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Conserved domains on  [gi|691757|gb|AAA62618|]
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3-isopropylmalate dehydrogenase [Cloning vector YIp351]

Protein Classification

isocitrate/isopropylmalate dehydrogenase family protein( domain architecture ID 296)

isocitrate/isopropylmalate dehydrogenase family protein such as isocitrate dehydrogenase that in the Krebs cycle catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO2, and isopropylmalate dehydrogenase that in leucine biosynthesis catalyzes the oxidation and decarboxylation of 3-isopropyl-l-malate to 4-methyl-2-oxovalerate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Iso_dh super family cl00445
Isocitrate/isopropylmalate dehydrogenase;
6-359 0e+00

Isocitrate/isopropylmalate dehydrogenase;


The actual alignment was detected with superfamily member TIGR00169:

Pssm-ID: 444908  Cd Length: 346  Bit Score: 557.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757       6 KIVVLPGDHVGQEITAEAIKVLKAISDvRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGTG 85
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAE-RFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757      86 --SVRPEQGLLKIRKELQLYANLRPCNFAsDSLLDLSPIKPQFAKGTDFVVVRELVGGIYFGKRKEDDGDGVAWDSEQYT 163
Cdd:TIGR00169  80 prDQRPEQGLLKLRKSLDLFANLRPAKVF-PGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGREGEGEAWDTEVYT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     164 VPEVQRITRMAAFMALQHEPplPIWTLDKANVLASSRLWRKTVEETIKnEFPTLKVQHQLIDSAAMILVKNPTHLNgIII 243
Cdd:TIGR00169 159 VPEIERIARVAFEMARKRRK--KVTSVDKANVLESSRLWRKTVEEIAK-EYPDVELEHQYIDNAAMQLVKSPTQFD-VVV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     244 TSNMFGDIISDEALRYPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPGFA-KNKVDPIATILSAAMMLKLSLNLPEEG 322
Cdd:TIGR00169 235 TSNLFGDILSDEASVITGSLGMLPSASLGS-----DGFGLFEPVHGSAPDIAgKGIANPIAQILSAAMLLRYSFNLEEAA 309

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 691757     323 KAIEDAVKKVLDAGIRTGDLgGSNSTTEVGDAVAEEV 359
Cdd:TIGR00169 310 DAIEAAVKKVLAEGYRTPDL-GSSATTAVGTAEMGEE 345
 
Name Accession Description Interval E-value
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 6-359 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 557.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757       6 KIVVLPGDHVGQEITAEAIKVLKAISDvRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGTG 85
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAE-RFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757      86 --SVRPEQGLLKIRKELQLYANLRPCNFAsDSLLDLSPIKPQFAKGTDFVVVRELVGGIYFGKRKEDDGDGVAWDSEQYT 163
Cdd:TIGR00169  80 prDQRPEQGLLKLRKSLDLFANLRPAKVF-PGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGREGEGEAWDTEVYT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     164 VPEVQRITRMAAFMALQHEPplPIWTLDKANVLASSRLWRKTVEETIKnEFPTLKVQHQLIDSAAMILVKNPTHLNgIII 243
Cdd:TIGR00169 159 VPEIERIARVAFEMARKRRK--KVTSVDKANVLESSRLWRKTVEEIAK-EYPDVELEHQYIDNAAMQLVKSPTQFD-VVV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     244 TSNMFGDIISDEALRYPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPGFA-KNKVDPIATILSAAMMLKLSLNLPEEG 322
Cdd:TIGR00169 235 TSNLFGDILSDEASVITGSLGMLPSASLGS-----DGFGLFEPVHGSAPDIAgKGIANPIAQILSAAMLLRYSFNLEEAA 309

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 691757     323 KAIEDAVKKVLDAGIRTGDLgGSNSTTEVGDAVAEEV 359
Cdd:TIGR00169 310 DAIEAAVKKVLAEGYRTPDL-GSSATTAVGTAEMGEE 345
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 5-361 7.47e-168

