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Conserved domains on  [gi|19353679|gb|AAH24861|]
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Actr1b protein, partial [Mus musculus]

Protein Classification

acetate and sugar kinases/Hsc70/actin family protein( domain architecture ID 99298)

acetate and sugar kinases/Hsc70/actin (ASKHA) family protein catalyzes phosphoryl transfer from ATP to their respective substrates

CATH:  3.30.420.40
Gene Ontology:  GO:0000166
PubMed:  8800467|7781919
SCOP:  3000092

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_ATPase-like super family cl49607
ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA ...
 2-173 1.61e-126

ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA superfamily, also known as actin-like ATPase domain superfamily, includes acetate and sugar kinases, heat-shock cognate 70 (Hsp70) and actin family proteins. They either function as conformational hydrolases (e.g. Hsp70, actin) that perform simple ATP hydrolysis, or as metabolite kinases (e.g. glycerol kinase) that catalyze the transfer of a phosphoryl group from ATP to their cognate substrates. Both activities depend on the presence of specific metal cations. ASKHA superfamily members share a common core fold that includes an actin-like ATPase domain consisting of two subdomains (denoted I _ II) with highly similar ribonuclease (RNase) H-like folds. The fold of each subdomain is characterized by a central five strand beta-sheet and flanking alpha-helices. The two subdomains form an active site cleft in which ATP binds at the bottom. Another common feature of ASKHA superfamily members is the coupling of phosphoryl-group transfer to conformational rearrangement, leading to domain closure. Substrate binding triggers protein motion.


The actual alignment was detected with superfamily member cd10216:

Pssm-ID: 483947 [Multi-domain]  Cd Length: 370  Bit Score: 359.94  E-value: 1.61e-126
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   2 DFHTSAEFEVVRTIKERACYLSINPQKDEALE---TEKVQYTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHEVLA 78
Cdd:cd10216 196 NFHTSAEFEIVREIKEKACYVALNPQKEEKLEeekTEKAQYTLPDGSTIEIGPERFRAPEILFNPELIGLEYPGVHEVLV 275

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  79 FAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQERLYSTWIGGSILASLDTFKKMWVSK 158
Cdd:cd10216 276 DSIQKSDLDLRKTLYSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIRISAPPERLYSTWIGGSILASLSTFKKMWVSK 355

                       170
                ....*....|....*
gi 19353679 159 KEYEEDGSRAIHRKT 173
Cdd:cd10216 356 KEYEEDGARILHRKT 370
 
Name Accession Description Interval E-value
ASKHA_NBD_Arp1 cd10216
nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, ...
 2-173 1.61e-126

nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, also called centractin, actin-like protein, alpha-centractin, actin-RPV, or centrosome-associated actin homolog, may be a component of a multi-subunit centrosomal complex involved in microtubule-based vesicle motility. In yeast, actin-related protein is essential for viability and is associated with the centrosome. In vertebrates, Arp1 is a core component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding. The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. ARP1 forms the backbone filament of the dynactin rod structure and serves as the scaffold for the remaining subunits. It is required for proper orientation of the mitotic spindle. Arp1 is the only actin-related protein known to form actin-like filaments. Human Arp1/centractin is encoded by the ACTR1A gene.


Pssm-ID: 466820 [Multi-domain]  Cd Length: 370  Bit Score: 359.94  E-value: 1.61e-126
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   2 DFHTSAEFEVVRTIKERACYLSINPQKDEALE---TEKVQYTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHEVLA 78
Cdd:cd10216 196 NFHTSAEFEIVREIKEKACYVALNPQKEEKLEeekTEKAQYTLPDGSTIEIGPERFRAPEILFNPELIGLEYPGVHEVLV 275

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  79 FAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQERLYSTWIGGSILASLDTFKKMWVSK 158
Cdd:cd10216 276 DSIQKSDLDLRKTLYSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIRISAPPERLYSTWIGGSILASLSTFKKMWVSK 355

                       170
                ....*....|....*
gi 19353679 159 KEYEEDGSRAIHRKT 173
Cdd:cd10216 356 KEYEEDGARILHRKT 370
PTZ00466 PTZ00466
actin-like protein; Provisional
 3-174 2.03e-86

actin-like protein; Provisional


Pssm-ID: 240426 [Multi-domain]  Cd Length: 380  Bit Score: 258.34  E-value: 2.03e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679    3 FHTSAEFEVVRTIKERACYLSINPQKDEAlETEK----VQYTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHEVLA 78
Cdd:PTZ00466 206 FNTSAEMEVVKNMKENCCYVSFNMNKEKN-SSEKalttLPYILPDGSQILIGSERYRAPEVLFNPSILGLEYLGLSELIV 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   79 FAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQERLYSTWIGGSILASLDTFKKMWVSK 158
Cdd:PTZ00466 285 TSITRADMDLRRTLYSHIVLSGGTTMFHGFGDRLLNEIRKFAPKDITIRISAPPERKFSTFIGGSILASLATFKKIWISK 364

                        170
                 ....*....|....*.
gi 19353679  159 KEYEEDGSRAIHRKTF 174
Cdd:PTZ00466 365 QEFDEYGSVILHRKTF 380
Actin pfam00022
Actin;
3-174 5.57e-85

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 255.69  E-value: 5.57e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679     3 FHTSAEFEVVRTIKERACYLSINPQKDEALETE--KVQYTLPDGSTLDVGPARFRAPELLFQPDLVGDESE--------G 72
Cdd:pfam00022 223 YKTYQERRVLEEIKESVCYVSDDPFGDETTSSSipTRVYELPDGSTIILGAERFRVPEILFNPSLIGSESElpppqtavG 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679    73 LHEVLAFAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQ---ERLYSTWIGGSILASLD 149
Cdd:pfam00022 303 IPELIVDAINACDVDLRPSLLANIVVTGGNSLFPGFTERLEKELAQLAPPGVKVKIIAPGntvERRYSAWIGGSILASLG 382

