|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
162-532 |
2.81e-108 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 331.73 E-value: 2.81e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 162 TFQQLdqeyKINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQPANKGFRALIIS 241
Cdd:COG0513 3 SFADL----GLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRPRAPQALILA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 242 PTRELASQIHRELIKISEGTGFRIHMIH-----KAAVAAKKFGPksskkfDILVTTPNRLIYLLKQDppGIDLASVEWLV 316
Cdd:COG0513 79 PTRELALQVAEELRKLAKYLGLRVATVYggvsiGRQIRALKRGV------DIVVATPGRLLDLIERG--ALDLSGVETLV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 317 VDESDKLLKM-----------------QTGsetswlpfswpahptrseepMFSATFAYDVEQWCNSTwtMSSvcP----L 375
Cdd:COG0513 151 LDEADRMLDMgfiedierilkllpkerQTL--------------------LFSATMPPEIRKLAKRY--LKN--PvrieV 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 376 EARNSAVETVEQELLFVGSETgKLLAVRELVKKGFNPPVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVH 455
Cdd:COG0513 207 APENATAETIEQRYYLVDKRD-KLELLRRLLRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALD 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4689114 456 SFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFFTEDDKPLLRSVANVIQQ 532
Cdd:COG0513 286 AFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKLIGQ 362
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
176-365 |
7.40e-90 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 276.01 E-value: 7.40e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 176 LLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQP-ANKGFRALIISPTRELASQIHREL 254
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKPrKKKGLRALILAPTRELASQIYREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 255 IKISEGTGFRIHMIHKAAVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPpgIDLASVEWLVVDESDKLLKM----QTGS 330
Cdd:cd17957 81 LKLSKGTGLRIVLLSKSLEAKAKDGPKSITKYDILVSTPLRLVFLLKQGP--IDLSSVEYLVLDEADKLFEPgfreQTDE 158
|
170 180 190
....*....|....*....|....*....|....*....
gi 4689114 331 etswlpfSWPA--HP--TRSeepMFSATFAYDVEQWCNS 365
Cdd:cd17957 159 -------ILAActNPnlQRS---LFSATIPSEVEELARS 187
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
129-538 |
5.61e-67 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 226.98 E-value: 5.61e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 129 SGKLENLRKEKINFLRNKHKIHVQGTDLPDPIATFQQLdqeyKINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLAS 208
Cdd:PLN00206 89 PGSTSGLSSSQAELLRRKLEIHVKGEAVPPPILSFSSC----GLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVS 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 209 APTGSGKTLAFSIPILMQLKQ------PANKGFRALIISPTRELASQIHRELIKISEGTGFRIHMIHKAAVAAKKFgPKS 282
Cdd:PLN00206 165 ADTGSGKTASFLVPIISRCCTirsghpSEQRNPLAMVLTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQL-YRI 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 283 SKKFDILVTTPNRLIYLL-KQDppgIDLASVEWLVVDESDKLLkmQTGSETSWLPFSWP-AHPtrsEEPMFSATFAYDVE 360
Cdd:PLN00206 244 QQGVELIVGTPGRLIDLLsKHD---IELDNVSVLVLDEVDCML--ERGFRDQVMQIFQAlSQP---QVLLFSATVSPEVE 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 361 QWCNSTWTMSSVCPLEARNSAVETVEQELLFVGSETGKLLAVRELVKKG-FNPPVLVFVQSIERAkELFHELI--YEGIN 437
Cdd:PLN00206 316 KFASSLAKDIILISIGNPNRPNKAVKQLAIWVETKQKKQKLFDILKSKQhFKPPAVVFVSSRLGA-DLLANAItvVTGLK 394
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 438 VDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFFTE 517
Cdd:PLN00206 395 ALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNE 474
|
410 420
....*....|....*....|.
gi 4689114 518 DDKPLLRSVANVIQQAGCPVP 538
Cdd:PLN00206 475 EDRNLFPELVALLKSSGAAIP 495
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
134-538 |
7.79e-66 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 224.65 E-value: 7.79e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 134 NLRKEKINFLRNKHKIH-VQGTDLPDPIATFQqldqEYKINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTG 212
Cdd:PTZ00110 102 ALSSKEVDEIRKEKEITiIAGENVPKPVVSFE----YTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETG 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 213 SGKTLAFSIPILMQLK-QPANK---GFRALIISPTRELASQIHRELIKIseGTGFRIHmiHKAAvaakkFG--PKSSKKF 286
Cdd:PTZ00110 178 SGKTLAFLLPAIVHINaQPLLRygdGPIVLVLAPTRELAEQIREQCNKF--GASSKIR--NTVA-----YGgvPKRGQIY 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 287 ------DILVTTPNRLIYLLKQDPpgIDLASVEWLVVDESDKLLKMqtGSETSWLPFSWPAHPTRsEEPMFSATFAYDVE 360
Cdd:PTZ00110 249 alrrgvEILIACPGRLIDFLESNV--TNLRRVTYLVLDEADRMLDM--GFEPQIRKIVSQIRPDR-QTLMWSATWPKEVQ 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 361 QW----CNSTWTMSSVCPLEARnsAVETVEQELlFVGSETGKLLAVRELVKKGF--NPPVLVFVQSIERAKELFHELIYE 434
Cdd:PTZ00110 324 SLardlCKEEPVHVNVGSLDLT--ACHNIKQEV-FVVEEHEKRGKLKMLLQRIMrdGDKILIFVETKKGADFLTKELRLD 400
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 435 GINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITF 514
Cdd:PTZ00110 401 GWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTF 480
|
410 420
....*....|....*....|....
gi 4689114 515 FTEDDKPLLRSVANVIQQAGCPVP 538
Cdd:PTZ00110 481 LTPDKYRLARDLVKVLREAKQPVP 504
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
162-598 |
3.01e-63 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 214.42 E-value: 3.01e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 162 TFQQLDqeykINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQL-----KQPankGF- 235
Cdd:PRK11192 2 TFSELE----LDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLldfprRKS---GPp 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 236 RALIISPTRELASQIHRELIKISEGTGFRIHMIhKAAVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDppGIDLASVEWL 315
Cdd:PRK11192 75 RILILTPTRELAMQVADQARELAKHTHLDIATI-TGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEE--NFDCRAVETL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 316 VVDESDKLLKMQTGS-------ETSWlpfswpahptRSEEPMFSATfaydveqwcnstwtmssvcpLEArnSAVETVEQE 388
Cdd:PRK11192 152 ILDEADRMLDMGFAQdietiaaETRW----------RKQTLLFSAT--------------------LEG--DAVQDFAER 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 389 LL----FVGSETG---------------------KLLA---VRELVKKGFnppvlVFVQSIERAKELFHELIYEGINVDV 440
Cdd:PRK11192 200 LLndpvEVEAEPSrrerkkihqwyyraddlehktALLChllKQPEVTRSI-----VFVRTRERVHELAGWLRKAGINCCY 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 441 IHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFFTEDDK 520
Cdd:PRK11192 275 LEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLVEAHDH 354
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4689114 521 PLLRSVANVIQQagcPV-PEYIKGFQKLLSKQKKKMIKKPlereSISTTPKCFLEKAKDKQKKvtgqnsKKKVALEDKS 598
Cdd:PRK11192 355 LLLGKIERYIEE---PLkARVIDELRPKTKAPSEKKTGKP----SKKVLAKRAEKKEKEKEKP------KVKKRHRDTK 420
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
172-532 |
1.67e-61 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 210.43 E-value: 1.67e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 172 INSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQL--KQPANKG---FRALIISPTREL 246
Cdd:PRK10590 8 LSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLitRQPHAKGrrpVRALILTPTREL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 247 ASQIHRELIKISEGTGFRiHMIHKAAVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDppGIDLASVEWLVVDESDKLLKM 326
Cdd:PRK10590 88 AAQIGENVRDYSKYLNIR-SLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQN--AVKLDQVEILVLDEADRMLDM 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 327 QTGSETSWLPFSWPAhptRSEEPMFSATFAYDVEQWCNSTWTMSSVCPLEARNSAVETVEQELLFVGSE-TGKLLAvrEL 405
Cdd:PRK10590 165 GFIHDIRRVLAKLPA---KRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFVDKKrKRELLS--QM 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 406 VKKGFNPPVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVIN 485
Cdd:PRK10590 240 IGKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVN 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 4689114 486 YDFPTSSVEYIHRIGRTGRAGNKGKAITFFTEDDKPLLRSVANVIQQ 532
Cdd:PRK10590 320 YELPNVPEDYVHRIGRTGRAAATGEALSLVCVDEHKLLRDIEKLLKK 366
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
168-538 |
2.81e-61 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 210.54 E-value: 2.81e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 168 QEYKINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQ--PANKGF----RALIIS 241
Cdd:PRK01297 90 HDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQtpPPKERYmgepRALIIA 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 242 PTRELASQIHRELIKISEGTGFRIHMIHKAAVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPPGIDLasVEWLVVDESD 321
Cdd:PRK01297 170 PTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARFCDILVATPGRLLDFNQRGEVHLDM--VEVMVLDEAD 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 322 KLLKMQTGSETSWLPFSWPaHPTRSEEPMFSATFAYDV----EQWCnstwTMSSVCPLEARNSAVETVEQELLFV-GSET 396
Cdd:PRK01297 248 RMLDMGFIPQVRQIIRQTP-RKEERQTLLFSATFTDDVmnlaKQWT----TDPAIVEIEPENVASDTVEQHVYAVaGSDK 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 397 GKLLavRELVKKGFNPPVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGID 476
Cdd:PRK01297 323 YKLL--YNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIH 400
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4689114 477 FKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFFTEDDKPLLRSVANVI-QQAGCPVP 538
Cdd:PRK01297 401 IDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDDAFQLPEIEELLgRKISCEMP 463
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
385-515 |
9.05e-57 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 187.33 E-value: 9.05e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 385 VEQELLFVGSETGKLLAVRELVKKGFNPPVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIWV 464
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 4689114 465 LICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFF 515
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
176-365 |
1.03e-53 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 181.49 E-value: 1.03e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 176 LLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQL---KQPANKGFRALIISPTRELASQIHR 252
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLlpePKKKGRGPQALVLAPTRELAMQIAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 253 ELIKISEGTGFRIHMIHkAAVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPpgIDLASVEWLVVDESDKLLKMQTGSET 332
Cdd:cd00268 81 VARKLGKGTGLKVAAIY-GGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGK--LDLSNVKYLVLDEADRMLDMGFEEDV 157
|
170 180 190
....*....|....*....|....*....|....*
gi 4689114 333 SWLpfswpAHPTRSEEP--MFSATFAYDVEQWCNS 365
Cdd:cd00268 158 EKI-----LSALPKDRQtlLFSATLPEEVKELAKK 187
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
176-519 |
3.54e-50 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 180.00 E-value: 3.54e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 176 LLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLkQPANKGFRALIISPTRELASQIHREL- 254
Cdd:PRK11776 15 LLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKL-DVKRFRVQALVLCPTRELADQVAKEIr 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 255 --------IKI---SEGTGFRI------HMIHkaavaakkfgpksskkfdILVTTPNRLIYLLKQDppGIDLASVEWLVV 317
Cdd:PRK11776 94 rlarfipnIKVltlCGGVPMGPqidsleHGAH------------------IIVGTPGRILDHLRKG--TLDLDALNTLVL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 318 DESDKLLKM-----------QTgsetswlpfswpahPTRSEEPMFSATFAYDVEQWcnSTWTMSSvcPLEARNSAVE--- 383
Cdd:PRK11776 154 DEADRMLDMgfqdaidaiirQA--------------PARRQTLLFSATYPEGIAAI--SQRFQRD--PVEVKVESTHdlp 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 384 TVEQELLFVgSETGKLLAVRELVKKgFNP-PVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKI 462
Cdd:PRK11776 216 AIEQRFYEV-SPDERLPALQRLLLH-HQPeSCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSC 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 4689114 463 WVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFFTEDD 519
