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Conserved domains on  [gi|39963586|gb|AAH64398|]
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PSMD1 protein, partial [Homo sapiens]

Protein Classification

26S proteasome non-ATPase regulatory subunit 1( domain architecture ID 1001948)

26S proteasome non-ATPase regulatory subunit 1 (PSMD1), also known as RPN2, is a non-ATPase subunit of the 19S regulatory complex of the 26S proteasome which plays a critical role in the recognition of ubiquitinated protein substrates by the proteasome and is involved in the ATP-dependent unfolding and translocation of these substrates into the proteasome core for degradation

Gene Ontology:  GO:0043161|GO:0005838

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RPN2 super family cl34911
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
 2-797 0e+00

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG5116:

Pssm-ID: 227446 [Multi-domain]  Cd Length: 926  Bit Score: 814.95  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586   2 ITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFYHLGAFEESLNYA 81
Cdd:COG5116   3 MTTARILPALLAELRDGRESEALDVINAHVDQLWPEISDDLRYIEALYDDDSFDPREMAALCLSKVYYVLGEYQQAIEYA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586  82 LGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVEnADLpEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLD 161
Cdd:COG5116  83 LRAGDRFLVDDGSFYYETIVYKSIEMYVHMMDS-AYI-GGDKDIIDRILDFVLEVIGAKCVDDSEIGYLLGIAAEGLRLD 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 162 VFEKTILESNDVpGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDN 241
Cdd:COG5116 161 IIEKYLSDGNDC-DIINYLLDLAITLVEEEGFRKEILRMLAEIGPGKPKPDYFYVIKAVVYLNDAEKAKALIEKLVKEND 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 242 LLMAYQICFDLYESASQQFLSSVIqnlrtvgtpiasvpgstnTGTVPGSEKDsdsmeteektssafvgktpeaspepkdq 321
Cdd:COG5116 240 LLLYAQVAFDLEDSASQEILEILV------------------TELVAQGYDQ---------------------------- 273

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 322 tlKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAV--RNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNW 399
Cdd:COG5116 274 --AVMSILSGEFTKKYLGAFLLEKNNTDFKFLNSSKSSLarKFSRFHYAVSLANSFMNLGTSNDSFYRNNLDWLGKASNW 351

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 400 AKFTATASLGVIHKGHEKEALQLMATYLPKDTSpGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASN---DIVRHG 476
Cdd:COG5116 352 AKFTATASLGVIHLGNSNPGYEILKPYLPSEVA-SSRQKEGGALYALGLIKAGFGREDTEYLLEYFLDTEDeltPELAYG 430

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 477 GSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVM 556
Cdd:COG5116 431 VCLGIGLINMGSANREIYEKLKELLKNDRALLGEAAVYGMGLLMLGTWSVEAIEDMRTYAGETQHERIKRGLGIGFALIL 510

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 557 YGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSV 636
Cdd:COG5116 511 YGRQEMADDYINELLYDKDSILRYNGVFSLALAYVGTGNLGVVSTLLHYAVSDGNDDVRRAAVIALGFVCCDDRDLLVGT 590

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 637 VSLLSESYNPHVRYGAAMALGICCAGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKV 716
Cdd:COG5116 591 VELLSESHNFHVRAGVAVALGIACAGTGDKVATDILEALMYDTNDFVRQSAMIAVGMILMQCNPELNPNVKRIIKKFNRV 670

                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 717 INDKHDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLSLAYTPTCVIGLNKDLK 796
Cdd:COG5116 671 IVDKHESGLAKLGAVLAQGISEAGGRNVTISLRNATGILSADRIVGLVLFLQYWYWFPLIHFVSLSFLPTTVIGIRGSQA 750


                .
gi 39963586 797 V 797
Cdd:COG5116 751 I 751
 
Name Accession Description Interval E-value
RPN2 COG5116
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
 2-797 0e+00

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227446 [Multi-domain]  Cd Length: 926  Bit Score: 814.95  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586   2 ITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFYHLGAFEESLNYA 81
Cdd:COG5116   3 MTTARILPALLAELRDGRESEALDVINAHVDQLWPEISDDLRYIEALYDDDSFDPREMAALCLSKVYYVLGEYQQAIEYA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586  82 LGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVEnADLpEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLD 161
Cdd:COG5116  83 LRAGDRFLVDDGSFYYETIVYKSIEMYVHMMDS-AYI-GGDKDIIDRILDFVLEVIGAKCVDDSEIGYLLGIAAEGLRLD 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 162 VFEKTILESNDVpGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDN 241
Cdd:COG5116 161 IIEKYLSDGNDC-DIINYLLDLAITLVEEEGFRKEILRMLAEIGPGKPKPDYFYVIKAVVYLNDAEKAKALIEKLVKEND 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 242 LLMAYQICFDLYESASQQFLSSVIqnlrtvgtpiasvpgstnTGTVPGSEKDsdsmeteektssafvgktpeaspepkdq 321
Cdd:COG5116 240 LLLYAQVAFDLEDSASQEILEILV------------------TELVAQGYDQ---------------------------- 273

