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Conserved domains on  [gi|28278189|gb|AAH46097|]
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Molybdenum cofactor synthesis 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 54-177 8.87e-61

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


:

Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 185.03  E-value: 8.87e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28278189  54 LSVDEVSQLVISPLCGAISLFVGTTRNNFEGKKVISLEYEAYLPMAENEVRKICSDIRQKWPVKHIAVFHRLGLVPVSEA 133
Cdd:cd00756   1 FDLAELLAALRDPEAGAVVTFVGTVRDHDEGKGVEALEYEAYPPMAEKELEEIAEEARERWGLLRVAIIHRVGRLPPGEA 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 28278189 134 SIIIAVSSAHRAASLEAVSYAIDTLKAKVPIWKKEIYEESSTWK 177
Cdd:cd00756  81 IVLVAVSSPHRKEAFEACEFLIDRLKHRAPIWKKEIFEGGEEWV 124
 
Name Accession Description Interval E-value
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 54-177 8.87e-61

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 185.03  E-value: 8.87e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28278189  54 LSVDEVSQLVISPLCGAISLFVGTTRNNFEGKKVISLEYEAYLPMAENEVRKICSDIRQKWPVKHIAVFHRLGLVPVSEA 133
Cdd:cd00756   1 FDLAELLAALRDPEAGAVVTFVGTVRDHDEGKGVEALEYEAYPPMAEKELEEIAEEARERWGLLRVAIIHRVGRLPPGEA 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 28278189 134 SIIIAVSSAHRAASLEAVSYAIDTLKAKVPIWKKEIYEESSTWK 177
Cdd:cd00756  81 IVLVAVSSPHRKEAFEACEFLIDRLKHRAPIWKKEIFEGGEEWV 124
MoaE pfam02391
MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of ...
 50-161 1.30e-58

MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of molybdopterin. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.


Pssm-ID: 460546  Cd Length: 113  Bit Score: 179.19  E-value: 1.30e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28278189    50 TAEKLSVDEVSQLVISPLCGAISLFVGTTRNNFEGKKVISLEYEAYLPMAENEVRKICSDIRQKWPVKHIAVFHRLGLVP 129
Cdd:pfam02391   2 TEEPLDVAEIAALVSDPEAGAVVTFVGTVRDHFDGKKVTALEYEAYPPMAEKELAEIAEEARERWPLLDVAIVHRVGRLP 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 28278189   130 VSEASIIIAVSSAHRAASLEAVSYAIDTLKAK 161
Cdd:pfam02391  82 VGEAIVLVAVSSPHRAEAFEACEYLIDELKAR 113
PLN02390 PLN02390
molybdopterin synthase catalytic subunit
 65-174 9.05e-58

molybdopterin synthase catalytic subunit


Pssm-ID: 178014  Cd Length: 111  Bit Score: 176.80  E-value: 9.05e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28278189   65 SPLCGAISLFVGTTRNNFEGKKVISLEYEAYLPMAENEVRKICSDIRQKWPVKHIAVFHRLGLVPVSEASIIIAVSSAHR 144
Cdd:PLN02390   1 DPQAGAIATFSGTTRDTFEGKTVLELRYEAYVPMALRELRKICDEARSRWSLHKIAVAHRLGPVPVGETSVFVAVSSVHR 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 28278189  145 AASLEAVSYAIDTLKAKVPIWKKEIYEESS 174
Cdd:PLN02390  81 ADALDACKFLIDELKASVPIWKKEVYDDGE 110
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 49-182 2.27e-56

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 174.21  E-value: 2.27e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28278189  49 FTAEKLSVDEVSQLVIS--PLCGAISLFVGTTRNNFEGKKVISLEYEAYLPMAENEVRKICSDIRQKWPVKHIAVFHRLG 126
Cdd:COG0314   6 VTEEPFDLAAELAALRAsdPEAGAVVTFVGTVRDHNDGRRVTALEYEAYPPMAEKELAEIAEEAAERWGLLDVAVIHRVG 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 28278189 127 LVPVSEASIIIAVSSAHRAASLEAVSYAIDTLKAKVPIWKKEIYEESSTWKGNKEC 182
Cdd:COG0314  86 RLEPGEPIVLVAVSSAHRKEAFEACRFLIDRLKTRAPIWKKEIFEDGEEWVEARSS 141
 
Name Accession Description Interval E-value
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 54-177 8.87e-61

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 185.03  E-value: 8.87e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28278189  54 LSVDEVSQLVISPLCGAISLFVGTTRNNFEGKKVISLEYEAYLPMAENEVRKICSDIRQKWPVKHIAVFHRLGLVPVSEA 133
Cdd:cd00756   1 FDLAELLAALRDPEAGAVVTFVGTVRDHDEGKGVEALEYEAYPPMAEKELEEIAEEARERWGLLRVAIIHRVGRLPPGEA 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 28278189 134 SIIIAVSSAHRAASLEAVSYAIDTLKAKVPIWKKEIYEESSTWK 177
Cdd:cd00756  81 IVLVAVSSPHRKEAFEACEFLIDRLKHRAPIWKKEIFEGGEEWV 124
MoaE pfam02391
MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of ...
 50-161 1.30e-58

MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of molybdopterin. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.