                         170       180
                  ....*....|....*....|....*
gi 19353679   150 TFKKMWVSKKEYEEDGSRAIHRKTF 174
Cdd:pfam00022 383 TFQQMWVSKQEYEEHGASVVERKCK 407
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
 3-174 6.37e-81

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 244.09  E-value: 6.37e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679      3 FHTSAEFEVVRTIKERACYLSINPQKDEALE-------TEKVQYTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHE 75
Cdd:smart00268 195 FNSSAEFEIVREIKEKLCYVAEDFEKEMKLAressessKLEKTYELPDGNTIKVGNERFRIPEILFSPELIGLEQKGIHE 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679     76 VLAFAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQERLYSTWIGGSILASLDTFKKMW 155
Cdd:smart00268 275 LVYESIQKCDIDVRKDLYENIVLSGGSTLIPGFGERLEKELKQLAPKKLKVKVIAPPERKYSVWLGGSILASLSTFEDMW 354

                          170
                   ....*....|....*....
gi 19353679    156 VSKKEYEEDGSRAIHRKTF 174
Cdd:smart00268 355 ITKKEYEESGSQIVERKCF 373
COG5277 COG5277
Actin-related protein [Cytoskeleton];
5-163 2.71e-26

Actin-related protein [Cytoskeleton];


Pssm-ID: 444088  Cd Length: 424  Bit Score: 102.95  E-value: 2.71e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   5 TSAEFEVVRTIKERACYL------SINPQKDEALETEKVqYTLPDGSTL----DVGPARFRAPELLFQPDLVGDESE--- 71
Cdd:COG5277 223 TAREEYVVRVVKEALGLVprdlakAIQKAASNPDSFEAK-VRLPNPTVEielgNYAWERFLIGEILFNPNHEGFESYiqq 301

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  72 -------------------GLHEVLAFAIHKSDMDLRRTLFSNIVLSGGSTLF---KGFGD-------RLLSEVKKLAPk 122
Cdd:COG5277 302 grlriedavigdvvlygemGLAEAIINSIMKCDVEIQDELYSNIILSGGAFNWsvpPGLEDvavdsvtRVQIELSELAP- 380

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 19353679 123 DVKIKISAPQERLYSTWIGGSILASLDTFKKMW--VSKKEYEE 163
Cdd:COG5277 381 ELKVNVRLVSDPQYSVWKGAIIYGYALPFSVKWswITKEGWYF 423
syringactin NF040575
syringactin; Syringactin are close homologs of the normally eukaryotic protein actin, found in ...
 107-172 4.72e-17

syringactin; Syringactin are close homologs of the normally eukaryotic protein actin, found in the plant pathogen Pseudomonas syringae and related species. This model was created, in part, to clarify that the family is real and distinct, rather than an artifact of eukaryotic contamination of bacterial genomic sequence data. As of the creation of this HMM, the family is uncharacterized.


Pssm-ID: 468549 [Multi-domain]  Cd Length: 132  Bit Score: 73.09  E-value: 4.72e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19353679  107 GFGDRLLSEVKKLAPKDVKIKISAPQERLYSTWIGGSILASLDTFKKMWVSKKEYEEDGSRAIHRK 172
Cdd:NF040575  66 GFYEKLKKSITEKAPKGALIGMTLDPKPESAAWRGAAMYAASEGFVEMAITKQEYDESGPSIVHRK 131
 
Name Accession Description Interval E-value
ASKHA_NBD_Arp1 cd10216
nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, ...
 2-173 1.61e-126

nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, also called centractin, actin-like protein, alpha-centractin, actin-RPV, or centrosome-associated actin homolog, may be a component of a multi-subunit centrosomal complex involved in microtubule-based vesicle motility. In yeast, actin-related protein is essential for viability and is associated with the centrosome. In vertebrates, Arp1 is a core component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding. The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. ARP1 forms the backbone filament of the dynactin rod structure and serves as the scaffold for the remaining subunits. It is required for proper orientation of the mitotic spindle. Arp1 is the only actin-related protein known to form actin-like filaments. Human Arp1/centractin is encoded by the ACTR1A gene.


Pssm-ID: 466820 [Multi-domain]  Cd Length: 370  Bit Score: 359.94  E-value: 1.61e-126
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   2 DFHTSAEFEVVRTIKERACYLSINPQKDEALE---TEKVQYTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHEVLA 78
Cdd:cd10216 196 NFHTSAEFEIVREIKEKACYVALNPQKEEKLEeekTEKAQYTLPDGSTIEIGPERFRAPEILFNPELIGLEYPGVHEVLV 275

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  79 FAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQERLYSTWIGGSILASLDTFKKMWVSK 158
Cdd:cd10216 276 DSIQKSDLDLRKTLYSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIRISAPPERLYSTWIGGSILASLSTFKKMWVSK 355

