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Conserved domains on  [gi|386953|gb|AAA98805|]
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prepro-Mullerian inhibiting substance [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AMH_N pfam04709
Anti-Mullerian hormone, N terminal region; Anti-Mullerian hormone, AMH is a signalling ...
 77-398 8.47e-116

Anti-Mullerian hormone, N terminal region; Anti-Mullerian hormone, AMH is a signalling molecule involved in male and female sexual differentiation. Defects in synthesis or action of AMH cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism. This family represents the N terminal part of the protein, which is not thought to be essential for activity. AMH contains a TGF-beta domain (pfam00019), at the C terminus.


:

Pssm-ID: 461402  Cd Length: 389  Bit Score: 348.73  E-value: 8.47e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953      77 SAYEQAFLGAVQR-ARWGPRDLATFGVCNTGDRQAALPSLRRLGAWLRDPGGQRLVVLHLEEVTWEPTPSLRFQEPPPGG 155
Cdd:pfam04709   1 SDYEAAFLEALGRdGEWGPQDLATFGICSPSDSSSALPLLQRLVAWLGEPGGQGLLVLHLEEVTWEPTITLTFQLPLLGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953     156 AGPPELALLVLYPGPG-----PEVTVTRAGLPGAQSLCPSRDTRYLVLAVDRPAGAWR----GSGLALTLQPRGEDSRLS 226
Cdd:pfam04709  81 ASPPELALLLLYPGPGtggslPEVTVTGAGLPNTQSLCISEDTRYLLLAVDRPTGAWSegqlRWGISLELRPRGNGSPLS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953     227 TARLQALLFGDDHRCFTRMTPALLLLP--------RSEPAPLPAHGQLDTVPFPPPRPSAELEE----SPPSADPFLETL 294
Cdd:pfam04709 161 TAELQALLFGGDSGCFTRMTPVLLLLSgeegtdtrLSGPSPLPAHGQLDTVPFPQPRPSPEPEEgsssAPPQTDPFLCEL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953     295 TRLVRALRVPPARAS---APRLALDPDALAGFPQGLVNLSDPAALERLLDGEEplllllrPTA-ATTGDPAPLHDpTSAP 370
Cdd:pfam04709 241 TRFLRALLGPPARAPqqkSPRLALDLDALASLPPLLLNLSDPAALERLINSEE-------PTLlLFTGWPAGLQG-HSGE 312

                         330       340       350
                  ....*....|....*....|....*....|
gi 386953     371 WAT--ALARRVAAELQAAAAELRSLPGLPP 398
Cdd:pfam04709 313 WALspALLRRLAQRLQAAAAELRDLPGLPP 342
TGF_beta_AMH cd13757
transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) ...
 461-560 3.99e-52

transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) and similar proteins; AMH, also termed Muellerian-inhibiting factor, or Muellerian-inhibiting substance (MIS), is a glycoprotein that causes regression of the Muellerian duct. It can also inhibit the growth of tumors derived from tissues of Muellerian duct origin.


:

Pssm-ID: 381635  Cd Length: 99  Bit Score: 172.94  E-value: 3.99e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   461 PCALRELSVDLRAERSVLIPETYQANNCQGVCGWPQSDRnPRYGNHVVLLLKMQARGAALARPPCCVPTAYAGKLLISLS 540
Cdd:cd13757   1 YCRLRELSVSLRSEKFILSPKRYNINNCQGPCRFPLSDR-PRYNNHAVLLLKMQERGLPLQRAPCCVPVAYEELLVVELS 79

                        90       100
                ....*....|....*....|
gi 386953   541 EERISAHHVPNMVATECGCR 560
Cdd:cd13757  80 DEGTEISLKPNMVATECGCR 99
 
Name Accession Description Interval E-value
AMH_N pfam04709
Anti-Mullerian hormone, N terminal region; Anti-Mullerian hormone, AMH is a signalling ...
 77-398 8.47e-116

Anti-Mullerian hormone, N terminal region; Anti-Mullerian hormone, AMH is a signalling molecule involved in male and female sexual differentiation. Defects in synthesis or action of AMH cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism. This family represents the N terminal part of the protein, which is not thought to be essential for activity. AMH contains a TGF-beta domain (pfam00019), at the C terminus.


Pssm-ID: 461402  Cd Length: 389  Bit Score: 348.73  E-value: 8.47e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953      77 SAYEQAFLGAVQR-ARWGPRDLATFGVCNTGDRQAALPSLRRLGAWLRDPGGQRLVVLHLEEVTWEPTPSLRFQEPPPGG 155
Cdd:pfam04709   1 SDYEAAFLEALGRdGEWGPQDLATFGICSPSDSSSALPLLQRLVAWLGEPGGQGLLVLHLEEVTWEPTITLTFQLPLLGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953     156 AGPPELALLVLYPGPG-----PEVTVTRAGLPGAQSLCPSRDTRYLVLAVDRPAGAWR----GSGLALTLQPRGEDSRLS 226
Cdd:pfam04709  81 ASPPELALLLLYPGPGtggslPEVTVTGAGLPNTQSLCISEDTRYLLLAVDRPTGAWSegqlRWGISLELRPRGNGSPLS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953     227 TARLQALLFGDDHRCFTRMTPALLLLP--------RSEPAPLPAHGQLDTVPFPPPRPSAELEE----SPPSADPFLETL 294
Cdd:pfam04709 161 TAELQALLFGGDSGCFTRMTPVLLLLSgeegtdtrLSGPSPLPAHGQLDTVPFPQPRPSPEPEEgsssAPPQTDPFLCEL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953     295 TRLVRALRVPPARAS---APRLALDPDALAGFPQGLVNLSDPAALERLLDGEEplllllrPTA-ATTGDPAPLHDpTSAP 370
Cdd:pfam04709 241 TRFLRALLGPPARAPqqkSPRLALDLDALASLPPLLLNLSDPAALERLINSEE-------PTLlLFTGWPAGLQG-HSGE 312

                         330       340       350
                  ....*....|....*....|....*....|
gi 386953     371 WAT--ALARRVAAELQAAAAELRSLPGLPP 398
Cdd:pfam04709 313 WALspALLRRLAQRLQAAAAELRDLPGLPP 342
TGF_beta_AMH cd13757
transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) ...
 461-560 3.99e-52

transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) and similar proteins; AMH, also termed Muellerian-inhibiting factor, or Muellerian-inhibiting substance (MIS), is a glycoprotein that causes regression of the Muellerian duct. It can also inhibit the growth of tumors derived from tissues of Muellerian duct origin.


