|
Name |
Accession |
Description |
Interval |
E-value |
| GrpE |
cd00446 |
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ... |
73-216 |
1.30e-47 |
|
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.
Pssm-ID: 271355 [Multi-domain] Cd Length: 136 Bit Score: 153.43 E-value: 1.30e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 73 QDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKccSEGAEPEdhrrtLEKVFQGLSLLEAR 152
Cdd:cd00446 1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALE--AAPKEEE-----LKNLLEGVEMTLKQ 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 127799456 153 LKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEV 216
Cdd:cd00446 74 LLKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESP-DKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
|
|
| GrpE |
pfam01025 |
GrpE; |
58-217 |
2.73e-41 |
|
GrpE;
Pssm-ID: 425996 [Multi-domain] Cd Length: 165 Bit Score: 138.12 E-value: 2.73e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 58 EQALRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKCCSEGAEPEDhrr 137
Cdd:pfam01025 13 IESLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSAPENEDVKS--- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 138 tlekVFQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:pfam01025 90 ----LLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSP-EKPEGTVVEVLQKGYKLHDRVLRPAMVVVS 164
|
|
| GrpE |
COG0576 |
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ... |
67-217 |
1.40e-40 |
|
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440341 [Multi-domain] Cd Length: 147 Bit Score: 135.67 E-value: 1.40e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 67 KLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKccsegAEPEDHrrTLEKVFQGL 146
Cdd:COG0576 3 ELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALA-----AAEEDE--DVKSLLEGV 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 127799456 147 SLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:COG0576 76 EMTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSP-DVEPGTVVEVLQKGYRLGDRVLRPAMVVVA 145
|
|
| PRK14155 |
PRK14155 |
heat shock protein GrpE; Provisional |
48-217 |
1.00e-30 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 237627 [Multi-domain] Cd Length: 208 Bit Score: 112.37 E-value: 1.00e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 48 PPDGLGPSLAEQALRLKAVKLEkeVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKtakccS 127
Cdd:PRK14155 7 PAEDGPFEADDAAQEIEALKAE--VAALKDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGR-----A 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 128 EGAEPEDHRRTLEKVF-QGLSLLEARLKSVFTKHGLEKMTP-IGDKYDPHEHELICHMPaGVGVQPGTVALVRQDGYKLH 205
Cdd:PRK14155 80 TAASPKDSADPAVKNFiIGVEMTEKELLGAFERNGLKKIDPaKGDKFDPHLHQAMMEQP-STEVAAGGVLQVMQAGYELM 158
|
170
....*....|..
gi 127799456 206 GRTIRLAQVEVA 217
Cdd:PRK14155 159 GRLVRPAMVAVA 170
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| GrpE |
cd00446 |
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ... |
73-216 |
1.30e-47 |
|
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.
Pssm-ID: 271355 [Multi-domain] Cd Length: 136 Bit Score: 153.43 E-value: 1.30e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 73 QDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKccSEGAEPEdhrrtLEKVFQGLSLLEAR 152
Cdd:cd00446 1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALE--AAPKEEE-----LKNLLEGVEMTLKQ 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 127799456 153 LKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEV 216
Cdd:cd00446 74 LLKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESP-DKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
|
|
| GrpE |
pfam01025 |
GrpE; |
58-217 |
2.73e-41 |
|
GrpE;
Pssm-ID: 425996 [Multi-domain] Cd Length: 165 Bit Score: 138.12 E-value: 2.73e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 58 EQALRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKCCSEGAEPEDhrr 137
Cdd:pfam01025 13 IESLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSAPENEDVKS--- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 138 tlekVFQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:pfam01025 90 ----LLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSP-EKPEGTVVEVLQKGYKLHDRVLRPAMVVVS 164
|
|
| GrpE |
COG0576 |
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ... |
67-217 |
1.40e-40 |
|
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440341 [Multi-domain] Cd Length: 147 Bit Score: 135.67 E-value: 1.40e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 67 KLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKccsegAEPEDHrrTLEKVFQGL 146
Cdd:COG0576 3 ELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALA-----AAEEDE--DVKSLLEGV 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 127799456 147 SLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:COG0576 76 EMTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSP-DVEPGTVVEVLQKGYRLGDRVLRPAMVVVA 145
|
|
| PRK14155 |
PRK14155 |
heat shock protein GrpE; Provisional |
48-217 |
1.00e-30 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 237627 [Multi-domain] Cd Length: 208 Bit Score: 112.37 E-value: 1.00e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 48 PPDGLGPSLAEQALRLKAVKLEkeVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKtakccS 127
Cdd:PRK14155 7 PAEDGPFEADDAAQEIEALKAE--VAALKDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGR-----A 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 128 EGAEPEDHRRTLEKVF-QGLSLLEARLKSVFTKHGLEKMTP-IGDKYDPHEHELICHMPaGVGVQPGTVALVRQDGYKLH 205
Cdd:PRK14155 80 TAASPKDSADPAVKNFiIGVEMTEKELLGAFERNGLKKIDPaKGDKFDPHLHQAMMEQP-STEVAAGGVLQVMQAGYELM 158
|
170
....*....|..