                       170
                ....*....|....*
gi 19353679 159 KEYEEDGSRAIHRKT 173
Cdd:cd10216 356 KEYEEDGARILHRKT 370
PTZ00466 PTZ00466
actin-like protein; Provisional
 3-174 2.03e-86

actin-like protein; Provisional


Pssm-ID: 240426 [Multi-domain]  Cd Length: 380  Bit Score: 258.34  E-value: 2.03e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679    3 FHTSAEFEVVRTIKERACYLSINPQKDEAlETEK----VQYTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHEVLA 78
Cdd:PTZ00466 206 FNTSAEMEVVKNMKENCCYVSFNMNKEKN-SSEKalttLPYILPDGSQILIGSERYRAPEVLFNPSILGLEYLGLSELIV 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   79 FAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQERLYSTWIGGSILASLDTFKKMWVSK 158
Cdd:PTZ00466 285 TSITRADMDLRRTLYSHIVLSGGTTMFHGFGDRLLNEIRKFAPKDITIRISAPPERKFSTFIGGSILASLATFKKIWISK 364

                        170
                 ....*....|....*.
gi 19353679  159 KEYEEDGSRAIHRKTF 174
Cdd:PTZ00466 365 QEFDEYGSVILHRKTF 380
Actin pfam00022
Actin;
3-174 5.57e-85

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 255.69  E-value: 5.57e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679     3 FHTSAEFEVVRTIKERACYLSINPQKDEALETE--KVQYTLPDGSTLDVGPARFRAPELLFQPDLVGDESE--------G 72
Cdd:pfam00022 223 YKTYQERRVLEEIKESVCYVSDDPFGDETTSSSipTRVYELPDGSTIILGAERFRVPEILFNPSLIGSESElpppqtavG 302

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679    73 LHEVLAFAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQ---ERLYSTWIGGSILASLD 149
Cdd:pfam00022 303 IPELIVDAINACDVDLRPSLLANIVVTGGNSLFPGFTERLEKELAQLAPPGVKVKIIAPGntvERRYSAWIGGSILASLG 382

                         170       180
                  ....*....|....*....|....*
gi 19353679   150 TFKKMWVSKKEYEEDGSRAIHRKTF 174
Cdd:pfam00022 383 TFQQMWVSKQEYEEHGASVVERKCK 407
ASKHA_NBD_actin_Arp-T1-3 cd13397
nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar ...
 3-165 1.31e-81

nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar proteins; The family includes actin and human actin-related proteins T1, T2, and T3. Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Arp-T1, encoded by ACTRT1/ARPT1 gene expressed in testis, negatively regulates the Hedgehog (SHH) signaling, binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression. Arp-T2 (also called actin-related protein M2; encoded by ACTRT2/ARPM2 gene expressed in testis and various other cell types) and Arp-T3 (also called actin-related protein M1; encoded by ACTRT3/ARPM1 gene expressed in all tested human tissues) play general roles in the organization of the cytoskeleton like other cytoplasmic actin-related proteins.


Pssm-ID: 466848 [Multi-domain]  Cd Length: 359  Bit Score: 245.17  E-value: 1.31e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   3 FHTSAEFEVVRTIKERACYLSINPQKDEALETEKVQ--YTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHEVLAFA 80
Cdd:cd13397 195 FTTTAEREIVRDIKEKLCYVALDYEEELKKKSEELEkeYTLPDGQVIKIGSERFRCPEALFRPSLIGREAPGIHKLVYNS 274

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  81 IHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQERLYSTWIGGSILASLDTFKKMWVSKKE 160
Cdd:cd13397 275 IMKCDIDIRKDLYSNIVLSGGSTMFPGLPERLQKELEALAPSSTKVKVIAPPERKYSVWIGGSILASLSTFKSMWITRAE 354


                ....*
gi 19353679 161 YEEDG 165
Cdd:cd13397 355 YDEFG 359
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
 3-174 6.37e-81

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 244.09  E-value: 6.37e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679      3 FHTSAEFEVVRTIKERACYLSINPQKDEALE-------TEKVQYTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHE 75
Cdd:smart00268 195 FNSSAEFEIVREIKEKLCYVAEDFEKEMKLAressessKLEKTYELPDGNTIKVGNERFRIPEILFSPELIGLEQKGIHE 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679     76 VLAFAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQERLYSTWIGGSILASLDTFKKMW 155
Cdd:smart00268 275 LVYESIQKCDIDVRKDLYENIVLSGGSTLIPGFGERLEKELKQLAPKKLKVKVIAPPERKYSVWLGGSILASLSTFEDMW 354

                          170
                   ....*....|....*....
gi 19353679    156 VSKKEYEEDGSRAIHRKTF 174
Cdd:smart00268 355 ITKKEYEESGSQIVERKCF 373
ASKHA_NBD_actin cd10224
nucleotide-binding domain (NBD) of actin and similar proteins; Actin is a ubiquitous protein ...
 2-165 4.69e-72

nucleotide-binding domain (NBD) of actin and similar proteins; Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Actin is a monomeric globular protein (G-actin) that reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. At low salt concentrations, actin exists as a monomer, and as the salt concentration rises F-actin forms, with the consequent hydrolysis of ATP. F-actin assembly is in constant flux with G-actin association occurring at the barbed end (+) and its disassociation at the pointed end (-). Actin monomers that have been released from the pointed end can be reused, if the ADP is exchanged for ATP. F-actin filaments can assemble into higher order structures, for example branched F-actin, and stress fibers. Actin binding proteins regulate actin filament dynamics by a range of functions including actin severing, depolymerizing, capping, stabilizing and de novo actin polymerization. Actins interaction with myosin is the basis of muscular contraction and many aspects of cell motility. In vertebrates there are three main groups of actin isoforms, alpha, beta and gamma. The alpha actins found in muscle tissues are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. In plants there are many isoforms which are probably involved in a variety of functions such as cytoplasmic streaming, cell shape determination, tip growth, graviperception, cell wall deposition, etc.