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 472.28  E-value: 7.47e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757      5 KKIVVLPGDHVGQEITAEAIKVLKAISDvRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGT 84
Cdd:PRK00772   3 YKIAVLPGDGIGPEVMAEAVKVLDAVAE-KFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWDN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     85 --GSVRPEQGLLKIRKELQLYANLRPCNFAsDSLLDLSPIKPQFAKGTDFVVVRELVGGIYFGK---RKEDDGDGVAWDS 159
Cdd:PRK00772  82 lpPDVRPERGLLALRKELGLFANLRPAKLY-PGLADASPLKPEIVAGLDILIVRELTGGIYFGEprgREGLGGEERAFDT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    160 EQYTVPEVQRITRMAAFMALQHEPPLpiwTL-DKANVLASSRLWRKTVEEtIKNEFPTLKVQHQLIDSAAMILVKNPTHL 238
Cdd:PRK00772 161 MVYTREEIERIARVAFELARKRRKKV---TSvDKANVLESSRLWREVVTE-VAKEYPDVELSHMYVDNAAMQLVRNPKQF 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    239 nGIIITSNMFGDIISDEALRYPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPGFA-KNKVDPIATILSAAMMLKLSLN 317
Cdd:PRK00772 237 -DVIVTENLFGDILSDEAAMLTGSLGMLPSASLGE-----SGPGLYEPIHGSAPDIAgKGIANPIATILSAAMMLRYSLG 310

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 691757    318 LPEEGKAIEDAVKKVLDAGIRTGDL---GGSNSTTEVGDAVAEEVKK 361
Cdd:PRK00772 311 LEEAADAIEAAVEKVLAQGYRTADIaegGGKVSTSEMGDAILAALAE 357
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
6-355 1.96e-160

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 453.29  E-value: 1.96e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757       6 KIVVLPGDHVGQEITAEAIKVLKAISDvRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGTG 85
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALE-KAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDPA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757      86 SVRPEQGLLKIRKELQLYANLRPCNFASdSLLDLSPIKPQfAKGTDFVVVRELVGGIYFGKRKEDDGDG--VAWDSEQYT 163
Cdd:pfam00180  80 GVRPENGLLALRKELGLFANLRPAKVFP-PLGDASPLKNE-VEGVDIVIVRELTGGIYFGIEKGIKGSGneVAVDTKLYS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     164 VPEVQRITRMAAFMALQHEPPlPIWTLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVKNPThLNGIII 243
Cdd:pfam00180 158 RDEIERIARVAFELARKRGRK-KVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPS-QFDVIV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     244 TSNMFGDIISDEALRYPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPGFA-KNKVDPIATILSAAMMLKLSLNLPEEG 322
Cdd:pfam00180 236 TPNLFGDILSDEASMLTGSLGLLPSASLGA-----NGFGIFEPVHGSAPDIAgKGIANPIATILSAAMMLRYSLGLEDAA 310

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 691757     323 KAIEDAVKKVLDAGIRTGDLGGSN---STTEVGDAV 355
Cdd:pfam00180 311 DKIEAAVLKVLESGIRTGDLAGSAtyvSTSEFGEAV 346
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 5-359 1.40e-151

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 430.59  E-value: 1.40e-151
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     5 KKIVVLPGDHVGQEITAEAIKVLKAISDvRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGT 84
Cdd:COG0473   2 YKIAVLPGDGIGPEVVAAALKVLEAAAE-RFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    85 GsVRPEQGLLKIRKELQLYANLRPCnfasdSLLD--LSPIKPQFAKGTDFVVVRELVGGIYFG---KRKEDDGDGVAWDS 159
Cdd:COG0473  81 G-VRPESGLLALRKELDLYANLRPA-----KLYPglPSPLKPEIVEGIDLVIVRENTEGLYFGiggRIGTGTGEEVAIDT 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757   160 EQYTVPEVQRITRMAAFMALQHEPPLpiwTL-DKANVLA-SSRLWRKTVEEtIKNEFPTLKVQHQLIDSAAMILVKNPTH 237
Cdd:COG0473 155 RVYTRKGIERIARYAFELARKRRKKV---TSvDKANVLKlTSGLWREVVRE-VAKEYPDVELDHMYVDAAAMQLVRNPEQ 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757   238 LNgIIITSNMFGDIISDEA--LryPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPGFA-KNKVDPIATILSAAMMLKL 314
Cdd:COG0473 231 FD-VIVTENLFGDILSDLAagL--TGSLGLAPSANIGD-----EGKALFEPVHGSAPDIAgKGIANPIATILSAAMMLRH 302

