPTTSQLASSAPSyaqtpwPVPHPSQTPEPPTTQSHIpetSAPRQWPMPLRPIPMRPLRMQPITFNV-LVFPTPHQP 654

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1091 ldPSSPYTMVSPS-GRAGNWPGSPQVSGPSpAARMPGMSPAN----PSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLP 1165
Cdd:PHA03378  655 --PQVEITPYKPTwTQIGHIPYQPSPTGAN-TMLPIQWAPGTmqppPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAP 731

                         170       180       190
                  ....*....|....*....|....*....|....*....
7ENA_n       1166 ---QRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGS 1201
Cdd:PHA03378  732 graRPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAA 770
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 1036-1162 8.26e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 50.45  E-value: 8.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1036 PSMMHTQSPGNLHAASSPSGALRAPSPAS--FVPTPPPSSHGISIGPGASFASPhGTLDPSSPYTMVSPSGRAgNW---P 1110
Cdd:PRK14959  363 PRLMPVESLRPSGGGASAPSGSAAEGPASggAATIPTPGTQGPQGTAPAAGMTP-SSAAPATPAPSAAPSPRV-PWddaP 440

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
7ENA_n       1111 GSPQVSG--PSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPR 1162
Cdd:PRK14959  441 PAPPRSGipPRPAPRMPEASPVPGAPDSVASASDAPPTLGDPSDTAEHTPSGPR 494
PHA03378 PHA03378
EBNA-3B; Provisional
 1019-1165 9.58e-06

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 50.45  E-value: 9.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1019 YPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGA--LRAPSPASFVPTPPPSSHGISIGP--GASFASPHGTLDPS 1094
Cdd:PHA03378  653 QPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQWApgTMQPPPRAPTPMRPPAAPPGRAQRpaAATGRARPPAAAPG 732

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
7ENA_n       1095 SPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSP-ANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLP 1165
Cdd:PHA03378  733 RARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPaAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGP 804
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 1030-1167 1.59e-05

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 46.95  E-value: 1.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        1030 STVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPsshgisigPGASFASPH--GTLDPSSPYTMVSPSGRAG 1107
Cdd:pfam15240   28 SPSLISEEEGQSQQGGQGPQGPPPGGFPPQPPASDDPPGPPP--------PGGPQQPPPqgGKQKPQGPPPQGGPRPPPG 99

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        1108 NWPGSPQVSGPSPAARMPgmsPANPslHSPVPDASHSPRAGTSSQTMPTnmPPPRKlPQR 1167
Cdd:pfam15240  100 KPQGPPPQGGNQQQGPPP---PGKP--QGPPPQGGGPPPQGGNQQGPPP--PPPGN-PQG 151
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1053-1199 2.12e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 2.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1053 PSGALRAPSPASfvpTPPPSSHGISigPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANP 1132
Cdd:PHA03247 2604 DRGDPRGPAPPS---PLPPDTHAPD--PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASS 2678

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
7ENA_n       1133 SLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLA 1199
Cdd:PHA03247 2679 PPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVP 2745
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 955-1197 4.26e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.24  E-value: 4.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        955 PAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPI---GGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPT----- 1026
Cdd:PHA03307    3 NAPDLYDLIEAAAEGGEFFPRPPATPGDAADDLLsgsQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTeapan 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1027 ------SYHSTVNQSPSMMHTQSPGNlHAASSPSGALRAPSPAsfvpTPPPSSHGISIGPGASFASPHGTLDPSSPYTMV 1100
Cdd:PHA03307   83 esrstpTWSLSTLAPASPAREGSPTP-PGPSSPDPPPPTPPPA----SPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1101 S----PSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPR-------KLPQRSW 1169
Cdd:PHA03307  158 SpaavASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPApgrsaadDAGASSS 237

                         250       260       270
                  ....*....|....*....|....*....|
7ENA_n       1170 --AASIPTILTHSALNILLLPSPTPGLVPG 1197
Cdd:PHA03307  238 dsSSSESSGCGWGPENECPLPRPAPITLPT 267
Gag_spuma pfam03276
Spumavirus gag protein;
1035-1212 5.07e-05

