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Conserved domains on  [gi|6760423|gb|AAF28345|]
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Toll-like receptor 2 [Mus musculus]

Protein Classification

toll-like receptor( domain architecture ID 18785053)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
640-784 3.30e-39

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 141.69  E-value: 3.30e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423     640 CYDAFVSYSEQDshWVENLMVQQLENSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDF 719
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6760423     720 SHFRLFDENNDAAILVLLEPIErKAIPQRFCKLRKIMnTKTYLEWPLDEgqQEVFWVNLRTAIKS 784
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIP-SDVRKQPGKFRKVF-KKNYLKWPEDE--KEQFWKKALYAVPS 139
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
335-555 2.55e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 2.55e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  335 LEKVKRITVENSKVFLVPCSFSQhLKSLEFLDLSENLM--VEEYLKNsackgaWPSLQTLVLSQNHLRSMqktGEILLTL 412
Cdd:COG4886 112 LTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLtdLPEPLGN------LTNLKSLDLSNNQLTDL---PEELGNL 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  413 KNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKTCIPQ--TLEVLDVSNNNLDSFSLF--LPRLQELYISRNK 488
Cdd:COG4886 182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPELgnLTNLEELDLSNNQ 261

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6760423  489 LKTLPDASLFPVLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHFVCSCELLSFTMETPALAQIL 555
Cdd:COG4886 262 LTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-295 3.30e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 3.30e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   43 FTSIPSGLT--AAMKSLDLSFNKITYIGHgDLRACANLQVLILKSSRINTIeGDAFYSLGSLEHLDLSDNHLSSLSSSwF 120
Cdd:COG4886 148 LTDLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-L 224

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  121 GPLSSLKYLNLMGNPYQTLgvtSLFPNLTNLQTLRIGN--VETFSEIrridfAGLTSLNELEIKALSLRNYQSQSLKSIR 198
Cdd:COG4886 225 ANLTNLETLDLSNNQLTDL---PELGNLTNLEELDLSNnqLTDLPPL-----ANLTNLKTLDLSNNQLTDLKLKELELLL 296

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  199 DIHHLTLHLSESAFLLEIFADILSSVRYLELRDTNLARFQFSPLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYILE 278
Cdd:COG4886 297 GLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLE 376

                       250
                ....*....|....*..
gi 6760423  279 LSEVEFDDCTLNGLGDF 295
Cdd:COG4886 377 ATLLTLALLLLTLLLLL 393
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
533-586 1.76e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 1.76e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 6760423     533 NHFVCSCELLSFTMEtpALAQILVDWPDSYLCDSPPRLHGhRLQDARPSVLECH 586
Cdd:smart00082   1 NPFICDCELRWLLRW--LQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
640-784 3.30e-39

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 141.69  E-value: 3.30e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423     640 CYDAFVSYSEQDshWVENLMVQQLENSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDF 719
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6760423     720 SHFRLFDENNDAAILVLLEPIErKAIPQRFCKLRKIMnTKTYLEWPLDEgqQEVFWVNLRTAIKS 784
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIP-SDVRKQPGKFRKVF-KKNYLKWPEDE--KEQFWKKALYAVPS 139
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 641-765 2.06e-18

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 83.18  E-value: 2.06e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423    641 YDAFVSYSEQDS-HWVENLMVQQLenSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDF 719
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVK 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 6760423    720 S-HFRLfdENNDAAILVLLEPIE---RKAI---PQRFCKLRKIMNTKTYLEWP 765
Cdd:pfam01582  79 IlECAL--DLGQKVIPIFYEVDPsdvRKQTgsfGKAFKKHKKVLTEEKVLKWR 129
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
335-555 2.55e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 2.55e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  335 LEKVKRITVENSKVFLVPCSFSQhLKSLEFLDLSENLM--VEEYLKNsackgaWPSLQTLVLSQNHLRSMqktGEILLTL 412
Cdd:COG4886 112 LTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLtdLPEPLGN------LTNLKSLDLSNNQLTDL---PEELGNL 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  413 KNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKTCIPQ--TLEVLDVSNNNLDSFSLF--LPRLQELYISRNK 488
Cdd:COG4886 182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPELgnLTNLEELDLSNNQ 261

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6760423  489 LKTLPDASLFPVLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHFVCSCELLSFTMETPALAQIL 555
Cdd:COG4886 262 LTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-295 3.30e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 3.30e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   43 FTSIPSGLT--AAMKSLDLSFNKITYIGHgDLRACANLQVLILKSSRINTIeGDAFYSLGSLEHLDLSDNHLSSLSSSwF 120
Cdd:COG4886 148 LTDLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-L 224