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 691757   315 sLNLPEEGKAIEDAVKKVLDAGIRTGDLGGSNSTTEVGDAVAEEV 359
Cdd:COG0473 303 -LGEEEAADAIEAAVEKVLAEGVRTPDLGGKAGTSEMGDAIIAAL 346
 
Name Accession Description Interval E-value
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 6-359 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 557.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757       6 KIVVLPGDHVGQEITAEAIKVLKAISDvRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGTG 85
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAE-RFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757      86 --SVRPEQGLLKIRKELQLYANLRPCNFAsDSLLDLSPIKPQFAKGTDFVVVRELVGGIYFGKRKEDDGDGVAWDSEQYT 163
Cdd:TIGR00169  80 prDQRPEQGLLKLRKSLDLFANLRPAKVF-PGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGREGEGEAWDTEVYT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     164 VPEVQRITRMAAFMALQHEPplPIWTLDKANVLASSRLWRKTVEETIKnEFPTLKVQHQLIDSAAMILVKNPTHLNgIII 243
Cdd:TIGR00169 159 VPEIERIARVAFEMARKRRK--KVTSVDKANVLESSRLWRKTVEEIAK-EYPDVELEHQYIDNAAMQLVKSPTQFD-VVV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     244 TSNMFGDIISDEALRYPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPGFA-KNKVDPIATILSAAMMLKLSLNLPEEG 322
Cdd:TIGR00169 235 TSNLFGDILSDEASVITGSLGMLPSASLGS-----DGFGLFEPVHGSAPDIAgKGIANPIAQILSAAMLLRYSFNLEEAA 309

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 691757     323 KAIEDAVKKVLDAGIRTGDLgGSNSTTEVGDAVAEEV 359
Cdd:TIGR00169 310 DAIEAAVKKVLAEGYRTPDL-GSSATTAVGTAEMGEE 345
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 5-361 7.47e-168

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 472.28  E-value: 7.47e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757      5 KKIVVLPGDHVGQEITAEAIKVLKAISDvRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGT 84
Cdd:PRK00772   3 YKIAVLPGDGIGPEVMAEAVKVLDAVAE-KFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWDN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     85 --GSVRPEQGLLKIRKELQLYANLRPCNFAsDSLLDLSPIKPQFAKGTDFVVVRELVGGIYFGK---RKEDDGDGVAWDS 159
Cdd:PRK00772  82 lpPDVRPERGLLALRKELGLFANLRPAKLY-PGLADASPLKPEIVAGLDILIVRELTGGIYFGEprgREGLGGEERAFDT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    160 EQYTVPEVQRITRMAAFMALQHEPPLpiwTL-DKANVLASSRLWRKTVEEtIKNEFPTLKVQHQLIDSAAMILVKNPTHL 238
Cdd:PRK00772 161 MVYTREEIERIARVAFELARKRRKKV---TSvDKANVLESSRLWREVVTE-VAKEYPDVELSHMYVDNAAMQLVRNPKQF 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    239 nGIIITSNMFGDIISDEALRYPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPGFA-KNKVDPIATILSAAMMLKLSLN 317
Cdd:PRK00772 237 -DVIVTENLFGDILSDEAAMLTGSLGMLPSASLGE-----SGPGLYEPIHGSAPDIAgKGIANPIATILSAAMMLRYSLG 310

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 691757    318 LPEEGKAIEDAVKKVLDAGIRTGDL---GGSNSTTEVGDAVAEEVKK 361
Cdd:PRK00772 311 LEEAADAIEAAVEKVLAQGYRTADIaegGGKVSTSEMGDAILAALAE 357
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
6-355 1.96e-160

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 453.29  E-value: 1.96e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757       6 KIVVLPGDHVGQEITAEAIKVLKAISDvRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGTG 85
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALE-KAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDPA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757      86 SVRPEQGLLKIRKELQLYANLRPCNFASdSLLDLSPIKPQfAKGTDFVVVRELVGGIYFGKRKEDDGDG--VAWDSEQYT 163
Cdd:pfam00180  80 GVRPENGLLALRKELGLFANLRPAKVFP-PLGDASPLKNE-VEGVDIVIVRELTGGIYFGIEKGIKGSGneVAVDTKLYS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     164 VPEVQRITRMAAFMALQHEPPlPIWTLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVKNPThLNGIII 243
Cdd:pfam00180 158 RDEIERIARVAFELARKRGRK-KVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPS-QFDVIV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     244 TSNMFGDIISDEALRYPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPGFA-KNKVDPIATILSAAMMLKLSLNLPEEG 322
Cdd:pfam00180 236 TPNLFGDILSDEASMLTGSLGLLPSASLGA-----NGFGIFEPVHGSAPDIAgKGIANPIATILSAAMMLRYSLGLEDAA 310