Cdd:PRK11776 294 SVLVATDVAARGLDIKALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAPEE 350
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
154-517 |
9.26e-48 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 175.91 E-value: 9.26e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 154 TDLPDPIATFQQLDqeykINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQL------ 227
Cdd:PRK04537 2 SDKPLTDLTFSSFD----LHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLlsrpal 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 228 --KQPANKgfRALIISPTRELASQIHRELIKISEGTGFRIHMIHkAAVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPP 305
Cdd:PRK04537 78 adRKPEDP--RALILAPTRELAIQIHKDAVKFGADLGLRFALVY-GGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 306 gIDLASVEWLVVDESDKLLKMQTGSETSWLPFSWPAHPTRsEEPMFSATFAYDVEQWCNSTWTMSSVCPLEARNSAVETV 385
Cdd:PRK04537 155 -VSLHACEICVLDEADRMFDLGFIKDIRFLLRRMPERGTR-QTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 386 EQELLFVGSETgKLLAVRELVKKGFNPPVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIWVL 465
Cdd:PRK04537 233 RQRIYFPADEE-KQTLLLGLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEIL 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 4689114 466 ICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFFTE 517
Cdd:PRK04537 312 VATDVAARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFACE 363
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
172-526 |
6.24e-46 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 171.57 E-value: 6.24e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 172 INSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKqPANKGFRALIISPTRELASQIH 251
Cdd:PRK11634 13 LKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLD-PELKAPQILVLAPTRELAVQVA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 252 RELikisegTGFRIHMIHKAAVA------------AKKFGPKsskkfdILVTTPNRLIYLLKQDPpgIDLASVEWLVVDE 319
Cdd:PRK11634 92 EAM------TDFSKHMRGVNVVAlyggqrydvqlrALRQGPQ------IVVGTPGRLLDHLKRGT--LDLSKLSGLVLDE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 320 SDKLLKMQTGSETSWLPFSWPA-HPTrseePMFSATFAYDVEQWCNStwTMSSvcPLEAR-NSAVET---VEQELLFVGS 394
Cdd:PRK11634 158 ADEMLRMGFIEDVETIMAQIPEgHQT----ALFSATMPEAIRRITRR--FMKE--PQEVRiQSSVTTrpdISQSYWTVWG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 395 ETGKLLAVRELVKKGFNPPVlVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARG 474
Cdd:PRK11634 230 MRKNEALVRFLEAEDFDAAI-IFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARG 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 4689114 475 IDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFFTEDDKPLLRSV 526
Cdd:PRK11634 309 LDVERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALLFVENRERRLLRNI 360
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
172-518 |
1.72e-42 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 158.21 E-value: 1.72e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 172 INSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAF-----------SIPILMQLKQPankgfRALII 240
Cdd:PRK04837 15 LHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFltatfhyllshPAPEDRKVNQP-----RALIM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 241 SPTRELASQIHRELIKISEGTGFrihmihKAAVAakkFGPKSSKK--------FDILVTTPNRLIYLLKQDPpgIDLASV 312
Cdd:PRK04837 90 APTRELAVQIHADAEPLAQATGL------KLGLA---YGGDGYDKqlkvlesgVDILIGTTGRLIDYAKQNH--INLGAI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 313 EWLVVDESDKLLKMQTGSETSWLPFSWPAhPTRSEEPMFSATFAYDV-----EQWCNSTWTmsSVCPLEARNSAVetveQ 387
Cdd:PRK04837 159 QVVVLDEADRMFDLGFIKDIRWLFRRMPP-ANQRLNMLFSATLSYRVrelafEHMNNPEYV--EVEPEQKTGHRI----K 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 388 ELLFVGSETGKLLAVRELVKKGFNPPVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIWVLIC 467
Cdd:PRK04837 232 EELFYPSNEEKMRLLQTLIEEEWPDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVA 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 4689114 468 TALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFFTED 518
Cdd:PRK04837 312 TDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISLACEE 362
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
171-528 |
7.55e-42 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 155.75 E-value: 7.55e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 171 KINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILmQLKQPANKGFRALIISPTRELASQI 250
Cdd:PTZ00424 34 KLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAAL-QLIDYDLNACQALILAPTRELAQQI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 251 HRELIKISEGTGFRIHMIHKAAVAAKKFGpKSSKKFDILVTTPNRLIYLLKQDPPGIDlaSVEWLVVDESDKLL----KM 326
Cdd:PTZ00424 113 QKVVLALGDYLKVRCHACVGGTVVRDDIN-KLKAGVHMVVGTPGRVYDMIDKRHLRVD--DLKLFILDEADEMLsrgfKG 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 327 QTGSETSWLPfswpahpTRSEEPMFSATFAYDVEQWcnSTWTMSSVCPLEARNS--AVETVEQELLFVGSETGKLLAVRE 404
Cdd:PTZ00424 190 QIYDVFKKLP-------PDVQVALFSATMPNEILEL--TTKFMRDPKRILVKKDelTLEGIRQFYVAVEKEEWKFDTLCD 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 405 LVKKGFNPPVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVI 484
Cdd:PTZ00424 261 LYETLTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVI 340
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 4689114 485 NYDFPTSSVEYIHRIGRTGRAGNKGKAITFFTEDDKPLLRSVAN 528
Cdd:PTZ00424 341 NYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIER 384
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
162-354 |
7.34e-40 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 144.37 E-value: 7.34e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 162 TFQQLDQEYKinsrLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQP-ANKGFRALII 240
Cdd:cd17959 2 GFQSMGLSPP----LLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKAHsPTVGARALIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 241 SPTRELASQIHRELIKISEGTGFRIHMIHKAAVAAKKFGPKSSKKfDILVTTPNRLIYLLKQDppGIDLASVEWLVVDES 320
Cdd:cd17959 78 SPTRELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNP-DIIIATPGRLLHLLVEM--NLKLSSVEYVVFDEA 154
|
170 180 190
....*....|....*....|....*....|....
gi 4689114 321 DKLLKMQTGSETSWLPFSWPahPTRsEEPMFSAT 354
Cdd:cd17959 155 DRLFEMGFAEQLHEILSRLP--ENR-QTLLFSAT 185
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
162-361 |
3.21e-39 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 143.40 E-value: 3.21e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 162 TFQQLDqeykINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQL---KQPANKGFR-- 236
Cdd:cd17967 1 SFEEAG----LRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLledGPPSVGRGRrk 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 237 ----ALIISPTRELASQIHRELIKISEGTGFRI-------HMIHKAAvaakkfgpKSSKKFDILVTTPNRLIYLLKQDPp 305
Cdd:cd17967 77 aypsALILAPTRELAIQIYEEARKFSYRSGVRSvvvyggaDVVHQQL--------QLLRGCDILVATPGRLVDFIERGR- 147
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 306 gIDLASVEWLVVDESDKLLKMqtGSEtswlpfswP------AHPTRseeP--------MFSATFAYDVEQ 361
Cdd:cd17967 148 -ISLSSIKFLVLDEADRMLDM--GFE--------PqirkivEHPDM---PpkgerqtlMFSATFPREIQR 203
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
140-361 |
9.65e-38 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 140.49 E-value: 9.65e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 140 INFLRNKH-KIHVQGTDLPDPIATFQqldqEYKINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLA 218
Cdd:cd18052 21 INFDKYDEiPVEVTGRNPPPAILTFE----EANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 219 FSIPILMQLKQ-----PANKGFR---ALIISPTRELASQIHRELIKISEGTGFRihmihkaAVAAkkFGPKSS------- 283
Cdd:cd18052 97 FLLPVLTGMMKegltaSSFSEVQepqALIVAPTRELANQIFLEARKFSYGTCIR-------PVVV--YGGVSVghqirqi 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 284 -KKFDILVTTPNRLIYLLKQDPpgIDLASVEWLVVDESDKLLKMQTGSETSWL--PFSWPAHPTRsEEPMFSATFAYDVE 360
Cdd:cd18052 168 eKGCHILVATPGRLLDFIGRGK--ISLSKLKYLILDEADRMLDMGFGPEIRKLvsEPGMPSKEDR-QTLMFSATFPEEIQ 244
|
.
gi 4689114 361 Q 361
Cdd:cd18052 245 R 245
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
189-361 |
5.48e-37 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 135.06 E-value: 5.48e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 189 TPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQPaNKGFRALIISPTRELASQIHRELIKISEGTGFRIHMI 268
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKL-DNGPQALVLAPTRELAEQIYEELKKLGKGLGLKVASL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 269 HKAAVAAKKFgpKSSKKFDILVTTPNRLIYLLKQDPpgiDLASVEWLVVDESDKLLKMQTGSETSWLPFSWPAHPTRSee 348
Cdd:pfam00270 80 LGGDSRKEQL--EKLKGPDILVGTPGRLLDLLQERK---LLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQIL-- 152
|
170
....*....|...
gi 4689114 349 pMFSATFAYDVEQ 361
Cdd:pfam00270 153 -LLSATLPRNLED 164
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
180-388 |
8.43e-37 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 136.08 E-value: 8.43e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 180 ILDAGFQMPTPIQMQAIPVMLHG-RELLASAPTGSGKTLAFSIPILMQLKQpaNKGFRALIISPTRELASQIHRELIKIS 258
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKR--GKGGRVLVLVPTRELAEQWAEELKKLG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 259 EGTGFRIHMIHKAAVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPpgIDLASVEWLVVDESDKLLKMQTGSETSWLPFS 338
Cdd:smart00487 79 PSLGLKVVGLYGGDSKREQLRKLESGKTDILVTTPGRLLDLLENDK--LSLSNVDLVILDEAHRLLDGGFGDQLEKLLKL 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 4689114 339 WPAHPTRSeepMFSATFAYDVEQwcNSTWTMSSVCPLEARNSAVETVEQE 388
Cdd:smart00487 157 LPKNVQLL---LLSATPPEEIEN--LLELFLNDPVFIDVGFTPLEPIEQF 201
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
151-361 |
2.04e-36 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 135.58 E-value: 2.04e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 151 VQGTDLPDPIATFQQLDqeykINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLK-Q 229
Cdd:cd17953 2 VRGKDCPKPIQKWSQCG----LSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKdQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 230 PANK---GFRALIISPTRELASQIHRELIKISEGTGFRIHMIHKAAVAAKKFGpKSSKKFDILVTTPNRLIYLLKQDPPG 306
Cdd:cd17953 78 RPVKpgeGPIGLIMAPTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQIA-ELKRGAEIVVCTPGRMIDILTANNGR 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 4689114 307 I-DLASVEWLVVDESDKLLKMqtGSETSWLPFSWPAHPTRsEEPMFSATFAYDVEQ 361
Cdd:cd17953 157 VtNLRRVTYVVLDEADRMFDM--GFEPQIMKIVNNIRPDR-QTVLFSATFPRKVEA 209
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
176-360 |
2.43e-36 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 135.45 E-value: 2.43e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 176 LLQNILDAGFQMPTPIQMQAIPVML---------HGRELLASAPTGSGKTLAFSIPILMQLKQPANKGFRALIISPTREL 246
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLpsskstppyRPGDLCVSAPTGSGKTLAYVLPIVQALSKRVVPRLRALIVVPTKEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 247 ASQIHRELIKISEGTGFRIHMIHKAAVAAKK-------FGPKSSKKFDILVTTPNRLIYLLKQdPPGIDLASVEWLVVDE 319
Cdd:cd17956 81 VQQVYKVFESLCKGTGLKVVSLSGQKSFKKEqklllvdTSGRYLSRVDILVATPGRLVDHLNS-TPGFTLKHLRFLVIDE 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 4689114 320 SDKLLK-------------MQTGSETSWLPFSWPAHPTRSEEPM----FSATFAYDVE 360
Cdd:cd17956 160 ADRLLNqsfqdwletvmkaLGRPTAPDLGSFGDANLLERSVRPLqkllFSATLTRDPE 217
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
176-361 |
4.04e-36 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 133.92 E-value: 4.04e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 176 LLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQL--KQPANKGFRALIISPTRELASQIHRE 253
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLlyRPKKKAATRVLVLVPTRELAMQCFSV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 254 LIKISEGTGFRIHMI-----HKAAVAAKKFGPksskkfDILVTTPNRLIYLLKqDPPGIDLASVEWLVVDESDKLLKMQT 328
Cdd:cd17947 81 LQQLAQFTDITFALAvgglsLKAQEAALRARP------DIVIATPGRLIDHLR-NSPSFDLDSIEILVLDEADRMLEEGF 153
|
170 180 190
....*....|....*....|....*....|....