Pssm-ID: 381635  Cd Length: 99  Bit Score: 172.94  E-value: 3.99e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   461 PCALRELSVDLRAERSVLIPETYQANNCQGVCGWPQSDRnPRYGNHVVLLLKMQARGAALARPPCCVPTAYAGKLLISLS 540
Cdd:cd13757   1 YCRLRELSVSLRSEKFILSPKRYNINNCQGPCRFPLSDR-PRYNNHAVLLLKMQERGLPLQRAPCCVPVAYEELLVVELS 79

                        90       100
                ....*....|....*....|
gi 386953   541 EERISAHHVPNMVATECGCR 560
Cdd:cd13757  80 DEGTEISLKPNMVATECGCR 99
TGFB smart00204
Transforming growth factor-beta (TGF-beta) family; Family members are active as ...
 462-560 1.17e-30

Transforming growth factor-beta (TGF-beta) family; Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.


Pssm-ID: 214556  Cd Length: 102  Bit Score: 115.07  E-value: 1.17e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953      462 CALRELSVDLRA---ERSVLIPETYQANNCQGVCGWPQSDRNPRYgNHVVLLLKMQARGAALARPPCCVPTAYAGKLLIS 538
Cdd:smart00204   1 CRRRQLYVDFKDlgwDDWIIAPKGYNAYYCEGECPFPLSTSLNAT-NHAIVQTLVHLLGPNPVPKPCCVPTKLSPLSMLY 79

                           90       100
                   ....*....|....*....|...
gi 386953      539 LSEE-RISAHHVPNMVATECGCR 560
Cdd:smart00204  80 YDDDgNVVLRNYPNMVVEECGCR 102
TGF_beta pfam00019
Transforming growth factor beta like domain;
461-559 2.05e-20

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 86.22  E-value: 2.05e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953     461 PCALRELSVDLRA---ERSVLIPETYQANNCQGVCGWPQSDRNPRYgNHVVLLLKMQARGAALARPPCCVPTAYAG-KLL 536
Cdd:pfam00019   1 ECRRHSLYVDFEDlgwDDWIIAPKGYNAYYCSGSCPSHLNPQLSAT-NHAILQSLLHSLKPANVPKPCCVPTKLSPlSVL 79

                          90       100
                  ....*....|....*....|...
gi 386953     537 ISLSEERISAHHVPNMVATECGC 559
Cdd:pfam00019  80 YYDDEGNVVLKTYPDMVVESCGC 102
 
Name Accession Description Interval E-value
AMH_N pfam04709
Anti-Mullerian hormone, N terminal region; Anti-Mullerian hormone, AMH is a signalling ...
 77-398 8.47e-116

Anti-Mullerian hormone, N terminal region; Anti-Mullerian hormone, AMH is a signalling molecule involved in male and female sexual differentiation. Defects in synthesis or action of AMH cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism. This family represents the N terminal part of the protein, which is not thought to be essential for activity. AMH contains a TGF-beta domain (pfam00019), at the C terminus.


Pssm-ID: 461402  Cd Length: 389  Bit Score: 348.73  E-value: 8.47e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953      77 SAYEQAFLGAVQR-ARWGPRDLATFGVCNTGDRQAALPSLRRLGAWLRDPGGQRLVVLHLEEVTWEPTPSLRFQEPPPGG 155
Cdd:pfam04709   1 SDYEAAFLEALGRdGEWGPQDLATFGICSPSDSSSALPLLQRLVAWLGEPGGQGLLVLHLEEVTWEPTITLTFQLPLLGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953     156 AGPPELALLVLYPGPG-----PEVTVTRAGLPGAQSLCPSRDTRYLVLAVDRPAGAWR----GSGLALTLQPRGEDSRLS 226
Cdd:pfam04709  81 ASPPELALLLLYPGPGtggslPEVTVTGAGLPNTQSLCISEDTRYLLLAVDRPTGAWSegqlRWGISLELRPRGNGSPLS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953     227 TARLQALLFGDDHRCFTRMTPALLLLP--------RSEPAPLPAHGQLDTVPFPPPRPSAELEE----SPPSADPFLETL 294
Cdd:pfam04709 161 TAELQALLFGGDSGCFTRMTPVLLLLSgeegtdtrLSGPSPLPAHGQLDTVPFPQPRPSPEPEEgsssAPPQTDPFLCEL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953     295 TRLVRALRVPPARAS---APRLALDPDALAGFPQGLVNLSDPAALERLLDGEEplllllrPTA-ATTGDPAPLHDpTSAP 370
Cdd:pfam04709 241 TRFLRALLGPPARAPqqkSPRLALDLDALASLPPLLLNLSDPAALERLINSEE-------PTLlLFTGWPAGLQG-HSGE 312

                         330       340       350
                  ....*....|....*....|....*....|
gi 386953     371 WAT--ALARRVAAELQAAAAELRSLPGLPP 398
Cdd:pfam04709 313 WALspALLRRLAQRLQAAAAELRDLPGLPP 342
TGF_beta_AMH cd13757
transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) ...
 461-560 3.99e-52

transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) and similar proteins; AMH, also termed Muellerian-inhibiting factor, or Muellerian-inhibiting substance (MIS), is a glycoprotein that causes regression of the Muellerian duct. It can also inhibit the growth of tumors derived from tissues of Muellerian duct origin.


Pssm-ID: 381635  Cd Length: 99  Bit Score: 172.94  E-value: 3.99e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   461 PCALRELSVDLRAERSVLIPETYQANNCQGVCGWPQSDRnPRYGNHVVLLLKMQARGAALARPPCCVPTAYAGKLLISLS 540
Cdd:cd13757   1 YCRLRELSVSLRSEKFILSPKRYNINNCQGPCRFPLSDR-PRYNNHAVLLLKMQERGLPLQRAPCCVPVAYEELLVVELS 79

                        90       100
                ....*....|....*....|
gi 386953   541 EERISAHHVPNMVATECGCR 560
Cdd:cd13757  80 DEGTEISLKPNMVATECGCR 99
TGFB smart00204
Transforming growth factor-beta (TGF-beta) family; Family members are active as ...
 462-560 1.17e-30

Transforming growth factor-beta (TGF-beta) family; Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types.