gi 127799456 206 GRTIRLAQVEVA 217
Cdd:PRK14155 159 GRLVRPAMVAVA 170
|
|
| PRK14141 |
PRK14141 |
heat shock protein GrpE; Provisional |
68-217 |
5.89e-27 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 172630 Cd Length: 209 Bit Score: 102.44 E-value: 5.89e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 68 LEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKccsegAEPEDHRRT----LEKVF 143
Cdd:PRK14141 43 LKAENAELKDRMLRLAAEMENLRKRTQRDVADARAYGIAGFARDMLSVSDNLRRALD-----AIPAEARAAadagLKALI 117
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 127799456 144 QGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPaGVGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14141 118 EGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQAMFEVP-NPDVPNNTVVQVVQAGYTIGERVLRPAMVGVA 190
|
|
| PRK14139 |
PRK14139 |
heat shock protein GrpE; Provisional |
34-217 |
2.30e-26 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 237621 [Multi-domain] Cd Length: 185 Bit Score: 100.43 E-value: 2.30e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 34 ATQRTAGEDCSSEDPPDGLGPSLAEqaLRLKAvkleKEVQDLTLRyqrAVADCENIRRRTQRCVEDAKIFGIQSFCKDLV 113
Cdd:PRK14139 19 AAQAAAAAAAAAEDAAPALEAELAE--AEAKA----AELQDSFLR---AKAETENVRRRAQEDVAKAHKFAIESFAESLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 114 EVADILEktakccsegAEPEDHRRTLEKVFQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAgvGVQPGT 193
Cdd:PRK14139 90 PVKDSLE---------AALADESGDLEKLREGVELTLKQLTSAFEKGRVVEINPVGEKFDPHQHQAISMVPA--EQEPNT 158
|
170 180
....*....|....*....|....
gi 127799456 194 VALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14139 159 VVAVLQKGYTIADRVLRPALVTVA 182
|
|
| PRK14150 |
PRK14150 |
heat shock protein GrpE; Provisional |
36-217 |
1.37e-23 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 184539 [Multi-domain] Cd Length: 193 Bit Score: 93.06 E-value: 1.37e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 36 QRTAGEDCSSEDPPDGLGPSLAEQALRLKAvkLEKEVQDLTLRyqrAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEV 115
Cdd:PRK14150 23 QQEEADEAELEDELDEADARIAELEAQLAE--AQAEERDSVLR---ARAEVENIRRRAEQDVEKAHKFALEKFANELLPV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 116 ADILEKTAkccsEGAEPEDhrRTLEKVFQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQPGTVA 195
Cdd:PRK14150 98 IDNLERAL----QAADKEN--EALKALIEGVELTLKSLLDTVAKFGVEVVGPVGEPFNPEVHQAISMQESE-DHEPNTVM 170
|
170 180
....*....|....*....|..