Pssm-ID: 466823  Cd Length: 365  Bit Score: 221.08  E-value: 4.69e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   2 DFHTSAEFEVVRTIKERACYLSINpqKDEALET-------EKvQYTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLH 74
Cdd:cd10224 194 SFTTTAEREIVRDIKEKLCYVALD--FEQEMQTaasssslEK-SYELPDGQVITIGNERFRCPEALFQPSFLGMEAAGIH 270

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  75 EVLAFAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQERLYSTWIGGSILASLDTFKKM 154
Cdd:cd10224 271 ETTYNSIMKCDVDIRKDLYANIVLSGGTTMFPGIADRMQKEITALAPSTMKIKIVAPPERKYSVWIGGSILASLSTFQQM 350

                       170
                ....*....|.
gi 19353679 155 WVSKKEYEEDG 165
Cdd:cd10224 351 WISKQEYDESG 361
PTZ00004 PTZ00004
actin-2; Provisional
 3-174 2.05e-68

actin-2; Provisional


Pssm-ID: 240225 [Multi-domain]  Cd Length: 378  Bit Score: 212.32  E-value: 2.05e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679    3 FHTSAEFEVVRTIKERACYLSINPQK-----DEALETEKVQYTLPDGSTLDVGPARFRAPELLFQPDLVG-DESEGLHEV 76
Cdd:PTZ00004 201 FTTTAEKEIVRDIKEKLCYIALDFDEemgnsAGSSDKYEESYELPDGTIITVGSERFRCPEALFQPSLIGkEEPPGIHEL 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   77 LAFAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQERLYSTWIGGSILASLDTFKKMWV 156
Cdd:PTZ00004 281 TFQSINKCDIDIRKDLYGNIVLSGGTTMYRGLPERLTKELTTLAPSTMKIKVVAPPERKYSVWIGGSILSSLPTFQQMWV 360

                        170
                 ....*....|....*...
gi 19353679  157 SKKEYEEDGSRAIHRKTF 174
Cdd:PTZ00004 361 TKEEYDESGPSIVHRKCF 378
ASKHA_NBD_Arp4_ACTL6-like cd13395
nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The ...
 3-165 9.97e-62

nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The Arp4-like subfamily includes Arp4, also called actin-like protein 4, from fungi and plants. Saccharomyces cerevisiae Arp4 acts synergistically with Arp8 to depolymerize F-actin; it binds ATP, but unlike conventional actin, does not form filaments. It is a component of the NuA4 histone acetyltransferase complex, the chromatin-remodeling INO80 complex and the SWR1 chromatin remodeling complex. Arabidopsis thaliana Arp4 is involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure. This family also includes human homologs of yeast and plant, which are actin-like protein 6A (encoded by the ACTL6A gene; also known as ArpNbeta, 53 kDa BRG1-associated factor A/BRG1-associated factor 53A/BAF35A, and INO80 complex subunit K/INO80K) and actin-like protein 6B (encoded by the ACTL6B gene; also known as ArpNalpha, 53 kDa BRG1-associated factor B/BRG1-associated factor 53B/BAF35B). ACTL6A and ACTL6B are involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). They are components of numerous complexes with chromatin remodeling and histone acetyltransferase activity. ACTL6A is also a putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Schizosaccharomyces pombe actin-related protein 42 (Arp42) is also included in this family. It is also a component of SWI/SNF and RSC complexes.


Pssm-ID: 466846 [Multi-domain]  Cd Length: 413  Bit Score: 196.25  E-value: 9.97e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   3 FHTSAEFEVVRTIKERACYLSINP-QKDEALETEKVQYTLPDGSTLDVGPARFRAPELLFQPDLV---------GDESEG 72
Cdd:cd13395 238 YHRYMVRRVLQDFKESVCQVSDSPfDESEAASIPTVSYELPDGYNIEFGAERFKIPELLFDPSLVkgipappseGNELLG 317

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  73 LHEVLAFAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQ---ERLYSTWIGGSILASLD 149
Cdd:cd13395 318 LPQLVYTSIGSCDVDIRPELYGNVVLTGGNSLLPGFTDRLNRELSEKAPGSLKLKILASGntvERRFSSWIGGSILASLG 397

                       170
                ....*....|....*.
gi 19353679 150 TFKKMWVSKKEYEEDG 165
Cdd:cd13395 398 SFQQMWISKQEYEEHG 413
PTZ00281 PTZ00281
actin; Provisional
 3-174 7.90e-60

actin; Provisional


Pssm-ID: 173506 [Multi-domain]  Cd Length: 376  Bit Score: 190.30  E-value: 7.90e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679    3 FHTSAEFEVVRTIKERACYLSINPQKD-------EALETekvQYTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHE 75
Cdd:PTZ00281 201 FTTTAEREIVRDIKEKLAYVALDFEAEmqtaassSALEK---SYELPDGQVITIGNERFRCPEALFQPSFLGMESAGIHE 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   76 VLAFAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQERLYSTWIGGSILASLDTFKKMW 155
Cdd:PTZ00281 278 TTYNSIMKCDVDIRKDLYGNVVLSGGTTMFPGIADRMNKELTALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMW 357

                        170
                 ....*....|....*....
gi 19353679  156 VSKKEYEEDGSRAIHRKTF 174
Cdd:PTZ00281 358 ISKEEYDESGPSIVHRKCF 376
ASKHA_NBD_ACTL7 cd10214
nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ...
 5-172 5.64e-58

nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ACTL7-like family includes ACTL7A, ACTL7B and ACTL9 (also known as ACTL7C). In mammalian, ACTL7A is expressed in a wide variety of adult tissues, while the ACTL7B is expressed in spermatids through the elongation phase of spermatid development. ACTL7A, also called actin-like-7-alpha, or T-ACTIN-2 in mouse, may play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis. ACTL7B, also called actin-like-7-beta, acts as a key regulator of spermiogenesis that is required for male fertility. ACTL9 is a testis-specific protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation.