Spumavirus gag protein;


Pssm-ID: 460872 [Multi-domain]  Cd Length: 614  Bit Score: 47.82  E-value: 5.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        1035 SPSMMHTQSPGNLHA-----ASSPSGALRAPSPASFVPTPP--PSSHGISIGPGASFAsphgtlDPSSPYTMVSPSGRAG 1107
Cdd:pfam03276  179 SPGAQGGIPPGASFSglpslPAIGGIHLPAIPGIHARAPPGniARSLGDDIMPSLGDA------GMPQPRFAFHPGNPFA 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        1108 NWPGSPqvsgPSPAAR-MPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKL-------PQRSwAASIPTILTH 1179
Cdd:pfam03276  253 EAEGHP----FAEAEGeRPRDIPRAPRIDAPSAPAIPAIQPIAPPMIPPIGAPIPIPHgasipgeHIRN-PREEPIRLGR 327

                          170       180       190
                   ....*....|....*....|....*....|....
7ENA_n        1180 SALNIL-LLPSPTPGLVPGLAGSYLCSPLERFLG 1212
Cdd:pfam03276  328 EAPAIDgRFAPAIDDLFCRIINALLCGIIGALLG 361
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1049-1174 5.10e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.06  E-value: 5.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1049 AASSPSGALRAPSPASfvpTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMS 1128
Cdd:PRK07764  616 AAPAAPAAPAAPAPAG---AAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAA 692

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
7ENA_n       1129 PANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKL--PQRSWAASIP 1174
Cdd:PRK07764  693 PAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGAsaPSPAADDPVP 740
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1022-1165 5.70e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.56  E-value: 5.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1022 TSPPTSYHSTVNQSPSmmhtqspgnlhAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVS 1101
Cdd:PRK12323  372 AGPATAAAAPVAQPAP-----------AAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQAS 440

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
7ENA_n       1102 PSGRAG-NWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQtmPTNMPPPRKLP 1165
Cdd:PRK12323  441 ARGPGGaPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPA--DDDPPPWEELP 503
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 965-1174 6.33e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.86  E-value: 6.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        965 MFVDSNQDARRRSVNEDDNPPSPI-----GGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYH------STVN 1033
Cdd:PHA03307   53 VTVVAGAAACDRFEPPTGPPPGPGteapaNESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPpaspppSPAP 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1034 QSPSMM-----------HTQSPGNLHAASSPSGALRAPSPASFV---------PTPPPSSHGISIGPGASFASPHGTLDP 1093
Cdd:PHA03307  133 DLSEMLrpvgspgpppaASPPAAGASPAAVASDAASSRQAALPLsspeetaraPSSPPAEPPPSTPPAAASPRPPRRSSP 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1094 SSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSwAASI 1173
Cdd:PHA03307  213 ISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASS-SSSP 291


                  .
7ENA_n       1174 P 1174
Cdd:PHA03307  292 R 292
PHA03379 PHA03379
EBNA-3A; Provisional
 1020-1196 7.76e-05

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 47.36  E-value: 7.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1020 PLTSPPTSYHSTVNQSPSMMHTQSPGnlhaasSPSGALRAP---SPASFVPTPPPSSHGISIGPGASFASPHGTLDPSS- 1095
Cdd:PHA03379  533 PVPVPTVALERPVCPAPPLIAMQGPG------ETSGIVRVRerwRPAPWTPNPPRSPSQMSVRDRLARLRAEAQPYQASv 606

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1096 -----PYTMVSPS--------GRAGNWPGSP--QVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTnmpP 1160
Cdd:PHA03379  607 evqppQLTQVSPQqpmeyplePEQQMFPGSPfsQVADVMRAGGVPAMQPQYFDLPLQQPISQGAPLAPLRASMGPV---P 683

                         170       180       190
                  ....*....|....*....|....*....|....*....
7ENA_n       1161 PRKLPQRSW---AASIPTILTHSALNILLLPSPTPGLVP 1196
Cdd:PHA03379  684 PVPATQPQYfdiPLTEPINQGASAAHFLPQQPMEGPLVP 722
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1049-1200 1.15e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.90  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1049 AASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPS--SPYTMVSPSGRAGNWPGSPQVSGPSPAARMPG 1126
Cdd:PRK07764  605 SSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPehHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPA 684