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  121 GPLSSLKYLNLMGNPYQTLgvtSLFPNLTNLQTLRIGN--VETFSEIrridfAGLTSLNELEIKALSLRNYQSQSLKSIR 198
Cdd:COG4886 225 ANLTNLETLDLSNNQLTDL---PELGNLTNLEELDLSNnqLTDLPPL-----ANLTNLKTLDLSNNQLTDLKLKELELLL 296

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  199 DIHHLTLHLSESAFLLEIFADILSSVRYLELRDTNLARFQFSPLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYILE 278
Cdd:COG4886 297 GLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLE 376

                       250
                ....*....|....*..
gi 6760423  279 LSEVEFDDCTLNGLGDF 295
Cdd:COG4886 377 ATLLTLALLLLTLLLLL 393
LRR_8 pfam13855
Leucine rich repeat;
77-135 3.84e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 3.84e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 6760423     77 NLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNP 135
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
340-558 2.33e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 64.33  E-value: 2.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   340 RITVENSKVFLVPCSFSQHLKSLeFLDLSENLMVEEYLKNSackgawpsLQTLVLSQNHLRSMQKT-----GEILLTLKN 414
Cdd:PRK15370 182 ELRLKILGLTTIPACIPEQITTL-ILDNNELKSLPENLQGN--------IKTLYANSNQLTSIPATlpdtiQEMELSINR 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   415 LT-----------SLDISRNTFHPMPDSCqwPEKMRFLNLSSTGIRVVKTCIPQTLEVLDVSNNNLDSFSLFLP-RLQEL 482
Cdd:PRK15370 253 ITelperlpsalqSLDLFHNKISCLPENL--PEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPpGLKTL 330

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   483 YISRNKLKTLPdASLFPVLLVMKIRENAVSTF-------------SKDQLGSFPK-----LETLEAGDNHFVCSCELL-S 543
Cdd:PRK15370 331 EAGENALTSLP-ASLPPELQVLDVSKNQITVLpetlpptittldvSRNALTNLPEnlpaaLQIMQASRNNLVRLPESLpH 409

                        250
                 ....*....|....*
gi 6760423   544 FTMETPALAQILVDW 558
Cdd:PRK15370 410 FRGEGPQPTRIIVEY 424
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 57-228 4.86e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.41  E-value: 4.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   57 LDLSFNKITYIGhgDLRACANLQVLILKSSRINTIEGdaFYSLGSLEHLDLSDNHLSSLSSswFGPLSSLKYLNLMGNpy 136
Cdd:cd21340   7 LYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN-- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  137 qTLGVTSLFPNLTNLQTLRIGNVETFSEIR-RIDFAGLTSL-NELEIkaLSLRNYQSQSLKSIRDIHHL-TLHLSESAFL 213
Cdd:cd21340  79 -RISVVEGLENLTNLEELHIENQRLPPGEKlTFDPRSLAALsNSLRV--LNISGNNIDSLEPLAPLRNLeQLDASNNQIS 155

                       170
                ....*....|....*.
gi 6760423  214 -LEIFADILSSVRYLE 228
Cdd:cd21340 156 dLEELLDLLSSWPSLR 171
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 45-489 5.50e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 5.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423    45 SIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSsriNTIEGDAFYSLG---SLEHLDLSDNHLSSLSSSWFG 121
Cdd:PLN00113 133 SIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGG---NVLVGKIPNSLTnltSLEFLTLASNQLVGQIPRELG 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   122 PLSSLK-----YLNLMGN-PYQTLGVTSL-----------------FPNLTNLQTLRIGNVETFSEIRRIDFaGLTSLNE 178
Cdd:PLN00113 210 QMKSLKwiylgYNNLSGEiPYEIGGLTSLnhldlvynnltgpipssLGNLKNLQYLFLYQNKLSGPIPPSIF-SLQKLIS 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   179 LEIKALSLRNyqsqslksirDIHHLTLHLsESAFLLEIFADILSSVRYLELrdTNLARFQFSPLPVDEVSSPMKKLAFRG 258
Cdd:PLN00113 289 LDLSDNSLSG----------EIPELVIQL-QNLEILHLFSNNFTGKIPVAL--TSLPRLQVLQLWSNKFSGEIPKNLGKH 355