gi 4689114 329 GSETSWLPFSWPahptRSEEPM-FSATFAYDVEQ 361
Cdd:cd17947 154 ADELKEILRLCP----RTRQTMlFSATMTDEVKD 183
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
397-506 |
3.39e-35 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 128.10 E-value: 3.39e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 397 GKLLAVRELVKKGFNPPVLVFVQSIERAK-ELFHELiyEGINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGI 475
Cdd:pfam00271 1 EKLEALLELLKKERGGKVLIFSQTKKTLEaELLLEK--EGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 4689114 476 DFKGVNLVINYDFPTSSVEYIHRIGRTGRAG 506
Cdd:pfam00271 79 DLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
176-326 |
8.32e-33 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 125.51 E-value: 8.32e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 176 LLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQL-KQPA------NKGFRALIISPTRELAS 248
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYIsRLPPldeetkDDGPYALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 249 QIHRELIKISEGTGFRIHMIhkaaVAAKKF---GPKSSKKFDILVTTPNRLIYLLkqDPPGIDLASVEWLVVDESDKLLK 325
Cdd:cd17945 81 QIEEETQKFAKPLGIRVVSI----VGGHSIeeqAFSLRNGCEILIATPGRLLDCL--ERRLLVLNQCTYVVLDEADRMID 154
|
.
gi 4689114 326 M 326
Cdd:cd17945 155 M 155
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
176-358 |
1.06e-32 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 125.43 E-value: 1.06e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 176 LLQNILDAGFQMPTPIQMQAIPV-MLHGRELLASAPTGSGKTLAFSIPIL---MQLKQ-----PANKGFRALIISPTREL 246
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAaIRDGKDVIGAAETGSGKTLAFGIPILerlLSQKSsngvgGKQKPLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 247 ASQIHRELIKISEGTGFRIhMIHKAAVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPPGID-LASVEWLVVDESDKLLk 325
Cdd:cd17946 81 AVQVKDHLKAIAKYTNIKI-ASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGNEHLAnLKSLRFLVLDEADRML- 158
|
170 180 190
....*....|....*....|....*....|....*....
gi 4689114 326 mQTGS--ETSWLPFSWPAHPTRSEEPM----FSATFAYD 358
Cdd:cd17946 159 -EKGHfaELEKILELLNKDRAGKKRKRqtfvFSATLTLD 196
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
162-331 |
1.59e-32 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 123.97 E-value: 1.59e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 162 TFQQLDqeykINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQpANKGFRALIIS 241
Cdd:cd17954 1 TFKELG----VCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLE-NPQRFFALVLA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 242 PTRELASQIHRELIKISEGTGFR-------IHMIHKAAVAAKKfgPKsskkfdILVTTPNRLIYLLkQDPPGIDLASVEW 314
Cdd:cd17954 76 PTRELAQQISEQFEALGSSIGLKsavlvggMDMMAQAIALAKK--PH------VIVATPGRLVDHL-ENTKGFSLKSLKF 146
|
170
....*....|....*..
gi 4689114 315 LVVDESDKLLKMQTGSE 331
Cdd:cd17954 147 LVMDEADRLLNMDFEPE 163
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
172-324 |
3.04e-32 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 123.46 E-value: 3.04e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 172 INSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPIL---MQLKQPANK--GFRALIISPTREL 246
Cdd:cd17961 1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIqkiLKAKAESGEeqGTRALILVPTREL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4689114 247 ASQIHRELIKISEGTGFRIHMIHKAA-VAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPPgIDLASVEWLVVDESDKLL 324
Cdd:cd17961 81 AQQVSKVLEQLTAYCRKDVRVVNLSAsSSDSVQRALLAEKPDIVVSTPARLLSHLESGSL-LLLSTLKYLVIDEADLVL 158
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
176-327 |
9.82e-32 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 121.91 E-value: 9.82e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 176 LLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQL----KQPANKGFRALIISPTRELASQIH 251
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILlkrkANLKKGQVGALIISPTRELATQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 252 RELIKISEGTGFRIHMI-----HKAAVAAKKFgpkSSKKFDILVTTPNRLIYLLKQDPPGIDLASVEWLVVDESDKLLKM 326
Cdd:cd17960 81 EVLQSFLEHHLPKLKCQlliggTNVEEDVKKF---KRNGPNILVGTPGRLEELLSRKADKVKVKSLEVLVLDEADRLLDL 157
|
.
gi 4689114 327 Q 327
Cdd:cd17960 158 G 158
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
168-359 |
1.24e-30 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 118.55 E-value: 1.24e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 168 QEYKINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLkQPANKGFRALIISPTRELA 247
Cdd:cd17940 2 EDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKI-DPKKDVIQALILVPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 248 SQIHRELIKISEGTGFRIhMIHKAAVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPpgIDLASVEWLVVDESDKLLKMQ 327
Cdd:cd17940 81 LQTSQVCKELGKHMGVKV-MVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGV--ADLSHCKTLVLDEADKLLSQD 157
|
170 180 190
....*....|....*....|....*....|...
gi 4689114 328 -TGSETSWLPFSwpahPTRSEEPMFSATFAYDV 359
Cdd:cd17940 158 fQPIIEKILNFL----PKERQILLFSATFPLTV 186
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
182-326 |
1.28e-30 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 118.55 E-value: 1.28e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 182 DAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQL---KQPANKGFRALIISPTRELASQIHRELIKIS 258
Cdd:cd17941 7 EAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLyreRWTPEDGLGALIISPTRELAMQIFEVLRKVG 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 259 EGTGFRIHMIhkaaVAAKKFGPKSSK--KFDILVTTPNRLIYLLKQDpPGIDLASVEWLVVDESDKLLKM 326
Cdd:cd17941 87 KYHSFSAGLI----IGGKDVKEEKERinRMNILVCTPGRLLQHMDET-PGFDTSNLQMLVLDEADRILDM 151
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
176-363 |
2.61e-30 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 117.52 E-value: 2.61e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 176 LLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQL-KQPA---NKGFRALIISPTRELASQIH 251
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHImDQRElekGEGPIAVIVAPTRELAQQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 252 RELIKISEGTGFRIHMIHKAA-----VAAKKFGPksskkfDILVTTPNRLIYLLKQDppGIDLASVEWLVVDESDKLLKM 326
Cdd:cd17952 81 LEAKKFGKAYNLRVVAVYGGGskweqAKALQEGA------EIVVATPGRLIDMVKKK--ATNLQRVTYLVLDEADRMFDM 152
|
170 180 190
....*....|....*....|....*....|....*..
gi 4689114 327 qtGSETSWLPFSWPAHPTRsEEPMFSATFAYDVEQWC 363
Cdd:cd17952 153 --GFEYQVRSIVGHVRPDR-QTLLFSATFKKKIEQLA 186
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
172-366 |
5.79e-30 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 117.30 E-value: 5.79e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 172 INSRLLQNILDAGFQMPTPIQMQAIPVML-HGRELLASAPTGSGKTLAFSIP----ILMQLKQPANKGFRALIISPTREL 246
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILsTGDDVLARAKTGTGKTLAFLLPaiqsLLNTKPAGRRSGVSALIISPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 247 ASQIHRELIKISEG-TGFRIHM------IHKAAVAAKKFGPksskkfDILVTTPNRLIYLLKQDPPGIDLASVEWLVVDE 319
Cdd:cd17964 81 ALQIAAEAKKLLQGlRKLRVQSavggtsRRAELNRLRRGRP------DILVATPGRLIDHLENPGVAKAFTDLDYLVLDE 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 4689114 320 SDKLLKMqtGSETSwLPFSWPAHPTRSEEP----MFSATFAYDVEQWCNST 366
Cdd:cd17964 155 ADRLLDM--GFRPD-LEQILRHLPEKNADPrqtlLFSATVPDEVQQIARLT 202
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
176-365 |
9.73e-30 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 116.11 E-value: 9.73e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 176 LLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQL----KQPAnkgfrALIISPTRELASQIH 251
Cdd:cd17962 1 LSSNLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCltehRNPS-----ALILTPTRELAVQIE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 252 RELIKISEGTgfrIHMIHKAAVAAKKFGP---KSSKKFDILVTTPNRLIYLLKQDppGIDLASVEWLVVDESDKLLKMqt 328
Cdd:cd17962 76 DQAKELMKGL---PPMKTALLVGGLPLPPqlyRLQQGVKVIIATPGRLLDILKQS--SVELDNIKIVVVDEADTMLKM-- 148
|
170 180 190
....*....|....*....|....*....|....*..
gi 4689114 329 GSETSWLPFsWPAHPTRSEEPMFSATFAYDVEQWCNS 365
Cdd:cd17962 149 GFQQQVLDI-LENISHDHQTILVSATIPRGIEQLAGQ 184
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
153-355 |
6.76e-29 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 115.14 E-value: 6.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 153 GTDLPDPIATFQQLDQEYKINSrllqNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQL----- 227
Cdd:cd18051 13 GENCPPHIETFSDLDLGEIIRN----NIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIyeqgp 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 228 -----KQPANKGFR-----ALIISPTRELASQIHRELIKISEGTGFRIHMIHKAAVAAKKFgpkssKKFD----ILVTTP 293
Cdd:cd18051 89 geslpSESGYYGRRkqyplALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQM-----RDLErgchLLVATP 163
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4689114 294 NRLIYLLKQDPPGIDlaSVEWLVVDESDKLLKMqtGSETSW--------LPfswpahPTRSEEP-MFSATF 355
Cdd:cd18051 164 GRLVDMLERGKIGLD--YCKYLVLDEADRMLDM--GFEPQIrriveqdtMP------PTGERQTlMFSATF 224
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
176-326 |
9.19e-29 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 113.33 E-value: 9.19e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 176 LLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQL-KQPANKGFR----ALIISPTRELASQI 250
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLdLQPIPREQRngpgVLVLTPTRELALQI 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4689114 251 HRELIKISEgTGFRIHMIHKAAVAAKKFgPKSSKKFDILVTTPNRLIYLlkQDPPGIDLASVEWLVVDESDKLLKM 326
Cdd:cd17958 81 EAECSKYSY-KGLKSVCVYGGGNRNEQI-EDLSKGVDIIIATPGRLNDL--QMNNVINLKSITYLVLDEADRMLDM 152
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
168-354 |
2.54e-28 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 112.32 E-value: 2.54e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 168 QEYKINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQ-PAnkGFRALIISPTREL 246
Cdd:cd17955 2 EDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRLSEdPY--GIFALVLTPTREL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 247 ASQIHRELIKISEGTGFR-------IHMIHKAAVAAKKfgPKsskkfdILVTTPNRLIYLLKQDPPGI-DLASVEWLVVD 318
Cdd:cd17955 80 AYQIAEQFRALGAPLGLRccvivggMDMVKQALELSKR--PH------IVVATPGRLADHLRSSDDTTkVLSRVKFLVLD 151
|
170 180 190
....*....|....*....|....*....|....*.
gi 4689114 319 ESDKLLkmqTGSETSWLPFSWPAHPTRSEEPMFSAT 354
Cdd:cd17955 152 EADRLL---TGSFEDDLATILSALPPKRQTLLFSAT 184
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
176-361 |
7.02e-28 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 110.92 E-value: 7.02e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 176 LLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLK-QP---ANKGFRALIISPTRELASQIH 251
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINaQPpleRGDGPIVLVLAPTRELAQQIQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 252 RELIKISEGTGFRIHMIHKAAvaakkfgPKSSKKFD------ILVTTPNRLIYLLKQDPpgIDLASVEWLVVDESDKLLK 325
Cdd:cd17966 81 QEANKFGGSSRLRNTCVYGGA-------PKGPQIRDlrrgveICIATPGRLIDFLDQGK--TNLRRVTYLVLDEADRMLD 151
|
170 180 190
....*....|....*....|....*....|....*.