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
7ENA_n       1127 MSPANPSLHSPVPDAS--HSPRAGTSSQTMPTNMPPPRKLPQRSWAASiptilTHSALNILLLPSPTPGLVPGLAG 1200
Cdd:PRK07764  685 PAPAAPAAPAGAAPAQpaPAPAATPPAGQADDPAAQPPQAAQGASAPS-----PAADDPVPLPPEPDDPPDPAGAP 755
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1018-1199 1.50e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1018 AYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGA-----------LRAPSPASFVPTPPPSSHGISIGPGASFAS 1086
Cdd:PHA03247 2621 THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGrvsrprrarrlGRAAQASSPPQRPRRRAARPTVGSLTSLAD 2700

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1087 PHGT-LDPSSPYTMVSPSGRAGNWPGSPQVSGPS-PAARMPGMSPANPSLhsPVPDASHSPRAGTSSQTMPTN-----MP 1159
Cdd:PHA03247 2701 PPPPpPTPEPAPHALVSATPLPPGPAAARQASPAlPAAPAPPAVPAGPAT--PGGPARPARPPTTAGPPAPAPpaapaAG 2778

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
7ENA_n       1160 PPRKLPQrswAASIPTILTHSALNILLLPSPTPGLVPGLA 1199
Cdd:PHA03247 2779 PPRRLTR---PAVASLSESRESLPSPWDPADPPAAVLAPA 2815
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 968-1197 1.67e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.30  E-value: 1.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n         968 DSNQDARRRSvnedDNPPSPIGGDMmDSLISQLQPPpqqqpfpkqpgtsgaypltspptsyhstVNQSPSMMHTQSPgnl 1047
Cdd:pfam03154  136 DIDQDNRSTS----PSIPSPQDNES-DSDSSAQQQI----------------------------LQTQPPVLQAQSG--- 179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        1048 hAASSPSGALRAPSPASfVPTPPPSSHGISIGPG-ASFASPHGTLDPSSPYTMV--SPSGRAGNWPgSP-----QVSGPS 1119
Cdd:pfam03154  180 -AASPPSPPPPGTTQAA-TAGPTPSAPSVPPQGSpATSQPPNQTQSTAAPHTLIqqTPTLHPQRLP-SPhpplqPMTQPP 256

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        1120 PAARMPGMSPANPSLHSPVPDASHSPRAGTSSqtMPTNMPP-PRKLPQRSWAASIP----TILTHSALNILLLPSPTPGL 1194
Cdd:pfam03154  257 PPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSH--MQHPVPPqPFPLTPQSSQSQVPpgpsPAAPGQSQQRIHTPPSQSQL 334


                   ...
7ENA_n        1195 VPG 1197
Cdd:pfam03154  335 QSQ 337
PHA03292 PHA03292
envelope glycoprotein I; Provisional
 1018-1163 4.05e-04

envelope glycoprotein I; Provisional


Pssm-ID: 177577  Cd Length: 413  Bit Score: 44.56  E-value: 4.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1018 AYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGAlrapspASFVPTPPPSSHGISIGP-------GASFASPHGT 1090
Cdd:PHA03292  178 TTARPEPAAGYVATPTPRYLNAVTTSTYSRSMSSQPAGA------ATATPTPTLDTGLTTVAPpnetvvtGETALLCHWF 251

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
7ENA_n       1091 LDPSSPYTM-VSPSGRAGNWPGSPQVSGPSPAARMPgmspanpslhSPVPDASHSPRAGTSSQTMPTNMPPPRK 1163
Cdd:PHA03292  252 QPSTRVPTLyLHLLGTTGNLTEDVLLTEDSEILRTP----------PPDPSSSRSPGAGDDFKQTNSTSPKRRN 315
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1040-1162 5.78e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 5.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1040 HTQSPGNLHAASSPSGalraPSPASFVPTPPPSshgisigPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPS 1119
Cdd:PHA03307  810 DAASRTASKRKSRSHT----PDGGSESSGPARP-------PGAAARPPPARSSESSKSKPAAAGGRARGKNGRRRPRPPE 878