Pssm-ID: 214556  Cd Length: 102  Bit Score: 115.07  E-value: 1.17e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953      462 CALRELSVDLRA---ERSVLIPETYQANNCQGVCGWPQSDRNPRYgNHVVLLLKMQARGAALARPPCCVPTAYAGKLLIS 538
Cdd:smart00204   1 CRRRQLYVDFKDlgwDDWIIAPKGYNAYYCEGECPFPLSTSLNAT-NHAIVQTLVHLLGPNPVPKPCCVPTKLSPLSMLY 79

                           90       100
                   ....*....|....*....|...
gi 386953      539 LSEE-RISAHHVPNMVATECGCR 560
Cdd:smart00204  80 YDDDgNVVLRNYPNMVVEECGCR 102
TGF_beta_BMPs_GDFs cd13756
transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP ...
 462-559 4.36e-22

transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP/GDF family consists of bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and similar proteins. BMPs are a group of growth factors also known as cytokines and as metabologens. They induce the formation of bone and cartilage and functions as pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. GDFs have functions predominantly in development.


Pssm-ID: 381634  Cd Length: 102  Bit Score: 90.84  E-value: 4.36e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   462 CALRELSVDLRA---ERSVLIPETYQANNCQGVCGWPQSDrNPRYGNHVVLLLKMQARGA-ALARPPCCVPTAYAG-KLL 536
Cdd:cd13756   1 CRRRPLYVDFSDlgwDDWIIAPKGYNANYCAGSCPFPLSS-HANATNHAILQALLHSLNPkKSVPKPCCVPTKYSPlSVL 79

                        90       100
                ....*....|....*....|...
gi 386953   537 ISLSEERISAHHVPNMVATECGC 559
Cdd:cd13756  80 YYDEDGNVVLKTYPDMVVEECGC 102
TGF_beta pfam00019
Transforming growth factor beta like domain;
461-559 2.05e-20

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 86.22  E-value: 2.05e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953     461 PCALRELSVDLRA---ERSVLIPETYQANNCQGVCGWPQSDRNPRYgNHVVLLLKMQARGAALARPPCCVPTAYAG-KLL 536
Cdd:pfam00019   1 ECRRHSLYVDFEDlgwDDWIIAPKGYNAYYCSGSCPSHLNPQLSAT-NHAILQSLLHSLKPANVPKPCCVPTKLSPlSVL 79

                          90       100
                  ....*....|....*....|...
gi 386953     537 ISLSEERISAHHVPNMVATECGC 559
Cdd:pfam00019  80 YYDDEGNVVLKTYPDMVVESCGC 102
TGF_beta_INHB cd13752
transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA), ...
 477-559 1.28e-13

transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), E chain (INHBE) and similar proteins; The family includes inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), and E chain (INHBE). INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.


Pssm-ID: 381630  Cd Length: 100  Bit Score: 66.91  E-value: 1.28e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   477 VLIPETYQANNCQGVCgwpQSDRNPRYGNHVVLLLKMQARGAALAR-PPCCVPTAYAG-KLLISLSEERISAHHVPNMVA 554
Cdd:cd13752  19 IIAPSGYYANYCKGSC---SGSSSPFRSHHTTILQKYLSKNKAKSElTPCCTPTKMSPlSLLYYDSDGNIVKKDLPNMIV 95


                ....*
gi 386953   555 TECGC 559
Cdd:cd13752  96 ESCGC 100
TGF_beta_BMP5_like cd13761
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins ...
 461-560 1.58e-10

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins BMP-5, BMP-6, BMP-7, BMP-8A/B and similar proteins; The family includes BMP-5, BMP-6, BMP-7 and BMP-8A/B, which may induce cartilage and bone formation.


Pssm-ID: 381639  Cd Length: 103  Bit Score: 57.97  E-value: 1.58e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   461 PCALRELSVDLRA---ERSVLIPETYQANNCQGVCGWPQSDR-NPRygNHVVLLLKMQARGAALARPPCCVPTAYAG-KL 535
Cdd:cd13761   1 SCRRHNLYVDFRDlgwQDWIIAPDGYNAYYCSGECSFPLNSHmNAT--NHAIVQTLVHLMNPNRVPKPCCAPTKLSPiSV 78

                        90       100
                ....*....|....*....|....*
gi 386953   536 LISLSEERISAHHVPNMVATECGCR 560
Cdd:cd13761  79 LYYDDNSNVVLKKYKNMVVESCGCH 103
TGF_beta_ADMP cd13765
transforming growth factor beta (TGF-beta) like domain found in anti-dorsalizing morphogenetic ...
 460-560 3.63e-10

transforming growth factor beta (TGF-beta) like domain found in anti-dorsalizing morphogenetic protein (ADMP) and similar proteins; ADMP is a bone morphogenetic protein (BMP)-like transforming growth factor beta ligand, functions in the trunk organizer to antagonize head formation, thereby regulating organizer patterning. It negatively affects the formation of the organizer, although it is robustly expressed within the organizer itself. The organizer-promoting signal of ADMP is mediated by the activin A type I receptor, ACVR1 (also known as activin receptor-like kinase-2, ALK2).


Pssm-ID: 381643  Cd Length: 105  Bit Score: 57.37  E-value: 3.63e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   460 GPCALRELSVDLRA---ERSVLIPETYQANNCQGVCGWPQSdRNPRYGNH-----VVLLLKMQARGAAlarpPCCVPTA- 530
Cdd:cd13765   1 RSCQRHELYVDFEEigwSGWIISPKGYNAYHCKGSCPFPLG-QNQKPTNHatvqsIVHALKLAKGVEM----PCCVPDKl 75

                        90       100       110
                ....*....|....*....|....*....|
gi 386953   531 YAGKLLISLSEERISAHHVPNMVATECGCR 560
Cdd:cd13765  76 YSISLLYFDDDENVVLKQYDDMVAASCGCH 105
TGF_beta_GDF1_3_like cd13764
transforming growth factor beta (TGF-beta) like domain found in embryonic growth ...
 462-560 3.69e-10

transforming growth factor beta (TGF-beta) like domain found in embryonic growth/differentiation factor 1 (GDF1), factor 3 (GDF3) and similar proteins; The family includes GDF-1 and GDF-3. GDF1 may mediate cell differentiation events during embryonic development. GDF3 is a growth factor involved in early embryonic development and adipose-tissue homeostasis. The family also contains protein DVR-1, also termed vegetal hemisphere VG1 protein (VG-1), which serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment.


