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Conserved domains on  [gi|18089061|gb|AAH20647|]
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Coiled-coil domain containing 59 [Homo sapiens]

Protein Classification

thyroid transcription factor 1-associated protein 26( domain architecture ID 709383)

thyroid transcription factor (TTF) 1-associated protein 26 (TAP26) similar to human TAP26 which interact with TTF-1 and enhance TTF-1-transactivated SP-B promoter activity.

Gene Ontology:  GO:0003723
PubMed:  12882447

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
rRNA_processing super family cl26553
rRNA processing; This is a family of proteins that are involved in rRNA processing. In a ...
 160-238 2.87e-08

rRNA processing; This is a family of proteins that are involved in rRNA processing. In a localization study they were found to localize to the nucleus and nucleolus. The family also includes other metazoa members from plants to mammals where the protein has been named BR22 and is associated with TTF-1, thyroid transcription factor 1. In the lungs, the family binds TTF-1 to form a complex which influences the expression of the key lung surfactant protein-B (SP-B) and -C (SP-C), the small hydrophobic surfactant proteins that maintain surface tension in alveoli.


The actual alignment was detected with superfamily member pfam08524:

Pssm-ID: 400708 [Multi-domain]  Cd Length: 142  Bit Score: 51.15  E-value: 2.87e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18089061   160 PKKNKKKTSNQKAQEEYEQIQAKRAAKKQEFERRKQEREEAQRQYKKKKMEVFKILNKKTKKGQPNLNVQMEYLLQKIQ 238
Cdd:pfam08524  62 ARELQGKTKFDERKEIKKERKEEKRERKLEARQKKLERIKALEKKKKEREKRKKQLSKKTKKGQPVMGPRIEDLLDKIK 140
 
Name Accession Description Interval E-value
rRNA_processing pfam08524
rRNA processing; This is a family of proteins that are involved in rRNA processing. In a ...
 160-238 2.87e-08

rRNA processing; This is a family of proteins that are involved in rRNA processing. In a localization study they were found to localize to the nucleus and nucleolus. The family also includes other metazoa members from plants to mammals where the protein has been named BR22 and is associated with TTF-1, thyroid transcription factor 1. In the lungs, the family binds TTF-1 to form a complex which influences the expression of the key lung surfactant protein-B (SP-B) and -C (SP-C), the small hydrophobic surfactant proteins that maintain surface tension in alveoli.


Pssm-ID: 400708 [Multi-domain]  Cd Length: 142  Bit Score: 51.15  E-value: 2.87e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18089061   160 PKKNKKKTSNQKAQEEYEQIQAKRAAKKQEFERRKQEREEAQRQYKKKKMEVFKILNKKTKKGQPNLNVQMEYLLQKIQ 238
Cdd:pfam08524  62 ARELQGKTKFDERKEIKKERKEEKRERKLEARQKKLERIKALEKKKKEREKRKKQLSKKTKKGQPVMGPRIEDLLDKIK 140
 
Name Accession Description Interval E-value
rRNA_processing pfam08524
rRNA processing; This is a family of proteins that are involved in rRNA processing. In a ...
 160-238 2.87e-08

rRNA processing; This is a family of proteins that are involved in rRNA processing. In a localization study they were found to localize to the nucleus and nucleolus. The family also includes other metazoa members from plants to mammals where the protein has been named BR22 and is associated with TTF-1, thyroid transcription factor 1. In the lungs, the family binds TTF-1 to form a complex which influences the expression of the key lung surfactant protein-B (SP-B) and -C (SP-C), the small hydrophobic surfactant proteins that maintain surface tension in alveoli.


Pssm-ID: 400708 [Multi-domain]  Cd Length: 142  Bit Score: 51.15  E-value: 2.87e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18089061   160 PKKNKKKTSNQKAQEEYEQIQAKRAAKKQEFERRKQEREEAQRQYKKKKMEVFKILNKKTKKGQPNLNVQMEYLLQKIQ 238
Cdd:pfam08524  62 ARELQGKTKFDERKEIKKERKEEKRERKLEARQKKLERIKALEKKKKEREKRKKQLSKKTKKGQPVMGPRIEDLLDKIK 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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