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Conserved domains on  [gi|682656|gb|AAA74942|]
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3-isopropylmalate dehydrogenase [Cloning vector pYEULCBX]

Protein Classification

isocitrate/isopropylmalate dehydrogenase family protein( domain architecture ID 296)

isocitrate/isopropylmalate dehydrogenase family protein such as isocitrate dehydrogenase that in the Krebs cycle catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO2, and isopropylmalate dehydrogenase that in leucine biosynthesis catalyzes the oxidation and decarboxylation of 3-isopropyl-l-malate to 4-methyl-2-oxovalerate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Iso_dh super family cl00445
Isocitrate/isopropylmalate dehydrogenase;
6-359 0e+00

Isocitrate/isopropylmalate dehydrogenase;


The actual alignment was detected with superfamily member TIGR00169:

Pssm-ID: 444908  Cd Length: 346  Bit Score: 568.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656       6 KIVVLPGDHVGQEITAEAIKVLKAISDvRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGTG 85
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAE-RFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656      86 --SVRPEQGLLKIRKELQLYANLRPCNFAsDSLLDLSPIKPQFAKGTDFVVVRELVGGIYFGKRKEDDGDGVAWDSEQYT 163
Cdd:TIGR00169  80 prDQRPEQGLLKLRKSLDLFANLRPAKVF-PGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGREGEGEAWDTEVYT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     164 VPEVQRITRMAAFMALQHEPplPIWSLDKANVLASSRLWRKTVEETIKnEFPTLKVQHQLIDSAAMILVKNPTHLNgIII 243
Cdd:TIGR00169 159 VPEIERIARVAFEMARKRRK--KVTSVDKANVLESSRLWRKTVEEIAK-EYPDVELEHQYIDNAAMQLVKSPTQFD-VVV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     244 TSNMFGDIISDEASVIPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPDLP-KNKVDPIATILSAAMMLKLSLNLPEEG 322
Cdd:TIGR00169 235 TSNLFGDILSDEASVITGSLGMLPSASLGS-----DGFGLFEPVHGSAPDIAgKGIANPIAQILSAAMLLRYSFNLEEAA 309

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 682656     323 KAIEDAVKKVLDAGIRTGDLgGSNSTTEVGDAVAEEV 359
Cdd:TIGR00169 310 DAIEAAVKKVLAEGYRTPDL-GSSATTAVGTAEMGEE 345
 
Name Accession Description Interval E-value
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 6-359 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 568.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656       6 KIVVLPGDHVGQEITAEAIKVLKAISDvRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGTG 85
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAE-RFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656      86 --SVRPEQGLLKIRKELQLYANLRPCNFAsDSLLDLSPIKPQFAKGTDFVVVRELVGGIYFGKRKEDDGDGVAWDSEQYT 163
Cdd:TIGR00169  80 prDQRPEQGLLKLRKSLDLFANLRPAKVF-PGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGREGEGEAWDTEVYT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     164 VPEVQRITRMAAFMALQHEPplPIWSLDKANVLASSRLWRKTVEETIKnEFPTLKVQHQLIDSAAMILVKNPTHLNgIII 243
Cdd:TIGR00169 159 VPEIERIARVAFEMARKRRK--KVTSVDKANVLESSRLWRKTVEEIAK-EYPDVELEHQYIDNAAMQLVKSPTQFD-VVV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     244 TSNMFGDIISDEASVIPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPDLP-KNKVDPIATILSAAMMLKLSLNLPEEG 322
Cdd:TIGR00169 235 TSNLFGDILSDEASVITGSLGMLPSASLGS-----DGFGLFEPVHGSAPDIAgKGIANPIAQILSAAMLLRYSFNLEEAA 309

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 682656     323 KAIEDAVKKVLDAGIRTGDLgGSNSTTEVGDAVAEEV 359
Cdd:TIGR00169 310 DAIEAAVKKVLAEGYRTPDL-GSSATTAVGTAEMGEE 345
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 5-361 1.02e-173