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 322 tlKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAV--RNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNW 399
Cdd:COG5116 274 --AVMSILSGEFTKKYLGAFLLEKNNTDFKFLNSSKSSLarKFSRFHYAVSLANSFMNLGTSNDSFYRNNLDWLGKASNW 351

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 400 AKFTATASLGVIHKGHEKEALQLMATYLPKDTSpGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASN---DIVRHG 476
Cdd:COG5116 352 AKFTATASLGVIHLGNSNPGYEILKPYLPSEVA-SSRQKEGGALYALGLIKAGFGREDTEYLLEYFLDTEDeltPELAYG 430

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 477 GSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVM 556
Cdd:COG5116 431 VCLGIGLINMGSANREIYEKLKELLKNDRALLGEAAVYGMGLLMLGTWSVEAIEDMRTYAGETQHERIKRGLGIGFALIL 510

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 557 YGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSV 636
Cdd:COG5116 511 YGRQEMADDYINELLYDKDSILRYNGVFSLALAYVGTGNLGVVSTLLHYAVSDGNDDVRRAAVIALGFVCCDDRDLLVGT 590

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 637 VSLLSESYNPHVRYGAAMALGICCAGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKV 716
Cdd:COG5116 591 VELLSESHNFHVRAGVAVALGIACAGTGDKVATDILEALMYDTNDFVRQSAMIAVGMILMQCNPELNPNVKRIIKKFNRV 670

                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 717 INDKHDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLSLAYTPTCVIGLNKDLK 796
Cdd:COG5116 671 IVDKHESGLAKLGAVLAQGISEAGGRNVTISLRNATGILSADRIVGLVLFLQYWYWFPLIHFVSLSFLPTTVIGIRGSQA 750


                .
gi 39963586 797 V 797
Cdd:COG5116 751 I 751
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 599-690 1.34e-12

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 63.90  E-value: 1.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586   599 IRRLLHVAVSDVNDDVRRAAVESLGfiLFRTPEQCPSVVSLLSESyNPHVRYGAAMALGIccagTGNKEAINLLEPM-TN 677
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALG--RIGDPEAVPALLELLKDE-DPAVRRAAAEALGK----IGDPEALPALLELlRD 73

                          90
                  ....*....|...
gi 39963586   678 DPVNYVRQGALIA 690
Cdd:pfam13646  74 DDDDVVRAAAAEA 86
 
Name Accession Description Interval E-value
RPN2 COG5116
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
 2-797 0e+00

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227446 [Multi-domain]  Cd Length: 926  Bit Score: 814.95  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586   2 ITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFAALVASKVFYHLGAFEESLNYA 81
Cdd:COG5116   3 MTTARILPALLAELRDGRESEALDVINAHVDQLWPEISDDLRYIEALYDDDSFDPREMAALCLSKVYYVLGEYQQAIEYA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586  82 LGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVEnADLpEGEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLD 161
Cdd:COG5116  83 LRAGDRFLVDDGSFYYETIVYKSIEMYVHMMDS-AYI-GGDKDIIDRILDFVLEVIGAKCVDDSEIGYLLGIAAEGLRLD 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 162 VFEKTILESNDVpGMLAYSLKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKEDN 241
Cdd:COG5116 161 IIEKYLSDGNDC-DIINYLLDLAITLVEEEGFRKEILRMLAEIGPGKPKPDYFYVIKAVVYLNDAEKAKALIEKLVKEND 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 242 LLMAYQICFDLYESASQQFLSSVIqnlrtvgtpiasvpgstnTGTVPGSEKDsdsmeteektssafvgktpeaspepkdq 321
Cdd:COG5116 240 LLLYAQVAFDLEDSASQEILEILV------------------TELVAQGYDQ---------------------------- 273

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 322 tlKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAV--RNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNW 399
Cdd:COG5116 274 --AVMSILSGEFTKKYLGAFLLEKNNTDFKFLNSSKSSLarKFSRFHYAVSLANSFMNLGTSNDSFYRNNLDWLGKASNW 351

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 400 AKFTATASLGVIHKGHEKEALQLMATYLPKDTSpGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASN---DIVRHG 476
Cdd:COG5116 352 AKFTATASLGVIHLGNSNPGYEILKPYLPSEVA-SSRQKEGGALYALGLIKAGFGREDTEYLLEYFLDTEDeltPELAYG 430

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 477 GSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKILRGLAVGIALVM 556
Cdd:COG5116 431 VCLGIGLINMGSANREIYEKLKELLKNDRALLGEAAVYGMGLLMLGTWSVEAIEDMRTYAGETQHERIKRGLGIGFALIL 510

