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Conserved domains on  [gi|12803485|gb|AAH02568|]
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Cytokine induced apoptosis inhibitor 1 [Homo sapiens]

Protein Classification

anamorsin( domain architecture ID 10353304)

anamorsin is a component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CIAPIN1 pfam05093
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named ...
 240-304 5.64e-32

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homolog of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS). CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress.


:

Pssm-ID: 398662  Cd Length: 99  Bit Score: 114.68  E-value: 5.64e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12803485   240 GKKRKACKNCTCGLAEELEKEKSREQMSSQP----------------------KSACGNCYLGDAFRCASCPYLGMPAFK 297
Cdd:pfam05093  13 KKRRKACKDCTCGLKELEEAEDAAQRALQDKalgkvkfteddlteidftvqgkTGSCGSCALGDAFRCSGCPYLGLPAFK 92


                  ....*..
gi 12803485   298 PGEKVLL 304
Cdd:pfam05093  93 PGEEVTI 99
Methyltransf_11 super family cl48003
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 3-95 1.63e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


The actual alignment was detected with superfamily member pfam08241:

Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 39.96  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12803485     3 DFGISAGQFVAVVWDKSSPVEAL---KGLVDKLQALTGNEGrvsvenIKQLLQSAHK----ESSFDIILSGLVpgsttLH 75
Cdd:pfam08241   2 DVGCGTGLLTELLARLGARVTGVdisPEMLELAREKAPREG------LTFVVGDAEDlpfpDNSFDLVLSSEV-----LH 70

                          90       100
                  ....*....|....*....|....
gi 12803485    76 SAE----ILAEIARILRPGGCLFL 95
Cdd:pfam08241  71 HVEdperALREIARVLKPGGILII 94
 
Name Accession Description Interval E-value
CIAPIN1 pfam05093
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named ...
 240-304 5.64e-32

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homolog of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS). CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress.


Pssm-ID: 398662  Cd Length: 99  Bit Score: 114.68  E-value: 5.64e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12803485   240 GKKRKACKNCTCGLAEELEKEKSREQMSSQP----------------------KSACGNCYLGDAFRCASCPYLGMPAFK 297
Cdd:pfam05093  13 KKRRKACKDCTCGLKELEEAEDAAQRALQDKalgkvkfteddlteidftvqgkTGSCGSCALGDAFRCSGCPYLGLPAFK 92


                  ....*..
gi 12803485   298 PGEKVLL 304
Cdd:pfam05093  93 PGEEVTI 99
COG5636 COG5636
Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];
204-305 9.71e-29

Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];


Pssm-ID: 227923 [Multi-domain]  Cd Length: 284  Bit Score: 111.78  E-value: 9.71e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12803485 204 DMEDDSMDLIDSDELLDPEDLKKpdpaSLRAASCG--EGKKRKACKNCTCGLAEELEKEKSR------------------ 263
Cdd:COG5636 155 MRKDTDPRTIMEDELLDEDSEDK----AIQRSECPpsKTKKKRACKDCTCGLKEEEENEIVRtrqdkvvkftedelteid 230

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 12803485 264 EQMSSQPKSACGNCYLGDAFRCASCPYLGMPAFKPGEKVLLS 305
Cdd:COG5636 231 FTIDGKKVSACGNCYLGDAFRCSGCPYLGLPAFEPGDVVSFS 272
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 3-95 1.63e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 39.96  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12803485     3 DFGISAGQFVAVVWDKSSPVEAL---KGLVDKLQALTGNEGrvsvenIKQLLQSAHK----ESSFDIILSGLVpgsttLH 75
Cdd:pfam08241   2 DVGCGTGLLTELLARLGARVTGVdisPEMLELAREKAPREG------LTFVVGDAEDlpfpDNSFDLVLSSEV-----LH 70

                          90       100
                  ....*....|....*....|....
gi 12803485    76 SAE----ILAEIARILRPGGCLFL 95
Cdd:pfam08241  71 HVEdperALREIARVLKPGGILII 94
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 8-96 6.39e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 38.57  E-value: 6.39e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12803485   8 AGQFVAVvwDKSSpvEALKGLVDKLQALTGNEGRVSVENIKQLLQSAHKesSFDIILSGLVPGSTTLHSAEILAEIARIL 87
Cdd:cd02440  21 GARVTGV--DISP--VALELARKAAAALLADNVEVLKGDAEELPPEADE--SFDVIISDPPLHHLVEDLARFLEEARRLL 94