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 487.30  E-value: 1.02e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656      5 KKIVVLPGDHVGQEITAEAIKVLKAISDvRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGT 84
Cdd:PRK00772   3 YKIAVLPGDGIGPEVMAEAVKVLDAVAE-KFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWDN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     85 --GSVRPEQGLLKIRKELQLYANLRPCNFAsDSLLDLSPIKPQFAKGTDFVVVRELVGGIYFGK---RKEDDGDGVAWDS 159
Cdd:PRK00772  82 lpPDVRPERGLLALRKELGLFANLRPAKLY-PGLADASPLKPEIVAGLDILIVRELTGGIYFGEprgREGLGGEERAFDT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    160 EQYTVPEVQRITRMAAFMALQHEPPLPiwSLDKANVLASSRLWRKTVEEtIKNEFPTLKVQHQLIDSAAMILVKNPTHLn 239
Cdd:PRK00772 161 MVYTREEIERIARVAFELARKRRKKVT--SVDKANVLESSRLWREVVTE-VAKEYPDVELSHMYVDNAAMQLVRNPKQF- 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    240 GIIITSNMFGDIISDEASVIPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPDLP-KNKVDPIATILSAAMMLKLSLNL 318
Cdd:PRK00772 237 DVIVTENLFGDILSDEAAMLTGSLGMLPSASLGE-----SGPGLYEPIHGSAPDIAgKGIANPIATILSAAMMLRYSLGL 311

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 682656    319 PEEGKAIEDAVKKVLDAGIRTGDL---GGSNSTTEVGDAVAEEVKK 361
Cdd:PRK00772 312 EEAADAIEAAVEKVLAQGYRTADIaegGGKVSTSEMGDAILAALAE 357
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
6-355 7.57e-165

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 464.46  E-value: 7.57e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656       6 KIVVLPGDHVGQEITAEAIKVLKAISDvRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGTG 85
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALE-KAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDPA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656      86 SVRPEQGLLKIRKELQLYANLRPCNFASdSLLDLSPIKPQfAKGTDFVVVRELVGGIYFGKRKEDDGDG--VAWDSEQYT 163
Cdd:pfam00180  80 GVRPENGLLALRKELGLFANLRPAKVFP-PLGDASPLKNE-VEGVDIVIVRELTGGIYFGIEKGIKGSGneVAVDTKLYS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     164 VPEVQRITRMAAFMALQHEPPlPIWSLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVKNPThLNGIII 243
Cdd:pfam00180 158 RDEIERIARVAFELARKRGRK-KVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPS-QFDVIV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     244 TSNMFGDIISDEASVIPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPDLP-KNKVDPIATILSAAMMLKLSLNLPEEG 322
Cdd:pfam00180 236 TPNLFGDILSDEASMLTGSLGLLPSASLGA-----NGFGIFEPVHGSAPDIAgKGIANPIATILSAAMMLRYSLGLEDAA 310

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 682656     323 KAIEDAVKKVLDAGIRTGDLGGSN---STTEVGDAV 355
Cdd:pfam00180 311 DKIEAAVLKVLESGIRTGDLAGSAtyvSTSEFGEAV 346
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 5-359 7.37e-157

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 444.07  E-value: 7.37e-157
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     5 KKIVVLPGDHVGQEITAEAIKVLKAISDvRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGT 84
Cdd:COG0473   2 YKIAVLPGDGIGPEVVAAALKVLEAAAE-RFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    85 GsVRPEQGLLKIRKELQLYANLRPCnfasdSLLD--LSPIKPQFAKGTDFVVVRELVGGIYFG---KRKEDDGDGVAWDS 159
Cdd:COG0473  81 G-VRPESGLLALRKELDLYANLRPA-----KLYPglPSPLKPEIVEGIDLVIVRENTEGLYFGiggRIGTGTGEEVAIDT 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656   160 EQYTVPEVQRITRMAAFMALQHEPPLpiWSLDKANVLA-SSRLWRKTVEEtIKNEFPTLKVQHQLIDSAAMILVKNPTHL 238
Cdd:COG0473 155 RVYTRKGIERIARYAFELARKRRKKV--TSVDKANVLKlTSGLWREVVRE-VAKEYPDVELDHMYVDAAAMQLVRNPEQF 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656   239 NgIIITSNMFGDIISDEASVIPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPDLP-KNKVDPIATILSAAMMLKLsLN 317
Cdd:COG0473 232 D-VIVTENLFGDILSDLAAGLTGSLGLAPSANIGD-----EGKALFEPVHGSAPDIAgKGIANPIATILSAAMMLRH-LG 304

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 682656   318 LPEEGKAIEDAVKKVLDAGIRTGDLGGSNSTTEVGDAVAEEV 359
Cdd:COG0473 305 EEEAADAIEAAVEKVLAEGVRTPDLGGKAGTSEMGDAIIAAL 346
 