Pssm-ID: 381642  Cd Length: 102  Bit Score: 57.09  E-value: 3.69e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   462 CALRELSVDLRA---ERSVLIPETYQANNCQGVCGWPQSDRnPRYGNHVVLLLKMQARGAALARPPCCVPTAYAG-KLLI 537
Cdd:cd13764   1 CKKRRLYISFRDvgwQNWIIAPQGYMANYCHGECPFPLTES-LNGTNHAILQTLVHSVDPEGTPQPCCVPTRLSPiSMLY 79

                        90       100
                ....*....|....*....|...
gi 386953   538 SLSEERISAHHVPNMVATECGCR 560
Cdd:cd13764  80 YDNNDNVVLRHYEDMVVDECGCR 102
TGF_beta_SF cd08698
transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta ...
 462-559 4.02e-10

transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta superfamily consists of a large group of cell regulatory proteins, such as TFG-betas, Nodal, Activins/Inhibins, glial cell-line-derived neurotrophic factor (GDNF) family of ligands, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs). They play important roles in developmental and physiological processes in a variety of species, including invertebrates as well as vertebrates, through specific receptor complexes that are composed of type I and type II serine/threonine receptor kinases. The receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Proteins from the TGF-beta superfamily are only active as homo- or heterodimer.


Pssm-ID: 381627  Cd Length: 100  Bit Score: 57.10  E-value: 4.02e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   462 CALRELSVDLRA---ERSVLIPETYQANNCQGVCG--WPQSDRNPRYGNHVVLLLKMQARgaalARPPCCVPTAYAGKLL 536
Cdd:cd08698   1 CCKQPLYVNFKDlggLNWIIAPSGFTANYCRGSCNseSSATTNHTKLLQWSRTRRHTPRE----ELKPCCVPTSYEPLSI 76

                        90       100
                ....*....|....*....|....
gi 386953   537 ISLSEERISAH-HVPNMVATECGC 559
Cdd:cd08698  77 LYYDNNGTVVEtLLPNLIVTECGC 100
TGF_beta_DAF7 cd19378
transforming growth factor beta (TGF-beta) like domain found in Caenorhabditis elegans Dauer ...
 462-559 1.47e-09

transforming growth factor beta (TGF-beta) like domain found in Caenorhabditis elegans Dauer larva development regulatory growth factor DAF-7 and similar proteins; DAF-7, also termed abnormal dauer formation protein 7, may act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. It is involved in sensitivity to CO2 levels.


Pssm-ID: 381648  Cd Length: 100  Bit Score: 55.42  E-value: 1.47e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   462 CALRELSVDLRAE--RSVLIPETYQANNCQGVCgwpqSDRNPRYGNHVVLLLKMQARGAALAR-PPCCVPTAYAG-KLLI 537
Cdd:cd19378   3 CCLYDLTIDFEEIgwNFIIAPKKYNANMCRGDC----KSNHHHRPNSASILLNPITRSESKQEhGSCCHPTEYDPiTVVY 78

                        90       100
                ....*....|....*....|..
gi 386953   538 SLSEERISAHHVPNMVATECGC 559
Cdd:cd19378  79 FNEDGQLKIKTINGMIAKKCSC 100
TGF_beta_NODAL cd13759
transforming growth factor beta (TGF-beta) like domain found in Nodal (NODAL)-related proteins; ...
 480-560 3.56e-09

transforming growth factor beta (TGF-beta) like domain found in Nodal (NODAL)-related proteins; NODAL is essential for mesoderm formation and axial patterning during embryonic development.


Pssm-ID: 381637  Cd Length: 103  Bit Score: 54.23  E-value: 3.56e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   480 PETYQANNCQGVCGWPQ-SDRNPRygNHVVL--LLKMQARGAAlaRPPCCVPTAYAGKLLISLSEERISAHHVPNMVATE 556
Cdd:cd13759  24 PKKYNAYRCEGECPSPVdEDFKPT--NHAYMqsLLKLYQPDRV--PLPCCVPTKLSPLSMLYYEHGEVVVRHHEDMIVEE 99


                ....
gi 386953   557 CGCR 560
Cdd:cd13759 100 CGCR 103
TGF_beta_BMP9_like cd13767
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins, ...
 460-560 1.56e-08

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins, BMP-9, BMP-10 and similar proteins; The family includes BMP9 (also known as GDF2) and BMP10. BMP-9 is a potent circulating inhibitor of angiogenesis. It signals through the type I activin receptor ACVRL1 but not other activin receptor-like kinases (ALKs). BMP-10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It inhibits endothelial cell migration and growth. It may reduce cell migration and cell matrix adhesion in breast cancer cell lines.


Pssm-ID: 381645  Cd Length: 105  Bit Score: 52.37  E-value: 1.56e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   460 GPCALRELSVDLRA---ERSVLIPETYQANNCQGVCGWPQSDR-NPRygNHVVLLLKMQARGAALARPPCCVPTAYAGKL 535
Cdd:cd13767   1 NSCRRKPLYVNFADigwDSWIIAPKGYEAYECSGKCFFPLADHlSPT--KHAIIQTLVHSKSPEKVSRACCVPTKLEPIS 78

                        90       100
                ....*....|....*....|....*..
gi 386953   536 LISLSEERISA--HHVPNMVATECGCR 560
Cdd:cd13767  79 LLYIDENGVLTykYKYEGMVVAECGCR 105
TGF_beta_TGFbeta1_2_3 cd13753
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ...
 462-559 2.85e-08

transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1), beta-2 (TGF-beta-2), beta-3 (TGF-beta-3) and similar proteins; The family includes TGF-beta-1, TGF-beta-2 and TGF-beta-3, which are polypeptide members of the transforming growth factor beta superfamily of cytokines. TGF-beta-1 is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. TGF-beta-2 is a secreted protein that performs many cellular functions and has a vital role during embryonic development. It can suppress the effects of interleukin-2 dependent T-cell growth. TGF-beta-3 is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.