                ....*....
gi 12803485  88 RPGGCLFLK 96
Cdd:cd02440  95 KPGGVLVLT 103
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 59-95 7.65e-04

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 39.21  E-value: 7.65e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 12803485  59 SFDIILSGLVpgsttLHS----AEILAEIARILRPGGCLFL 95
Cdd:COG2226  87 SFDLVISSFV-----LHHlpdpERALAEIARVLKPGGRLVV 122
 
Name Accession Description Interval E-value
CIAPIN1 pfam05093
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named ...
 240-304 5.64e-32

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homolog of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS). CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress.


Pssm-ID: 398662  Cd Length: 99  Bit Score: 114.68  E-value: 5.64e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12803485   240 GKKRKACKNCTCGLAEELEKEKSREQMSSQP----------------------KSACGNCYLGDAFRCASCPYLGMPAFK 297
Cdd:pfam05093  13 KKRRKACKDCTCGLKELEEAEDAAQRALQDKalgkvkfteddlteidftvqgkTGSCGSCALGDAFRCSGCPYLGLPAFK 92


                  ....*..
gi 12803485   298 PGEKVLL 304
Cdd:pfam05093  93 PGEEVTI 99
COG5636 COG5636
Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];
204-305 9.71e-29

Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];


Pssm-ID: 227923 [Multi-domain]  Cd Length: 284  Bit Score: 111.78  E-value: 9.71e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12803485 204 DMEDDSMDLIDSDELLDPEDLKKpdpaSLRAASCG--EGKKRKACKNCTCGLAEELEKEKSR------------------ 263
Cdd:COG5636 155 MRKDTDPRTIMEDELLDEDSEDK----AIQRSECPpsKTKKKRACKDCTCGLKEEEENEIVRtrqdkvvkftedelteid 230

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 12803485 264 EQMSSQPKSACGNCYLGDAFRCASCPYLGMPAFKPGEKVLLS 305
Cdd:COG5636 231 FTIDGKKVSACGNCYLGDAFRCSGCPYLGLPAFEPGDVVSFS 272
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 3-95 1.63e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 39.96  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12803485     3 DFGISAGQFVAVVWDKSSPVEAL---KGLVDKLQALTGNEGrvsvenIKQLLQSAHK----ESSFDIILSGLVpgsttLH 75
Cdd:pfam08241   2 DVGCGTGLLTELLARLGARVTGVdisPEMLELAREKAPREG------LTFVVGDAEDlpfpDNSFDLVLSSEV-----LH 70

                          90       100
                  ....*....|....*....|....
gi 12803485    76 SAE----ILAEIARILRPGGCLFL 95
Cdd:pfam08241  71 HVEdperALREIARVLKPGGILII 94
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 8-96 6.39e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 38.57  E-value: 6.39e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12803485   8 AGQFVAVvwDKSSpvEALKGLVDKLQALTGNEGRVSVENIKQLLQSAHKesSFDIILSGLVPGSTTLHSAEILAEIARIL 87
Cdd:cd02440  21 GARVTGV--DISP--VALELARKAAAALLADNVEVLKGDAEELPPEADE--SFDVIISDPPLHHLVEDLARFLEEARRLL 94


                ....*....
gi 12803485  88 RPGGCLFLK 96
Cdd:cd02440  95 KPGGVLVLT 103
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 59-95 7.65e-04

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 39.21  E-value: 7.65e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 12803485  59 SFDIILSGLVpgsttLHS----AEILAEIARILRPGGCLFL 95
Cdd:COG2226  87 SFDLVISSFV-----LHHlpdpERALAEIARVLKPGGRLVV 122
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 57-91 6.41e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 35.62  E-value: 6.41e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 12803485    57 ESSFDIILSGLVPGSTTLHSAE-ILAEIARILRPGG 91
Cdd:pfam13649  61 DGSFDLVVSSGVLHHLPDPDLEaALREIARVLKPGG 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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