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 691757     323 KAIEDAVKKVLDAGIRTGDLGGSN---STTEVGDAV 355
Cdd:pfam00180 311 DKIEAAVLKVLESGIRTGDLAGSAtyvSTSEFGEAV 346
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 5-359 1.40e-151

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 430.59  E-value: 1.40e-151
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     5 KKIVVLPGDHVGQEITAEAIKVLKAISDvRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGT 84
Cdd:COG0473   2 YKIAVLPGDGIGPEVVAAALKVLEAAAE-RFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    85 GsVRPEQGLLKIRKELQLYANLRPCnfasdSLLD--LSPIKPQFAKGTDFVVVRELVGGIYFG---KRKEDDGDGVAWDS 159
Cdd:COG0473  81 G-VRPESGLLALRKELDLYANLRPA-----KLYPglPSPLKPEIVEGIDLVIVRENTEGLYFGiggRIGTGTGEEVAIDT 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757   160 EQYTVPEVQRITRMAAFMALQHEPPLpiwTL-DKANVLA-SSRLWRKTVEEtIKNEFPTLKVQHQLIDSAAMILVKNPTH 237
Cdd:COG0473 155 RVYTRKGIERIARYAFELARKRRKKV---TSvDKANVLKlTSGLWREVVRE-VAKEYPDVELDHMYVDAAAMQLVRNPEQ 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757   238 LNgIIITSNMFGDIISDEA--LryPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPGFA-KNKVDPIATILSAAMMLKL 314
Cdd:COG0473 231 FD-VIVTENLFGDILSDLAagL--TGSLGLAPSANIGD-----EGKALFEPVHGSAPDIAgKGIANPIATILSAAMMLRH 302

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 691757   315 sLNLPEEGKAIEDAVKKVLDAGIRTGDLGGSNSTTEVGDAVAEEV 359
Cdd:COG0473 303 -LGEEEAADAIEAAVEKVLAEGVRTPDLGGKAGTSEMGDAIIAAL 346
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 7-342 1.74e-84

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 261.93  E-value: 1.74e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757      7 IVVLPGDHVGQEITAEAIKVLKAISDVRSnVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGTGS 86
Cdd:PLN02329  49 IALLPGDGIGPEVISVAKNVLQKAGSLEG-LEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDKNE 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     87 --VRPEQGLLKIRKELQLYANLRPCNFASdSLLDLSPIKPQFAKGTDFVVVRELVGGIYFGKRK----EDDGDGVAWDSE 160
Cdd:PLN02329 128 khLRPEMALFYLRRDLKVFANLRPATVLP-QLVDASTLKKEVAEGVDMMIVRELTGGIYFGEPRgitiNENGEEVGVSTE 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    161 QYTVPEVQRITRMAAFMALQHEPPLpiWTLDKANVLASSRLWRKTVeETIKNEFPTLKVQHQLIDSAAMILVKNPTHLNg 240
Cdd:PLN02329 207 IYAAHEIDRIARVAFETARKRRGKL--CSVDKANVLDASILWRKRV-TALASEYPDVELSHMYVDNAAMQLIRDPKQFD- 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    241 IIITSNMFGDIISDEALRYPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPGFA-KNKVDPIATILSAAMMLKLSLNLP 319
Cdd:PLN02329 283 TIVTNNIFGDILSDEASMITGSIGMLPSASLGE-----SGPGLFEPIHGSAPDIAgQDKANPLATILSAAMLLKYGLGEE 357

                        330       340
                 ....*....|....*....|...
gi 691757    320 EEGKAIEDAVKKVLDAGIRTGDL 342
Cdd:PLN02329 358 KAAKRIEDAVVDALNKGFRTGDI 380
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 5-359 7.81e-71