Pssm-ID: 466819 [Multi-domain]  Cd Length: 368  Bit Score: 185.32  E-value: 5.64e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   5 TSAEFEVVRTIKERACYLSINPQKDEALETE--KVQYTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHEVLAFAIH 82
Cdd:cd10214 199 TDDQLHIVEDIKKKCCYVALDFEEEMGLPPQeyTVDYELPDGHLITIGKERFRCPEMLFNPSLIGSKQPGLHTLTMNSLN 278

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  83 KSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPqERLYSTWIGGSILASLDTFKKMWVSKKEYE 162
Cdd:cd10214 279 KCDANLKKDLAKNILLCGGSTMFDGFPDRFQKELSKLCPNDNPIVAASP-ERKYSVWTGGSILASLKSFQQLWVRRREYE 357

                       170
                ....*....|
gi 19353679 163 EDGSRAIHRK 172
Cdd:cd10214 358 ERGPFVIYRK 367
ASKHA_NBD_Arp2 cd10220
nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, ...
 3-169 1.91e-55

nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, also called actin-like protein 2, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp2 is encoded by the ACTR2 gene.


Pssm-ID: 466821  Cd Length: 381  Bit Score: 178.91  E-value: 1.91e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   3 FHTSAEFEVVRTIKERACYLSINPQKDE--ALETEKV--QYTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHEVLA 78
Cdd:cd10220 197 FNRTADFETVREIKEKLCYVAYDIELEQklALETTVLveSYTLPDGRVIKVGGERFEAPEALFQPHLIDVEGPGIAELLF 276

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  79 FAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDV-----------KIKISAPQERLYSTWIGGSILAS 147
Cdd:cd10220 277 NTIQAADIDTRPELYKHIVLSGGSTMYPGLPSRLEKEIKQLYLERVlkgdterlskfKIRIEDPPRRKHMVFLGGAVLAD 356

                       170       180
                ....*....|....*....|....*.
gi 19353679 148 L----DTFkkmWVSKKEYEEDGSRAI 169
Cdd:cd10220 357 ImkdkDEF---WITRQEYEEQGVRVL 379
PTZ00452 PTZ00452
actin; Provisional
 11-174 2.30e-50

actin; Provisional


Pssm-ID: 185631  Cd Length: 375  Bit Score: 165.70  E-value: 2.30e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   11 VVRTIKERACYLSINPQKDEAL----ETEKVQYTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHEVLAFAIHKSDM 86
Cdd:PTZ00452 208 IVKNIKERLCYTALDPQDEKRIykesNSQDSPYKLPDGNILTIKSQKFRCSEILFQPKLIGLEVAGIHHLAYSSIKKCDL 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   87 DLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQERLYSTWIGGSILASLDTFKKMWVSKKEYEEDGS 166
Cdd:PTZ00452 288 DLRQELCRNIVLSGGTTLFPGIANRLSNELTNLVPSQLKIQVAAPPDRRFSAWIGGSIQCTLSTQQPQWIKRQEYDEQGP 367


                 ....*...
gi 19353679  167 RAIHRKTF 174
Cdd:PTZ00452 368 SIVHRKCF 375
ASKHA_NBD_actin-like cd10169
nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ...
 3-165 4.25e-50

nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ubiquitous in eukaryotes, and the major component of the actin cytoskeleton; monomeric globular protein (G-actin) reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. F-actin filaments form with the consequent hydrolysis of ATP. Some actin-related proteins (Arps) have roles in cytoskeletal functions, such as actin polymerization (Arp2/3) and dynein motor activity (Arp1). Both conventional actin and specific Arps have been implicated in chromatin remodeling and/or transcription regulation. The actin/ARP family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466810 [Multi-domain]  Cd Length: 258  Bit Score: 161.50  E-value: 4.25e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   3 FHTSAEFEVVRTIKERACylsinpqkdealetekvqytlpdgstldvgparfrapellfqpdlvgdeseGLHEVLAFAIH 82
Cdd:cd10169 147 FSTSAEREIVRDIKEKLC---------------------------------------------------GLHELIYDSIM 175

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  83 KSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQERLYSTWIGGSILASLDTFKKMWVSKKEYE 162
Cdd:cd10169 176 KCDIDLRKELYSNIVLSGGTTLFPGFAERLQKELSKLAPSSVKVKVIAPPERKYSAWIGGSILASLSTFQQMWITKEEYE 255


                ...
gi 19353679 163 EDG 165
Cdd:cd10169 256 EHG 258
ASKHA_NBD_Arp6 cd10210
nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, ...
 8-165 9.87e-43

nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, also called actin-like protein 6, is required for formation and/or maintenance of proper nucleolar structure and function, plays a dual role in the regulation of ribosomal DNA (rDNA) transcription. In the presence of high glucose, Arp6 maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, it is required for the repression of rDNA transcription, and this function may be independent of H2A.Z. Arp6 is also required for telomere silencing in both fission and budding yeast. It is a component of the budding yeast and Arabidopsis SWR1 complex (SWR1C) and the human SWI2/SNF2-related CBP activator protein (SRCAP) chromatin remodeling complexes which catalyze the exchange of the histone H2A with the H2AZ. Drosophila Arp6 colocalizes with HP1 (heterochromatin protein 1) in the pericentric heterochromatin, and vertebrate Arp6 also interacts with HP1. Human Arp6 is encoded by the ACTR6 gene. Arabidopsis thaliana ACTIN RELATED PROTEIN 6/EARLY IN SHORT DAYS 1/SUPPRESSOR OF FRIGIDA 3 (encoded by ARP6/ESD1/SUF3) participates in regulating several leaf and flower development stages. It is needed for Flowering locus C (FLC, the master repressor of flowering) and FLC-like gene expression in the shoot and root apex, and for the activity of the floral repressor pathway.