Pssm-ID: 381631  Cd Length: 97  Bit Score: 51.54  E-value: 2.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   462 CALRELSVDLRAE---RSVLIPETYQANNCQGVC--GWPQSDrnprygNHVVLLLKMQARGAALARPPCCVPTAYAGKLL 536
Cdd:cd13753   1 CCLRPLYINFRRDlgwKWIHEPKGFNANYCAGACpyLWSADT------QHSTVLQLYNRLNPVASAAPCCSPRELEPLTI 74

                        90       100
                ....*....|....*....|...
gi 386953   537 ISLSEERISAHHVPNMVATECGC 559
Cdd:cd13753  75 LYYDGRNPKIETLSNMIVTSCKC 97
TGF_beta_GDP9_9B_like cd13762
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 462-560 5.38e-08

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9), growth/differentiation factor 9B (GDF-9B) and similar proteins; The family includes GDF-9B (also known as BMP15) and GDF9. GDF-9B acts as oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. GDF-9 is required for ovarian folliculogenesis. It promotes primordial follicle development and stimulates granulosa cell proliferation.


Pssm-ID: 381640  Cd Length: 104  Bit Score: 50.91  E-value: 5.38e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   462 CALRELSV---DLRAERSVLIPETYQANNCQGVC-GWPQSDRNPRygNHVVLLLKMQARGAALARPPCCVPTAYAGKLLI 537
Cdd:cd13762   3 CRRHRLRVrfrDLKWNGWIIAPTRYTANYCKGTCpRVLGQDLNPT--NHAIVQNILHHLLDKSVPRPSCVPTELHPLSVL 80

                        90       100
                ....*....|....*....|....
gi 386953   538 SLSEE-RISAHHVPNMVATECGCR 560
Cdd:cd13762  81 YYEEDgSIIYKEYPDMVASSCGCR 104
TGF_beta_GDF8 cd19388
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 462-559 9.95e-08

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 8 (GDF8) and similar proteins; GDF8, also termed myostatin, acts specifically as a negative regulator of skeletal muscle growth.


Pssm-ID: 381658  Cd Length: 108  Bit Score: 50.42  E-value: 9.95e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   462 CALRELSVDLRA--ERSVLIPETYQANNCQGVCGWPQSDRNPrygnHVVLLLKMQARGAAlarPPCCVPTAYAG-KLLIS 538
Cdd:cd19388  14 CCRYPLTVDFEAfgWDWIIAPKRYKANYCSGECEFVFLQKYP----HTHLVHQANPRGSA---GPCCTPTKMSPiNMLYF 86

                        90       100
                ....*....|....*....|.
gi 386953   539 LSEERISAHHVPNMVATECGC 559
Cdd:cd19388  87 NGKEQIIYGKIPAMVVDRCGC 107
TGF_beta_GDF15 cd19376
transforming growth factor beta (TGF-beta) like domain found in mammalian growth ...
 477-560 1.28e-07

transforming growth factor beta (TGF-beta) like domain found in mammalian growth/differentiation factor 15 (GDF-15) and similar proteins; GDF-15, also termed macrophage inhibitory cytokine 1 (MIC-1), or NSAID-activated gene 1 protein (NAG-1), or NSAID-regulated gene 1 protein (NRG-1), or placental TGF-beta, or placental bone morphogenetic protein, or prostate differentiation factor, regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses.


Pssm-ID: 381646  Cd Length: 101  Bit Score: 49.62  E-value: 1.28e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   477 VLIPETYQANNCQGVCGwpqsdrnPRY---GNHVVLLLKMQARGAALARPPCCVPTAYAGKLLISL-SEERISAHHVPNM 552
Cdd:cd19376  21 VLAPESYNAYYCDGSCP-------HNYkpaNMHAQIKSRLHRLNPGAVPAPCCVPSSYEPLTLLHYdSDGKLTLTEFDDM 93


                ....*...
gi 386953   553 VATECGCR 560
Cdd:cd19376  94 IVKDCHCA 101
TGF_beta_GDF5 cd19399
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 462-560 2.51e-07

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5) and similar proteins; GDF5, also termed bone morphogenetic protein 14 (BMP-14), or cartilage-derived morphogenetic protein 1 (CDMP-1), or lipopolysaccharide-associated protein 4 (LAP-4), or LPS-associated protein 4, or radotermin, is a growth factor involved in bone and cartilage formation.


Pssm-ID: 381669  Cd Length: 103  Bit Score: 49.23  E-value: 2.51e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   462 CALRELSVDLRA---ERSVLIPETYQANNCQGVCGWP-QSDRNPRygNHVVLLLKMQARGAALARPPCCVPTAYAG-KLL 536
Cdd:cd19399   2 CSRKALHVNFKDmgwDDWIIAPLEYEAFHCEGLCEFPlRSHLEPT--NHAVIQTLMNSMDPESTPPTCCVPTRLSPiSIL 79

                        90       100
                ....*....|....*....|....
gi 386953   537 ISLSEERISAHHVPNMVATECGCR 560
Cdd:cd19399  80 FIDSANNVVYKQYEDMVVESCGCR 103
TGF_beta_BMP2 cd19390
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 ...
 477-560 2.78e-07

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins; BMP-2, also termed BMP-2A, induces cartilage and bone formation. It stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway.


Pssm-ID: 381660  Cd Length: 103  Bit Score: 48.83  E-value: 2.78e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   477 VLIPETYQANNCQGVCGWPQSDrNPRYGNHVVLLLKMQARGAALARPpCCVPTAYAGKLLISLSE-ERISAHHVPNMVAT 555
Cdd:cd19390  21 IVAPPGYHAFYCHGECPFPLAD-HLNSTNHAIVQTLVNSVNSKIPKA-CCVPTELSAISMLYLDEnEKVVLKNYQDMVVE 98


                ....*
gi 386953   556 ECGCR 560
Cdd:cd19390  99 GCGCR 103
TGF_beta_GDF8_like cd13751
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factors, ...
 477-559 5.92e-07

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factors, GDF8 and GDF11, and similar proteins; The family includes GDF8 and GDF11. GDF8, also termed myostatin, acts specifically as a negative regulator of skeletal muscle growth. GDF11, also termed bone morphogenetic protein 11 (BMP-11), is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development.