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   259 SVLT--DESFNELLKllryilELSEVEFDDCTLNGLGDFNPS-ESDVVSELGKVEtvTIRRLHIPQFYLFYDLSTVYSLL 335
Cdd:PLN00113 356 NNLTvlDLSTNNLTG------EIPEGLCSSGNLFKLILFSNSlEGEIPKSLGACR--SLRRVRLQDNSFSGELPSEFTKL 427

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   336 EKVKritvenskvflvpcsfsqhlksleFLDLSENLMVEeylKNSACKGAWPSLQTLVLSQNHLrsmqkTGEI--LLTLK 413
Cdd:PLN00113 428 PLVY------------------------FLDISNNNLQG---RINSRKWDMPSLQMLSLARNKF-----FGGLpdSFGSK 475

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   414 NLTSLDISRNTFHPM-PDSC-QWPEKMRfLNLSSTGIRVVktcIPQTLEV------LDVSNNNL-----DSFSLFlPRLQ 480
Cdd:PLN00113 476 RLENLDLSRNQFSGAvPRKLgSLSELMQ-LKLSENKLSGE---IPDELSSckklvsLDLSHNQLsgqipASFSEM-PVLS 550


                 ....*....
gi 6760423   481 ELYISRNKL 489
Cdd:PLN00113 551 QLDLSQNQL 559
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-554 1.88e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.31  E-value: 1.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423    75 CANLQVLILKSSRINTIE----------GDAFYSLGSLEHLDLSDNHLS-SLSSSWFGPLSSLKYLNLMGNPYqtlgvTS 143
Cdd:PLN00113  58 CLWQGITCNNSSRVVSIDlsgknisgkiSSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNF-----TG 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   144 LFPN--LTNLQTLRIGN----------VETFSEIRRIDFAG----------LTSLNELEIKALSLRNYQSQSLKSIRDIH 201
Cdd:PLN00113 133 SIPRgsIPNLETLDLSNnmlsgeipndIGSFSSLKVLDLGGnvlvgkipnsLTNLTSLEFLTLASNQLVGQIPRELGQMK 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   202 HLT-LHLSESAFLLEIFADI--LSSVRYLELRDTNLArfqfSPLPVDEVS-SPMKKLAFRGSVLTDESFNELLKLLRYIl 277
Cdd:PLN00113 213 SLKwIYLGYNNLSGEIPYEIggLTSLNHLDLVYNNLT----GPIPSSLGNlKNLQYLFLYQNKLSGPIPPSIFSLQKLI- 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   278 elsEVEFDDCTLNGlgdfnpsesDVVSELGKVETVTIrrLHipqfyLFydlstvysllekvkritvENSKVFLVPCSFSQ 357
Cdd:PLN00113 288 ---SLDLSDNSLSG---------EIPELVIQLQNLEI--LH-----LF------------------SNNFTGKIPVALTS 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   358 hLKSLEFLDLSENLMVEEYLKNSackGAWPSLQTLVLSQNHLrsmqkTGEILLTL---KNLTSLDISRNTFH-PMPDS-- 431
Cdd:PLN00113 331 -LPRLQVLQLWSNKFSGEIPKNL---GKHNNLTVLDLSTNNL-----TGEIPEGLcssGNLFKLILFSNSLEgEIPKSlg 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   432 -CQWPEKMRFLNLSSTGIRVVKTCIPQTLEVLDVSNNNL----DSFSLFLPRLQELYISRNK-LKTLPDAS--------- 496
Cdd:PLN00113 402 aCRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLqgriNSRKWDMPSLQMLSLARNKfFGGLPDSFgskrlenld 481

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6760423   497 ---------------LFPVLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHFvcSCELLSFTMETPALAQI 554
Cdd:PLN00113 482 lsrnqfsgavprklgSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL--SGQIPASFSEMPVLSQL 552
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 387-528 5.00e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 5.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  387 PSLQTLVLSQNHLRSMqktgEILLTLKNLTSLDISRNTFHPmpdscqwPEKMRFLNLSSTGIRvvktcipQTLEVLDVSN 466
Cdd:cd21340  68 VNLKKLYLGGNRISVV----EGLENLTNLEELHIENQRLPP-------GEKLTFDPRSLAALS-------NSLRVLNISG 129