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 224.24  E-value: 7.81e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757      5 KKIVVLPGDHVGQEITAEAIKVLKAIsdvrsNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGgpkwgt 84
Cdd:PRK14025   2 HKICVIEGDGIGKEVVPAALHVLEAT-----GLPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAG------ 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     85 gsVRPEQGLLKIRKELQLYANLRPCNfasdSLLDLSPIKPqfakGTDFVVVRELVGGIYFGKrKEDDGDGVAWDSEQYTV 164
Cdd:PRK14025  71 --ETAADVIVKLRRILDTYANVRPVK----SYKGVKCLYP----DIDYVIVRENTEGLYKGI-EAEIADGVTVATRVITR 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    165 PEVQRITRMAAFMAlQHEPPLPIWT----LDKANVLA-SSRLWRKTVEEtIKNEFPTLKVQHQLIDSAAMILVKNPTHLN 239
Cdd:PRK14025 140 KASERIFRFAFEMA-KRRKKMGKEGkvtcAHKANVLKkTDGLFKKTFYE-VAKEYPDIKAEDYYVDAMNMYIITRPQTFD 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    240 gIIITSNMFGDIISDEALRYPGSLGLLPSASLAslpDKNtafGLYEPCHGSAPGFA-KNKVDPIATILSAAMMLKlSLNL 318
Cdd:PRK14025 218 -VVVTSNLFGDILSDGAAGLVGGLGLAPSANIG---DKY---GLFEPVHGSAPDIAgKGIANPTATILTAVLMLR-HLGE 289

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 691757    319 PEEGKAIEDAVKKVLDAGIRTGDLGGSNSTTEVGDAVAEEV 359
Cdd:PRK14025 290 NEEADKVEKALEEVLALGLTTPDLGGNLSTMEMAEEVAKRV 330
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 6-359 8.39e-67

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 214.41  E-value: 8.39e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757      6 KIVVLPGDHVGQEITAEAIKVLKAISDVRsnVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPkwgtg 85
Cdd:PRK03437   6 KLAVIPGDGIGPEVVAEALKVLDAVAAGG--PGVETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIGDP----- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     86 SVRP---EQG-LLKIRKELQLYANLRPCNFASDSLldlSPIKPQfaKGTDFVVVRELVGGIYFGKR---KEDDGDGVAWD 158
Cdd:PRK03437  79 SVPSgvlERGlLLKLRFALDHYVNLRPSKLYPGVT---SPLAGP--GDIDFVVVREGTEGPYTGNGgalRVGTPHEVATE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    159 SEQYTVPEVQRITRMAaFMALQHEPPLPIWTLDKANVLA-SSRLWRKTVEEtIKNEFPTLKVQHQLIDSAAMILVKNPTH 237
Cdd:PRK03437 154 VSVNTAFGVERVVRDA-FERAQKRPRKHLTLVHKTNVLTfAGDLWQRTVDE-VAAEYPDVTVDYQHVDAATIFMVTDPSR 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    238 LNgIIITSNMFGDIISDEALRYPGSLGLLPSASLAslPDkNTAFGLYEPCHGSAPGFA-KNKVDPIATILSAAMMLKlSL 316
Cdd:PRK03437 232 FD-VIVTDNLFGDIITDLAAAVTGGIGLAASGNIN--PT-GTNPSMFEPVHGSAPDIAgQGIADPTAAILSVALLLD-HL 306

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 691757    317 NLPEEGKAIEDAVKKVLdagirTGDLGGSNSTTEVGDAVAEEV 359
Cdd:PRK03437 307 GEEDAAARIEAAVEADL-----AERGKMGRSTAEVGDRIAARL 344
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 6-362 3.18e-56