Pssm-ID: 381629  Cd Length: 96  Bit Score: 47.65  E-value: 5.92e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   477 VLIPETYQANNCQGVCgwpQSDRNPRY-GNHVVlllkmQARGAALARPPCCVPTAyagklLISLS------EERISAHHV 549
Cdd:cd13751  20 IIAPKTYDANYCSGEC---PFVYLQSYpHTHLV-----QQANPRGSAGPCCTPTK-----MSPLSmlyfdeDGNIIYGTL 86

                        90
                ....*....|
gi 386953   550 PNMVATECGC 559
Cdd:cd13751  87 PDMVVERCGC 96
TGF_beta_univin cd19387
transforming growth factor beta (TGF-beta) like domain found in Strongylocentrotus purpuratus ...
 462-560 6.12e-07

transforming growth factor beta (TGF-beta) like domain found in Strongylocentrotus purpuratus univin and similar proteins; Univin may have a critical role in early developmental decisions in the sea urchin embryo.


Pssm-ID: 381657  Cd Length: 104  Bit Score: 47.88  E-value: 6.12e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   462 CALRELSVDLRA---ERSVLIPETYQANNCQGVCGWPQSDR-NPRygNHVVLLLKMQARGAALARPPCCVPTAYAG-KLL 536
Cdd:cd19387   3 CQRHSLYVDFKDvgwSDWIIAPRGYQAYRCAGECPFPLNEHlNGT--NHAIIQTLVNSIDPSNVPKACCAPTKLSSiSML 80

                        90       100
                ....*....|....*....|....
gi 386953   537 ISLSEERISAHHVPNMVATECGCR 560
Cdd:cd19387  81 YFDNNDNVVLRQYEDMVVEACGCR 104
TGF_beta_BMP3 cd19393
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 ...
 462-560 7.81e-07

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3) and similar proteins; BMP-3, also termed BMP-3A, or osteogenin, negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.


Pssm-ID: 381663  Cd Length: 110  Bit Score: 47.72  E-value: 7.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   462 CALRELSVDLRA---ERSVLIPETYQANNCQGVCGWPQSdRNPRYGNHVVLLLKMQARGAALARP-PCCVPTAYAGKLLI 537
Cdd:cd19393   8 CARRYLKVDFADigwSEWIISPKSFDAYYCSGACQFPMP-KSLKPSNHATIQSIVRAVGVVPGIPePCCVPEKMSSLSIL 86

                        90       100
                ....*....|....*....|....
gi 386953   538 SLSE-ERISAHHVPNMVATECGCR 560
Cdd:cd19393  87 FFDEnKNVVLKVYPNMTVESCACR 110
TGF_beta_GDF5_6_7 cd13766
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 462-560 9.46e-07

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5), factor 6 (GDF6), factor 7 (GDF7) and similar proteins; The family includes GDF5, GDF6 and GDF7. GDF5, also termed bone morphogenetic protein 14 (BMP-14), or cartilage-derived morphogenetic protein 1 (CDMP-1), or lipopolysaccharide-associated protein 4 (LAP-4), or LPS-associated protein 4, or radotermin, is a growth factor involved in bone and cartilage formation. GDF6, also termed bone morphogenetic protein 13 (BMP-13), or growth/differentiation factor 16, is a growth factor that controls proliferation and cellular differentiation in the retina and bone formation. GDF7, also termed bone morphogenetic protein 12 (BMP-12), may play an active role in the motor area of the primate neocortex.


Pssm-ID: 381644  Cd Length: 102  Bit Score: 47.43  E-value: 9.46e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   462 CALRELSVDLRA---ERSVLIPETYQANNCQGVCGWP-QSDRNPRygNHVVLLLKMQARGAALARPPCCVPTAyagklLI 537
Cdd:cd13766   1 CSRKPLHVNFKDlgwDDWIIAPLDYEAYHCEGVCDFPlRSHLEPT--NHAIIQTLMNSMDPESTPPSCCVPTK-----LS 73

                        90       100
                ....*....|....*....|....*....
gi 386953   538 SLSEERISAHHV------PNMVATECGCR 560
Cdd:cd13766  74 PISILYIDSANNvvykqyEDMVVESCGCR 102
TGF_beta_GDF11 cd19389
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 457-559 5.92e-06

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 11 (GDF11) and similar proteins; GDF11, also termed bone morphogenetic protein 11 (BMP-11), is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development.


Pssm-ID: 381659  Cd Length: 109  Bit Score: 45.41  E-value: 5.92e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   457 AADGPCALRELSVDLRA--ERSVLIPETYQANNCQGVCGWPQSDRNPrygnHVVLLLKMQARGAAlarPPCCVPTAYAG- 533
Cdd:cd19389  10 STESRCCRYPLTVDFEAfgWDWIIAPKRYKANYCSGQCEYMFMQKYP----HTHLVQQANPRGSA---GPCCTPTKMSPi 82

                        90       100
                ....*....|....*....|....*.
gi 386953   534 KLLISLSEERISAHHVPNMVATECGC 559
Cdd:cd19389  83 NMLYFNDKQQIIYGKIPGMVVDRCGC 108
TGF_beta_DPP cd19392
transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster ...
 459-560 7.15e-06

transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster protein decapentaplegic (Dpp) and similar proteins; decapentaplegic (Dpp) and similar proteins Dpp, also termed as protein DPP-C, is required later in embryogenesis for dorsal closure and patterning of the hindgut. It also functions postembryonically as a long-range morphogen during imaginal disk development and is responsible for the progression of the morphogenetic furrow during eye development.