Name Accession Description Interval E-value
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 6-359 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 568.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656       6 KIVVLPGDHVGQEITAEAIKVLKAISDvRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGTG 85
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAE-RFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656      86 --SVRPEQGLLKIRKELQLYANLRPCNFAsDSLLDLSPIKPQFAKGTDFVVVRELVGGIYFGKRKEDDGDGVAWDSEQYT 163
Cdd:TIGR00169  80 prDQRPEQGLLKLRKSLDLFANLRPAKVF-PGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGREGEGEAWDTEVYT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     164 VPEVQRITRMAAFMALQHEPplPIWSLDKANVLASSRLWRKTVEETIKnEFPTLKVQHQLIDSAAMILVKNPTHLNgIII 243
Cdd:TIGR00169 159 VPEIERIARVAFEMARKRRK--KVTSVDKANVLESSRLWRKTVEEIAK-EYPDVELEHQYIDNAAMQLVKSPTQFD-VVV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     244 TSNMFGDIISDEASVIPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPDLP-KNKVDPIATILSAAMMLKLSLNLPEEG 322
Cdd:TIGR00169 235 TSNLFGDILSDEASVITGSLGMLPSASLGS-----DGFGLFEPVHGSAPDIAgKGIANPIAQILSAAMLLRYSFNLEEAA 309

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 682656     323 KAIEDAVKKVLDAGIRTGDLgGSNSTTEVGDAVAEEV 359
Cdd:TIGR00169 310 DAIEAAVKKVLAEGYRTPDL-GSSATTAVGTAEMGEE 345
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 5-361 1.02e-173

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 487.30  E-value: 1.02e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656      5 KKIVVLPGDHVGQEITAEAIKVLKAISDvRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGT 84
Cdd:PRK00772   3 YKIAVLPGDGIGPEVMAEAVKVLDAVAE-KFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWDN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     85 --GSVRPEQGLLKIRKELQLYANLRPCNFAsDSLLDLSPIKPQFAKGTDFVVVRELVGGIYFGK---RKEDDGDGVAWDS 159
Cdd:PRK00772  82 lpPDVRPERGLLALRKELGLFANLRPAKLY-PGLADASPLKPEIVAGLDILIVRELTGGIYFGEprgREGLGGEERAFDT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    160 EQYTVPEVQRITRMAAFMALQHEPPLPiwSLDKANVLASSRLWRKTVEEtIKNEFPTLKVQHQLIDSAAMILVKNPTHLn 239
Cdd:PRK00772 161 MVYTREEIERIARVAFELARKRRKKVT--SVDKANVLESSRLWREVVTE-VAKEYPDVELSHMYVDNAAMQLVRNPKQF- 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    240 GIIITSNMFGDIISDEASVIPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPDLP-KNKVDPIATILSAAMMLKLSLNL 318
Cdd:PRK00772 237 DVIVTENLFGDILSDEAAMLTGSLGMLPSASLGE-----SGPGLYEPIHGSAPDIAgKGIANPIATILSAAMMLRYSLGL 311

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 682656    319 PEEGKAIEDAVKKVLDAGIRTGDL---GGSNSTTEVGDAVAEEVKK 361
Cdd:PRK00772 312 EEAADAIEAAVEKVLAQGYRTADIaegGGKVSTSEMGDAILAALAE 357
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
6-355 7.57e-165

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 464.46  E-value: 7.57e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656       6 KIVVLPGDHVGQEITAEAIKVLKAISDvRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGTG 85
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALE-KAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDPA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656      86 SVRPEQGLLKIRKELQLYANLRPCNFASdSLLDLSPIKPQfAKGTDFVVVRELVGGIYFGKRKEDDGDG--VAWDSEQYT 163
Cdd:pfam00180  80 GVRPENGLLALRKELGLFANLRPAKVFP-PLGDASPLKNE-VEGVDIVIVRELTGGIYFGIEKGIKGSGneVAVDTKLYS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     164 VPEVQRITRMAAFMALQHEPPlPIWSLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVKNPThLNGIII 243
Cdd:pfam00180 158 RDEIERIARVAFELARKRGRK-KVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPS-QFDVIV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     244 TSNMFGDIISDEASVIPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPDLP-KNKVDPIATILSAAMMLKLSLNLPEEG 322
Cdd:pfam00180 236 TPNLFGDILSDEASMLTGSLGLLPSASLGA-----NGFGIFEPVHGSAPDIAgKGIANPIATILSAAMMLRYSLGLEDAA 310

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 682656     323 KAIEDAVKKVLDAGIRTGDLGGSN---STTEVGDAV 355
Cdd:pfam00180 311 DKIEAAVLKVLESGIRTGDLAGSAtyvSTSEFGEAV 346
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 5-359 7.37e-157