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6760423  467 NNLDSFSLF--LPRLQELYISRNKLKTLPDA----SLFPVLLVMKIRENAVSTFSK--DQL-GSFPKLETL 528
Cdd:cd21340 130 NNIDSLEPLapLRNLEQLDASNNQISDLEELldllSSWPSLRELDLTGNPVCKKPKyrDKIiLASKSLEVL 200
LRR_8 pfam13855
Leucine rich repeat;
477-535 1.20e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 1.20e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6760423    477 PRLQELYISRNKLKTLPDASLF--PVLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHF 535
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKglSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
533-586 1.76e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 1.76e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 6760423     533 NHFVCSCELLSFTMEtpALAQILVDWPDSYLCDSPPRLHGhRLQDARPSVLECH 586
Cdd:smart00082   1 NPFICDCELRWLLRW--LQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
640-784 3.30e-39

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 141.69  E-value: 3.30e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423     640 CYDAFVSYSEQDshWVENLMVQQLENSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDF 719
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6760423     720 SHFRLFDENNDAAILVLLEPIErKAIPQRFCKLRKIMnTKTYLEWPLDEgqQEVFWVNLRTAIKS 784
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIP-SDVRKQPGKFRKVF-KKNYLKWPEDE--KEQFWKKALYAVPS 139
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 641-765 2.06e-18

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 83.18  E-value: 2.06e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423    641 YDAFVSYSEQDS-HWVENLMVQQLenSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDF 719
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVK 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 6760423    720 S-HFRLfdENNDAAILVLLEPIE---RKAI---PQRFCKLRKIMNTKTYLEWP 765
Cdd:pfam01582  79 IlECAL--DLGQKVIPIFYEVDPsdvRKQTgsfGKAFKKHKKVLTEEKVLKWR 129
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
335-555 2.55e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 2.55e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  335 LEKVKRITVENSKVFLVPCSFSQhLKSLEFLDLSENLM--VEEYLKNsackgaWPSLQTLVLSQNHLRSMqktGEILLTL 412
Cdd:COG4886 112 LTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLtdLPEPLGN------LTNLKSLDLSNNQLTDL---PEELGNL 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  413 KNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKTCIPQ--TLEVLDVSNNNLDSFSLF--LPRLQELYISRNK 488
Cdd:COG4886 182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPELgnLTNLEELDLSNNQ 261

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6760423  489 LKTLPDASLFPVLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHFVCSCELLSFTMETPALAQIL 555
Cdd:COG4886 262 LTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-295 3.30e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 3.30e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   43 FTSIPSGLT--AAMKSLDLSFNKITYIGHgDLRACANLQVLILKSSRINTIeGDAFYSLGSLEHLDLSDNHLSSLSSSwF 120
Cdd:COG4886 148 LTDLPEPLGnlTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-L 224

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  121 GPLSSLKYLNLMGNPYQTLgvtSLFPNLTNLQTLRIGN--VETFSEIrridfAGLTSLNELEIKALSLRNYQSQSLKSIR 198
Cdd:COG4886 225 ANLTNLETLDLSNNQLTDL---PELGNLTNLEELDLSNnqLTDLPPL-----ANLTNLKTLDLSNNQLTDLKLKELELLL 296

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  199 DIHHLTLHLSESAFLLEIFADILSSVRYLELRDTNLARFQFSPLPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYILE 278
Cdd:COG4886 297 GLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLE 376

                       250
                ....*....|....*..
gi 6760423  279 LSEVEFDDCTLNGLGDF 295
Cdd:COG4886 377 ATLLTLALLLLTLLLLL 393
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 644-718 1.50e-14

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 70.42  E-value: 1.50e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6760423    644 FVSYSEQDSHWVENLmVQQLENSDppFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELD 718
Cdd:pfam13676   2 FISYAGEDRAWAEWL-ADALEAAG--YRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWE 73
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-300 9.52e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 9.52e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   52 AAMKSLDLSFNKITYIGHgDLRACANLQVLILKSSRINTIeGDAFYSLGSLEHLDLSDNHLSSLSSSwFGPLSSLKYLNL 131
Cdd:COG4886 113 TNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDL 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  132 MGNPYQTLGVTslFPNLTNLQTLRIGNvetfSEIRRI--DFAGLTSLNEleikaLSLRNYQSQSLKSIRDIHHLT-LHLS 208
Cdd:COG4886 190 SNNQITDLPEP--LGNLTNLEELDLSG----NQLTDLpePLANLTNLET-----LDLSNNQLTDLPELGNLTNLEeLDLS 258

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  209 ESAFLLEIFADILSSVRYLELRDTNLARFQFSPLPVD-EVSSPMKKLAFRGSVLTDESFNELLKLLRYILELSEVEFDDC 287
Cdd:COG4886 259 NNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLlGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338

