![](files/infoQ.gif)
Chain e, 26S proteasome complex subunit DSS1
26S proteasome complex subunit SEM1( domain architecture ID 10524293)
26S proteasome complex subunit SEM1 is a component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins
List of domain hits
![](files/help.png)
Name | Accession | Description | Interval | E-value | ||
DSS1_SEM1 | pfam05160 | DSS1/SEM1 family; This family contains the breast cancer tumour suppressor BRCA2-interacting ... |
23-62 | 3.92e-09 | ||
DSS1/SEM1 family; This family contains the breast cancer tumour suppressor BRCA2-interacting protein DSS1 and its homolog SEM1, both of which are short acidic proteins. DSS1 has been shown to be a conserved component of the Rae1 mediated mRNA export pathway in Schizosaccharomyces pombe. : Pssm-ID: 461563 Cd Length: 59 Bit Score: 47.18 E-value: 3.92e-09
|
||||||
Name | Accession | Description | Interval | E-value | ||
DSS1_SEM1 | pfam05160 | DSS1/SEM1 family; This family contains the breast cancer tumour suppressor BRCA2-interacting ... |
23-62 | 3.92e-09 | ||
DSS1/SEM1 family; This family contains the breast cancer tumour suppressor BRCA2-interacting protein DSS1 and its homolog SEM1, both of which are short acidic proteins. DSS1 has been shown to be a conserved component of the Rae1 mediated mRNA export pathway in Schizosaccharomyces pombe. Pssm-ID: 461563 Cd Length: 59 Bit Score: 47.18 E-value: 3.92e-09
|
||||||
DSS1_Sem1 | cd13768 | proteasome complex subunit DSS1/Sem1; The evolutionarily conserved deleted in split hand/split ... |
23-63 | 6.05e-08 | ||
proteasome complex subunit DSS1/Sem1; The evolutionarily conserved deleted in split hand/split foot protein 1 (DSS1)/Sem1 is a subunit of the regulatory particle (RP) of the proteasome. It is implicated in ubiquitin-mediated proteolysis, is required for the maintenance of genomic stability, and functions in DNA damage response. DSS1/Sem1 also displays RP-independent functions; it serves as a functional component of the nuclear pore associated TREX-2 transcription-export complex and is required for proper nuclear export of mRNA. In mammalian cells, DSS1 binds and stabilizes the tumor suppressor BRCA2, and contributes to its function in mediating homologous recombinational repair. In yeast, Sem1 also complexes with the COP9 signalosome, which is involved in de-neddylation. DSS1/Sem1 may be a versatile protein which contributes to the functional integrity of multiple protein complexes involved in various biological processes. Pssm-ID: 259841 Cd Length: 61 Bit Score: 44.30 E-value: 6.05e-08
|
||||||
Name | Accession | Description | Interval | E-value | ||
DSS1_SEM1 | pfam05160 | DSS1/SEM1 family; This family contains the breast cancer tumour suppressor BRCA2-interacting ... |
23-62 | 3.92e-09 | ||
DSS1/SEM1 family; This family contains the breast cancer tumour suppressor BRCA2-interacting protein DSS1 and its homolog SEM1, both of which are short acidic proteins. DSS1 has been shown to be a conserved component of the Rae1 mediated mRNA export pathway in Schizosaccharomyces pombe. Pssm-ID: 461563 Cd Length: 59 Bit Score: 47.18 E-value: 3.92e-09
|
||||||
DSS1_Sem1 | cd13768 | proteasome complex subunit DSS1/Sem1; The evolutionarily conserved deleted in split hand/split ... |
23-63 | 6.05e-08 | ||
proteasome complex subunit DSS1/Sem1; The evolutionarily conserved deleted in split hand/split foot protein 1 (DSS1)/Sem1 is a subunit of the regulatory particle (RP) of the proteasome. It is implicated in ubiquitin-mediated proteolysis, is required for the maintenance of genomic stability, and functions in DNA damage response. DSS1/Sem1 also displays RP-independent functions; it serves as a functional component of the nuclear pore associated TREX-2 transcription-export complex and is required for proper nuclear export of mRNA. In mammalian cells, DSS1 binds and stabilizes the tumor suppressor BRCA2, and contributes to its function in mediating homologous recombinational repair. In yeast, Sem1 also complexes with the COP9 signalosome, which is involved in de-neddylation. DSS1/Sem1 may be a versatile protein which contributes to the functional integrity of multiple protein complexes involved in various biological processes. Pssm-ID: 259841 Cd Length: 61 Bit Score: 44.30 E-value: 6.05e-08
|
||||||
Blast search parameters | ||||
|