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 557 YGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSV 636
Cdd:COG5116 511 YGRQEMADDYINELLYDKDSILRYNGVFSLALAYVGTGNLGVVSTLLHYAVSDGNDDVRRAAVIALGFVCCDDRDLLVGT 590

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 637 VSLLSESYNPHVRYGAAMALGICCAGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKV 716
Cdd:COG5116 591 VELLSESHNFHVRAGVAVALGIACAGTGDKVATDILEALMYDTNDFVRQSAMIAVGMILMQCNPELNPNVKRIIKKFNRV 670

                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 717 INDKHDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLSLAYTPTCVIGLNKDLK 796
Cdd:COG5116 671 IVDKHESGLAKLGAVLAQGISEAGGRNVTISLRNATGILSADRIVGLVLFLQYWYWFPLIHFVSLSFLPTTVIGIRGSQA 750


                .
gi 39963586 797 V 797
Cdd:COG5116 751 I 751
RPN1 COG5110
26S proteasome regulatory complex component [Posttranslational modification, protein turnover, ...
 373-801 1.99e-25

26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227441 [Multi-domain]  Cd Length: 881  Bit Score: 113.10  E-value: 1.99e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 373 NSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEALQLMATYLPKDTSpgsaYQEGGGLYALGLIH-A 451
Cdd:COG5110 368 NDPINLGYENDSLIPLDDEWIYKCKVPGLISAFASIGVIESWNSDKGLETLDKYLYADES----YRKAGALLGIGLSGlR 443

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 452 NHG-GDIIDYLLNQLKNASNDIVRHGGSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGEA--AGLALGLVMLGSKNAQA 528
Cdd:COG5110 444 VFEeRPPALALLSNYLQSSSSKHVIAAILGLGAAFSGTQAEEVLELLQPIMFSTDSPIEVVffASLTLGSVFVGTCNGDL 523

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 529 IEDMV-------GYAQETQhekILRGLAVGIALVMYGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIRR 601
Cdd:COG5110 524 TSLILqtfvergKIESETQ---WFRFLALGLASLFYGRKDQVDDVEETIMAIEGALSKHEEILVKGCQYVGTGDVLVIQS 600

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 602 LLHVAVSDVNDDVRR--AAVES---LGFILFRTPEQCPSVVSLLSESY-----NPHVRYGAAMALGICCAGTGNKEAINL 671
Cdd:COG5110 601 LLHVKDEFTGDTLKNeeALIESlalLGCALIAMGEDIGSEMVLRHFSHsmhygSSHIRSVLPLAYGILSPSNPQMNVFDT 680

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 672 LEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVnqFRQLYSKVindkHDDVMAKFGAILAQGILDAGGHNVTISLQSR 751
Cdd:COG5110 681 LERSSHDGDLNVIINTIFAMGLIGAGTLNARLAQL--LRQLASYY----YKESKALFVLRIAQGLLSLGKGTMTISPLYF 754

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 39963586 752 TGHTHMPSVVGVLVFTQFWFW----FPL--SH----FLSLAYTPTCVIGLNKD---LKVSTAV 801
Cdd:COG5110 755 DKTTLMPKNTAGLFTTVFMLLdssiFPLvsSHalmyFLLCQIRPQKYVTLSEKgepIKVNVRV 817
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 599-690 1.34e-12

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 63.90  E-value: 1.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586   599 IRRLLHVAVSDVNDDVRRAAVESLGfiLFRTPEQCPSVVSLLSESyNPHVRYGAAMALGIccagTGNKEAINLLEPM-TN 677
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALG--RIGDPEAVPALLELLKDE-DPAVRRAAAEALGK----IGDPEALPALLELlRD 73

                          90
                  ....*....|...
gi 39963586   678 DPVNYVRQGALIA 690
Cdd:pfam13646  74 DDDDVVRAAAAEA 86
HEAT COG1413
HEAT repeat [General function prediction only];
545-690 3.14e-12

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 64.65  E-value: 3.14e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 545 LRGLAVGiALVMYGRMEEADALIESLcRDKDPILRRSGMYTVAMAycgsGNNKAIRRLLHvAVSDVNDDVRRAAVESLGF 624
Cdd:COG1413   1 VRRAAAR-ALGRLGDPAAVPALIAAL-ADEDPDVRAAAARALGRL----GDPRAVPALLE-ALKDPDPEVRAAAAEALGR 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 39963586 625 IlfRTPEQCPSVVSLLSESyNPHVRYGAAMALGiccaGTGNKEAINLLEPMTNDPVNYVRQGALIA 690
Cdd:COG1413  74 I--GDPEAVPALIAALKDE-DPEVRRAAAEALG----RLGDPAAVPALLEALKDPDWEVRRAAARA 132
HEAT COG1413
HEAT repeat [General function prediction only];
510-657 1.60e-10