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 444.07  E-value: 7.37e-157
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     5 KKIVVLPGDHVGQEITAEAIKVLKAISDvRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGT 84
Cdd:COG0473   2 YKIAVLPGDGIGPEVVAAALKVLEAAAE-RFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    85 GsVRPEQGLLKIRKELQLYANLRPCnfasdSLLD--LSPIKPQFAKGTDFVVVRELVGGIYFG---KRKEDDGDGVAWDS 159
Cdd:COG0473  81 G-VRPESGLLALRKELDLYANLRPA-----KLYPglPSPLKPEIVEGIDLVIVRENTEGLYFGiggRIGTGTGEEVAIDT 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656   160 EQYTVPEVQRITRMAAFMALQHEPPLpiWSLDKANVLA-SSRLWRKTVEEtIKNEFPTLKVQHQLIDSAAMILVKNPTHL 238
Cdd:COG0473 155 RVYTRKGIERIARYAFELARKRRKKV--TSVDKANVLKlTSGLWREVVRE-VAKEYPDVELDHMYVDAAAMQLVRNPEQF 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656   239 NgIIITSNMFGDIISDEASVIPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPDLP-KNKVDPIATILSAAMMLKLsLN 317
Cdd:COG0473 232 D-VIVTENLFGDILSDLAAGLTGSLGLAPSANIGD-----EGKALFEPVHGSAPDIAgKGIANPIATILSAAMMLRH-LG 304

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 682656   318 LPEEGKAIEDAVKKVLDAGIRTGDLGGSNSTTEVGDAVAEEV 359
Cdd:COG0473 305 EEEAADAIEAAVEKVLAEGVRTPDLGGKAGTSEMGDAIIAAL 346
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 7-342 2.16e-87

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 269.63  E-value: 2.16e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656      7 IVVLPGDHVGQEITAEAIKVLKAISDVRSnVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGTGS 86
Cdd:PLN02329  49 IALLPGDGIGPEVISVAKNVLQKAGSLEG-LEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDKNE 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     87 --VRPEQGLLKIRKELQLYANLRPCNFASdSLLDLSPIKPQFAKGTDFVVVRELVGGIYFGKRK----EDDGDGVAWDSE 160
Cdd:PLN02329 128 khLRPEMALFYLRRDLKVFANLRPATVLP-QLVDASTLKKEVAEGVDMMIVRELTGGIYFGEPRgitiNENGEEVGVSTE 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    161 QYTVPEVQRITRMAAFMALQHEPPLpiWSLDKANVLASSRLWRKTVeETIKNEFPTLKVQHQLIDSAAMILVKNPTHLNg 240
Cdd:PLN02329 207 IYAAHEIDRIARVAFETARKRRGKL--CSVDKANVLDASILWRKRV-TALASEYPDVELSHMYVDNAAMQLIRDPKQFD- 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    241 IIITSNMFGDIISDEASVIPGSLGLLPSASLASlpdknTAFGLYEPCHGSAPDLP-KNKVDPIATILSAAMMLKLSLNLP 319
Cdd:PLN02329 283 TIVTNNIFGDILSDEASMITGSIGMLPSASLGE-----SGPGLFEPIHGSAPDIAgQDKANPLATILSAAMLLKYGLGEE 357

                        330       340
                 ....*....|....*....|...
gi 682656    320 EEGKAIEDAVKKVLDAGIRTGDL 342
Cdd:PLN02329 358 KAAKRIEDAVVDALNKGFRTGDI 380
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 5-359 4.08e-72

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 227.71  E-value: 4.08e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656      5 KKIVVLPGDHVGQEITAEAIKVLKAIsdvrsNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGgpkwgt 84
Cdd:PRK14025   2 HKICVIEGDGIGKEVVPAALHVLEAT-----GLPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAG------ 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     85 gsVRPEQGLLKIRKELQLYANLRPCNfasdSLLDLSPIKPqfakGTDFVVVRELVGGIYFGKrKEDDGDGVAWDSEQYTV 164
Cdd:PRK14025  71 --ETAADVIVKLRRILDTYANVRPVK----SYKGVKCLYP----DIDYVIVRENTEGLYKGI-EAEIADGVTVATRVITR 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    165 PEVQRITRMAAFMAlQHEPPLPIWS----LDKANVLA-SSRLWRKTVEEtIKNEFPTLKVQHQLIDSAAMILVKNPTHLN 239
Cdd:PRK14025 140 KASERIFRFAFEMA-KRRKKMGKEGkvtcAHKANVLKkTDGLFKKTFYE-VAKEYPDIKAEDYYVDAMNMYIITRPQTFD 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    240 gIIITSNMFGDIISDEASVIPGSLGLLPSASLAslpDKNtafGLYEPCHGSAPDLP-KNKVDPIATILSAAMMLKlSLNL 318
Cdd:PRK14025 218 -VVVTSNLFGDILSDGAAGLVGGLGLAPSANIG---DKY---GLFEPVHGSAPDIAgKGIANPTATILTAVLMLR-HLGE 289