Pssm-ID: 466816 [Multi-domain]  Cd Length: 389  Bit Score: 146.16  E-value: 9.87e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   8 EFEVVRTIKERACYLSIN-------PQKDEALETEKVQYTLPDGST------LDVGPA-----------------RFRAP 57
Cdd:cd10210 202 ETYLVNQIKEDLCFVSTDfyedleiAKKKGKENTIRRDYVLPDYTTskrgyvRDPEEPnrgklkedeqvlrlnneRFTVP 281

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  58 ELLFQPDLVGDESEGLHEVLAFAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQERLYS 137
Cdd:cd10210 282 ELLFHPSDIGIQQAGIAEAIVQSINACPEELQPLLYANIVLTGGNALFPGFRERLEAELRSLAPDDYDVNVTLPEDPITY 361

                       170       180
                ....*....|....*....|....*...
gi 19353679 138 TWIGGSILASLDTFKKMWVSKKEYEEDG 165
Cdd:cd10210 362 AWEGGSLLAQSPEFEELAVTRAEYEEHG 389
ASKHA_NBD_Arp3-like cd10221
nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; Arp3, ...
 9-165 5.41e-34

nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; Arp3, also called actin-like protein 3, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp3 and Arp3B are encoded by the ACTR3 and ACTR3B genes respectively. Arp3B is also known as actin-related protein Arp4.


Pssm-ID: 466822  Cd Length: 404  Bit Score: 123.45  E-value: 5.41e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   9 FEVVRTIKERACYLSinpqKDEALETEK---------VQYTLPDGST-----LDVGPARFRAPELLFQPDLV-GDESEGL 73
Cdd:cd10221 215 LEVAKRIKERYCYVC----PDIVKEFAKydsdpakyiKQYTGINSVTgkpytVDVGYERFLAPEIFFNPEIAsSDFTTPL 290

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  74 HEVLAFAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKL------------------APKDVKIkISAPQERl 135
Cdd:cd10221 291 PEVVDQVIQSCPIDTRRGLYKNIVLSGGSTMFKDFGRRLQRDVKRIvdarlkaseelsggklkpKPIDVNV-ISHPMQR- 368

                       170       180       190
                ....*....|....*....|....*....|
gi 19353679 136 YSTWIGGSILASLDTFKKMWVSKKEYEEDG 165
Cdd:cd10221 369 YAVWFGGSMLASTPEFYTVCHTKAEYEEYG 398
PTZ00280 PTZ00280
Actin-related protein 3; Provisional
 10-165 4.44e-32

Actin-related protein 3; Provisional


Pssm-ID: 240343 [Multi-domain]  Cd Length: 414  Bit Score: 118.68  E-value: 4.44e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   10 EVVRTIKERACYLSINPQK-----DEALETEKVQYTLPDGST-----LDVGPARFRAPELLFQPDLV-GDESEGLHEVLA 78
Cdd:PTZ00280 219 LLAQRIKEKYCYVAPDIAKefekyDSDPKNHFKKYTAVNSVTkkpytVDVGYERFLGPEMFFHPEIFsSEWTTPLPEVVD 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   79 FAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKL------------------APKDVKIkISAPQERlYSTWI 140
Cdd:PTZ00280 299 DAIQSCPIDCRRPLYKNIVLSGGSTMFKGFDKRLQRDVRKRvdrrlkkaeelsggklkpIPIDVNV-VSHPRQR-YAVWY 376

                        170       180
                 ....*....|....*....|....*
gi 19353679  141 GGSILASLDTFKKMWVSKKEYEEDG 165
Cdd:PTZ00280 377 GGSMLASSPEFEKVCHTKAEYDEYG 401
ASKHA_NBD_AtARP7-like cd10209
nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar ...
 4-170 2.60e-27

nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar proteins; Arabidopsis thaliana ARP7 is an essential nuclear protein, ubiquitously expressed in all cell types. It is needed for normal embryogenesis, plant architecture, and floral organ abscission. It may play a role in regulating various phases of plant development through chromatin-mediated gene regulation.


Pssm-ID: 466815 [Multi-domain]  Cd Length: 354  Bit Score: 104.78  E-value: 2.60e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   4 HTSAEFEVVRTIKERACYLSINPQKDEA--LETEKVQYTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHEVLAFAI 81
Cdd:cd10209 180 KVKLDRSIVERLKEAVAWSADDEEAYEKkvLTCSPETYTLPDGRVISVGKERYCVGEALFRPSILGIEEYGIVEQLVRAV 259

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  82 HKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQERL------YSTWIGGSILASLDTFKKMW 155
Cdd:cd10209 260 STSPSENRRQLLENIVLCGGTSSVPGLEARLQKEIRLLSSPSSRPALVKPPEYMpentlrYSAWIGGAILAKVVFPQNQH 339

                       170
                ....*....|....*
gi 19353679 156 VSKKEYEEDGSRAIH 170
Cdd:cd10209 340 VTKADYDETGPSVVH 354
COG5277 COG5277
Actin-related protein [Cytoskeleton];
5-163 2.71e-26