                       250
                ....*....|...
gi 6760423  288 TLNGLGDFNPSES 300
Cdd:COG4886 339 TLALSLSLLALLT 351
LRR_8 pfam13855
Leucine rich repeat;
77-135 3.84e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.47  E-value: 3.84e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 6760423     77 NLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNP 135
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
267-545 3.78e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 3.78e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  267 NELLKLLRYILELSEVEFDDCTLNGLGDFNPSESDVVSELGKVETVTIRRLHIpqfylfYDLSTVYSLLEKVKRITVENS 346
Cdd:COG4886  73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQL------TDLPEELANLTNLKELDLSNN 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  347 KVFLVPCSFSQhLKSLEFLDLSENLMVEeyLKNSAckGAWPSLQTLVLSQNHLRSMQKTgeiLLTLKNLTSLDISRNTFH 426
Cdd:COG4886 147 QLTDLPEPLGN-LTNLKSLDLSNNQLTD--LPEEL--GNLTNLKELDLSNNQITDLPEP---LGNLTNLEELDLSGNQLT 218

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  427 PMPDSCQWPEKMRFLNLSSTGIrvvkTCIPQ-----TLEVLDVSNNNLDSF--SLFLPRLQELYISRNKLKTLPDASLFP 499
Cdd:COG4886 219 DLPEPLANLTNLETLDLSNNQL----TDLPElgnltNLEELDLSNNQLTDLppLANLTNLKTLDLSNNQLTDLKLKELEL 294

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 6760423  500 VLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHFVCSCELLSFT 545
Cdd:COG4886 295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-273 1.07e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 1.07e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   55 KSLDLSFNKityighgDLRACANLQVLILKSSRINTIeGDAFYSLGSLEHLDLSDNHLSSLSSSwFGPLSSLKYLNLMGN 134
Cdd:COG4886  99 TELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNN 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  135 PYQTLGvtSLFPNLTNLQTLRIGN--VETFSEirriDFAGLTSLNEleikaLSLRNYQSQSL-KSIRDIHHLT-LHLSES 210
Cdd:COG4886 170 QLTDLP--EELGNLTNLKELDLSNnqITDLPE----PLGNLTNLEE-----LDLSGNQLTDLpEPLANLTNLEtLDLSNN 238

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6760423  211 AflLEIFADI--LSSVRYLELRDTNLARfqfspLPVDEVSSPMKKLAFRGSVLTDESFNELLKLL 273
Cdd:COG4886 239 Q--LTDLPELgnLTNLEELDLSNNQLTD-----LPPLANLTNLKTLDLSNNQLTDLKLKELELLL 296
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
340-558 2.33e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 64.33  E-value: 2.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   340 RITVENSKVFLVPCSFSQHLKSLeFLDLSENLMVEEYLKNSackgawpsLQTLVLSQNHLRSMQKT-----GEILLTLKN 414
Cdd:PRK15370 182 ELRLKILGLTTIPACIPEQITTL-ILDNNELKSLPENLQGN--------IKTLYANSNQLTSIPATlpdtiQEMELSINR 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   415 LT-----------SLDISRNTFHPMPDSCqwPEKMRFLNLSSTGIRVVKTCIPQTLEVLDVSNNNLDSFSLFLP-RLQEL 482
Cdd:PRK15370 253 ITelperlpsalqSLDLFHNKISCLPENL--PEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPpGLKTL 330

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   483 YISRNKLKTLPdASLFPVLLVMKIRENAVSTF-------------SKDQLGSFPK-----LETLEAGDNHFVCSCELL-S 543
Cdd:PRK15370 331 EAGENALTSLP-ASLPPELQVLDVSKNQITVLpetlpptittldvSRNALTNLPEnlpaaLQIMQASRNNLVRLPESLpH 409

                        250
                 ....*....|....*
gi 6760423   544 FTMETPALAQILVDW 558
Cdd:PRK15370 410 FRGEGPQPTRIIVEY 424
LRR_8 pfam13855
Leucine rich repeat;
55-112 8.82e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 8.82e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 6760423     55 KSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNHL 112
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 57-228 4.86e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.41  E-value: 4.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   57 LDLSFNKITYIGhgDLRACANLQVLILKSSRINTIEGdaFYSLGSLEHLDLSDNHLSSLSSswFGPLSSLKYLNLMGNpy 136
Cdd:cd21340   7 LYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN-- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  137 qTLGVTSLFPNLTNLQTLRIGNVETFSEIR-RIDFAGLTSL-NELEIkaLSLRNYQSQSLKSIRDIHHL-TLHLSESAFL 213
Cdd:cd21340  79 -RISVVEGLENLTNLEELHIENQRLPPGEKlTFDPRSLAALsNSLRV--LNISGNNIDSLEPLAPLRNLeQLDASNNQIS 155