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 682656    319 PEEGKAIEDAVKKVLDAGIRTGDLGGSNSTTEVGDAVAEEV 359
Cdd:PRK14025 290 NEEADKVEKALEEVLALGLTTPDLGGNLSTMEMAEEVAKRV 330
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 1-359 7.92e-70

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 222.11  E-value: 7.92e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656      1 MSAPKKIVVLPGDHVGQEITAEAIKVLKAISDVRsnVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGP 80
Cdd:PRK03437   1 MAKTMKLAVIPGDGIGPEVVAEALKVLDAVAAGG--PGVETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIGDP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     81 kwgtgSVRP---EQG-LLKIRKELQLYANLRPCNFASDSLldlSPIKPQfaKGTDFVVVRELVGGIYFGKR---KEDDGD 153
Cdd:PRK03437  79 -----SVPSgvlERGlLLKLRFALDHYVNLRPSKLYPGVT---SPLAGP--GDIDFVVVREGTEGPYTGNGgalRVGTPH 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    154 GVAWDSEQYTVPEVQRITRMAaFMALQHEPPLPIWSLDKANVLA-SSRLWRKTVEEtIKNEFPTLKVQHQLIDSAAMILV 232
Cdd:PRK03437 149 EVATEVSVNTAFGVERVVRDA-FERAQKRPRKHLTLVHKTNVLTfAGDLWQRTVDE-VAAEYPDVTVDYQHVDAATIFMV 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    233 KNPTHLNgIIITSNMFGDIISDEASVIPGSLGLLPSASLAslPDkNTAFGLYEPCHGSAPDLP-KNKVDPIATILSAAMM 311
Cdd:PRK03437 227 TDPSRFD-VIVTDNLFGDIITDLAAAVTGGIGLAASGNIN--PT-GTNPSMFEPVHGSAPDIAgQGIADPTAAILSVALL 302

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 682656    312 LKlSLNLPEEGKAIEDAVKKVLdagirTGDLGGSNSTTEVGDAVAEEV 359
Cdd:PRK03437 303 LD-HLGEEDAAARIEAAVEADL-----AERGKMGRSTAEVGDRIAARL 344
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 6-362 1.67e-59

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 195.71  E-value: 1.67e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656      6 KIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPK---- 81
Cdd:PRK08194   5 KIAVIPGDGVGKEVVPAAVRVLKAVAEVHGGLKFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPKlvpd 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     82 ----WGTgsvrpeqgLLKIRKELQLYANLRPCNFasdslldLSPIKPQFA--KGTDFVVVRELVGGIY--FGKRKEDDGD 153
Cdd:PRK08194  85 hislWGL--------LIKIRREFEQVINIRPAKQ-------LRGIKSPLAnpKDFDLLVVRENSEGEYseVGGRIHRGED 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    154 GVAWDSEQYTVPEVQRITRMAafMALQHEPPLPIWSLDKAN-VLASSRLWRKTVEETIKnEFPTLKVQHQLIDSAAMILV 232
Cdd:PRK08194 150 EIAIQNAVFTRKGTERAMRYA--FELAAKRRKHVTSATKSNgIVHSMPFWDEVFQEVGK-DYPEIETDSQHIDALAAFFV 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    233 KNPTHLNgIIITSNMFGDIISDEASVIPGSLGLLPSASLaslpDKNTAF-GLYEPCHGSAPDLP-KNKVDPIATILSAAM 310
Cdd:PRK08194 227 TRPEEFD-VIVASNLFGDILTDIGAAIMGSIGIAPAANI----NVNGKYpSMFEPVHGSAPDIAgKGIANPIGQIWTAKL 301

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 682656    311 MLKlSLNLPEEGKAIEDAVKKVLDAGIRTGDLGGSNSTTEVGDAVAEEVKKI 362
Cdd:PRK08194 302 MLD-HFGEEELGSHLLDVIEDVTEDGIKTPDIGGRATTDEVTDEIISRLKKL 352
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 5-357 8.42e-50