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 59.64  E-value: 1.60e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 510 EAAGLALGLVmlgsKNAQAIEDMVGYAQETQHEkiLRGLAVgIALVMYGRMEEADALIESLcRDKDPILRRSgmytVAMA 589
Cdd:COG1413   3 RAAARALGRL----GDPAAVPALIAALADEDPD--VRAAAA-RALGRLGDPRAVPALLEAL-KDPDPEVRAA----AAEA 70

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 39963586 590 YCGSGNNKAIRRLLHvAVSDVNDDVRRAAVESLGFIlfRTPEQCPSVVSLLSESyNPHVRYGAAMALG 657
Cdd:COG1413  71 LGRIGDPEAVPALIA-ALKDEDPEVRRAAAEALGRL--GDPAAVPALLEALKDP-DWEVRRAAARALG 134
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 563-657 2.97e-10

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 57.35  E-value: 2.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586   563 ADALIESLCRDKDPILRRsgmyTVAMAyCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLGFIlfRTPEQCPSVVSLLSE 642
Cdd:pfam13646   1 LPALLQALLRDPDPEVRA----AAIRA-LGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKI--GDPEALPALLELLRD 73

                          90
                  ....*....|....*
gi 39963586   643 SYNPHVRYGAAMALG 657
Cdd:pfam13646  74 DDDDVVRAAAAEALA 88
PC_rep pfam01851
Proteasome/cyclosome repeat;
651-685 8.34e-07

Proteasome/cyclosome repeat;


Pssm-ID: 460361 [Multi-domain]  Cd Length: 35  Bit Score: 45.87  E-value: 8.34e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 39963586   651 GAAMALGICCAGTGNKEAINLLEPMTNDPVNYVRQ 685
Cdd:pfam01851   1 GAALALGLIHAGSGNEEALDLLLPYLSDTSAESRA 35
HEAT COG1413
HEAT repeat [General function prediction only];
614-694 9.30e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.16  E-value: 9.30e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39963586 614 VRRAAVESLGFIlfRTPEQCPSVVSLLSESyNPHVRYGAAMALGiccaGTGNKEAINLLEPMTNDPVNYVRQGALIASAL 693
Cdd:COG1413   1 VRRAAARALGRL--GDPAAVPALIAALADE-DPDVRAAAARALG----RLGDPRAVPALLEALKDPDPEVRAAAAEALGR 73


                .
gi 39963586 694 I 694
Cdd:COG1413  74 I 74
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 545-623 1.78e-04

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 41.17  E-value: 1.78e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 39963586   545 LRGLAVgIALVMYGRMEEADALIEsLCRDKDPILRRsgmyTVAMAYCGSGNNKAIRRLLHVAVSDVNDDVRRAAVESLG 623
Cdd:pfam13646  16 VRAAAI-RALGRIGDPEAVPALLE-LLKDEDPAVRR----AAAEALGKIGDPEALPALLELLRDDDDDVVRAAAAEALA 88
PC_rep pfam01851
Proteasome/cyclosome repeat;
511-544 2.07e-04

Proteasome/cyclosome repeat;


Pssm-ID: 460361 [Multi-domain]  Cd Length: 35  Bit Score: 39.33  E-value: 2.07e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 39963586   511 AAGLALGLVMLGSKNAQAIEDMVGYAQETQHEKI 544
Cdd:pfam01851   1 GAALALGLIHAGSGNEEALDLLLPYLSDTSAESR 34
PC_rep pfam01851
Proteasome/cyclosome repeat;
476-510 8.79e-04

Proteasome/cyclosome repeat;


Pssm-ID: 460361 [Multi-domain]  Cd Length: 35  Bit Score: 37.40  E-value: 8.79e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 39963586   476 GGSLGLGLAAMGTARQDVYDLLKTNLYQDDAVTGE 510
Cdd:pfam01851   1 GAALALGLIHAGSGNEEALDLLLPYLSDTSAESRA 35
PC_rep pfam01851
Proteasome/cyclosome repeat;
441-474 9.14e-04

Proteasome/cyclosome repeat;


Pssm-ID: 460361 [Multi-domain]  Cd Length: 35  Bit Score: 37.40  E-value: 9.14e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 39963586   441 GGLYALGLIHANHG-GDIIDYLLNQLKNASNDIVR 474
Cdd:pfam01851   1 GAALALGLIHAGSGnEEALDLLLPYLSDTSAESRA 35
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 646-690 2.00e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.96  E-value: 2.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 39963586   646 PHVRYGAAMALGICCAGTGN------KEAINLLEPMTNDPVNYVRQGALIA 690
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDllapavPELLPALLPLLNDDSDLVREAAAWA 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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