                       170
                ....*....|....*.
gi 6760423  214 -LEIFADILSSVRYLE 228
Cdd:cd21340 156 dLEELLDLLSSWPSLR 171
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 72-135 3.85e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 3.85e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6760423   72 LRACAN-LQVLILKSSRINTIEGdaFYSLGSLEHLDLSDNHLSSLS--SSWFGPLSSLKYLNLMGNP 135
Cdd:cd21340 115 LAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNP 179
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 45-489 5.50e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 5.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423    45 SIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSsriNTIEGDAFYSLG---SLEHLDLSDNHLSSLSSSWFG 121
Cdd:PLN00113 133 SIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGG---NVLVGKIPNSLTnltSLEFLTLASNQLVGQIPRELG 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   122 PLSSLK-----YLNLMGN-PYQTLGVTSL-----------------FPNLTNLQTLRIGNVETFSEIRRIDFaGLTSLNE 178
Cdd:PLN00113 210 QMKSLKwiylgYNNLSGEiPYEIGGLTSLnhldlvynnltgpipssLGNLKNLQYLFLYQNKLSGPIPPSIF-SLQKLIS 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   179 LEIKALSLRNyqsqslksirDIHHLTLHLsESAFLLEIFADILSSVRYLELrdTNLARFQFSPLPVDEVSSPMKKLAFRG 258
Cdd:PLN00113 289 LDLSDNSLSG----------EIPELVIQL-QNLEILHLFSNNFTGKIPVAL--TSLPRLQVLQLWSNKFSGEIPKNLGKH 355

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   259 SVLT--DESFNELLKllryilELSEVEFDDCTLNGLGDFNPS-ESDVVSELGKVEtvTIRRLHIPQFYLFYDLSTVYSLL 335
Cdd:PLN00113 356 NNLTvlDLSTNNLTG------EIPEGLCSSGNLFKLILFSNSlEGEIPKSLGACR--SLRRVRLQDNSFSGELPSEFTKL 427

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   336 EKVKritvenskvflvpcsfsqhlksleFLDLSENLMVEeylKNSACKGAWPSLQTLVLSQNHLrsmqkTGEI--LLTLK 413
Cdd:PLN00113 428 PLVY------------------------FLDISNNNLQG---RINSRKWDMPSLQMLSLARNKF-----FGGLpdSFGSK 475

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   414 NLTSLDISRNTFHPM-PDSC-QWPEKMRfLNLSSTGIRVVktcIPQTLEV------LDVSNNNL-----DSFSLFlPRLQ 480
Cdd:PLN00113 476 RLENLDLSRNQFSGAvPRKLgSLSELMQ-LKLSENKLSGE---IPDELSSckklvsLDLSHNQLsgqipASFSEM-PVLS 550


                 ....*....
gi 6760423   481 ELYISRNKL 489
Cdd:PLN00113 551 QLDLSQNQL 559
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-235 8.19e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 8.19e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   43 FTSIPSGLTA--AMKSLDLSFNKITYIGhgDLRACANLQVLILKSSRINTIegDAFYSLGSLEHLDLSDNHLSSLSSSWF 120
Cdd:COG4886 217 LTDLPEPLANltNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKEL 292

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  121 GPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGNVETFSEirrIDFAGLTSLNELEIKALSLRNYQSQSLKSIRDI 200
Cdd:COG4886 293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT---LTTLALSLSLLALLTLLLLLNLLSLLLTLLLTL 369