gi 4689114 326 MqtGSETSWLPFSWPAHPTRsEEPMFSATFAYDVEQ 361
Cdd:cd17966 152 M--GFEPQIRKIVDQIRPDR-QTLMWSATWPKEVRR 184
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
425-506 |
8.09e-28 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 106.53 E-value: 8.09e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 425 KELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGR 504
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 4689114 505 AG 506
Cdd:smart00490 81 AG 82
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
176-367 |
6.02e-26 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 105.48 E-value: 6.02e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 176 LLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILmQLkqpankgFRALIISPTRELASQIHRELI 255
Cdd:cd17938 10 LIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVL-QI-------VVALILEPSRELAEQTYNCIE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 256 KIS-EGTGFRI-HMIHKAAVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPpgIDLASVEWLVVDESDKLLKMQTGSETS 333
Cdd:cd17938 82 NFKkYLDNPKLrVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGK--LDLSSVRFFVLDEADRLLSQGNLETIN 159
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 4689114 334 WLPFSWPAHPT---RSEEPMFSATF-AYDVEQWC-----NSTW 367
Cdd:cd17938 160 RIYNRIPKITSdgkRLQVIVCSATLhSFEVKKLAdkimhFPTW 202
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
184-326 |
1.89e-25 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 104.59 E-value: 1.89e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 184 GFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLkQPA------NKGFRALIISPTRELASQIHRELIKI 257
Cdd:cd17949 10 GIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRL-LSLeprvdrSDGTLALVLVPTRELALQIYEVLEKL 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4689114 258 segtGFRIHMIHKAAVAA--KKFGPKSS--KKFDILVTTPNRLIYLLkQDPPGIDLASVEWLVVDESDKLLKM 326
Cdd:cd17949 89 ----LKPFHWIVPGYLIGgeKRKSEKARlrKGVNILIATPGRLLDHL-KNTQSFDVSNLRWLVLDEADRLLDM 156
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
177-361 |
4.10e-25 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 102.82 E-value: 4.10e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 177 LQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIP---ILMQLK-QPANkGFRALIISPTRELASQIH- 251
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPaieLLYKLKfKPRN-GTGVIIISPTRELALQIYg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 252 --RELIKISEGT-GFRIHMIHKAAVAAkkfgpKSSKKFDILVTTPNRLIYLLkQDPPGIDLASVEWLVVDESDKLLKMQT 328
Cdd:cd17942 81 vaKELLKYHSQTfGIVIGGANRKAEAE-----KLGKGVNILVATPGRLLDHL-QNTKGFLYKNLQCLIIDEADRILEIGF 154
|
170 180 190
....*....|....*....|....*....|....*..
gi 4689114 329 GSE----TSWLpfswpahPTRSEEPMFSATFAYDVEQ 361
Cdd:cd17942 155 EEEmrqiIKLL-------PKRRQTMLFSATQTRKVED 184
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
176-355 |
9.56e-25 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 101.57 E-value: 9.56e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 176 LLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKqPANKGFRALIISPTRELASQIHRELI 255
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLD-LERRHPQVLILAPTREIAVQIHDVFK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 256 KISE-GTGFRIH-MIHKAAVAAKKfgpKSSKKFDILVTTPNRLIYLLKQDppGIDLASVEWLVVDESDKLLKMQTGSETS 333
Cdd:cd17943 80 KIGKkLEGLKCEvFIGGTPVKEDK---KKLKGCHIAVGTPGRIKQLIELG--ALNVSHVRLFVLDEADKLMEGSFQKDVN 154
|
170 180
....*....|....*....|..
gi 4689114 334 WLpFSwpAHPTRSEEPMFSATF 355
Cdd:cd17943 155 WI-FS--SLPKNKQVIAFSATY 173
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
131-361 |
1.46e-23 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 100.47 E-value: 1.46e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 131 KLENLRKEKINFLRNKHKIHVQGTDLPDPIATFQQLDqeykINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAP 210
Cdd:cd18050 32 EVARMTQYDVEELRRKKEITIRGVGCPKPVFAFHQAN----FPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQ 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 211 TGSGKTLAFSIPILMQLK-QP---ANKGFRALIISPTRELASQIHRelIKISEGTGFRIHMIHKAAVAAKkfGPKS---S 283
Cdd:cd18050 108 TGSGKTLAYLLPAIVHINhQPyleRGDGPICLVLAPTRELAQQVQQ--VADDYGKSSRLKSTCIYGGAPK--GPQIrdlE 183
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4689114 284 KKFDILVTTPNRLIYLLKQDPpgIDLASVEWLVVDESDKLLKMqtGSETSWLPFSWPAHPTRsEEPMFSATFAYDVEQ 361
Cdd:cd18050 184 RGVEICIATPGRLIDFLEAGK--TNLRRCTYLVLDEADRMLDM--GFEPQIRKIVDQIRPDR-QTLMWSATWPKEVRQ 256
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
176-324 |
2.46e-23 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 98.98 E-value: 2.46e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 176 LLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQ-LKQPANKGF-----RALIISPTRELASQ 249
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRlLRYKLLAEGpfnapRGLVITPSRELAEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 250 IHRELIKISEGTGFRIHMIH----KAAVAAKKFGpksskKFDILVTTPNRLIYLLKQdppGI-DLASVEWLVVDESDKLL 324
Cdd:cd17948 81 IGSVAQSLTEGLGLKVKVITggrtKRQIRNPHFE-----EVDILVATPGALSKLLTS---RIySLEQLRHLVLDEADTLL 152
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
176-326 |
3.21e-23 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 97.79 E-value: 3.21e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 176 LLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILM-----QLKQP--ANKGFRALIISPTRELAS 248
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMfaleqEKKLPfiKGEGPYGLIVCPSRELAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 249 QIHrELI-----KISEGTGFRIH---------MIHKAAVAakkfgpksSKKFDILVTTPNRLIYLLKQDPpgIDLASVEW 314
Cdd:cd17951 81 QTH-EVIeyyckALQEGGYPQLRcllciggmsVKEQLEVI--------RKGVHIVVATPGRLMDMLNKKK--INLDICRY 149
|
170
....*....|..
gi 4689114 315 LVVDESDKLLKM 326
Cdd:cd17951 150 LCLDEADRMIDM 161
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
201-528 |
4.04e-23 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 103.57 E-value: 4.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 201 HGRELLASAPTGSGKTLAFSIpILMQLKQPAnkgfRALIISPTRELASQIHRELIKISEGTGFrihmihkaavaakkFGP 280
Cdd:COG1061 99 GGGRGLVVAPTGTGKTVLALA-LAAELLRGK----RVLVLVPRRELLEQWAEELRRFLGDPLA--------------GGG 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 281 KSSKKFDILVTTPNRLIYLLKQD--PPGIDLasvewLVVDES--------DKLLKMQTgsetswlpfswPAH-------P 343
Cdd:COG1061 160 KKDSDAPITVATYQSLARRAHLDelGDRFGL-----VIIDEAhhagapsyRRILEAFP-----------AAYrlgltatP 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 344 TRSEE-PMFSATF---AYDV-------EQWCNSTWTMSSVCPLEARNSAVETVEQEL--LFVGSETGKLLAVRELVKK-G 409
Cdd:COG1061 224 FRSDGrEILLFLFdgiVYEYslkeaieDGYLAPPEYYGIRVDLTDERAEYDALSERLreALAADAERKDKILRELLREhP 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 410 FNPPVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDfP 489
Cdd:COG1061 304 DDRKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLR-P 382
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 4689114 490 TSS-VEYIHRIGRTGR-AGNKGKAITF-FTEDDKPLLRSVAN 528
Cdd:COG1061 383 TGSpREFIQRLGRGLRpAPGKEDALVYdFVGNDVPVLEELAK 424
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
138-361 |
1.69e-22 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 96.62 E-value: 1.69e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 138 EKINFLRNKHKIHVQGTDLPDPIATFQqldqEYKINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTL 217
Cdd:cd18049 1 QEVEQYRRSKEITVRGHNCPKPVLNFY----EANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 218 AFSIPILMQLK-QP---ANKGFRALIISPTRELASQIHRELIKISEGTGFRIHMIHKAAVAakkfGPKS---SKKFDILV 290
Cdd:cd18049 77 SYLLPAIVHINhQPfleRGDGPICLVLAPTRELAQQVQQVAAEYGRACRLKSTCIYGGAPK----GPQIrdlERGVEICI 152
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4689114 291 TTPNRLIYLLKQDPpgIDLASVEWLVVDESDKLLKMqtGSETSWLPFSWPAHPTRsEEPMFSATFAYDVEQ 361
Cdd:cd18049 153 ATPGRLIDFLEAGK--TNLRRCTYLVLDEADRMLDM--GFEPQIRKIVDQIRPDR-QTLMWSATWPKEVRQ 218
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
168-363 |
1.14e-21 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 93.56 E-value: 1.14e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 168 QEYKINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKqPANKGFRALIISPTRELA 247
Cdd:cd17950 5 RDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLE-PVDGQVSVLVICHTRELA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 248 SQIHRELIKISE-------GTGFRIHMIHKAAVAAKKFGPksskkfDILVTTPNRLIYLLKQDppGIDLASVEWLVVDES 320
Cdd:cd17950 84 FQISNEYERFSKympnvktAVFFGGVPIKKDIEVLKNKCP------HIVVGTPGRILALVREK--KLKLSHVKHFVLDEC 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 4689114 321 DKL---LKMQTGSETSWLpfswpAHPTRSEEPMFSATFAYDVEQWC 363
Cdd:cd17950 156 DKMleqLDMRRDVQEIFR-----ATPHDKQVMMFSATLSKEIRPVC 196
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
188-336 |
1.27e-21 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 94.37 E-value: 1.27e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 188 PTPIQMQAIPVMLHGR----------------ELLASAPTGSGKTLAFSIPILMQLKQ----------------PANKGF 235
Cdd:cd17965 31 PSPIQTLAIKKLLKTLmrkvtkqtsneepkleVFLLAAETGSGKTLAYLAPLLDYLKRqeqepfeeaeeeyesaKDTGRP 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 236 RALIISPTRELASQIHRELIKISEGTGFRIHMI-HKAAVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPPgiDLASVEW 314
Cdd:cd17965 111 RSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFsSGFGPSYQRLQLAFKGRIDILVTTPGKLASLAKSRPK--ILSRVTH 188
|
170 180
....*....|....*....|..
gi 4689114 315 LVVDESDKLLkmqtgsETSWLP 336
Cdd:cd17965 189 LVVDEADTLF------DRSFLQ 204
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
172-360 |
4.42e-21 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 91.48 E-value: 4.42e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 172 INSRLLQNILDAGFQMPTPIQMQAIPVMLHG--RELLASAPTGSGKTLAFSIPILMQLkQPANKGFRALIISPTRELASQ 249
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRV-DPTLKSPQALCLAPTRELARQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 250 IHRELIKISEGTGFRIHMihkaAVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDppGIDLASVEWLVVDESDKLLKMQTG 329
Cdd:cd17963 80 IGEVVEKMGKFTGVKVAL----AVPGNDVPRGKKITAQIVIGTPGTVLDWLKKR--QLDLKKIKILVLDEADVMLDTQGH 153
|
170 180 190
....*....|....*....|....*....|....*.
gi 4689114 330 SETS-----WLPFSWpahptrsEEPMFSATFAYDVE 360
Cdd:cd17963 154 GDQSirikrMLPRNC-------QILLFSATFPDSVR 182
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
169-325 |
7.96e-19 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 85.07 E-value: 7.96e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 169 EYKINSRLLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQPANKgFRALIISPTRELAS 248
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRE-TQALVLAPTRELAQ 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4689114 249 QIHRELIKISEGTGFRIH-MIHKAAVAAKKFgpKSSKKFDILVTTPNRLIYLLKQDppGIDLASVEWLVVDESDKLLK 325
Cdd:cd17939 80 QIQKVVKALGDYMGVKVHaCIGGTSVREDRR--KLQYGPHIVVGTPGRVFDMLQRR--SLRTDKIKMFVLDEADEMLS 153
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
202-319 |
1.68e-17 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 80.32 E-value: 1.68e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 202 GRELLASAPTGSGKTLAFSIPILMQLKQPANKGFRALIISPTRELASQIHRELIKISEGTGFRIHMIHKAAVAAKKFGPK 281
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPEKGVQVLYISPLKALINDQERRLEEPLDEIDLEIPVAVRHGDTSQSEKAK 80
|
90 100 110
....*....|....*....|....*....|....*....