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
7ENA_n       1120 PAARMPGMSP---ANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPR 1162
Cdd:PHA03307  879 PRARPGAAAPpkaAAAAPPAGAPAPRPRPAPRVKLGPMPPGGPDPR 924
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1008-1196 8.57e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 8.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1008 PFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNlhAASSPSGALRAPSPASfvPTPPPSShgisigpgASFASP 1087
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA--GPATPGGPARPARPPT--TAGPPAP--------APPAAP 2775

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1088 HGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAArMPGMSPANPSLHSPvpdASHSPRAGTSSQTMPTNMPPP------ 1161
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA-VLAPAAALPPAASP---AGPLPPPTSAQPTAPPPPPGPpppslp 2851

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
7ENA_n       1162 ------------RKLPQRSwAASIPTILTHSALNILLLPSPTPGLVP 1196
Cdd:PHA03247 2852 lggsvapggdvrRRPPSRS-PAAKPAAPARPPVRRLARPAVSRSTES 2897
DUF4045 pfam13254
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ...
 1023-1162 1.18e-03

Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.


Pssm-ID: 433066 [Multi-domain]  Cd Length: 415  Bit Score: 43.23  E-value: 1.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        1023 SPPTSYHSTVNQSPSMMHTQSPGNLHAAS---SPSGALRAPSPASFVPTPPPSSH-------GISIGPGASFASPHGTLD 1092
Cdd:pfam13254  163 SPKPKAQPSQPAQPAWMKELNKIRQSRASvdlGRPNSFKEVTPVGLMRSPAPGGHskspsvsGISADSSPTKEEPSEEAD 242

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
7ENA_n        1093 PSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANP-SLHSPVPDASHSPRAGTSSQTMPTNMPPPR 1162
Cdd:pfam13254  243 TLSTDKEQSPAPTSASEPPPKTKELPKDSEEPAAPSKSAEaSTEKKEPDTESSPETSSEKSAPSLLSPVSK 313
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 1049-1174 1.22e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 43.01  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1049 AASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLdPSSPYTMVSPSGRAGNWPgSPQVSGPSPAARMPGMS 1128
Cdd:PTZ00436  225 AAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKA-AAPPAKAAAPPAKAAAPP-AKAAAPPAKAAAAPAKA 302

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
7ENA_n       1129 PANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIP 1174
Cdd:PTZ00436  303 AAAPAKAAAAPAKAAAPPAKAAAPPAKAATPPAKAAAPPAKAAAAP 348
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1049-1266 1.71e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.78  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1049 AASSPSGALRAPSPASFVPTPPPSSHgisIGPGASFASPHGTLDPSSPYTMVSPSgragnwPGSPQVSGPSPAARMPGMS 1128
Cdd:PRK14951  373 AAPAEKKTPARPEAAAPAAAPVAQAA---AAPAPAAAPAAAASAPAAPPAAAPPA------PVAAPAAAAPAAAPAAAPA 443

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1129 PANPSLHSPVPDASH--SPRAGTSSQTMPTNMPPPRKLPQRSwAASIPTILT---HSALNILLLPSPTPGLVPGLAgsyl 1203
Cdd:PRK14951  444 AVALAPAPPAQAAPEtvAIPVRVAPEPAVASAAPAPAAAPAA-ARLTPTEEGdvwHATVQQLAAAEAITALARELA---- 518

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
7ENA_n       1204 csplerfLGSVIMRR---HLQRIIQQETLQLINSNEpgvimfktdalKCRVALSPKTNQTLQLKVT 1266
Cdd:PRK14951  519 -------LQSELVARdgdQWLLRVERESLNQPGARE-----------RLRAALEAALGHAVRLEVE 566
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 1030-1203 3.98e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 41.77  E-value: 3.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1030 STVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMvspsgragnW 1109
Cdd:PRK07994  362 AAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQR---------A 432

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1110 PGSPQVSGPSPAARmPGMSPANPSLHsPVPDASHSPRAgtsSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPS 1189
Cdd:PRK07994  433 QGATKAKKSEPAAA-SRARPVNSALE-RLASVRPAPSA---LEKAPAKKEAYRWKATNPVEVKKEPVATPKALKKALEHE 507