                       170       180       190
                ....*....|....*....|....*....|....*
gi 6760423  201 HHLTLHLSESAFLLEIFADILSSVRYLELRDTNLA 235
Cdd:COG4886 370 GLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLT 404
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-554 1.88e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.31  E-value: 1.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423    75 CANLQVLILKSSRINTIE----------GDAFYSLGSLEHLDLSDNHLS-SLSSSWFGPLSSLKYLNLMGNPYqtlgvTS 143
Cdd:PLN00113  58 CLWQGITCNNSSRVVSIDlsgknisgkiSSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNF-----TG 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   144 LFPN--LTNLQTLRIGN----------VETFSEIRRIDFAG----------LTSLNELEIKALSLRNYQSQSLKSIRDIH 201
Cdd:PLN00113 133 SIPRgsIPNLETLDLSNnmlsgeipndIGSFSSLKVLDLGGnvlvgkipnsLTNLTSLEFLTLASNQLVGQIPRELGQMK 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   202 HLT-LHLSESAFLLEIFADI--LSSVRYLELRDTNLArfqfSPLPVDEVS-SPMKKLAFRGSVLTDESFNELLKLLRYIl 277
Cdd:PLN00113 213 SLKwIYLGYNNLSGEIPYEIggLTSLNHLDLVYNNLT----GPIPSSLGNlKNLQYLFLYQNKLSGPIPPSIFSLQKLI- 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   278 elsEVEFDDCTLNGlgdfnpsesDVVSELGKVETVTIrrLHipqfyLFydlstvysllekvkritvENSKVFLVPCSFSQ 357
Cdd:PLN00113 288 ---SLDLSDNSLSG---------EIPELVIQLQNLEI--LH-----LF------------------SNNFTGKIPVALTS 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   358 hLKSLEFLDLSENLMVEEYLKNSackGAWPSLQTLVLSQNHLrsmqkTGEILLTL---KNLTSLDISRNTFH-PMPDS-- 431
Cdd:PLN00113 331 -LPRLQVLQLWSNKFSGEIPKNL---GKHNNLTVLDLSTNNL-----TGEIPEGLcssGNLFKLILFSNSLEgEIPKSlg 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   432 -CQWPEKMRFLNLSSTGIRVVKTCIPQTLEVLDVSNNNL----DSFSLFLPRLQELYISRNK-LKTLPDAS--------- 496
Cdd:PLN00113 402 aCRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLqgriNSRKWDMPSLQMLSLARNKfFGGLPDSFgskrlenld 481

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6760423   497 ---------------LFPVLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHFvcSCELLSFTMETPALAQI 554
Cdd:PLN00113 482 lsrnqfsgavprklgSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL--SGQIPASFSEMPVLSQL 552
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 54-177 2.20e-05

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 44.46  E-value: 2.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423     54 MKSLDLSfNKITYIGHGDLRACANLQVLILKSSrINTIEGDAFYSLgSLEHLDLSDNhLSSLSSSWFGPLSSLKYLNLMG 133
Cdd:pfam13306  13 LTSITIP-SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLKSITLPS 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 6760423    134 NpyqtlgVTSLFPNL---TNLQTLRIGNveTFSEIRRIDFAGLTSLN 177
Cdd:pfam13306  89 N------LTSIGSYAfsnCSLKSITIPS--SVTTIGSYAFSNCSNLK 127
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 387-528 5.00e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 5.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  387 PSLQTLVLSQNHLRSMqktgEILLTLKNLTSLDISRNTFHPmpdscqwPEKMRFLNLSSTGIRvvktcipQTLEVLDVSN 466
Cdd:cd21340  68 VNLKKLYLGGNRISVV----EGLENLTNLEELHIENQRLPP-------GEKLTFDPRSLAALS-------NSLRVLNISG 129

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6760423  467 NNLDSFSLF--LPRLQELYISRNKLKTLPDA----SLFPVLLVMKIRENAVSTFSK--DQL-GSFPKLETL 528
Cdd:cd21340 130 NNIDSLEPLapLRNLEQLDASNNQISDLEELldllSSWPSLRELDLTGNPVCKKPKyrDKIiLASKSLEVL 200
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
39-243 6.58e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.61  E-value: 6.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423    39 RSRSFTSIPSGLTAAMKSLDLSFNKITYIGHgdlRACANLQVLILKSSRINTIEGDAfysLGSLEHLDLSDNHLSSLSSS 118
Cdd:PRK15370 228 NSNQLTSIPATLPDTIQEMELSINRITELPE---RLPSALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAH 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   119 WfgPlSSLKYLNLMGNPYQTLGVTsLFPNLTNLQTlrignvetfseirriDFAGLTSLNEL---EIKALSLRNYQSQSLK 195
Cdd:PRK15370 302 L--P-SGITHLNVQSNSLTALPET-LPPGLKTLEA---------------GENALTSLPASlppELQVLDVSKNQITVLP 362