gi 127799456 196 LVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14150 171 MVMQKGYTLNGRLLRPAMVMVS 192
|
|
| PRK14144 |
PRK14144 |
heat shock protein GrpE; Provisional |
29-217 |
6.21e-21 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 184535 [Multi-domain] Cd Length: 199 Bit Score: 86.70 E-value: 6.21e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 29 HPFSTATQRTAGEDCSSEDPPDGLGPSLAEqaLRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSF 108
Cdd:PRK14144 20 HKVENEILEEETDEESQHQEPALGHPSYTA--LEEQLTLAEQKAHENWEKSVRALAELENVRRRMEREVANAHKYGVEKL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 109 CKDLVEVADILEKTAKCCSEGAEPEDHrrtlekvfQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvG 188
Cdd:PRK14144 98 ISALLPVVDSLEQALQLADKNSDPSMH--------EGLELTMKLFLDALQKFDVEQIDPLGQTFDPQQHEAMSMQPAP-G 168
|
170 180
....*....|....*....|....*....
gi 127799456 189 VQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14144 169 APPNSVITVFQKGYKLSDRVIRPARVIVS 197
|
|
| PRK14140 |
PRK14140 |
heat shock protein GrpE; Provisional |
68-217 |
6.62e-21 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 237622 [Multi-domain] Cd Length: 191 Bit Score: 86.21 E-value: 6.62e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 68 LEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKccsegAEPEDHrrTLEKVFQGLS 147
Cdd:PRK14140 49 LEAKLDELEERYLRLQADFENYKRRIQKENEAAEKYRAQSLASDLLPALDNFERALQ-----IEADDE--QTKSLLKGVE 121
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 148 LLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14140 122 MVHRQLLEALKKEGVEVIEAVGEQFDPNLHQAVMQDEDE-DFESNEVVEELQKGYKLKDRVIRPSMVKVN 190
|
|
| PRK14148 |
PRK14148 |
heat shock protein GrpE; Provisional |
55-214 |
1.23e-20 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 172637 [Multi-domain] Cd Length: 195 Bit Score: 85.57 E-value: 1.23e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 55 SLAEQALRLKAV--KLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKccsegaep 132
Cdd:PRK14148 37 SVEEQLERAKDTikELEDSCDQFKDEALRAKAEMENIRKRAERDVSNARKFGIEKFAKELLPVIDSIEQALK-------- 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 133 edHRRTLEKVF---QGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPaGVGVQPGTVALVRQDGYKLHGRTI 209
Cdd:PRK14148 109 --HEVKLEEAIamkEGIELTAKMLVDILKKNGVEELDPKGEKFDPNLHEAMAMIP-NPEFEDNTIFDVFQKGYMLNGRIV 185
|
....*
gi 127799456 210 RLAQV 214
Cdd:PRK14148 186 RAAKV 190
|
|
| PRK14151 |
PRK14151 |
heat shock protein GrpE; Provisional |
57-217 |
2.17e-20 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 172640 [Multi-domain] Cd Length: 176 Bit Score: 84.44 E-value: 2.17e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 57 AEQALRLKAVKLEKEVQDLTLRYQ-------RAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAkccsEG 129
Cdd:PRK14151 14 AAQAEAAAGDDLTARVQELEEQLAaakdqslRAAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPVVDSLERGL----EL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 130 AEPEDhrRTLEKVFQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELIChMPAGVGVQPGTVALVRQDGYKLHGRTI 209
Cdd:PRK14151 90 SSADD--EAIKPMREGVELTLKMFQDTLKRYQLEAVDPHGEPFNPEHHQAMA-MQESADVEPNSVLKVFQKGYLLNGRLL 166
|
....*...
