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Conserved domains on  [gi|6841188|gb|AAF28947|]
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HSPC269, partial [Homo sapiens]

Protein Classification

DAHP synthetase I family protein( domain architecture ID 107023)

DAHP synthetase I family protein similar to phospho-2-keto-3-deoxyheptonate aldolase and phospho-2-dehydro-3-deoxyoctonate aldose

EC:  2.5.1.-
Gene Ontology:  GO:0016765
SCOP:  4003245

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DAHP_synth_1 super family cl17225
DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino ...
 3-57 7.55e-26

DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino acid biosynthesis from chorismate. E-coli has three related synthetases, which are inhibited by different aromatic amino acids. This family also includes KDSA which has very similar catalytic activity but is involved in the first step of liposaccharide biosynthesis. The enzyme is also part of the shikimate pathway, EC:2.5.1.54.


The actual alignment was detected with superfamily member pfam03102:

Pssm-ID: 450174  Cd Length: 239  Bit Score: 96.43  E-value: 7.55e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 6841188      3 EDVNLRVISEYQKLFPdIPIGYSGHETGIAISVAAVALGAKVLERHITLDKTWKG 57
Cdd:pfam03102 155 EDVNLRAIPTLKEAFG-VPVGYSDHTLGIAAPIAAVALGAKVIEKHFTLDRNLPG 208
 
Name Accession Description Interval E-value
NeuB pfam03102
NeuB family; NeuB is the prokaryotic N-acetylneuraminic acid (Neu5Ac) synthase. It catalyzes ...
 3-57 7.55e-26

NeuB family; NeuB is the prokaryotic N-acetylneuraminic acid (Neu5Ac) synthase. It catalyzes the direct formation of Neu5Ac (the most common sialic acid) by condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine (ManNAc). This reaction has only been observed in prokaryotes; eukaryotes synthesize the 9-phosphate form, Neu5Ac-9-P, and utilize ManNAc-6-P instead of ManNAc. Such eukaryotic enzymes are not present in this family. This family also contains SpsE spore coat polysaccharide biosynthesis proteins.


Pssm-ID: 427137  Cd Length: 239  Bit Score: 96.43  E-value: 7.55e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 6841188      3 EDVNLRVISEYQKLFPdIPIGYSGHETGIAISVAAVALGAKVLERHITLDKTWKG 57
Cdd:pfam03102 155 EDVNLRAIPTLKEAFG-VPVGYSDHTLGIAAPIAAVALGAKVIEKHFTLDRNLPG 208
SpsE COG2089
Sialic acid synthase SpsE, contains C-terminal SAF domain [Cell wall/membrane/envelope ...
 3-58 2.42e-25

Sialic acid synthase SpsE, contains C-terminal SAF domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441692 [Multi-domain]  Cd Length: 335  Bit Score: 97.09  E-value: 2.42e-25
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6841188    3 EDVNLRVISEYQKLFpDIPIGYSGHETGIAISVAAVALGAKVLERHITLDKTWKGV 58
Cdd:COG2089 179 EDVNLRAIPTLKEAF-GVPVGLSDHTLGIEVPIAAVALGASVIEKHFTLDRSLPGP 233
PRK08195 PRK08195
4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated
 3-45 4.36e-03

4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated


Pssm-ID: 181282 [Multi-domain]  Cd Length: 337  Bit Score: 35.19  E-value: 4.36e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 6841188     3 EDVNLRVISEYQKLFPDIPIGYSGHET---GIAISVAAVALGAKVL 45
Cdd:PRK08195 173 EDVRDRVRALRAALKPDTQVGFHGHNNlglGVANSLAAVEAGATRI 218
 
Name Accession Description Interval E-value
NeuB pfam03102
NeuB family; NeuB is the prokaryotic N-acetylneuraminic acid (Neu5Ac) synthase. It catalyzes ...
 3-57 7.55e-26

NeuB family; NeuB is the prokaryotic N-acetylneuraminic acid (Neu5Ac) synthase. It catalyzes the direct formation of Neu5Ac (the most common sialic acid) by condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine (ManNAc). This reaction has only been observed in prokaryotes; eukaryotes synthesize the 9-phosphate form, Neu5Ac-9-P, and utilize ManNAc-6-P instead of ManNAc. Such eukaryotic enzymes are not present in this family. This family also contains SpsE spore coat polysaccharide biosynthesis proteins.


Pssm-ID: 427137  Cd Length: 239  Bit Score: 96.43  E-value: 7.55e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 6841188      3 EDVNLRVISEYQKLFPdIPIGYSGHETGIAISVAAVALGAKVLERHITLDKTWKG 57
Cdd:pfam03102 155 EDVNLRAIPTLKEAFG-VPVGYSDHTLGIAAPIAAVALGAKVIEKHFTLDRNLPG 208
SpsE COG2089
Sialic acid synthase SpsE, contains C-terminal SAF domain [Cell wall/membrane/envelope ...
 3-58 2.42e-25

Sialic acid synthase SpsE, contains C-terminal SAF domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441692 [Multi-domain]  Cd Length: 335  Bit Score: 97.09  E-value: 2.42e-25
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6841188    3 EDVNLRVISEYQKLFpDIPIGYSGHETGIAISVAAVALGAKVLERHITLDKTWKGV 58
Cdd:COG2089 179 EDVNLRAIPTLKEAF-GVPVGLSDHTLGIEVPIAAVALGASVIEKHFTLDRSLPGP 233
PRK08195 PRK08195
4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated
 3-45 4.36e-03

4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated


Pssm-ID: 181282 [Multi-domain]  Cd Length: 337  Bit Score: 35.19  E-value: 4.36e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 6841188     3 EDVNLRVISEYQKLFPDIPIGYSGHET---GIAISVAAVALGAKVL 45
Cdd:PRK08195 173 EDVRDRVRALRAALKPDTQVGFHGHNNlglGVANSLAAVEAGATRI 218
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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