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 6760423   196 SIRDIHHLTLHLSESAfLLEIFADILSSVRYLELRDTNLARFQFSpLP 243
Cdd:PRK15370 363 ETLPPTITTLDVSRNA-LTNLPENLPAALQIMQASRNNLVRLPES-LP 408
LRR_8 pfam13855
Leucine rich repeat;
477-535 1.20e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 1.20e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6760423    477 PRLQELYISRNKLKTLPDASLF--PVLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHF 535
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKglSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
441-535 1.54e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.15  E-value: 1.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   441 LNLSSTGIRVVKTCIPQTLEVLDVSNNNLDSFSLFLPRLQELYISRNKLKTLPdaSLFPVLLVMKIRENAVSTFSK---- 516
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLP--VLPPGLLELSIFSNPLTHLPAlpsg 283

                         90       100       110
                 ....*....|....*....|....*....|.
gi 6760423   517 --------DQLGSF----PKLETLEAGDNHF 535
Cdd:PRK15387 284 lcklwifgNQLTSLpvlpPGLQELSVSDNQL 314
LRRCT smart00082
Leucine rich repeat C-terminal domain;
533-586 1.76e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 1.76e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 6760423     533 NHFVCSCELLSFTMEtpALAQILVDWPDSYLCDSPPRLHGhRLQDARPSVLECH 586
Cdd:smart00082   1 NPFICDCELRWLLRW--LQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
362-533 7.78e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 7.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  362 LEFLDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQKTGEILLTLKNLTSLDISRNTFHPMPDSCQWPEKMRFL 441
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  442 NLSSTGIRVVKTCIPQTLEVLDVSNNNLDSfslFLPRLQELYISRNKLKTLPDA-SLFPVLLVMKIRENAVSTFSKDqLG 520
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGNEELS---NLTNLESLDLSGNQLTDLPEElANLTNLKELDLSNNQLTDLPEP-LG 156

                       170
                ....*....|...
gi 6760423  521 SFPKLETLEAGDN 533
Cdd:COG4886 157 NLTNLKSLDLSNN 169
LRR_8 pfam13855
Leucine rich repeat;
414-489 8.11e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 8.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423    414 NLTSLDISRNTFHPMPDSCqwpekmrFLNLSStgirvvktcipqtLEVLDVSNNNLDSFSL----FLPRLQELYISRNKL 489
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGA-------FKGLSN-------------LKVLDLSNNLLTTLSPgafsGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-234 1.40e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 1.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   42 SFTSIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNhlsslssSWFG 121
Cdd:COG4886  38 LLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELS 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423  122 PLSSLKYLNLMGNPYQTLGVTslFPNLTNLQTLRIGN--VETFSEirriDFAGLTSLneleiKALSLRNYQSQSL-KSIR 198
Cdd:COG4886 111 NLTNLESLDLSGNQLTDLPEE--LANLTNLKELDLSNnqLTDLPE----PLGNLTNL-----KSLDLSNNQLTDLpEELG 179

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 6760423  199 DIHHLT-LHLSESAfLLEIFADI--LSSVRYLELRDTNL 234
Cdd:COG4886 180 NLTNLKeLDLSNNQ-ITDLPEPLgnLTNLEELDLSGNQL 217
PLN03150 PLN03150
hypothetical protein; Provisional
 71-134 2.36e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.34  E-value: 2.36e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6760423    71 DLRACANLQVLILKSsriNTIEGDAFYSLG---SLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGN 134
Cdd:PLN03150 437 DISKLRHLQSINLSG---NSIRGNIPPSLGsitSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGN 500
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 55-151 3.44e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 3.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6760423   55 KSLDLSFNK-----ITYIGHGdLRACANLQVLILKSSRINTIEG----DAFYSLGSLEHLDLSDNHLSS-----LSSSWF 120
Cdd:cd00116 168 KELNLANNGigdagIRALAEG-LKANCNLEVLDLNNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTDagaaaLASALL 246

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 6760423  121 GPLSSLKYLNLMGNPYQTLGVTSL------FPNLTNL 151
Cdd:cd00116 247 SPNISLLTLSLSCNDITDDGAKDLaevlaeKESLLEL 283
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 101-135 3.66e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 3.66e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 6760423    101 SLEHLDLSDNHLSSLSSswFGPLSSLKYLNLMGNP 135
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNN 34
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 352-423 4.06e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 4.06e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6760423  352 PCSFSQHLKSLEFLDLSENLMVE----EYLKNsackgawpsLQTLVLSQNHLRSMQKTGEILLTLKNLTSLDISRN 423
Cdd:cd21340 112 PRSLAALSNSLRVLNISGNNIDSleplAPLRN---------LEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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