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 187.24  E-value: 3.18e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757      6 KIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPK---- 81
Cdd:PRK08194   5 KIAVIPGDGVGKEVVPAAVRVLKAVAEVHGGLKFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPKlvpd 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     82 ----WGTgsvrpeqgLLKIRKELQLYANLRPCNFasdslldLSPIKPQFA--KGTDFVVVRELVGGIY--FGKRKEDDGD 153
Cdd:PRK08194  85 hislWGL--------LIKIRREFEQVINIRPAKQ-------LRGIKSPLAnpKDFDLLVVRENSEGEYseVGGRIHRGED 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    154 GVAWDSEQYTVPEVQRITRMAAFMALQHEPPLPIWTldKAN-VLASSRLWRKTVEETIKnEFPTLKVQHQLIDSAAMILV 232
Cdd:PRK08194 150 EIAIQNAVFTRKGTERAMRYAFELAAKRRKHVTSAT--KSNgIVHSMPFWDEVFQEVGK-DYPEIETDSQHIDALAAFFV 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    233 KNPTHLNgIIITSNMFGDIISDEALRYPGSLGLLPSASLaslpDKNTAF-GLYEPCHGSAPGFA-KNKVDPIATILSAAM 310
Cdd:PRK08194 227 TRPEEFD-VIVASNLFGDILTDIGAAIMGSIGIAPAANI----NVNGKYpSMFEPVHGSAPDIAgKGIANPIGQIWTAKL 301

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 691757    311 MLKlSLNLPEEGKAIEDAVKKVLDAGIRTGDLGGSNSTTEVGDAVAEEVKKI 362
Cdd:PRK08194 302 MLD-HFGEEELGSHLLDVIEDVTEDGIKTPDIGGRATTDEVTDEIISRLKKL 352
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 4-359 9.72e-37

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 136.55  E-value: 9.72e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757      4 PKKIVVLPGDHVGQEITAEAIKVLKAisdvrSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPkWG 83
Cdd:PLN00118  41 PITATLFPGDGIGPEIAESVKQVFTA-----AGVPIEWEEHYVGTTVDPRTGSFLTWESLESVRRNKVGLKGPMATP-IG 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     84 TGsvrpEQGL-LKIRKELQLYANLRPCnfasdslLDLSPIKPQFaKGTDFVVVRELVGGIYFGKRKEdDGDGVawdseqy 162
Cdd:PLN00118 115 KG----HRSLnLTLRKELGLYANVRPC-------YSLPGYKTRY-DDVDLVTIRENTEGEYSGLEHQ-VVRGV------- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    163 tVPEVQRITRMA-------AFMALQHEPPLPIWTLDKANVLASSR-LWRKTVEEtIKNEFPTLKVQHQLIDSAAMILVKN 234
Cdd:PLN00118 175 -VESLKIITRQAslrvaeyAFHYAKTHGRKRVSAIHKANIMKKTDgLFLKCCRE-VAEKYPEIVYEEVIIDNCCMMLVKN 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    235 PThLNGIIITSNMFGDIISDEALRYPGSLGLLPSASLAslpdkNTAFGLYEPCHGSAPGFA-KNKVDPIATILSAAMMLK 313
Cdd:PLN00118 253 PA-LFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIG-----ENGLALAEAVHGSAPDIAgKNLANPTALLLSAVMMLR 326

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 691757    314 lSLNLPEEGKAIEDAVKKVLDAG-IRTGDLGGSNSTTEVGDAVAEEV 359
Cdd:PLN00118 327 -HLKLNEQAEQIHNAILNTIAEGkYRTADLGGSSTTTDFTKAICDHL 372
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
1-357 9.81e-30

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 118.84  E-value: 9.81e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757      1 MFVPKKIVVLPGDHVGQEITAEAIKVLKAisdvrSNVKFDFENHLIGgAAIDATGVP--LPDEALEASKKVDAVLLGAVG 78
Cdd:PRK09222   1 MAEKTPITVAYGDGIGPEIMEAVLKILEA-----AGAPLEIETIEIG-EKVYKKGWTsgISPSAWESIRRTKVLLKAPIT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     79 GPKwGTGsvrpEQGL-LKIRKELQLYANLRPCnfasdslLDLSPIKPQFAKGTDFVVVRE----LVGGIYFgkRKEDDgd 153
Cdd:PRK09222  75 TPQ-GGG----YKSLnVTLRKTLGLYANVRPC-------VSYHPFVETKHPNLDVVIIREneedLYAGIEH--RQTPD-- 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    154 gVAWDSEQYTVPEVQRITRMAAFMALQHEPPlPIWTLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVK 233
Cdd:PRK09222 139 -VYQCLKLISRPGSEKIIRYAFEYARANGRK-KVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLAT 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    234 NPTHLNgIIITSNMFGDIISDEALRYPGSLGLLPSASLASlpdkntAFGLYEPCHGSAPGFA-KNKVDPIATILSAAMML 312
Cdd:PRK09222 217 NPENFD-VIVTPNLYGDILSDIAAEISGSVGLAGSANIGE------EYAMFEAVHGSAPDIAgKNIANPSGLLNAAVMML 289