Actin-related protein [Cytoskeleton];


Pssm-ID: 444088  Cd Length: 424  Bit Score: 102.95  E-value: 2.71e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   5 TSAEFEVVRTIKERACYL------SINPQKDEALETEKVqYTLPDGSTL----DVGPARFRAPELLFQPDLVGDESE--- 71
Cdd:COG5277 223 TAREEYVVRVVKEALGLVprdlakAIQKAASNPDSFEAK-VRLPNPTVEielgNYAWERFLIGEILFNPNHEGFESYiqq 301

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  72 -------------------GLHEVLAFAIHKSDMDLRRTLFSNIVLSGGSTLF---KGFGD-------RLLSEVKKLAPk 122
Cdd:COG5277 302 grlriedavigdvvlygemGLAEAIINSIMKCDVEIQDELYSNIILSGGAFNWsvpPGLEDvavdsvtRVQIELSELAP- 380

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 19353679 123 DVKIKISAPQERLYSTWIGGSILASLDTFKKMW--VSKKEYEE 163
Cdd:COG5277 381 ELKVNVRLVSDPQYSVWKGAIIYGYALPFSVKWswITKEGWYF 423
ASKHA_NBD_AtArp8-like cd13396
nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 8 (AtArp8) and ...
 12-165 7.64e-26

nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 8 (AtArp8) and similar proteins; Arabidopsis thaliana ARP8, also called F-box protein ARP8, is an F-Box protein localized to the nucleolus. It is ubiquitously expressed in all organs and cell types and has a cell cycle-dependent subcellular pattern of distribution: it is localized to the nucleolus in interphase cells and dispersed in the cytoplasm in mitotic cells.


Pssm-ID: 466847  Cd Length: 332  Bit Score: 100.70  E-value: 7.64e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  12 VRTIKERACYLSINPQKDEALETEKVQYTLPDGSTLdVGPARFRAPELLFQPDLVGDESEGLHEVLAFAIHKSDMDLR-- 89
Cdd:cd13396 174 VRTIKEKLCYVAEDYEAELAKDTQASCEVAGEGWFT-LSNERFKTGEILFQPGLGGMRAMGLHQAVALCMDHCALVHSqg 252

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  90 -RTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVK--IKISAPQERLYSTWIGGSILASLDTFKKMW-VSKKEYEEDG 165
Cdd:cd13396 253 dDGWFKTIVLSGGSACLPGLSERLERELRKLLPKSLSegIRIIPPPLGPDSAWQGAKLISNLSNFPDGWcITKKQFRNKP 332
ASKHA_NBD_Arp10 cd10207
nucleotide-binding domain (NBD) of actin-related protein 10 (Arp10) and similar proteins; ...
 9-166 1.17e-20

nucleotide-binding domain (NBD) of actin-related protein 10 (Arp10) and similar proteins; Arp10, also known as actin-related protein 11 (Arp11), is a subunit of the cargo-binding portion of the dynein activator, dynactin. It, together with dynactin4 (p62), -5(p25), and -6(p27), forms a heterotetrameric complex located at the pointed end of Arp1. Arp1 forms a mini-filament of uniform size, with proteins bound along its length and at both ends. Human Arp10 is encoded by the ACTR10 gene.


Pssm-ID: 466813 [Multi-domain]  Cd Length: 375  Bit Score: 86.92  E-value: 1.17e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   9 FEVVRTIKERACYL-SINPQKDEALETEKVQYTLP----------DGSTLDVGPARFRAP--ELLFQPDlvgDESEGLHE 75
Cdd:cd10207 190 EEVLEDIKVRACFVtSLERGKTLQSATEEGSTEEPsppppvdyplDGEKILIVPGSIRESaeELLFEGD---NEEKSLPT 266

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  76 VLAFAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDV-KIKISAPQERLYST----------WIGGSI 144
Cdd:cd10207 267 LILDSLLKCPIDVRKQLAENIVVIGGTSMLPGFKHRLLEELRALLRKPKyFEELAPKTFRFHTPpsvfkpnylaWLGGSI 346

                       170       180
                ....*....|....*....|..
gi 19353679 145 LASLDTFKKMWVSKKEYEEDGS 166
Cdd:cd10207 347 FGALESILGRSLSREAYLQTGR 368
ASKHA_NBD_Arp5 cd10211
nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, ...
 72-165 7.19e-19

nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, also called actin-like protein 5, may act as a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. It is involved in DNA double-strand break repair and UV-damage excision repair. Human Arp5 is encoded by the ACTR5 gene. Arabidopsis thaliana ARP5 (AtARp5) is a ubiquitously expressed nuclear protein involved in DNA repair and required for multicellular development of all organs. AtARp5 may be part of other chromatin remodeling machines in addition to INO80.


Pssm-ID: 466817 [Multi-domain]  Cd Length: 345  Bit Score: 81.85  E-value: 7.19e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  72 GLHEVLAFAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQERLYSTWIGGSILASLDTF 151
Cdd:cd10211 245 GLVETIEFVLKRYPAEQQDRLVQNVFLTGGNALFPGLKERLEKELRAIRPFGSPFNVVRAKDPVLDAWRGAAKWALDSTF 324

                        90
                ....*....|....
gi 19353679 152 KKMWVSKKEYEEDG 165
Cdd:cd10211 325 EKVWITKQEYEEKG 338
syringactin NF040575
syringactin; Syringactin are close homologs of the normally eukaryotic protein actin, found in ...
 107-172 4.72e-17

syringactin; Syringactin are close homologs of the normally eukaryotic protein actin, found in the plant pathogen Pseudomonas syringae and related species. This model was created, in part, to clarify that the family is real and distinct, rather than an artifact of eukaryotic contamination of bacterial genomic sequence data. As of the creation of this HMM, the family is uncharacterized.