gi 4689114 282 SSKKF-DILVTTPNRLIYLLKQDPPGIDLASVEWLVVDE 319
Cdd:cd17922 81 QLKNPpGILITTPESLELLLVNKKLRELFAGLRYVVVDE 119
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
189-506 |
2.88e-17 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 84.95 E-value: 2.88e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 189 TPIQMQAIP-VMLHGRELLASAPTGSGKTLAFSIPILMQLkqpaNKGFRALIISPTRELASQIHRELIKISEGTGFRIhm 267
Cdd:COG1204 24 YPPQAEALEaGLLEGKNLVVSAPTASGKTLIAELAILKAL----LNGGKALYIVPLRALASEKYREFKRDFEELGIKV-- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 268 ihKAAVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPPGIDlaSVEWLVVDESDKLlkmqtGSETSWlpfswpahPT--- 344
Cdd:COG1204 98 --GVSTGDYDSDDEWLGRYDILVATPEKLDSLLRNGPSWLR--DVDLVVVDEAHLI-----DDESRG--------PTlev 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 345 -----RSEEP----MF-SATF--AYDVEQWCN-----STWTmssvcplearnsaveTVEQELLFV---------GSETGK 398
Cdd:COG1204 161 llarlRRLNPeaqiVAlSATIgnAEEIAEWLDaelvkSDWR---------------PVPLNEGVLydgvlrfddGSRRSK 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 399 ---LLAVRELVKKGfnPPVLVFVQSIERA-----------------------KELFHELIYEGINVDVI----------- 441
Cdd:COG1204 226 dptLALALDLLEEG--GQVLVFVSSRRDAeslakkladelkrrltpeereelEELAEELLEVSEETHTNekladclekgv 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 442 ---HAERTQQQRDNTVHSFRAGKIWVLICTALLArgidfKGVNL----VI--------NYDFPTSsvEYIHRIGRTGRAG 506
Cdd:COG1204 304 afhHAGLPSELRRLVEDAFREGLIKVLVATPTLA-----AGVNLparrVIirdtkrggMVPIPVL--EFKQMAGRAGRPG 376
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
176-326 |
3.35e-17 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 80.20 E-value: 3.35e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 176 LLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILmQLKQPANKGFRALIISPTRELASQIHRELI 255
Cdd:cd18045 10 LLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVL-QCLDIQVRETQALILSPTRELAVQIQKVLL 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4689114 256 KISEGTGFRIHmihkAAVAAKKFGPKSSK---KFDILVTTPNRLIYLLKQDppGIDLASVEWLVVDESDKLLKM 326
Cdd:cd18045 89 ALGDYMNVQCH----ACIGGTSVGDDIRKldyGQHIVSGTPGRVFDMIRRR--SLRTRHIKMLVLDEADEMLNK 156
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
176-324 |
5.64e-17 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 79.80 E-value: 5.64e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 176 LLQNILDAGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLkQPANKGFRALIISPTRELASQIHRELI 255
Cdd:cd18046 10 LLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQI-DTSLKATQALVLAPTRELAQQIQKVVM 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 256 KISEGTGFRIHM-IHKAAVAAKKFGPKSSKKfdILVTTPNRLIYLLKQDppGIDLASVEWLVVDESDKLL 324
Cdd:cd18046 89 ALGDYMGIKCHAcIGGTSVRDDAQKLQAGPH--IVVGTPGRVFDMINRR--YLRTDYIKMFVLDEADEML 154
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
185-319 |
1.93e-16 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 83.23 E-value: 1.93e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 185 FQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQL-----KQPANKGFRALIISPTRELASQIHRELIK--- 256
Cdd:COG1201 22 FGAPTPPQREAWPAIAAGESTLLIAPTGSGKTLAAFLPALDELarrprPGELPDGLRVLYISPLKALANDIERNLRAple 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4689114 257 -ISEGTGFRIHMIhKAAV------AAKKfgpkssKKF-----DILVTTPNRLiYLLKQDPPGID-LASVEWLVVDE 319
Cdd:COG1201 102 eIGEAAGLPLPEI-RVGVrtgdtpASER------QRQrrrppHILITTPESL-ALLLTSPDARElLRGVRTVIVDE 169
|
|
| DEXH_lig_assoc |
TIGR04121 |
DEXH box helicase, DNA ligase-associated; Members of this protein family are DEAD/DEAH box ... |
188-512 |
1.01e-15 |
|
DEXH box helicase, DNA ligase-associated; Members of this protein family are DEAD/DEAH box helicases found associated with a bacterial ATP-dependent DNA ligase, part of a four-gene system that occurs in about 12 % of prokaryotic reference genomes. The actual motif in this family is DE[VILW]H.
Pssm-ID: 274994 [Multi-domain] Cd Length: 804 Bit Score: 80.67 E-value: 1.01e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 188 PTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQL---KQPANKGFRALIISPTRELASQIHRELIKISEGTG-- 262
Cdd:TIGR04121 14 PRPFQLEMWAAALEGRSGLLIAPTGSGKTLAGFLPSLIDLagpEAPKEKGLHTLYITPLRALAVDIARNLQAPIEELGlp 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 263 FRIHM------IHKAAvAAKKFGPksskkfDILVTTPNRLIYLLKQ-DPPGI--DLASVewlVVDESDKLLKMQTGSET- 332
Cdd:TIGR04121 94 IRVETrtgdtsSSERA-RQRKKPP------DILLTTPESLALLLSYpDAARLfkDLRCV---VVDEWHELAGSKRGDQLe 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 333 ---SWLpfswpahptRSEEPMF-----SATFAyDVEQWCN-----STWTMSSVCPLEARNSAVETV--EQELLFVGSETG 397
Cdd:TIGR04121 164 lalARL---------RRLAPGLrrwglSATIG-NLEEARRvllgvGGAPAVLVRGKLPKAIEVISLlpESEERFPWAGHL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 398 KLLAVRELVKK-GFNPPVLVFVQSIERAKELFHELIYegINVD---VI---HAERTQQQRDNTVHSFRAGKIWVLICTAL 470
Cdd:TIGR04121 234 GLRALPEVYAEiDQARTTLVFTNTRSQAELWFQALWE--ANPEfalPIalhHGSLDREQRRWVEAAMAAGRLRAVVCTSS 311
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 4689114 471 LARGIDFKGVNLVINYDFPTSSVEYIHRIGRTG-RAGNKGKAI 512
Cdd:TIGR04121 312 LDLGVDFGPVDLVIQIGSPKGVARLLQRAGRSNhRPGEPSRAL 354
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
189-319 |
1.10e-14 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 72.29 E-value: 1.10e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 189 TPIQMQAI-PVMLHGRELLASAPTGSGKTLAFSIPILMQLKQpanKGFRALIISPTRELASQIHRELIKISEGTGFRIHM 267
Cdd:cd17921 3 NPIQREALrALYLSGDSVLVSAPTSSGKTLIAELAILRALAT---SGGKAVYIAPTRALVNQKEADLRERFGPLGKNVGL 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 4689114 268 IhkaaVAAKKFGPKSSKKFDILVTTPNRL-IYLLKqdPPGIDLASVEWLVVDE 319
Cdd:cd17921 80 L----TGDPSVNKLLLAEADILVATPEKLdLLLRN--GGERLIQDVRLVVVDE 126
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
147-355 |
1.93e-14 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 73.13 E-value: 1.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 147 HKIHVQGTDLPDPIATFQQLdQEYKINSRLLQNILDAGFQMPTPIQMQAIPVMLHG--RELLASAPTGSGKTLAFSIPIL 224
Cdd:cd18048 1 HRVEVLQRDPTSPLFSVKSF-EELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAML 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 225 MQLKqpANKGF-RALIISPTRELASQIHR---ELIKISEGtgfrIHMIHkaAVAAKKFGPKSSKKFDILVTTPNRLI--- 297
Cdd:cd18048 80 SRVD--ALKLYpQCLCLSPTFELALQTGKvveEMGKFCVG----IQVIY--AIRGNRPGKGTDIEAQIVIGTPGTVLdwc 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 4689114 298 YLLKQdppgIDLASVEWLVVDESDKLLKMQTGSETSWLPFSwpAHPTRSEEPMFSATF 355
Cdd:cd18048 152 FKLRL----IDVTNISVFVLDEADVMINVQGHSDHSVRVKR--SMPKECQMLLFSATF 203
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
192-522 |
2.74e-14 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 76.03 E-value: 2.74e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 192 QMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQpaNKGFRALIISPTRELASQIHRELIKISEGTGFRIHmihka 271
Cdd:COG1205 61 QAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLE--DPGATALYLYPTKALARDQLRRLRELAEALGLGVR----- 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 272 avAAKKFG--PKSSKKF-----DILVTTPNRLIY-LLKQDPPGID-LASVEWLVVDEsdkllkMQT-----GSETSWL-- 335
Cdd:COG1205 134 --VATYDGdtPPEERRWirehpDIVLTNPDMLHYgLLPHHTRWARfFRNLRYVVIDE------AHTyrgvfGSHVANVlr 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 336 ------PFsWPAHPTrseepmF---SATFAydveqwcNstwtmssvcPLE-ARN---SAVETV--------EQELLFV-- 392
Cdd:COG1205 206 rlrricRH-YGSDPQ------FilaSATIG-------N---------PAEhAERltgRPVTVVdedgsprgERTFVLWnp 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 393 -----------GSETGKLLAvrELVKKGFNppVLVFVQSI-------ERAKELFHELIYeGINVDVIHAERTQQQRDNTV 454
Cdd:COG1205 263 plvddgirrsaLAEAARLLA--DLVREGLR--TLVFTRSRrgaellaRYARRALREPDL-ADRVAAYRAGYLPEERREIE 337
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 455 HSFRAGKIWVLICT-AL-LarGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFFTEDdkPL 522
Cdd:COG1205 338 RGLRSGELLGVVSTnALeL--GIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQDSLVVLVAGDD--PL 403
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
202-325 |
5.55e-14 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 69.35 E-value: 5.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 202 GRELLASAPTGSGKTLAFSIPILMQLKQpanKGFRALIISPTRELASQIHRELIKISeGTGFRIHMIHkaavAAKKFGPK 281
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLLLK---KGKKVLVLVPTKALALQTAERLRELF-GPGIRVAVLV----GGSSAEER 72
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 4689114 282 SSKKF---DILVTTPNRlIYLLKQDPPGIDLASVEWLVVDESDKLLK 325
Cdd:cd00046 73 EKNKLgdaDIIIATPDM-LLNLLLREDRLFLKDLKLIIVDEAHALLI 118
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
398-518 |
5.69e-14 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 75.15 E-value: 5.69e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 398 KLLAVRELVKK--GFNPP--VLVFVQSIERAKELFHELIYEGINVD--VIHAER------TQQQRDNTVHSFRAGKIWVL 465
Cdd:COG1111 336 KLSKLREILKEqlGTNPDsrIIVFTQYRDTAEMIVEFLSEPGIKAGrfVGQASKegdkglTQKEQIEILERFRAGEFNVL 415
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 4689114 466 ICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRaGNKGKAITFFTED 518
Cdd:COG1111 416 VATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQRKGRTGR-KREGRVVVLIAKG 467
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
190-326 |
1.79e-13 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 69.49 E-value: 1.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 190 PIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLK---QPANKGF--RALIISPTRELASQIHRELIKISEgtgfr 264
Cdd:cd17944 15 PIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQedqQPRKRGRapKVLVLAPTRELANQVTKDFKDITR----- 89
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4689114 265 ihmihKAAVAAKKFGPKSSKKF-------DILVTTPNRLIYLLKQDPpgIDLASVEWLVVDESDKLLKM 326
Cdd:cd17944 90 -----KLSVACFYGGTPYQQQIfairngiDILVGTPGRIKDHLQNGR--LDLTKLKHVVLDEVDQMLDM 151
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
192-506 |
2.44e-13 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 72.99 E-value: 2.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 192 QMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKqpanKGFRALIISPTRELASQIHRELIKISEgTGFRIHMihka 271
Cdd:PRK01172 27 QRMAIEQLRKGENVIVSVPTAAGKTLIAYSAIYETFL----AGLKSIYIVPLRSLAMEKYEELSRLRS-LGMRVKI---- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 272 AVAAKKFGPKSSKKFDILVTTPNRLIYLLKQDPPGIDlaSVEWLVVDESDKLlkmqtGSETSWLPFSWPAHPTRSEEP-- 349
Cdd:PRK01172 98 SIGDYDDPPDFIKRYDVVILTSEKADSLIHHDPYIIN--DVGLIVADEIHII-----GDEDRGPTLETVLSSARYVNPda 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 350 ---MFSATF--AYDVEQWCNSTWTMSSVCPLEARNSAVetVEQELLFVGSETGKL---LAVRELVKKGFNppVLVFVQSI 421
Cdd:PRK01172 171 rilALSATVsnANELAQWLNASLIKSNFRPVPLKLGIL--YRKRLILDGYERSQVdinSLIKETVNDGGQ--VLVFVSSR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 422 ERAK---------------------------ELFHELIYEGINVDviHAERTQQQRDNTVHSFRAGKIWVLICTALLARG 474
Cdd:PRK01172 247 KNAEdyaemliqhfpefndfkvssennnvydDSLNEMLPHGVAFH--HAGLSNEQRRFIEEMFRNRYIKVIVATPTLAAG 324
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 4689114 475 IDFKGvNLVINYDF---------PTSSVEYIHRIGRTGRAG 506
Cdd:PRK01172 325 VNLPA-RLVIVRDItrygnggirYLSNMEIKQMIGRAGRPG 364
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
413-516 |
5.59e-12 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 61.57 E-value: 5.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 413 PVLVFVQSIERAKELFHELIyeginvdvihaertqqqrdntvhsfragkiwVLICTALLARGIDFKGVNLVINYDFPTSS 492
Cdd:cd18785 5 KIIVFTNSIEHAEEIASSLE-------------------------------ILVATNVLGEGIDVPSLDTVIFFDPPSSA 53
|
90 100
....*....|....*....|....