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 691757    313 kLSLNLPEEGKAIEDAVKKVLDAGIRTGDLGGSN------STTEVGDAVAE 357
Cdd:PRK09222 290 -VHIGQFDIAELIENAWLKTLEDGIHTADIYNEGvskkkvGTKEFAEAVIE 339
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 4-355 1.09e-24

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 103.41  E-value: 1.09e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757      4 PKKIVVLPGDHVGQEITAEAIKVLKAIsdvrsNVKFDFENHLIGGAAIDatgvpLPDEALEASKKVDAVLLGAVGGP-KW 82
Cdd:PLN00123  30 PRAVTLIPGDGIGPLVTGAVEQVMEAM-----HAPVYFERYEVHGDMKK-----VPEEVLESIRRNKVCLKGGLATPvGG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     83 GTGSVRpeqglLKIRKELQLYANLRPC-NFasdslldlsPIKPQFAKGTDFVVVRELVGGIYFGKRKEDDgDGVAWDSEQ 161
Cdd:PLN00123 100 GVSSLN-----VQLRKELDLFASLVNCfNL---------PGLPTRHENVDIVVIRENTEGEYSGLEHEVV-PGVVESLKV 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    162 YTVPEVQRITRMA-AFMALQHEPPlpIWTLDKANVLA-SSRLWRKTVEETIKNeFPTLKVQHQLIDSAAMILVKNPTHLN 239
Cdd:PLN00123 165 ITKFCSERIAKYAfEYAYLNNRKK--VTAVHKANIMKlADGLFLESCREVAKK-YPGIKYNEIIVDNCCMQLVSKPEQFD 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    240 gIIITSNMFGDIISDEALRYPGSLGLLPSASLAslpDKNTAF--GLYEPCHGSAPGFAKNKVDPIATILSAAMMLKlSLN 317
Cdd:PLN00123 242 -VMVTPNLYGNLVANTAAGIAGGTGVMPGGNVG---ADHAVFeqGASAGNVGNEKLVEQKKANPVALLLSSAMMLR-HLQ 316

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 691757    318 LPEEGKAIEDAVKKVLDAG-IRTGDLGGSNSTTEVGDAV 355
Cdd:PLN00123 317 FPSFADRLETAVKRVIAEGkYRTKDLGGSSTTQEVVDAV 355
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
3-362 2.96e-21

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 94.13  E-value: 2.96e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757      3 VPKKIVVL--PGDHVGQEITAEAIKVL-KAISDV-RSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVG 78
Cdd:PRK06451  20 VPKKPIILyvEGDGIGPEITHAAMKVInKAVEKAyGSDREIKWVEVLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLE 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     79 GP---KWGTGSVRpeqgllkIRKELQLYANLRPCNFASDslLDlSPIKPqfAKGTDFVVVRELVGGIYFG---------- 145
Cdd:PRK06451 100 TPigkGWKSINVA-------IRLMLDLYANIRPVKYIPG--IE-SPLKN--PEKIDLIIFRENTDDLYRGieypydseea 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    146 KR-------------KEDDGDGVAWDSEQYTvpevQRITRMAAFMALQHEPPlPIWTLDKANVLASSR-LWRKTVEETIK 211
Cdd:PRK06451 168 KKirdflrkelgvevEDDTGIGIKLISKFKT----QRIARMAIKYAIDHKRK-KVTIMHKGNVMKYTEgAFREWAYEVAL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    212 NEF------------------PTLKV--QHQLIDSAAMILVKNPTHLNgIIITSNMFGDIISDEALRYPGSLGLLPSASL 271
Cdd:PRK06451 243 KEFrdyvvteeevtknyngvpPSGKViiNDRIADNMFQQIIIRPDEYD-IILAPNVNGDYISDAAGALVGNIGMLGGANI 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    272 AslpdkNTAfGLYEPCHGSAPGFA-KNKVDPIATILSAAMMLKLsLNLPEEGKAIEDAVKKVLDAGIRTGDLG-----GS 345
Cdd:PRK06451 322 G-----DTG-GMFEAIHGTAPKYAgKNVANPTGIIKGGELMLRF-MGWDKAADLIDKAIMESIKQKKVTQDLArfmgvRA 394