Pssm-ID: 381662  Cd Length: 109  Bit Score: 45.21  E-value: 7.15e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   459 DGPCALRELSVDLRA---ERSVLIPETYQANNCQGVCGWPQSDrNPRYGNHVVLLLKMQARGAALARPPCCVPTAYAGKL 535
Cdd:cd19392   5 QNLCRRHPLYVDFSDvgwDDWIVAPLGYDAYYCNGECPFPLAD-YLNATNHAVVQTLVNSVDPQAVPKACCVPTELSSIA 83

                        90       100
                ....*....|....*....|....*.
gi 386953   536 LISLSE-ERISAHHVPNMVATECGCR 560
Cdd:cd19392  84 MLYVDEhDKVVLKNYQDMVVEGCGCR 109
TGF_beta_INHBB cd19405
transforming growth factor beta (TGF-beta) like domain found in inhibin beta B chain (INHBB) ...
 462-559 1.15e-05

transforming growth factor beta (TGF-beta) like domain found in inhibin beta B chain (INHBB) and similar proteins; INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.


Pssm-ID: 381675  Cd Length: 107  Bit Score: 44.54  E-value: 1.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   462 CALRELSVDLRA---ERSVLIPETYQANNCQGVC-----GWPQSDRNprYGNHVVLLLKMQARGAAlARPPCCVPTAYAG 533
Cdd:cd19405   3 CCRQQFYIDFRLigwNDWIIAPVGYYGNYCEGSCpaymaGVPGSASS--FHTAVVNQYRMRGMNPG-TVNSCCIPTKLST 79

                        90       100
                ....*....|....*....|....*..
gi 386953   534 KLLISLSEE-RISAHHVPNMVATECGC 559
Cdd:cd19405  80 MSMLYFDDEyNIVKRDVPNMIVEECGC 106
TGF_beta_BMP3_like cd13763
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 ...
 462-560 1.94e-05

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3), growth/differentiation factor 10 (GDF10) and similar proteins; The family includes BMP-3 (also known as BMP-3A or osteogenin) and GDF10 (also known as BMP-3B). BMP-3 negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. GDF10 is a growth factor involved in osteogenesis and adipogenesis.


Pssm-ID: 381641  Cd Length: 103  Bit Score: 43.50  E-value: 1.94e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   462 CALRELSVDLRA---ERSVLIPETYQANNCQGVCGWPQSdRNPRYGNHVVLLLKMQARGAALARP-PCCVPTAYAGKLLI 537
Cdd:cd13763   1 CSRRPLTVDFADigwSDWIISPKSFDAYYCAGSCPFPLT-KELRPSNHATIQSIVHAVGIQPGVPaPCCVPDKMSSLTLL 79

                        90       100
                ....*....|....*....|....
gi 386953   538 SLSEER-ISAHHVPNMVATECGCR 560
Cdd:cd13763  80 YFDENRnVVLKNYPNMTVESCACR 103
TGF_beta_INHBC_E cd19406
transforming growth factor beta (TGF-beta) like domain found in inhibin beta C chain (INHBC), ...
 462-559 2.10e-05

transforming growth factor beta (TGF-beta) like domain found in inhibin beta C chain (INHBC), inhibin beta E chain (INHBE) and similar proteins; The family includes INHBC and INHBE. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.


Pssm-ID: 381676  Cd Length: 104  Bit Score: 43.60  E-value: 2.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   462 CALRELSVDLRA---ERSVLIPETYQANNCQGVCGwPQSDRNPRYGN--HVVLLLKMQARGAALARPPCCVPTAYAG-KL 535
Cdd:cd19406   1 CCRRDFYVDFKDigwNDWIIKPEGYQMNYCMGQCP-LHIAGSPGIAAsfHTAVLNLVKANNIATAVHSCCVPTARRPlSL 79

                        90       100
                ....*....|....*....|....
gi 386953   536 LISLSEERISAHHVPNMVATECGC 559
Cdd:cd19406  80 LYFDRNSNIVKTDIPDMIVEACGC 103
TGF_beta_BMP4_BMP2B cd19391
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 ...
 477-560 2.70e-05

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins; BMP-4, also termed BMP-2B, induces cartilage and bone formation. It also acts in mesoderm induction, tooth development, limb formation and fracture repair.


Pssm-ID: 381661  Cd Length: 107  Bit Score: 43.50  E-value: 2.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   477 VLIPETYQANNCQGVCGWPQSDrNPRYGNHVVLLLKMQARGAALARpPCCVPTAYAGKLLISLSE-ERISAHHVPNMVAT 555
Cdd:cd19391  25 IVAPPGYQAFYCHGDCPFPLAD-HLNSTNHAIVQTLVNSVNSSIPK-ACCVPTELSAISMLYLDEyDKVVLKNYQEMVVE 102


                ....*
gi 386953   556 ECGCR 560
Cdd:cd19391 103 GCGCR 107
TGF_beta_BMP2_like cd13760
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 ...
 477-560 3.22e-05

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2), 4 (BMP-4) and similar proteins; The family includes BMP2 and BMP4 (also known as BMP2B), both of which induce cartilage and bone formation. BMP-2 stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP-4 acts in mesoderm induction, tooth development, limb formation and fracture repair.


Pssm-ID: 381638  Cd Length: 102  Bit Score: 42.86  E-value: 3.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   477 VLIPETYQANNCQGVCGWPQSDrNPRYGNHVVLLLKMQARGAALARPPCCVPTAYAGKLLISLSE-ERISAHHVPNMVAT 555
Cdd:cd13760  19 IVAPPGYHAFYCHGECPFPLAD-HLNSTNHAIVQTLVNSVNPGAVPKACCVPTELSPISMLYLDEyDKVVLKNYQDMVVE 97


                ....*
gi 386953   556 ECGCR 560
Cdd:cd13760  98 GCGCR 102
TGF_beta_BMP9 cd19400
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 9 ...
 477-560 1.02e-04

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 9 (BMP-9) and similar proteins; BMP-9, also termed growth/differentiation factor 2 (GDF-2), is a potent circulating inhibitor of angiogenesis. It signals through the type I activin receptor ACVRL1 but not other activin receptor-like kinases (ALKs).