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 169.90  E-value: 8.42e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656      5 KKIVVLPGDHVGQEITAEAIKVLKAIsdvrsNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGA----VGGp 80
Cdd:PRK08997   3 QTITVIPGDGIGPSIIDATLKILDKL-----GCDFEYEFADAGLTALEKHGELLPQRTLDLIEKNKIALKGPlttpVGE- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     81 kwGTGSVRpeqglLKIRKELQLYANLRPcnfasdsLLDLSPIKPQFAkGTDFVVVRELVGGIYFGKRKEDDGDG-VAWDS 159
Cdd:PRK08997  77 --GFTSIN-----VTLRKKFDLYANVRP-------VLSFPGTKARYD-NIDIITVRENTEGMYSGEGQTVSEDGeTAEAT 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    160 EQYTVPEVQRITRMAAFMALQhEPPLPIWSLDKANVLAS-SRLWRKTVEEtIKNEFPTLKVQHQLIDSAAMILVKNPTHL 238
Cdd:PRK08997 142 SIITRKGAERIVRFAYELARK-EGRKKVTAVHKANIMKStSGLFLKVARE-VALRYPDIEFEEMIVDATCMQLVMNPEQF 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    239 NgIIITSNMFGDIISDEASVIPGSLGLLPSASLAslpdKNTAfgLYEPCHGSAPDLP-KNKVDPIATILSAAMMLKlSLN 317
Cdd:PRK08997 220 D-VIVTTNLFGDILSDLCAGLVGGLGMAPGANIG----RDAA--IFEAVHGSAPDIAgKNLANPTSVILAAIQMLE-YLG 291

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 682656    318 LPEEGKAIEDAVKKVLDAGIR-TGDLGGSNSTTEVGDAVAE 357
Cdd:PRK08997 292 MPDKAERIRKAIVAVIEAGDRtTRDLGGTHGTTDFTQAVID 332
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 2-359 1.64e-38

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 141.17  E-value: 1.64e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656      2 SAPKKIVVLPGDHVGQEITAEAIKVLKAisdvrSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPk 81
Cdd:PLN00118  39 STPITATLFPGDGIGPEIAESVKQVFTA-----AGVPIEWEEHYVGTTVDPRTGSFLTWESLESVRRNKVGLKGPMATP- 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     82 WGTGsvrpEQGL-LKIRKELQLYANLRPCnfasdslLDLSPIKPQFaKGTDFVVVRELVGGIYFGKRKEdDGDGVawdse 160
Cdd:PLN00118 113 IGKG----HRSLnLTLRKELGLYANVRPC-------YSLPGYKTRY-DDVDLVTIRENTEGEYSGLEHQ-VVRGV----- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    161 qytVPEVQRITRMA-------AFMALQHEPPLPIWSLDKANVLASSR-LWRKTVEEtIKNEFPTLKVQHQLIDSAAMILV 232
Cdd:PLN00118 175 ---VESLKIITRQAslrvaeyAFHYAKTHGRKRVSAIHKANIMKKTDgLFLKCCRE-VAEKYPEIVYEEVIIDNCCMMLV 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    233 KNPThLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLAslpdkNTAFGLYEPCHGSAPDLP-KNKVDPIATILSAAMM 311
Cdd:PLN00118 251 KNPA-LFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIG-----ENGLALAEAVHGSAPDIAgKNLANPTALLLSAVMM 324

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 682656    312 LKlSLNLPEEGKAIEDAVKKVLDAG-IRTGDLGGSNSTTEVGDAVAEEV 359
Cdd:PLN00118 325 LR-HLKLNEQAEQIHNAILNTIAEGkYRTADLGGSSTTTDFTKAICDHL 372
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
1-357 2.82e-33