gi 4689114 493 VEYIHRIGRTGRAGNKGKAITFFT 516
Cdd:cd18785 54 ASYIQRVGRAGRGGKDEGEVILFV 77
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
192-319 |
1.26e-11 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 63.76 E-value: 1.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 192 QMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQpaNKGFRALIISPTRELA-SQIhRELIKISEGTGFRIHMihk 270
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLR--DPGSRALYLYPTKALAqDQL-RSLRELLEQLGLGIRV--- 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 4689114 271 AAVAAKKfgPKSSKKF------DILVTTPNRLIYLLkqDPPGID----LASVEWLVVDE 319
Cdd:cd17923 79 ATYDGDT--PREERRAiirnppRILLTNPDMLHYAL--LPHHDRwarfLRNLRYVVLDE 133
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
190-319 |
2.81e-11 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 62.35 E-value: 2.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 190 PIQMQAI-PVMLHGRELLASAPTGSGKTLafsIPILMQLKQpANKGFRALIISPTRELASQIHRELiKISEGTGFRIhmi 268
Cdd:cd18028 4 PPQAEAVrAGLLKGENLLISIPTASGKTL---IAEMAMVNT-LLEGGKALYLVPLRALASEKYEEF-KKLEEIGLKV--- 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 4689114 269 hkaAVAAKKF--GPKSSKKFDILVTTPNRLIYLLKQDPPGIDLASVewLVVDE 319
Cdd:cd18028 76 ---GISTGDYdeDDEWLGDYDIIVATYEKFDSLLRHSPSWLRDVGV--VVVDE 123
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
189-319 |
3.25e-11 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 66.45 E-value: 3.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 189 TPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQPANKG-----FRALIISPTRELASQIHRELI-------K 256
Cdd:PRK13767 34 TPPQRYAIPLIHEGKNVLISSPTGSGKTLAAFLAIIDELFRLGREGeledkVYCLYVSPLRALNNDIHRNLEeplteirE 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4689114 257 ISEGTGFRIHMIhKAAVaakKFGPKSS--------KKFDILVTTPNRLIYLL-----KQDppgidLASVEWLVVDE 319
Cdd:PRK13767 114 IAKERGEELPEI-RVAI---RTGDTSSyekqkmlkKPPHILITTPESLAILLnspkfREK-----LRTVKWVIVDE 180
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
168-333 |
4.84e-11 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 62.43 E-value: 4.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 168 QEYKINSRLLQNILDAGFQMPTPIQMQAIPVMLHG--RELLASAPTGSGKTLAFSIPILMQLkQPANKGFRALIISPTRE 245
Cdd:cd18047 4 EELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQV-EPANKYPQCLCLSPTYE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 246 LASQIHRELIKISEgtgFRIHMIHKAAVAAKKFGPKSSKKFDILVTTPNRLI-YLLKQDPpgIDLASVEWLVVDESDKLL 324
Cdd:cd18047 83 LALQTGKVIEQMGK---FYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLdWCSKLKF--IDPKKIKVFVLDEADVMI 157
|
....*....
gi 4689114 325 KMQTGSETS 333
Cdd:cd18047 158 ATQGHQDQS 166
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
388-515 |
1.32e-10 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 59.53 E-value: 1.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 388 ELLFVGSETGKLLAVRELVKKGFNPPVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIWVLIC 467
Cdd:cd18794 7 SVRPKDKKDEKLDLLKRIKVEHLGGSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVA 86
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 4689114 468 TALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFF 515
Cdd:cd18794 87 TVAFGMGIDKPDVRFVIHYSLPKSMESYYQESGRAGRDGLPSECILFY 134
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
398-512 |
1.68e-10 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 59.29 E-value: 1.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 398 KLLAVRELVKKGF-------NPPVLVFVQSIERAKELFHELIYEGINVDVI----HAER------TQQQRDNTVHSFRAG 460
Cdd:cd18801 10 KLEKLEEIVKEHFkkkqegsDTRVIIFSEFRDSAEEIVNFLSKIRPGIRATrfigQASGksskgmSQKEQKEVIEQFRKG 89
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 4689114 461 KIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRaGNKGKAI 512
Cdd:cd18801 90 GYNVLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR-KRQGRVV 140
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
398-518 |
5.61e-10 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 62.20 E-value: 5.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 398 KLLAVRELVKK--GFNPP--VLVFVQSIERAKELFHELIYEGINvdvihAER-------------TQQQRDNTVHSFRAG 460
Cdd:PRK13766 348 KLEKLREIVKEqlGKNPDsrIIVFTQYRDTAEKIVDLLEKEGIK-----AVRfvgqaskdgdkgmSQKEQIEILDKFRAG 422
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 4689114 461 KIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRaGNKGKAITFFTED 518
Cdd:PRK13766 423 EFNVLVSTSVAEEGLDIPSVDLVIFYEPVPSEIRSIQRKGRTGR-QEEGRVVVLIAKG 479
|
|
| ComFA |
COG4098 |
Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [Replication, ... |
398-504 |
1.84e-09 |
|
Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [Replication, recombination and repair];
Pssm-ID: 443274 [Multi-domain] Cd Length: 451 Bit Score: 60.27 E-value: 1.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 398 KLLA-VRELVKKGFnpPVLVFVQSIERAKELFHEL--IYEGINVDVIHAErtQQQRDNTVHSFRAGKIWVLICTALLARG 474
Cdd:COG4098 307 KLLKwLKKRLKEGR--QLLIFVPTIELLEQLVALLqkLFPEERIAGVHAE--DPERKEKVQAFRDGEIPILVTTTILERG 382
|
90 100 110
....*....|....*....|....*....|....
gi 4689114 475 IDFKGVN-LVINYD---FPTSSVEYIHriGRTGR 504
Cdd:COG4098 383 VTFPNVDvAVLGADhpvFTEAALVQIA--GRVGR 414
|
|
| SF2_C_TRCF |
cd18810 |
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair ... |
418-522 |
3.34e-09 |
|
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350197 [Multi-domain] Cd Length: 151 Bit Score: 55.81 E-value: 3.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 418 VQSIERAKELFHELIYEgINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIH 497
Cdd:cd18810 35 IESIEKLATQLRQLVPE-ARIAIAHGQMTENELEEVMLEFAKGEYDILVCTTIIESGIDIPNANTIIIERADKFGLAQLY 113
|
90 100
....*....|....*....|....*.
gi 4689114 498 RI-GRTGRAGNKGKAItFFTEDDKPL 522
Cdd:cd18810 114 QLrGRVGRSKERAYAY-FLYPDQKKL 138
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
397-500 |
1.62e-08 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 53.25 E-value: 1.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 397 GKLLAVRELVKKGFNPP--VLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAG-KIWV-LICTALLA 472
Cdd:cd18793 11 GKLEALLELLEELREPGekVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDpDIRVfLLSTKAGG 90
|
90 100 110
....*....|....*....|....*....|....
gi 4689114 473 RGIDFKGVNLVINYDFP-TSSVEY-----IHRIG 500
Cdd:cd18793 91 VGLNLTAANRVILYDPWwNPAVEEqaidrAHRIG 124
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
395-502 |
1.87e-08 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 57.54 E-value: 1.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 395 ETGKLLAVRELVKKGFNP--PVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGK-IWV-LICTAL 470
Cdd:COG0553 531 RSAKLEALLELLEELLAEgeKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPeAPVfLISLKA 610
|
90 100 110
....*....|....*....|....*....|....*...