gi 127799456 210 RLAQVEVA 217
Cdd:PRK14151 167 RPAMVVVS 174
|
|
| PRK14154 |
PRK14154 |
heat shock protein GrpE; Provisional |
36-217 |
1.21e-18 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 237626 [Multi-domain] Cd Length: 208 Bit Score: 80.62 E-value: 1.21e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 36 QRTAGEDCSSEDPP--DGLG-PSlaEQALRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDL 112
Cdd:PRK14154 31 QEEGGGDGSQEMEPhrEGLEfPS--REKLEGQLTRMERKVDEYKTQYLRAQAEMDNLRKRIEREKADIIKFGSKQLITDL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 113 VEVADILektakccSEGAE-PEDHRRTLEKVFQGLSLLEARLKSVFTKHGLEKMTP-IGDKYDPHEHELIcHMPAGVGVQ 190
Cdd:PRK14154 109 LPVADSL-------IHGLEsPASEDPQVKSMRDGMSLTLDLLHNTLAKHGVQVINPnPGDPFDPALHEAM-SVQAVPDAK 180
|
170 180
....*....|....*....|....*..
gi 127799456 191 PGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14154 181 PDTIIQVLQKGYQLNGRVLRAARVIVA 207
|
|
| PRK14147 |
PRK14147 |
heat shock protein GrpE; Provisional |
45-217 |
4.21e-18 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 237625 [Multi-domain] Cd Length: 172 Bit Score: 78.45 E-value: 4.21e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 45 SEDPPDGLGPSLAEQALRLKAVKLEKEvqdlTLRYQ---------RAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEV 115
Cdd:PRK14147 2 NQDHPEFDSEDLAQNPPETDPLKAEVE----SLRSEialvkadalRERADLENQRKRIARDVEQARKFANEKLLGELLPV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 116 ADILEktAKCCSEGAEPEDHRrtlekvfQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAgVGVQPGTVA 195
Cdd:PRK14147 78 FDSLD--AGLTAAGTEPSPLR-------DGLELTYKQLLKVAADNGLTLLDPVGQPFNPEHHQAISQGEA-EGVAPGHVV 147
|
170 180
....*....|....*....|..
gi 127799456 196 LVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14147 148 QVFQKGYLLNERLLRPALVVVA 169
|
|
| PRK14159 |
PRK14159 |
heat shock protein GrpE; Provisional |
67-217 |
4.63e-18 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 172647 [Multi-domain] Cd Length: 176 Bit Score: 78.19 E-value: 4.63e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 67 KLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKCcseGAEPEDHRRTLEKVFQGL 146
Cdd:PRK14159 34 KLQKDYDELKDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDVLDALEAAVNV---ECHDEISLKIKEGVQNTL 110
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 127799456 147 SLLEARLKsvftKHGLEKMTPIGDkYDPHEHELICHMPaGVGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14159 111 DLFLKKLE----KHGVALIKEEKE-FDPNLHEAMFHVD-SENHQSGEVVQVLQKGYKIADRVIRPTKVSVA 175
|
|
| PRK10325 |
PRK10325 |
heat shock protein GrpE; Provisional |
42-217 |
6.26e-17 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 182379 [Multi-domain] Cd Length: 197 Bit Score: 75.86 E-value: 6.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 42 DCSSE--DPPDglgpslaEQALRLKA--VKLEKEVQDLTLRYQravADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVAD 117
Cdd:PRK10325 31 EASAEqvDPRD-------EKIANLEAqlAEAQTRERDGILRVK---AEMENLRRRTELDIEKAHKFALEKFINELLPVID 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 118 ILEKTAKcCSEGAEPEdhrrtLEKVFQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELIChMPAGVGVQPGTVALV 197
Cdd:PRK10325 101 SLDRALE-VADKANPD-----MSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIA-MVESDDVAPGNVLGI 173
|
170 180
....*....|....*....|
gi 127799456 198 RQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK10325 174 MQKGYTLNGRTIRAAMVTVA 193
|
|
| PRK14153 |
PRK14153 |
heat shock protein GrpE; Provisional |
32-217 |
8.10e-17 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 184540 [Multi-domain] Cd Length: 194 Bit Score: 75.26 E-value: 8.10e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 32 STATQRTAGEDCSSEDPPDGLGPSLAEQALRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKD 111
Cdd:PRK14153 9 DKAENSEARNSGSSAEEAEELKEEPEDSTADSETEKCREEIESLKEQLFRLAAEFDNFRKRTAREMEENRKFVLEQVLLD 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 112 LVEVADILEKTAKccsEGAEPEDhrrtLEKVFQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQP 191
Cdd:PRK14153 89 LLEVTDNFERALE---SARTAED----MNSIVEGIEMVSKQFFSILEKYGLERIECEGEEFDPHRHEAMMHVETS-EVPD 160
|
170 180
....*....|....*....|....*.