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 128.86  E-value: 2.82e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656      1 MSAPKKIVVLPGDHVGQEITAEAIKVLKAisdvrSNVKFDFENHLIGgAAIDATGVP--LPDEALEASKKVDAVLLGAVG 78
Cdd:PRK09222   1 MAEKTPITVAYGDGIGPEIMEAVLKILEA-----AGAPLEIETIEIG-EKVYKKGWTsgISPSAWESIRRTKVLLKAPIT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     79 GPKwGTGsvrpEQGL-LKIRKELQLYANLRPCnfasdslLDLSPIKPQFAKGTDFVVVRE----LVGGIYFgkRKEDDgd 153
Cdd:PRK09222  75 TPQ-GGG----YKSLnVTLRKTLGLYANVRPC-------VSYHPFVETKHPNLDVVIIREneedLYAGIEH--RQTPD-- 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    154 gVAWDSEQYTVPEVQRITRMAAFMALQHEPPlPIWSLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVK 233
Cdd:PRK09222 139 -VYQCLKLISRPGSEKIIRYAFEYARANGRK-KVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLAT 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    234 NPTHLNgIIITSNMFGDIISDEASVIPGSLGLLPSASLASlpdkntAFGLYEPCHGSAPDLP-KNKVDPIATILSAAMML 312
Cdd:PRK09222 217 NPENFD-VIVTPNLYGDILSDIAAEISGSVGLAGSANIGE------EYAMFEAVHGSAPDIAgKNIANPSGLLNAAVMML 289

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 682656    313 kLSLNLPEEGKAIEDAVKKVLDAGIRTGDLGGSN------STTEVGDAVAE 357
Cdd:PRK09222 290 -VHIGQFDIAELIENAWLKTLEDGIHTADIYNEGvskkkvGTKEFAEAVIE 339
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 3-355 9.62e-27

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 108.80  E-value: 9.62e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656      3 APKKIVVLPGDHVGQEITAEAIKVLKAIsdvrsNVKFDFENHLIGGAAIDatgvpLPDEALEASKKVDAVLLGAVGGP-K 81
Cdd:PLN00123  29 APRAVTLIPGDGIGPLVTGAVEQVMEAM-----HAPVYFERYEVHGDMKK-----VPEEVLESIRRNKVCLKGGLATPvG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     82 WGTGSVRpeqglLKIRKELQLYANLRPC-NFasdslldlsPIKPQFAKGTDFVVVRELVGGIYFGKRKEDDgDGVAWDSE 160
Cdd:PLN00123  99 GGVSSLN-----VQLRKELDLFASLVNCfNL---------PGLPTRHENVDIVVIRENTEGEYSGLEHEVV-PGVVESLK 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    161 QYTVPEVQRITRMA-AFMALQHEPPlpIWSLDKANVLA-SSRLWRKTVEETIKNeFPTLKVQHQLIDSAAMILVKNPTHL 238
Cdd:PLN00123 164 VITKFCSERIAKYAfEYAYLNNRKK--VTAVHKANIMKlADGLFLESCREVAKK-YPGIKYNEIIVDNCCMQLVSKPEQF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    239 NgIIITSNMFGDIISDEASVIPGSLGLLPSASLAslpDKNTAF--GLYEPCHGSAPDLPKNKVDPIATILSAAMMLKlSL 316
Cdd:PLN00123 241 D-VMVTPNLYGNLVANTAAGIAGGTGVMPGGNVG---ADHAVFeqGASAGNVGNEKLVEQKKANPVALLLSSAMMLR-HL 315

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 682656    317 NLPEEGKAIEDAVKKVLDAG-IRTGDLGGSNSTTEVGDAV 355
Cdd:PLN00123 316 QFPSFADRLETAVKRVIAEGkYRTKDLGGSSTTQEVVDAV 355
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
4-362 7.34e-20

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 89.89  E-value: 7.34e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656      4 PKKIVVL--PGDHVGQEITAEAIKVL-KAISDV-RSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGG 79
Cdd:PRK06451  21 PKKPIILyvEGDGIGPEITHAAMKVInKAVEKAyGSDREIKWVEVLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLET 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     80 P---KWGTGSVRpeqgllkIRKELQLYANLRPCNFASDslLDlSPIKPqfAKGTDFVVVRELVGGIYFG----------K 146
Cdd:PRK06451 101 PigkGWKSINVA-------IRLMLDLYANIRPVKYIPG--IE-SPLKN--PEKIDLIIFRENTDDLYRGieypydseeaK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    147 R-------------KEDDGDGVAWDSEQYTvpevQRITRMAAFMALQHEPPlPIWSLDKANVLASSR-LWRKTVEETIKN 212
Cdd:PRK06451 169 KirdflrkelgvevEDDTGIGIKLISKFKT----QRIARMAIKYAIDHKRK-KVTIMHKGNVMKYTEgAFREWAYEVALK 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    213 EF------------------PTLKV--QHQLIDSAAMILVKNPTHLNgIIITSNMFGDIISDEASVIPGSLGLLPSASLA 272
Cdd:PRK06451 244 EFrdyvvteeevtknyngvpPSGKViiNDRIADNMFQQIIIRPDEYD-IILAPNVNGDYISDAAGALVGNIGMLGGANIG 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    273 slpdkNTAfGLYEPCHGSAPDLP-KNKVDPIATILSAAMMLKLsLNLPEEGKAIEDAVKKVLDAGIRTGDLG-----GSN 346
Cdd:PRK06451 323 -----DTG-GMFEAIHGTAPKYAgKNVANPTGIIKGGELMLRF-MGWDKAADLIDKAIMESIKQKKVTQDLArfmgvRAL 395