                        410
                 ....*....|....*..
gi 691757    346 NSTTEVGDAVAEEVKKI 362
Cdd:PRK06451 395 LSTTEYTDELISIIDML 411
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 12-341 1.89e-14

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 73.94  E-value: 1.89e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     12 GDHVGQEITAEAIKVLKAISD--VRSNVKFDFENHLIGGAAIDATG--VPLPDEALEASKK----VDAVLLGAVGGpkwG 83
Cdd:PRK07006  27 GDGIGPDITPAMLKVVDAAVEkaYKGERKISWMEIYAGEKATKVYGedVWLPEETLDLIREyrvaIKGPLTTPVGG---G 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757     84 TGSVRpeqglLKIRKELQLYANLRPCNFASDSLldlSPIK-PQFakgTDFVVVRELVGGIYfgkrkeddgDGVAWDSEQy 162
Cdd:PRK07006 104 IRSLN-----VALRQELDLYVCLRPVRYFKGVP---SPVKrPED---TDMVIFRENSEDIY---------AGIEWKAGS- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    163 tvPEVQRITRMaafmaLQHE--------PP---LPIWTLDKAnvlASSRLWRKTVEETIKNEFPTLKVQH---------- 221
Cdd:PRK07006 163 --AEAKKVIKF-----LQEEmgvkkirfPEtsgIGIKPVSEE---GTERLVRAAIEYAIDNDRKSVTLVHkgnimkfteg 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    222 ----------------QLIDSAAMILVKNPTHLNGIII-----------------------TSNMFGDIISDEALRYPGS 262
Cdd:PRK07006 233 afkdwgyqlaeeefgdELIDGGPWDKIKNPETGKEIIVkdsiadaflqqillrpaeydviaTMNLNGDYISDALAAQVGG 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    263 LGLLPSASLaslpdkNTAFGLYEPCHGSAPGFA-KNKVDPIATILSAAMMLKlSLNLPEEGKAIEDAVKKVLDAGIRTGD 341
Cdd:PRK07006 313 IGIAPGANI------NDGHAIFEATHGTAPKYAgLDKVNPGSVILSAEMMLR-HMGWTEAADLIIKSMEKTIASKTVTYD 385
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
241-312 3.41e-06

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 48.56  E-value: 3.41e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 691757    241 IIITSNMFGDIISDEALRYPGSLGLLPSASLAslpDKNTAFglyEPCHGSAPGFAK-NKVDPIATILSAAMML 312
Cdd:PRK07362 355 ILATLNLNGDYISDAAAAIVGGLGMAPGANIG---DNAAIF---EATHGTAPKHAGlDRINPGSVILSGVMML 421
PTZ00435 PTZ00435
isocitrate dehydrogenase; Provisional
 207-364 4.13e-03

isocitrate dehydrogenase; Provisional


Pssm-ID: 240417  Cd Length: 413  Bit Score: 38.82  E-value: 4.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    207 EETIKNEFPTLKV--QHQLIDSAAMILVKNpthlNGIII--TSNMFGDIISDEALRYPGSLGLLPSASLAslPDKNTAfg 282
Cdd:PTZ00435 233 DEEYKAKFEKAGLwyEHRLIDDMVAQAIKS----EGGFVwaCKNYDGDVQSDIVAQGYGSLGLMTSVLVC--PDGKTV-- 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 691757    283 LYEPCHGSAP--------GfAKNKVDPIATILSAAMML----KLSLN--LPEEGKAIEDAVKKVLDAGIRTGDL-----G 343
Cdd:PTZ00435 305 EAEAAHGTVTrhyrqhqkG-KETSTNSIASIFAWTRGLahraKLDNNqeLVKFCQALERSCIETIEAGFMTKDLaicvhG 383

                        170       180
                 ....*....|....*....|....*...
gi 691757    344 GSN-------STTEVGDAVAEEVKKILA 364
Cdd:PTZ00435 384 SSKvtrsdylNTEEFIDKVAEKLKKKLG 411
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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