gi 127799456 192 GTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14153 161 NTIVDVCKPGYALNSKVIRPAMVSVA 186
|
|
| PRK14161 |
PRK14161 |
heat shock protein GrpE; Provisional |
66-217 |
1.54e-15 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 237630 [Multi-domain] Cd Length: 178 Bit Score: 71.54 E-value: 1.54e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 66 VKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAkccseGAEPEDHRRTLEKVFQG 145
Cdd:PRK14161 29 TALKAEIEELKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVSDNLSRAL-----AHKPANSDVEVTNIIAG 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 127799456 146 LSLLEARLKSVFTKHGLEKMTP-IGDKYDPHEHELICHMpAGVGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14161 104 VQMTKDELDKVFHKHHIEEIKPeIGSMFDYNLHNAISQI-EHPDHAPNSIITLMQSGYKIRDRLLRPATVQVV 175
|
|
| PRK14149 |
PRK14149 |
heat shock protein GrpE; Provisional |
43-217 |
3.04e-15 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 184538 [Multi-domain] Cd Length: 191 Bit Score: 71.06 E-value: 3.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 43 CSSEDPPDGLGPSLAEQALRLKAvKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKT 122
Cdd:PRK14149 24 CACKEQQGEEKQEASEKEGEIKE-DFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 123 AKCCSEGAEPedhrrtlEKVFQGLSLLEARLKSVFTKHGLEKMTPIGDkYDPHEHELICHMPAGvGVQPGTVALVRQDGY 202
Cdd:PRK14149 103 LKSAAEVDKE-------SALTKGLELTMEKLHEVLARHGIEGIECLEE-FDPNFHNAIMQVKSE-EKENGKIVQVLQQGY 173
|
170
....*....|....*
gi 127799456 203 KLHGRTIRLAQVEVA 217
Cdd:PRK14149 174 KYKGRVLRPAMVSIA 188
|
|
| PRK14143 |
PRK14143 |
heat shock protein GrpE; Provisional |
39-217 |
3.91e-14 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 237624 [Multi-domain] Cd Length: 238 Bit Score: 68.99 E-value: 3.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 39 AGEDCSSEDPPDGLGPSLAEQALRLKAVK-----LEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLV 113
Cdd:PRK14143 45 AAEAESSPDSGSAASETAADNAARLAQLEqelesLKQELEELNSQYMRIAADFDNFRKRTSREQEDLRLQLKCNTLSEIL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 114 EVADILEKTakccSEGAEPE-DHRRTLEKVFQGLSlleARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGVGVQpG 192
Cdd:PRK14143 125 PVVDNFERA----RQQLKPEgEEAQALHRSYQGLY---KQLVDVLKRLGVSPMRVVGQEFDPNLHEAVLREPSDEHPE-D 196
|
170 180
....*....|....*....|....*
gi 127799456 193 TVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14143 197 VVLEELQRGYHLGGRVLRHAMVKVS 221
|
|
| PRK14162 |
PRK14162 |
heat shock protein GrpE; Provisional |
54-217 |
1.12e-11 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 237631 [Multi-domain] Cd Length: 194 Bit Score: 61.39 E-value: 1.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 54 PSLAEQALRLKAVKLEKEVQDLTLR-------YQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEK--TAK 124
Cdd:PRK14162 30 PKEEDQEKQNPVEDLEKEIADLKAKnkdledkYLRSQAEIQNMQNRYAKERAQLIKYESQSLAKDVLPAMDNLERalAVK 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 125 CCSEGAepedhrRTLEKvfqGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGVGVQPGTVALVRQDGYKL 204
Cdd:PRK14162 110 ADDEAA------KQLKK---GVQMTLDHLVKALKDHGVTEIKADGEKFDPTLHQAVQTVAAENDDQKDHVVQVLQKGYQY 180
|
170
....*....|...