                        410
                 ....*....|....*.
gi 682656    347 STTEVGDAVAEEVKKI 362
Cdd:PRK06451 396 STTEYTDELISIIDML 411
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 12-341 1.83e-13

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 70.86  E-value: 1.83e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     12 GDHVGQEITAEAIKVLKAISD--VRSNVKFDFENHLIGGAAIDATG--VPLPDEALEASKK----VDAVLLGAVGGpkwG 83
Cdd:PRK07006  27 GDGIGPDITPAMLKVVDAAVEkaYKGERKISWMEIYAGEKATKVYGedVWLPEETLDLIREyrvaIKGPLTTPVGG---G 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656     84 TGSVRpeqglLKIRKELQLYANLRPCNFASDSLldlSPIK-PQFakgTDFVVVRELVGGIYfgkrkeddgDGVAWDSEQy 162
Cdd:PRK07006 104 IRSLN-----VALRQELDLYVCLRPVRYFKGVP---SPVKrPED---TDMVIFRENSEDIY---------AGIEWKAGS- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    163 tvPEVQRITRMaafmaLQHE--------PPLPIWSLDKANVLASSRLWRKTVEETIKNEFPTLKVQH------------- 221
Cdd:PRK07006 163 --AEAKKVIKF-----LQEEmgvkkirfPETSGIGIKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHkgnimkftegafk 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    222 -------------QLIDSAAMILVKNPTHLNGIII-----------------------TSNMFGDIISDEASVIPGSLGL 265
Cdd:PRK07006 236 dwgyqlaeeefgdELIDGGPWDKIKNPETGKEIIVkdsiadaflqqillrpaeydviaTMNLNGDYISDALAAQVGGIGI 315

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 682656    266 LPSASLaslpdkNTAFGLYEPCHGSAPDLP-KNKVDPIATILSAAMMLKlSLNLPEEGKAIEDAVKKVLDAGIRTGD 341
Cdd:PRK07006 316 APGANI------NDGHAIFEATHGTAPKYAgLDKVNPGSVILSAEMMLR-HMGWTEAADLIIKSMEKTIASKTVTYD 385
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
241-312 1.51e-06

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 49.71  E-value: 1.51e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 682656    241 IIITSNMFGDIISDEASVIPGSLGLLPSASLAslpDKNTAFglyEPCHGSAPDLPK-NKVDPIATILSAAMML 312
Cdd:PRK07362 355 ILATLNLNGDYISDAAAAIVGGLGMAPGANIG---DNAAIF---EATHGTAPKHAGlDRINPGSVILSGVMML 421
PTZ00435 PTZ00435
isocitrate dehydrogenase; Provisional
 207-364 4.96e-03

isocitrate dehydrogenase; Provisional


Pssm-ID: 240417  Cd Length: 413  Bit Score: 38.82  E-value: 4.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    207 EETIKNEFPTLKV--QHQLIDSAAMILVKNpthlNGIII--TSNMFGDIISDEASVIPGSLGLLPSASLAslPDKNTAfg 282
Cdd:PTZ00435 233 DEEYKAKFEKAGLwyEHRLIDDMVAQAIKS----EGGFVwaCKNYDGDVQSDIVAQGYGSLGLMTSVLVC--PDGKTV-- 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 682656    283 LYEPCHGSAP----DLPKNKV---DPIATILSAAMML----KLSLN--LPEEGKAIEDAVKKVLDAGIRTGDL-----GG 344
Cdd:PTZ00435 305 EAEAAHGTVTrhyrQHQKGKEtstNSIASIFAWTRGLahraKLDNNqeLVKFCQALERSCIETIEAGFMTKDLaicvhGS 384

                        170       180
                 ....*....|....*....|....*..
gi 682656    345 SN-------STTEVGDAVAEEVKKILA 364
Cdd:PTZ00435 385 SKvtrsdylNTEEFIDKVAEKLKKKLG 411
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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