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Conserved domains on  [gi|13937789|gb|AAH06994|]
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Translocase of inner mitochondrial membrane 8 homolog A (yeast) [Homo sapiens]

Protein Classification

Tim10/DDP family zinc finger protein( domain architecture ID 10503014)

Tim10/DDP (deafness/dystonia peptide) family zinc finger protein such as mitochondrial import inner membrane translocase subunits Tim8, Tim9, Tim10, and Tim13, which are mitochondrial intermembrane chaperones that participate in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-Tim10_DDP pfam02953
Tim10/DDP family zinc finger; Putative zinc binding domain with four conserved cysteine ...
 21-83 3.71e-25

Tim10/DDP family zinc finger; Putative zinc binding domain with four conserved cysteine residues. This domain is found in the human disease protein Swiss:O60220. Members of this family such as Tim9 and Tim10 are involved in mitochondrial protein import. Members of this family seem to be localized to the mitochondrial intermembrane space.


:

Pssm-ID: 460764  Cd Length: 64  Bit Score: 89.16  E-value: 3.71e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13937789   21 HFIEVETQKQRFQQLVHQMTELCWEKCMDK-PGPKLDSRAEACFVNCVERFIDTSQFILNRLEQ 83
Cdd:pfam02953  1 QFLMQEQQKANFQELVNKLTERCFDKCIPDyPGSSLSSGEESCLDRCVEKYLDASNRVGKRLQE 64
 
Name Accession Description Interval E-value
zf-Tim10_DDP pfam02953
Tim10/DDP family zinc finger; Putative zinc binding domain with four conserved cysteine ...
 21-83 3.71e-25

Tim10/DDP family zinc finger; Putative zinc binding domain with four conserved cysteine residues. This domain is found in the human disease protein Swiss:O60220. Members of this family such as Tim9 and Tim10 are involved in mitochondrial protein import. Members of this family seem to be localized to the mitochondrial intermembrane space.


Pssm-ID: 460764  Cd Length: 64  Bit Score: 89.16  E-value: 3.71e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13937789   21 HFIEVETQKQRFQQLVHQMTELCWEKCMDK-PGPKLDSRAEACFVNCVERFIDTSQFILNRLEQ 83
Cdd:pfam02953  1 QFLMQEQQKANFQELVNKLTERCFDKCIPDyPGSSLSSGEESCLDRCVEKYLDASNRVGKRLQE 64
 
Name Accession Description Interval E-value
zf-Tim10_DDP pfam02953
Tim10/DDP family zinc finger; Putative zinc binding domain with four conserved cysteine ...
 21-83 3.71e-25

Tim10/DDP family zinc finger; Putative zinc binding domain with four conserved cysteine residues. This domain is found in the human disease protein Swiss:O60220. Members of this family such as Tim9 and Tim10 are involved in mitochondrial protein import. Members of this family seem to be localized to the mitochondrial intermembrane space.


Pssm-ID: 460764  Cd Length: 64  Bit Score: 89.16  E-value: 3.71e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13937789   21 HFIEVETQKQRFQQLVHQMTELCWEKCMDK-PGPKLDSRAEACFVNCVERFIDTSQFILNRLEQ 83
Cdd:pfam02953  1 QFLMQEQQKANFQELVNKLTERCFDKCIPDyPGSSLSSGEESCLDRCVEKYLDASNRVGKRLQE 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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