Pssm-ID: 468549 [Multi-domain]  Cd Length: 132  Bit Score: 73.09  E-value: 4.72e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19353679  107 GFGDRLLSEVKKLAPKDVKIKISAPQERLYSTWIGGSILASLDTFKKMWVSKKEYEEDGSRAIHRK 172
Cdd:NF040575  66 GFYEKLKKSITEKAPKGALIGMTLDPKPESAAWRGAAMYAASEGFVEMAITKQEYDESGPSIVHRK 131
ASKHA_NBD_Arp8-like cd10206
nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The ...
 9-169 1.22e-16

nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The Arp8-like family includes Arp8, also called actin-like protein 8, from vertebrates and fungi. Human Arp8 is encoded by the ACTR8 gene and is also known as INO80 complex subunit N. It plays an important role in the functional organization of mitotic chromosomes. Arp8 exhibits low basal ATPase activity, and is unable to polymerize. It is probably a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication, and probably DNA repair. it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Arp8 strongly prefers nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. This subfamily also contains Arabidopsis thaliana Arp9.


Pssm-ID: 466812 [Multi-domain]  Cd Length: 447  Bit Score: 76.13  E-value: 1.22e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   9 FEVVRTIKERACYLS---INPQKDEALETEKVQytlpdgstldvgparfraPELLFQPDLVgdeseGLHEvlafAIHKS- 84
Cdd:cd10206 296 FLLLERLKETYCTLDqddIGVQLHEFYVREPGQ------------------PTLKYQFKLL-----PLDE----AIVQSi 348

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  85 ----DMDLRRTLFSNIVLSGGSTLFKGFG----DRLLSEVKKL--APKDVKIkISAPQER--LYSTWIGGSILASLDTFK 152
Cdd:cd10206 349 lscaSDELKRKMYSSILLVGGGAKIPGLAealeDRLLIKIPSLfeAVETVEV-LPPPKDMdpSLLAWKGGAVLACLDSAQ 427

                       170
                ....*....|....*..
gi 19353679 153 KMWVSKKEYEEDGSRAI 169
Cdd:cd10206 428 ELWITRKEWQRLGVRAL 444
ASKHA_NBD_ScArp9-like cd10208
nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and ...
 41-172 2.45e-16

nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and similar proteins; Saccharomyces cerevisiae Arp9, also called actin-like protein 9, chromatin structure-remodeling complex protein ARP9, or SWI/SNF complex component ARP9, is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. It is also part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. Arp9 forms a stable heterodimer with Arp7 protein in both the RSC and SWI/SNF chromatin-remodeling complexes. It has been suggested that this dimer functions as a module with DNA bending proteins, to achieve correct architecture and facilitate complex-complex interactions. Fission yeast SWI/SNF and RSC complexes do not contain Arp7 and Arp8, but instead contain Arp9 and Arp42.


Pssm-ID: 466814  Cd Length: 356  Bit Score: 75.04  E-value: 2.45e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  41 LPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHEVLAFAIHKS-DMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKL 119
Cdd:cd10208 203 LASGTEITVGKERFRACEPLFKPSSLRVDLLIAAIAGALVLNASdEPDKRPALWENIIIVGGGSRIRGLKEALLSELQQF 282

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19353679 120 -----------APKDVKI-KI----SAPQERLY--STWIGGSILASL---DTFKKMWVSKKEYEEDGSRAIHRK 172
Cdd:cd10208 283 hlisetsaspqQPRIIRLaKIpdyfPEWKKSGYeeAAFLGASIVAKLvfnDPSSKHYISKVDYNEKGPAAIHTK 356
ASKHA_NBD_ScArp7-like cd10212
nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein7 (Arp7) and ...
 9-162 7.11e-10

nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein7 (Arp7) and similar proteins; Saccharomyces cerevisiae Arp7, also called actin-like protein 7, is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. It is also part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. Arp7 forms a stable heterodimer with Arp9 protein in both the RSC and SWI/SNF chromatin-remodeling complexes. It has been suggested that this dimer functions as a module with DNA bending proteins, to achieve correct architecture and facilitate complex-complex interactions. Fission yeast SWI/SNF and RSC complexes do not contain Arp7 and Arp8, but instead contain Arp9 and Arp42.


Pssm-ID: 466818 [Multi-domain]  Cd Length: 424  Bit Score: 56.65  E-value: 7.11e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679   9 FEVVRTIKERAcylSINPQKDEALET--EKVQYTLPDGS--------------------TLDVGPArFRAPELLFQPDLV 66
Cdd:cd10212 242 FELERYYKEQA---DIYAKQQEQLKQmdQQLQYTALTGSpnnplvqkknflfkplnktlTLDLKEC-YQFAEYLFKPQLI 317

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19353679  67 GDE---SEGLHEVLAFAIHKSDMDLRRTLFSNIVLSGGSTLFKGFGDRLLSEVKKLAPKdVKIKISAPQ---ERLYSTWI 140
Cdd:cd10212 318 SDKfspEDGLGPLMAKSVKKAPEQVYSLLLTNVIITGSTSLIEGMEQRIIKELSIRFPQ-YKLTTFANQvmmDRKIQGWL 396

                       170       180
                ....*....|....*....|...
gi 19353679 141 GGSILASLDTFK-KMWVSKKEYE 162
Cdd:cd10212 397 GALTMANLPSWSlGKWYSKEDYE 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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