gi 4689114 471 LARGIDFKGVNLVINYDFP-TSSVEY-----IHRIGRT 502
Cdd:COG0553 611 GGEGLNLTAADHVIHYDLWwNPAVEEqaidrAHRIGQT 648
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
398-524 |
1.99e-08 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 57.07 E-value: 1.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 398 KLLAVRELVKKGFNPPVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDF 477
Cdd:COG0514 217 KLAQLLDFLKEHPGGSGIVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVATIAFGMGIDK 296
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 4689114 478 KGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAITFFTEDDKPLLR 524
Cdd:COG0514 297 PDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYGPEDVAIQR 343
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
444-508 |
3.31e-08 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 52.59 E-value: 3.31e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4689114 444 ERTQQQRdnTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNK 508
Cdd:cd18802 75 TQRKQKE--TLDKFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGRARAPNSK 137
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
414-507 |
5.39e-08 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 52.27 E-value: 5.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 414 VLVFVQSIERAKELFHEL------IYEGINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYD 487
Cdd:cd18796 41 TLVFTNTRSQAERLAQRLrelcpdRVPPDFIALHHGSLSRELREEVEAALKRGDLKVVVATSSLELGIDIGDVDLVIQIG 120
|
90 100
....*....|....*....|
gi 4689114 488 FPTSSVEYIHRIGRTGRAGN 507
Cdd:cd18796 121 SPKSVARLLQRLGRSGHRPG 140
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
169-319 |
1.68e-07 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 54.44 E-value: 1.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 169 EYKINSRLLQNILDAGFQMPTPIQMQAIPV-MLHGRELLASAPTGSGKTLAFSIPILMQLKQpanKGFRALIISPTRELA 247
Cdd:PRK00254 5 ELRVDERIKRVLKERGIEELYPPQAEALKSgVLEGKNLVLAIPTASGKTLVAEIVMVNKLLR---EGGKAVYLVPLKALA 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4689114 248 SQIHRELiKISEGTGFRIHMIHkaavaakkfGPKSSK-----KFDILVTTPNRLIYLLKQDPPGIDlaSVEWLVVDE 319
Cdd:PRK00254 82 EEKYREF-KDWEKLGLRVAMTT---------GDYDSTdewlgKYDIIIATAEKFDSLLRHGSSWIK--DVKLVVADE 146
|
|
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
197-319 |
2.41e-07 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 51.45 E-value: 2.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 197 PVMLHGRELLASAPTGSGKTLAFSipILMqLKQPANKGFRALIISPTRELASQIHRELIKISEGTGFRI--HMIHKaava 274
Cdd:cd18026 28 PGLLEGRNLVYSLPTSGGKTLVAE--ILM-LKRLLERRKKALFVLPYVSIVQEKVDALSPLFEELGFRVegYAGNK---- 100
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 4689114 275 aKKFGPKSSKKFDILVTTP-------NRLIYLLKQDppgiDLASVewlVVDE 319
Cdd:cd18026 101 -GRSPPKRRKSLSVAVCTIekanslvNSLIEEGRLD----ELGLV---VVDE 144
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
398-512 |
3.95e-07 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 49.86 E-value: 3.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 398 KLLAVRELVKKGfnpPVLVFVQSieR------AKEL----FHeliyeginvdviHAERTQQQRDnTVHS-FRAGKIWVLI 466
Cdd:cd18795 33 VLLKIETVSEGK---PVLVFCSS--RkecektAKDLagiaFH------------HAGLTREDRE-LVEElFREGLIKVLV 94
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4689114 467 CTALLArgidfKGVNL----VI----------NYDFPTSSvEYIHRIGRTGRAG--NKGKAI 512
Cdd:cd18795 95 ATSTLA-----AGVNLpartVIikgtqrydgkGYRELSPL-EYLQMIGRAGRPGfdTRGEAI 150
|
|
| DDXDc_reverse_gyrase |
cd17924 |
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ... |
200-325 |
5.48e-07 |
|
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350682 [Multi-domain] Cd Length: 189 Bit Score: 50.40 E-value: 5.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 200 LHGRELLASAPTGSGKT---LAFSIPIlmqlkqpANKGFRALIISPTRELASQIHRELIKISEGTGFRIHMIHKAAVAAK 276
Cdd:cd17924 30 LRGKSFAIIAPTGVGKTtfgLATSLYL-------ASKGKRSYLIFPTKSLVKQAYERLSKYAEKAGVEVKILVYHSRLKK 102
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 4689114 277 KFGPKSSKK-----FDILVTTpNRLIY----LLKQDPPGIdlasvewLVVDESDKLLK 325
Cdd:cd17924 103 KEKEELLEKiekgdFDILVTT-NQFLSknfdLLSNKKFDF-------VFVDDVDAVLK 152
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
190-319 |
1.22e-06 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 48.46 E-value: 1.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 190 PIQMQAIPVML---HGRELLASAPTGSGKTLaFSIPILMQLKQpankgFRALIISPTRELASQIHRELIKISEGtgfriH 266
Cdd:cd17926 3 PYQEEALEAWLahkNNRRGILVLPTGSGKTL-TALALIAYLKE-----LRTLIVVPTDALLDQWKERFEDFLGD-----S 71
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 4689114 267 MIHkaavaakKFGPKSSKKFD---ILVTTPNRLIYLLKQDPPGIDLASVewLVVDE 319
Cdd:cd17926 72 SIG-------LIGGGKKKDFDdanVVVATYQSLSNLAEEEKDLFDQFGL--LIVDE 118
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
191-253 |
4.13e-06 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 47.74 E-value: 4.13e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4689114 191 IQMQAIPVMLHGRE-LLASAPTGSGKTLAFSIPILMQLKQPANKG---FRALIISPTRELASQIHRE 253
Cdd:cd18023 5 IQSEVFPDLLYSDKnFVVSAPTGSGKTVLFELAILRLLKERNPLPwgnRKVVYIAPIKALCSEKYDD 71
|
|
| PRK09751 |
PRK09751 |
putative ATP-dependent helicase Lhr; Provisional |
209-503 |
5.18e-06 |
|
putative ATP-dependent helicase Lhr; Provisional
Pssm-ID: 137505 [Multi-domain] Cd Length: 1490 Bit Score: 49.92 E-value: 5.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 209 APTGSGKTLA---FSIPILMQLKQPANK------GFRALIISPTRELASQIHRELIKISEGTG------------FRIHM 267
Cdd:PRK09751 3 APTGSGKTLAaflYALDRLFREGGEDTReahkrkTSRILYISPIKALGTDVQRNLQIPLKGIAderrrrgetevnLRVGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 268 IHKAAVAAKKFGpKSSKKFDILVTTPNRLiYLLKQDPPGIDLASVEWLVVDESDKLLKMQTGSEtswLPFSW----PAHP 343
Cdd:PRK09751 83 RTGDTPAQERSK-LTRNPPDILITTPESL-YLMLTSRARETLRGVETVIIDEVHAVAGSKRGAH---LALSLerldALLH 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 344 TRSEEPMFSATF--AYDVEQWCNSTWTMSSVCPLEARNSAVETV-----EQELLFVGSETG------KLLAVRELVKKGF 410
Cdd:PRK09751 158 TSAQRIGLSATVrsASDVAAFLGGDRPVTVVNPPAMRHPQIRIVvpvanMDDVSSVASGTGedshagREGSIWPYIETGI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 411 NPPVL------VFVQS-------IERAKELFHELI------------YEGIN---------VDVI-----HAERTQQQRD 451
Cdd:PRK09751 238 LDEVLrhrstiVFTNSrglaeklTARLNELYAARLqrspsiavdaahFESTSgatsnrvqsSDVFiarshHGSVSKEQRA 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 4689114 452 NTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTG 503
Cdd:PRK09751 318 ITEQALKSGELRCVVATSSLELGIDMGAVDLVIQVATPLSVASGLQRIGRAG 369
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
188-264 |
7.63e-06 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 46.64 E-value: 7.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 188 PTPIQMQAIPVMLHG------RELLASAPTGSGKTLAFSIPILMQLkqpaNKGFRALIISPTRELASQIHREL------I 255
Cdd:cd17918 16 LTKDQAQAIKDIEKDlhspepMDRLLSGDVGSGKTLVALGAALLAY----KNGKQVAILVPTEILAHQHYEEArkflpfI 91
|
....*....
gi 4689114 256 KISEGTGFR 264
Cdd:cd17918 92 NVELVTGGT 100
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
415-516 |
9.89e-06 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 44.86 E-value: 9.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 415 LVFVQSIERAKELFHELIYEGINVDVIHAERTQQQR-DNTVHSFRAGKIW--VLICTALLARGIDFKGVNLVInYDFPT- 490
Cdd:cd18799 10 LIFCVSIEHAEFMAEAFNEAGIDAVALNSDYSDRERgDEALILLFFGELKppILVTVDLLTTGVDIPEVDNVV-FLRPTe 88
|
90 100
....*....|....*....|....*..
gi 4689114 491 SSVEYIHRIGR-TGRAGNKgkaiTFFT 516
Cdd:cd18799 89 SRTLFLQMLGRgLRLHEGK----DFFT 111
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
394-512 |
1.03e-05 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 45.71 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 394 SETGKLLAvrELVKKGFNppVLVFVQS---IER-AKELFHELIYEGINVDVIHAER---TQQQRDNTVHSFRAGKIWVLI 466
Cdd:cd18797 22 REAARLFA--DLVRAGVK--TIVFCRSrklAELlLRYLKARLVEEGPLASKVASYRagyLAEDRREIEAELFNGELLGVV 97
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 4689114 467 CTALLARGIDFKGVNLVINYDFPTSSVEYIHRIGRTGRAGNKGKAI 512
Cdd:cd18797 98 ATNALELGIDIGGLDAVVLAGYPGSLASLWQQAGRAGRRGKDSLVI 143
|
|
| SF2_C_RecG_TRCF |
cd18792 |
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family ... |
418-527 |
1.10e-05 |
|
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family contains recombination factor RecG and transcription-repair coupling factor TrcF. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350179 [Multi-domain] Cd Length: 160 Bit Score: 45.72 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 418 VQSIERAKELFHELIYEgINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVEYIH 497
Cdd:cd18792 44 LKSIEALAEELKELVPE-ARVALLHGKMTEDEKEAVMLEFREGEYDILVSTTVIEVGIDVPNANTMIIEDADRFGLSQLH 122
|
90 100 110
....*....|....*....|....*....|.
gi 4689114 498 RI-GRTGRAGNKGKAitFFTEDDKPLLRSVA 527
Cdd:cd18792 123 QLrGRVGRGKHQSYC--YLLYPDPKKLTETA 151
|
|
| SF2_C_priA |
cd18804 |
C-terminal helicase domain of ATP-dependent helicase PriA; PriA, also known as replication ... |
413-526 |
1.40e-05 |
|
C-terminal helicase domain of ATP-dependent helicase PriA; PriA, also known as replication factor Y or primosomal protein N', is a 3'-->5' DNA helicase that acts to remodel stalled replication forks and as a specificity factor for origin-independent assembly of a new replisome at the stalled fork. PriA is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350191 [Multi-domain] Cd Length: 238 Bit Score: 46.85 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 413 PVLVFV----QSIERA-KELFHEliYEGINVDVIHAeRTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLV--IN 485
Cdd:cd18804 94 EDLVFKgigtERVEEElKTLFPE--ARIARIDRDTT-RKKGALEKLLDQFERGEIDILIGTQMIAKGLDFPNVTLVgiLN 170
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 4689114 486 YDFPTSSVEY---------IHRI-GRTGRAGNKGKAI--TFFTEDdkPLLRSV 526
Cdd:cd18804 171 ADSGLNSPDFraserafqlLTQVsGRAGRGDKPGKVIiqTYNPEH--PLIQAA 221
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
359-517 |
1.76e-05 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 44.93 E-value: 1.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 359 VEQWCNSTwtmssvcPLEARNSAVETVEQE--LLFVGSeTGKLLAVRELVKKGFNP-PVLVFVQSIERAKElfhelIYEG 435
Cdd:cd18789 2 AEIRCPMT-------PEFYREYLGLGAHRKrrLLAAMN-PNKLRALEELLKRHEQGdKIIVFTDNVEALYR-----YAKR 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 436 INVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDF--KGVNLVINYDFpTSSVEYIHRIGRTGRAGNKGKAIT 513
Cdd:cd18789 69 LLKPFITGETPQSEREEILQNFREGEYNTLVVSKVGDEGIDLpeANVAIQISGHG-GSRRQEAQRLGRILRPKKGGGKNA 147
|
....
gi 4689114 514 FFTE 517
Cdd:cd18789 148 FFYS 151
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
190-319 |
2.53e-05 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 47.26 E-value: 2.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 190 PIQMQAIPV-MLHGRELLASAPTGSGKTLafsIPILMQLKQPANKGfRALIISPTRELASQIHRELIKISEgTGFRIhmi 268
Cdd:PRK02362 26 PPQAEAVEAgLLDGKNLLAAIPTASGKTL---IAELAMLKAIARGG-KALYIVPLRALASEKFEEFERFEE-LGVRV--- 97
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 4689114 269 hkaAVAAKKFGPKSS--KKFDILVTTPNRLIYLLKQDPPGIDLASVewLVVDE 319
Cdd:PRK02362 98 ---GISTGDYDSRDEwlGDNDIIVATSEKVDSLLRNGAPWLDDITC--VVVDE 145
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
175-319 |
2.92e-05 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 45.32 E-value: 2.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 175 RLLQNILdaGFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIP-ILMQLKQPAnkgfRALIISPTREL-ASQIHR 252
Cdd:cd18018 2 KLLRRVF--GHPSFRPGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLPaLLLRRRGPG----LTLVVSPLIALmKDQVDA 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4689114 253 eLIKISEGTgfRIHMIHKAAVAAKKFGPKSSKKFDILVTTPNRL-----IYLLKQdPPGIDLasvewLVVDE 319
Cdd:cd18018 76 -LPRAIKAA--ALNSSLTREERRRILEKLRAGEVKILYVSPERLvnesfRELLRQ-TPPISL-----LVVDE 138
|
|
| VirD4 |
COG3505 |
Type IV secretory pathway, VirD4 component, TraG/TraD family ATPase [Intracellular trafficking, ... |
209-269 |
6.58e-05 |
|
Type IV secretory pathway, VirD4 component, TraG/TraD family ATPase [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 442728 [Multi-domain] Cd Length: 402 Bit Score: 45.75 E-value: 6.58e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4689114 209 APTGSGKTLAFSIPILMQLKqpanKGFRALIISPTRELASQIHRELIKisegTGFRIHMIH 269
Cdd:COG3505 6 GPTGSGKTVGLVIPNLTQLA----RGESVVVTDPKGDLAELTAGFRRR----AGYDVYVFD 58
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
184-242 |
9.92e-05 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 43.68 E-value: 9.92e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 4689114 184 GFQMPTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMqlkqpaNKGFrALIISP 242
Cdd:cd17920 9 GYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPALL------LDGV-TLVVSP 60
|
|
| SF2_C_UvrB |
cd18790 |
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) ... |
402-512 |
1.31e-04 |
|
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) plays a central role in nucleotide excision repair (NER). Together with other components of the NER system, like UvrA, UvrC, UvrD (helicase II), and DNA polymerase I, it recognizes and cleaves damaged DNA in a multistep ATP-dependent reaction. UvrB is critical for the second phase of damage recognition by verifying the nature of the damage and forming the pre-incision complex. Its ATPase site becomes activated in the presence of UvrA and damaged DNA. Its activity is strand destabilization via distortion of the DNA at lesion site, with very limited DNA unwinding. UvrB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350177 [Multi-domain] Cd Length: 171 Bit Score: 43.00 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 402 VRELVKKGFNppVLVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVN 481
Cdd:cd18790 20 IRKRVARGER--VLVTTLTKRMAEDLTEYLQELGVKVRYLHSEIDTLERVEIIRDLRLGEFDVLVGINLLREGLDLPEVS 97
|
90 100 110
....*....|....*....|....*....|....*.