Pssm-ID: 460546  Cd Length: 113  Bit Score: 179.19  E-value: 1.30e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28278189    50 TAEKLSVDEVSQLVISPLCGAISLFVGTTRNNFEGKKVISLEYEAYLPMAENEVRKICSDIRQKWPVKHIAVFHRLGLVP 129
Cdd:pfam02391   2 TEEPLDVAEIAALVSDPEAGAVVTFVGTVRDHFDGKKVTALEYEAYPPMAEKELAEIAEEARERWPLLDVAIVHRVGRLP 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 28278189   130 VSEASIIIAVSSAHRAASLEAVSYAIDTLKAK 161
Cdd:pfam02391  82 VGEAIVLVAVSSPHRAEAFEACEYLIDELKAR 113
PLN02390 PLN02390
molybdopterin synthase catalytic subunit
 65-174 9.05e-58

molybdopterin synthase catalytic subunit


Pssm-ID: 178014  Cd Length: 111  Bit Score: 176.80  E-value: 9.05e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28278189   65 SPLCGAISLFVGTTRNNFEGKKVISLEYEAYLPMAENEVRKICSDIRQKWPVKHIAVFHRLGLVPVSEASIIIAVSSAHR 144
Cdd:PLN02390   1 DPQAGAIATFSGTTRDTFEGKTVLELRYEAYVPMALRELRKICDEARSRWSLHKIAVAHRLGPVPVGETSVFVAVSSVHR 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 28278189  145 AASLEAVSYAIDTLKAKVPIWKKEIYEESS 174
Cdd:PLN02390  81 ADALDACKFLIDELKASVPIWKKEVYDDGE 110
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 49-182 2.27e-56

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 174.21  E-value: 2.27e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28278189  49 FTAEKLSVDEVSQLVIS--PLCGAISLFVGTTRNNFEGKKVISLEYEAYLPMAENEVRKICSDIRQKWPVKHIAVFHRLG 126
Cdd:COG0314   6 VTEEPFDLAAELAALRAsdPEAGAVVTFVGTVRDHNDGRRVTALEYEAYPPMAEKELAEIAEEAAERWGLLDVAVIHRVG 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 28278189 127 LVPVSEASIIIAVSSAHRAASLEAVSYAIDTLKAKVPIWKKEIYEESSTWKGNKEC 182
Cdd:COG0314  86 RLEPGEPIVLVAVSSAHRKEAFEACRFLIDRLKTRAPIWKKEIFEDGEEWVEARSS 141
moaE PRK10678
molybdopterin synthase catalytic subunit MoaE;
47-176 5.14e-23

molybdopterin synthase catalytic subunit MoaE;


Pssm-ID: 182642  Cd Length: 150  Bit Score: 89.42  E-value: 5.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28278189   47 INFTAEKLSV-DEVSQLVISPLCGAISLFVGTTRNNFEGKKVISLEYEAYLPMAENEVRKICSDIRQKWPVKHIAVFHRL 125
Cdd:PRK10678   6 IVVGPAPFSVgEEYPWLAERDEDGAVVTFTGKVRNHNLGDSVKALTLEHYPGMTEKALAEIVDEARSRWPLGRVTVIHRV 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 28278189  126 GLVPVSEASIIIAVSSAHRAASLEAVSYAIDTLKAKVPIWKKEIYEESSTW 176
Cdd:PRK10678  86 GELWPGDEIVFVGVTSAHRSSAFEAGQFIMDYLKTRAPFWKREATPEGDRW 136
PRK14493 PRK14493
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; ...
 50-176 1.18e-19

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; Provisional


Pssm-ID: 237730 [Multi-domain]  Cd Length: 274  Bit Score: 83.51  E-value: 1.18e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28278189   50 TAEKLsVDEVSQLVISPLCGAISLFVGTTRNN--FEGKKVISLEYEAYLPMAENEVRKICSDIRQKWPVKHIAVFHRLGL 127
Cdd:PRK14493 142 TLESL-VAKVKRSPDADKAGAIATFTGRVRAKedADDEPTEYLEFEKYDGVADERMAAIREELKQRDGVFEVLLHHRTGV 220

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 28278189  128 VPVSEASIIIAVSSAHRAASLEAVSYAIDTLKAKVPIWKKEIYEESSTW 176
Cdd:PRK14493 221 IEAGEDIVFVVVLAGHRQEAFRAVSDGIDRLKDEVPIFKKEVTVDEEFW 269
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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