Pssm-ID: 381670  Cd Length: 105  Bit Score: 41.79  E-value: 1.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   477 VLIPETYQANNCQGVCGWPQSDrNPRYGNHVVLLLKMQARGAALARPPCCVPTAYAGKLLISLSEERISA--HHVPNMVA 554
Cdd:cd19400  21 IIAPKEYDAYECKGGCYFPLTD-DVTPTKHAIIQTLVHLKNPKKAGKACCVPTKLDPISVLYKDDMGVPTlkYHYEGMKV 99


                ....*.
gi 386953   555 TECGCR 560
Cdd:cd19400 100 AECGCR 105
TGF_beta_INHBA cd19404
transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) ...
 477-559 1.50e-04

transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins; INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland.


Pssm-ID: 381674  Cd Length: 108  Bit Score: 41.45  E-value: 1.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   477 VLIPETYQANNCQGVCgwPQ-----SDRNPRYGNHVVLLLKMQARGAALARPPCCVPTAY-AGKLLISLSEERISAHHVP 550
Cdd:cd19404  21 IIAPSGYHANYCEGEC--PShiagtSGSSLSFHSTVINHYRMRGYSPFANLKSCCVPTKLrAMSMLYYDDGQNIIKKDIQ 98


                ....*....
gi 386953   551 NMVATECGC 559
Cdd:cd19404  99 NMIVEECGC 107
TGF_beta_BMP10 cd19401
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 10 ...
 477-560 1.64e-04

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 10 (BMP-10) and similar proteins; BMP-10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It inhibits endothelial cell migration and growth. It may reduce cell migration and cell matrix adhesion in breast cancer cell lines.


Pssm-ID: 381671  Cd Length: 105  Bit Score: 40.99  E-value: 1.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   477 VLIPETYQANNCQGVCGWPQSDR-NPRygNHVVLLLKMQARGAALARPPCCVPTAYAGKLLISLSEERISAHHVP--NMV 553
Cdd:cd19401  21 IIAPTGYEAYECRGVCYYPLTEHvTPT--KHAIVQTLVHLKNPQKASKACCVPTKLDPISILYLDDAGVVTYKFKyeGMV 98


                ....*..
gi 386953   554 ATECGCR 560
Cdd:cd19401  99 VAECGCR 105
TGF_beta_INHA_B_like cd19377
transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA), ...
 469-559 2.12e-04

transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA), beta chain (INHB) and similar proteins; INHA is a component of inhibins (inhibin A or inhibin B) that inhibit the secretion of follitropin by the pituitary gland. INHB includes inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), and E chain (INHBE). INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress.


Pssm-ID: 381647  Cd Length: 101  Bit Score: 40.54  E-value: 2.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   469 VDLRAERSVLIPETYQANNCQGVCGW---PQSDRNPRYGNHVvlllKMQARGAALARPPCCVPTAYAGKLLISLSEER-I 544
Cdd:cd19377  11 EELGWNRWIIAPPGFNFHFCHGGCALhivPDLSLPVPSAPPT----PARPYSVLPGAQPCCAPTKVTPLSVLYTSDGGtI 86

                        90
                ....*....|....*
gi 386953   545 SAHHVPNMVATECGC 559
Cdd:cd19377  87 KYETIPDLIVQECGC 101
TGF_beta_GDF10 cd19394
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 462-560 2.26e-04

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 10 (GDF10) and similar proteins; GDF10, also termed bone morphogenetic protein 3B (BMP-3B), or bone-inducing protein (BIP), is a growth factor involved in osteogenesis and adipogenesis.


Pssm-ID: 381664  Cd Length: 112  Bit Score: 41.05  E-value: 2.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   462 CALRELSVDLRA---ERSVLIPETYQANNCQGVCGWPQSdRNPRYGNHVVLLLKMQARGAALARP-PCCVPTAYAGKLLI 537
Cdd:cd19394  10 CSRRYLKVDFADigwSEWIISPKSFDAYYCAGACEFPMP-KVVRPSNHATIQSIVKAVGIIPGVPePCCVPDKMNSLSVL 88

                        90       100
                ....*....|....*....|....
gi 386953   538 SLSEERISAHHV-PNMVATECGCR 560
Cdd:cd19394  89 FLDENRNVVLKVyPNMSVETCACR 112
TGF_beta_BMP8 cd19398
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 8A ...
 462-559 7.72e-04

transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 8A (BMP-8A), 8B (BMP-8B) and similar proteins; BMP-8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. BMP-8B, also termed BMP-8, or osteogenic protein 2 (OP-2), may act as secreted factor in cancer progression. It also plays an essential role in bone metabolism and can regulate thermogenesis and energy balance. Like BMP-8A, BMP-8B plays a role in spermatogenesis and placental development. Mutation in either of the genes encoding BMP-8A or BMP-8B causes postnatal depletion of spermatogonia in mice.


Pssm-ID: 381668  Cd Length: 105  Bit Score: 39.13  E-value: 7.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   462 CALRELSV---DLRAERSVLIPETYQANNCQGVCGWPQsDRNPRYGNHVVLLLKMQARGAALARPPCCVPTAY-AGKLLI 537
Cdd:cd19398   4 CKRHELYVsfqDLGWLDWVIAPQGYSAYYCEGECSFPL-DSCMNATNHAILQSLVHLMKPEAVPKACCAPTKLsATSVLY 82

                        90       100
                ....*....|....*....|..
gi 386953   538 SLSEERISAHHVPNMVATECGC 559
Cdd:cd19398  83 YDSNNNVILKKHRNMVVKSCGC 104
TGF_beta_GDF9B cd19402
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ...
 462-560 5.91e-03

transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9B (GDF-9B) and similar proteins; GDF-9B, also termed bone morphogenetic protein 15 (BMP15), acts as oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.


Pssm-ID: 381672  Cd Length: 104  Bit Score: 36.72  E-value: 5.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386953   462 CALRELSVDLRA---ERSVLIPETYQANNCQGVCgwpqsDRNPRYG----NHVVLLLKMQARGAALARPPCCVPTAYAG- 533
Cdd:cd19402   3 CSLHSFWVSFHQlgwDHWIIAPHRYNPGYCKGDC-----PRILHYGynspNHAIVQNFINQLVDANVPRPSCVPYKYGPi 77

                        90       100
                ....*....|....*....|....*..
gi 386953   534 KLLISLSEERISAHHVPNMVATECGCR 560
Cdd:cd19402  78 SVLMIEPNGNILYKEYEDMIAESCTCR 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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