gi 4689114 482 LVINYD-----FPTSSVEYIHRIGRTGRAGNkGKAI 512
Cdd:cd18790 98 LVAILDadkegFLRSETSLIQTIGRAARNVN-GKVI 132
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
188-319 |
2.53e-04 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 42.42 E-value: 2.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 188 PTPIQMQAIPVMLHGRELLASAPTGSGKTLAfSIPILMQL--KQPANKGFRALIISPTRELASQIHRELIKISEGTGFRI 265
Cdd:cd17927 3 PRNYQLELAQPALKGKNTIICLPTGSGKTFV-AVLICEHHlkKFPAGRKGKVVFLANKVPLVEQQKEVFRKHFERPGYKV 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 4689114 266 HMIhKAAVAAKKFGPKSSKKFDILVTTPNRLIYLLKqDPPGIDLASVEWLVVDE 319
Cdd:cd17927 82 TGL-SGDTSENVSVEQIVESSDVIIVTPQILVNDLK-SGTIVSLSDFSLLVFDE 133
|
|
| DEXHc_ASCC3_2 |
cd18022 |
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
190-293 |
3.39e-04 |
|
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350780 [Multi-domain] Cd Length: 189 Bit Score: 41.98 E-value: 3.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 190 PIQMQAIPVMLHGRE-LLASAPTGSGKTLAFSIPILMQLKQpaNKGFRALIISPTRELAsqihRELI-----KISEGTGF 263
Cdd:cd18022 4 PIQTQVFHTLYHTDNnVLLGAPTGSGKTIAAELAMFRAFNK--YPGSKVVYIAPLKALV----RERVddwkkRFEEKLGK 77
|
90 100 110
....*....|....*....|....*....|
gi 4689114 264 RIHMIHKAAVAakkfGPKSSKKFDILVTTP 293
Cdd:cd18022 78 KVVELTGDVTP----DMKALADADIIITTP 103
|
|
| DEXHc_RLR |
cd18036 |
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ... |
188-301 |
3.49e-04 |
|
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350794 [Multi-domain] Cd Length: 204 Bit Score: 42.08 E-value: 3.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 188 PTPIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQ--PANKGFRALIISPTRELASQIHRELIKISEGtGFRI 265
Cdd:cd18036 3 LRNYQLELVLPALRGKNTIICAPTGSGKTRVAVYICRHHLEKrrSAGEKGRVVVLVNKVPLVEQQLEKFFKYFRK-GYKV 81
|
90 100 110
....*....|....*....|....*....|....*.
gi 4689114 266 HMIHkAAVAAKKFGPKSSKKFDILVTTPNRLIYLLK 301
Cdd:cd18036 82 TGLS-GDSSHKVSFGQIVKASDVIICTPQILINNLL 116
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
190-297 |
4.56e-04 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 41.48 E-value: 4.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 190 PIQMQAIPVMLHGRE-LLASAPTGSGKTLAFSIPILMQLKQPANKgfRALIISPTRELASQIHRELikisegtgfrihmi 268
Cdd:cd18021 6 PIQTQVFNSLYNTDDnVFVGAPTGSGKTVCAELALLRHWRQNPKG--RAVYIAPMQELVDARYKDW-------------- 69
|
90 100 110
....*....|....*....|....*....|..
gi 4689114 269 hkaavaAKKFGPKSSKKFDIL---VTTPNRLI 297
Cdd:cd18021 70 ------RAKFGPLLGKKVVKLtgeTSTDLKLL 95
|
|
| DEXHc_ASCC3_1 |
cd18020 |
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
191-319 |
6.31e-04 |
|
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350778 [Multi-domain] Cd Length: 199 Bit Score: 41.26 E-value: 6.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 191 IQMQAIPVMLHGRE-LLASAPTGSGKTLAFSIPILMQLKQPANKG-------FRALIISPTRELASQIHREL-------- 254
Cdd:cd18020 5 IQSLVFPVAYKTNEnMLICAPTGAGKTNIAMLTILHEIRQHVNQGgvikkddFKIVYIAPMKALAAEMVEKFskrlaplg 84
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4689114 255 IKISEGTGfriHM-IHKAAVAAKKfgpksskkfdILVTTPNRLIYLLKQDPPGIDLAS-VEWLVVDE 319
Cdd:cd18020 85 IKVKELTG---DMqLTKKEIAETQ----------IIVTTPEKWDVVTRKSSGDVALSQlVRLLIIDE 138
|
|
| DEXHc_RecQ1 |
cd18015 |
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ ... |
175-242 |
7.10e-04 |
|
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350773 [Multi-domain] Cd Length: 209 Bit Score: 41.20 E-value: 7.10e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 175 RLLQNIldagFQMPT--PIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMqlkqpaNKGFrALIISP 242
Cdd:cd18015 8 DTLKNV----FKLEKfrPLQLETINATMAGRDVFLVMPTGGGKSLCYQLPALC------SDGF-TLVVSP 66
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
201-319 |
8.60e-04 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 40.63 E-value: 8.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 201 HGRELLASAPtGSGKTLAfSIPILMQLKQPANKGFRALIISPtrelASQIH---RELIKISEGtgFRIHMIHKA-AVAAK 276
Cdd:cd17919 19 GPGGILADEM-GLGKTLQ-AIAFLAYLLKEGKERGPVLVVCP----LSVLEnweREFEKWTPD--LRVVVYHGSqRERAQ 90
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 4689114 277 KFGPKSSKKFDILVTTPNRLIYLLKQdppgidLASVEW--LVVDE 319
Cdd:cd17919 91 IRAKEKLDKFDVVLTTYETLRRDKAS------LRKFRWdlVVVDE 129
|
|
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
190-257 |
9.89e-04 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 42.23 E-value: 9.89e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4689114 190 PIQMQAIPVMLHGRELLASAPTGSGKTLAFSIPILMQLKQpankGFRALIISPTRELASQIHRELIKI 257
Cdd:COG4581 28 PFQEEAILALEAGRSVLVAAPTGSGKTLVAEFAIFLALAR----GRRSFYTAPIKALSNQKFFDLVER 91
|
|
| TrwB_TraG_TraD_VirD4 |
cd01127 |
TrwB/TraG/TraD/VirD4 family of bacterial conjugation proteins; The TraG/TraD/VirD4 family are ... |
209-246 |
1.18e-03 |
|
TrwB/TraG/TraD/VirD4 family of bacterial conjugation proteins; The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion (T4S) systems, versatile bacterial secretion systems mediating transport of protein and/or DNA. They are present in gram-negative and gram-positive bacteria, as well as archaea. They form hexameric rings and belong to the RecA-like NTPases superfamily, which also includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases.
Pssm-ID: 410871 [Multi-domain] Cd Length: 144 Bit Score: 39.51 E-value: 1.18e-03
10 20 30
....*....|....*....|....*....|....*...
gi 4689114 209 APTGSGKTLAFSIPILMQlkqpANKGFRALIISPTREL 246
Cdd:cd01127 6 GTTGSGKTTSIVIPLLDQ----AARGGSVIITDPKGEL 39
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
201-319 |
1.39e-03 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 40.01 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 201 HGRELLaSAPTGSGKTLAfsIPILMqLKQPANKGFRALIISPTRELASQIHRELIK-----ISEGTGFRIHMIHkaavaa 275
Cdd:cd17990 17 GGQVVL-EAPPGAGKTTR--VPLAL-LAELWIAGGKIIVLEPRRVAARAAARRLATllgeaPGETVGYRVRGES------ 86
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 4689114 276 kkfgpKSSKKFDILVTTPNRLIYLLKQDPpgiDLASVEWLVVDE 319
Cdd:cd17990 87 -----RVGRRTRVEVVTEGVLLRRLQRDP---ELSGVGAVILDE 122
|
|
| DEAHc_XPD-like |
cd17915 |
DEAH-box helicase domain of XPD family DEAD-like helicases; The xeroderma pigmentosum group D ... |
209-323 |
1.79e-03 |
|
DEAH-box helicase domain of XPD family DEAD-like helicases; The xeroderma pigmentosum group D (XPD)-like family members are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350673 [Multi-domain] Cd Length: 138 Bit Score: 38.95 E-value: 1.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 209 APTGSGKTLaFSIPILMQLkQPANKGFRALIISPTRELASQIHRELIKISEGTGFRihmihkaavaakkFGPKSSKKFDI 288
Cdd:cd17915 8 SPTGSGKTL-SLLCSALSY-QREFHKTKVLYCSRTHSQIEQIIRELRKLLEKRKIR-------------ALALSSRDADI 72
|
90 100 110
....*....|....*....|....*....|....*
gi 4689114 289 LVTTPNRLIYLLKQDPPGIDLaSVEWLVVDESDKL 323
Cdd:cd17915 73 VVLPYPYLLDARIREFIGIDL-REQVVIIDEAHNL 106
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
188-320 |
1.80e-03 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 39.58 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 188 PTPIQMQAI----PVMLHGRE-LLASAPTGSGKTL-AFSIPILMQLKQPANKgfrALIISPTRELASQIHRELIKISEGT 261
Cdd:pfam04851 4 LRPYQIEAIenllESIKNGQKrGLIVMATGSGKTLtAAKLIARLFKKGPIKK---VLFLVPRKDLLEQALEEFKKFLPNY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4689114 262 GFRIhmihkaAVAAKKFGPKSSKKFDILVTTPNRL--IYLLKQDPPGIDLASVewLVVDES 320
Cdd:pfam04851 81 VEIG------EIISGDKKDESVDDNKIVVTTIQSLykALELASLELLPDFFDV--IIIDEA 133
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
206-319 |
2.32e-03 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 39.56 E-value: 2.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 206 LASAPTGSGKTLafsIPILM------QLKQPANKGFRALIISPTRELASQIHRElikISEGTGFRIHMIHKAAVAAKKFG 279
Cdd:cd18034 20 IVVLPTGSGKTL---IAVMLikemgeLNRKEKNPKKRAVFLVPTVPLVAQQAEA---IRSHTDLKVGEYSGEMGVDKWTK 93
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 4689114 280 PKSS---KKFDILVTTPNRLIYLLKQdppG-IDLASVEWLVVDE 319
Cdd:cd18034 94 ERWKeelEKYDVLVMTAQILLDALRH---GfLSLSDINLLIFDE 134
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
415-524 |
4.30e-03 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 40.08 E-value: 4.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4689114 415 LVFVQSIERAKELFHELIYEGINVDVIHAERTQQQRDNTVHSFRAGKIWVLICTALLARGIDFKGVNLVINYDFPTSSVE 494
Cdd:PRK11057 240 IIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIES 319
|
90 100 110
....*....|....*....|....*....|
gi 4689114 495 YIHRIGRTGRAGNKGKAITFFTEDDKPLLR 524
Cdd:PRK11057 320 YYQETGRAGRDGLPAEAMLFYDPADMAWLR 349
|
|
| |