gi 127799456 205 HGRTIRLAQVEVA 217
Cdd:PRK14162 181 KDRTLRPAMVVVA 193
|
|
| PRK14157 |
PRK14157 |
heat shock protein GrpE; Provisional |
32-217 |
9.54e-10 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 184543 [Multi-domain] Cd Length: 227 Bit Score: 56.50 E-value: 9.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 32 STATQRTAGEDCSSEDPPDGLGPSLAEQALRLKAVklekevqdltlryQRAVADCENIRRRTQRCVEDAKIFGIQSFCKD 111
Cdd:PRK14157 66 KAAAEKTGEAQSDSDDTLTPLGQAKKEAAEYLEAL-------------QRERAEFINYRNRTQKEQDRFRQHGIIDVLTA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 112 LVEVADILEKTakccSEGAEPEDHrrtlekvFQGLSlleARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPaGVGVQP 191
Cdd:PRK14157 133 LLPALDDIDRI----REHSEMDDS-------FKAVA---AKIDKAFEKFGVEKFGEKGEDFDPTKHDAILHKP-DPDAEK 197
|
170 180
....*....|....*....|....*.
gi 127799456 192 GTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14157 198 ETVDTVVEAGYRIGDRVIRAARVVVA 223
|
|
| PRK14145 |
PRK14145 |
heat shock protein GrpE; Provisional |
41-217 |
1.57e-09 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 184536 [Multi-domain] Cd Length: 196 Bit Score: 55.70 E-value: 1.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 41 EDCSSEDPPDGL--------GPSLAE-QALRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKD 111
Cdd:PRK14145 21 SNEQMEGPPEDEqaqqnqpqQQTVDEiEELKQKLQQKEVEAQEYLDIAQRLKAEFENYRKRTEKEKSEMVEYGKEQVILE 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 112 LVEVADILEKTAKccSEGaepeDHRRTLEkvfqGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQP 191
Cdd:PRK14145 101 LLPVMDNFERALA--SSG----DYNSLKE----GIELIYRQFKKILDKFGVKEIEAEGQIFDPYKHHAVMQEEVE-GKQP 169
|
170 180
....*....|....*....|....*.
gi 127799456 192 GTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14145 170 NEIIEVFQKGYYLKDKVIRPSLVKVA 195
|
|
| PRK14163 |
PRK14163 |
heat shock protein GrpE; Provisional |
32-217 |
5.40e-09 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 184546 [Multi-domain] Cd Length: 214 Bit Score: 54.36 E-value: 5.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 32 STATQRTAGEDCSSEDPPDGLGPSLAEQALRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKD 111
Cdd:PRK14163 16 SGATPDDAEPKAASEEGAAPAGDAAATAGLTAQLDQVRTALGERTADLQRLQAEYQNYRRRVERDRVTVKEIAVANLLSE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 112 LVEVADILEKTakccsegaepedhrRTLEKVFQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGVGVQP 191
Cdd:PRK14163 96 LLPVLDDVGRA--------------REHGELVGGFKSVAESLETTVAKLGLQQFGKEGEPFDPTIHEALMHSYAPDVTET 161
|
170 180
....*....|....*....|....*.