                         170
                  ....*....|....
7ENA_n       1190 PTPGLVPGLAGSYL 1203
Cdd:PRK07994  508 KTPELAAKLAAEAI 521
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1007-1192 5.27e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 5.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1007 QPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSP--GNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGAS- 1083
Cdd:PHA03247 2738 APAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPaaGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAa 2817

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1084 ---FASPHGTLDPSSPYTMVSPSGRAGNWP------GSPQVSGP---SPAARMPGMSPANPslhsPVPDASHSPRAGTSS 1151
Cdd:PHA03247 2818 lppAASPAGPLPPPTSAQPTAPPPPPGPPPpslplgGSVAPGGDvrrRPPSRSPAAKPAAP----ARPPVRRLARPAVSR 2893

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
7ENA_n       1152 QTMPTNMPPPRKLPQRSWAASIPTiLTHSALNILLLPSPTP 1192
Cdd:PHA03247 2894 STESFALPPDQPERPPQPQAPPPP-QPQPQPPPPPQPQPPP 2933
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1014-1209 5.50e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.31  E-value: 5.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1014 GTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALR-APSPASFVPTPPPSSHGISIGPGASFASPHGTLD 1092
Cdd:PHA03307  202 ASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGcGWGPENECPLPRPAPITLPTRIWEASGWNGPSSR 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1093 PSSPYTMVSPSGRAGNW-PGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAA 1171
Cdd:PHA03307  282 PGPASSSSSPRERSPSPsPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPAD 361

                         170       180       190
                  ....*....|....*....|....*....|....*...
7ENA_n       1172 SIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLER 1209
Cdd:PHA03307  362 PSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRAR 399
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 1036-1145 5.60e-03

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 41.15  E-value: 5.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n        1036 PSMMHTQSP---GNLHAASSPSGALRAPSPAsfVPTP-PPSSHGISIGPGASFASPHgtLDPSSpytmvspsgragnwpg 1111
Cdd:pfam09606  370 PGMMSSPSPvpgQQVRQVTPNQFMRQSPQPS--VPSPqGPGSQPPQSHPGGMIPSPA--LIPSP---------------- 429

                           90       100       110
                   ....*....|....*....|....*....|....
7ENA_n        1112 SPQVSGPSPAARMPGMSPANPSLHSPVPDASHSP 1145
Cdd:pfam09606  430 SPQMSQQPAQQRTIGQDSPGGSLNTPGQSAVNSP 463
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1020-1173 8.44e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 8.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1020 PLTSPPTSYHSTVNQSPSMMhTQSPGNLHAASSPSGAL--RAPS-------------PASFVPTPPPSShgisigPGASF 1084
Cdd:PHA03247 2826 GPLPPPTSAQPTAPPPPPGP-PPPSLPLGGSVAPGGDVrrRPPSrspaakpaaparpPVRRLARPAVSR------STESF 2898

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1085 ASPHgtlDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPA-------------------NPSLHSPVPDASHSP 1145
Cdd:PHA03247 2899 ALPP---DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPplapttdpagagepsgavpQPWLGALVPGRVAVP 2975

                         170       180       190
                  ....*....|....*....|....*....|....*.
7ENA_n       1146 RAGTSSQTMPTNMPPPRKLPQR--------SWAASI 1173
Cdd:PHA03247 2976 RFRVPQPAPSREAPASSTPPLTghslsrvsSWASSL 3011
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1022-1151 8.46e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.60  E-value: 8.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7ENA_n       1022 TSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASfvpTPPPSShgisiGPgASFASPHGTLDPSSPYTMVS 1101
Cdd:PRK07003  430 PAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPA---DSGSAS-----AP-ASDAPPDAAFEPAPRAAAPS 500

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
7ENA_n       1102 PSGRAGNWPGSPQVSGPSPAARMPGMSPAnPSLHSPVPDASHSP-RAGTSS 1151
Cdd:PRK07003  501 AATPAAVPDARAPAAASREDAPAAAAPPA-PEARPPTPAAAAPAaRAGGAA 550
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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