gi 127799456 192 GTVALVrQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14163 162 TCVAIL-QPGYRIGERTIRPARVAVA 186
|
|
| PRK14160 |
PRK14160 |
heat shock protein GrpE; Provisional |
41-217 |
1.38e-07 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 237629 [Multi-domain] Cd Length: 211 Bit Score: 50.14 E-value: 1.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 41 EDCSSEDPPDGLGPS---LAEQALRLKA--VKLEKEVQDLTLRYQRAVADCENIRRRTQRcvEDAKIFgiQSFCKD---- 111
Cdd:PRK14160 41 KEEIIEDSEESNEVKieeLKDENNKLKEenKKLENELEALKDRLLRTVAEYDNYRKRTAK--EKEGIY--SDACEDvlke 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 112 LVEVADILEKTAKccSEGaepedhrrTLEKVFQGLSLLEARLKSVFTKHGLEKMTPIGDkYDPHEHELICHMPAGvGVQP 191
Cdd:PRK14160 117 LLPVLDNLERAAA--VEG--------SVEDLKKGIEMTVKQFKTSLEKLGVEEISTEGE-FDPNLHNAVMHVEDE-NYGE 184
|
170 180
....*....|....*....|....*.
gi 127799456 192 GTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14160 185 NEIVEVFQKGYKRGDKVIRYSMVKVA 210
|
|
| PRK14146 |
PRK14146 |
heat shock protein GrpE; Provisional |
69-216 |
6.75e-07 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 172635 [Multi-domain] Cd Length: 215 Bit Score: 48.19 E-value: 6.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 69 EKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKCCSEGAEpedhrrtLEKVFQGLSL 148
Cdd:PRK14146 67 KKEIESLKDSWARERAEFQNFKRRSAQEFVSIRKEAVKSLVSGFLNPIDNLERVGATQNQSEE-------LKPFVEGVKM 139
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 127799456 149 LEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHmPAGVGVQPGTVALVRQDGYKLH----GRTIRLAQVEV 216
Cdd:PRK14146 140 ILKEFYSVLEKSNVIRFDPKGEPFDPMSMEALSS-EEGDQYSEETVIDVYQAGYYYKenedKFTLRPARVRI 210
|
|
| PRK14142 |
PRK14142 |
heat shock protein GrpE; Provisional |
47-216 |
1.51e-05 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 237623 Cd Length: 223 Bit Score: 44.61 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 47 DPPDGLGPSlaeqalrlKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKCC 126
Cdd:PRK14142 32 DMPGGTAAA--------DAAHTEDKVAELTADLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDLERARKHG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 127 SEGAEPedhrrtlekvfqgLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHM-PAGVGVQPGTVALVRQdGYKLH 205
Cdd:PRK14142 104 DLESGP-------------LKSVADKLDSALTGLGLVAFGAEGEDFDPVLHEAVQHEgDGGQGSKPVIGTVMRQ-GYQLG 169
|
170
....*....|.
gi 127799456 206 GRTIRLAQVEV 216
Cdd:PRK14142 170 EQVLRHALVGV 180
|
|
| PRK14156 |
PRK14156 |
heat shock protein GrpE; Provisional |
41-217 |
1.58e-05 |
|
heat shock protein GrpE; Provisional
Pssm-ID: 237628 [Multi-domain] Cd Length: 177 Bit Score: 44.05 E-value: 1.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 41 EDCSSEDPPDGLGPSLAEQALRlKAVKLEKEVQDLTL----------RYQRAVADCENIRRRTQRCVEDAKIFGIQSFCK 110
Cdd:PRK14156 3 EEIKNEEVEEEVEATETEETVE-EVVEETPEKSELELaneradefenKYLRAHAEMQNIQRRANEERQQLQRYRSQDLAK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 111 DLVEVADILEKTAKCcsEGAEpedhrrtlEKVFQGLSLLEARLKSVFTKHGLEKMTpiGDKYDPHEHELICHMPAGVGVQ 190
Cdd:PRK14156 82 AILPSLDNLERALAV--EGLT--------DDVKKGLEMVQESLIQALKEEGVEEVA--VDSFDHNLHMAVQTLPADDEHP 149
|
170 180
....*....|....*....|....*..
gi 127799456 191 PGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14156 150 ADSIAQVFQKGYKLHERLLRPAMVVVY 176
|
|
|