NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|127799456|gb|AAH68232|]
View 

GrpE-like 2, mitochondrial [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
73-216 1.30e-47

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


:

Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 153.43  E-value: 1.30e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  73 QDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKccSEGAEPEdhrrtLEKVFQGLSLLEAR 152
Cdd:cd00446    1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALE--AAPKEEE-----LKNLLEGVEMTLKQ 73
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 127799456 153 LKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEV 216
Cdd:cd00446   74 LLKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESP-DKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
 
Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
73-216 1.30e-47

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 153.43  E-value: 1.30e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  73 QDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKccSEGAEPEdhrrtLEKVFQGLSLLEAR 152
Cdd:cd00446    1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALE--AAPKEEE-----LKNLLEGVEMTLKQ 73
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 127799456 153 LKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEV 216
Cdd:cd00446   74 LLKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESP-DKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
58-217 2.73e-41

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 138.12  E-value: 2.73e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456   58 EQALRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKCCSEGAEPEDhrr 137
Cdd:pfam01025  13 IESLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSAPENEDVKS--- 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  138 tlekVFQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:pfam01025  90 ----LLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSP-EKPEGTVVEVLQKGYKLHDRVLRPAMVVVS 164
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
67-217 1.40e-40

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 135.67  E-value: 1.40e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  67 KLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKccsegAEPEDHrrTLEKVFQGL 146
Cdd:COG0576    3 ELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALA-----AAEEDE--DVKSLLEGV 75
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 127799456 147 SLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:COG0576   76 EMTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSP-DVEPGTVVEVLQKGYRLGDRVLRPAMVVVA 145
PRK14155 PRK14155
heat shock protein GrpE; Provisional
48-217 1.00e-30

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 112.37  E-value: 1.00e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  48 PPDGLGPSLAEQALRLKAVKLEkeVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKtakccS 127
Cdd:PRK14155   7 PAEDGPFEADDAAQEIEALKAE--VAALKDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGR-----A 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 128 EGAEPEDHRRTLEKVF-QGLSLLEARLKSVFTKHGLEKMTP-IGDKYDPHEHELICHMPaGVGVQPGTVALVRQDGYKLH 205
Cdd:PRK14155  80 TAASPKDSADPAVKNFiIGVEMTEKELLGAFERNGLKKIDPaKGDKFDPHLHQAMMEQP-STEVAAGGVLQVMQAGYELM 158
                        170
                 ....*....|..
gi 127799456 206 GRTIRLAQVEVA 217
Cdd:PRK14155 159 GRLVRPAMVAVA 170
 
Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
73-216 1.30e-47

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 153.43  E-value: 1.30e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  73 QDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKccSEGAEPEdhrrtLEKVFQGLSLLEAR 152
Cdd:cd00446    1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALE--AAPKEEE-----LKNLLEGVEMTLKQ 73
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 127799456 153 LKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEV 216
Cdd:cd00446   74 LLKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESP-DKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
58-217 2.73e-41

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 138.12  E-value: 2.73e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456   58 EQALRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKCCSEGAEPEDhrr 137
Cdd:pfam01025  13 IESLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSAPENEDVKS--- 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  138 tlekVFQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:pfam01025  90 ----LLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSP-EKPEGTVVEVLQKGYKLHDRVLRPAMVVVS 164
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
67-217 1.40e-40

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 135.67  E-value: 1.40e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  67 KLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKccsegAEPEDHrrTLEKVFQGL 146
Cdd:COG0576    3 ELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALA-----AAEEDE--DVKSLLEGV 75
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 127799456 147 SLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:COG0576   76 EMTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSP-DVEPGTVVEVLQKGYRLGDRVLRPAMVVVA 145
PRK14155 PRK14155
heat shock protein GrpE; Provisional
48-217 1.00e-30

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 112.37  E-value: 1.00e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  48 PPDGLGPSLAEQALRLKAVKLEkeVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKtakccS 127
Cdd:PRK14155   7 PAEDGPFEADDAAQEIEALKAE--VAALKDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGR-----A 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 128 EGAEPEDHRRTLEKVF-QGLSLLEARLKSVFTKHGLEKMTP-IGDKYDPHEHELICHMPaGVGVQPGTVALVRQDGYKLH 205
Cdd:PRK14155  80 TAASPKDSADPAVKNFiIGVEMTEKELLGAFERNGLKKIDPaKGDKFDPHLHQAMMEQP-STEVAAGGVLQVMQAGYELM 158
                        170
                 ....*....|..
gi 127799456 206 GRTIRLAQVEVA 217
Cdd:PRK14155 159 GRLVRPAMVAVA 170
PRK14141 PRK14141
heat shock protein GrpE; Provisional
68-217 5.89e-27

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 102.44  E-value: 5.89e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  68 LEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKccsegAEPEDHRRT----LEKVF 143
Cdd:PRK14141  43 LKAENAELKDRMLRLAAEMENLRKRTQRDVADARAYGIAGFARDMLSVSDNLRRALD-----AIPAEARAAadagLKALI 117
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 127799456 144 QGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPaGVGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14141 118 EGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQAMFEVP-NPDVPNNTVVQVVQAGYTIGERVLRPAMVGVA 190
PRK14139 PRK14139
heat shock protein GrpE; Provisional
34-217 2.30e-26

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 100.43  E-value: 2.30e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  34 ATQRTAGEDCSSEDPPDGLGPSLAEqaLRLKAvkleKEVQDLTLRyqrAVADCENIRRRTQRCVEDAKIFGIQSFCKDLV 113
Cdd:PRK14139  19 AAQAAAAAAAAAEDAAPALEAELAE--AEAKA----AELQDSFLR---AKAETENVRRRAQEDVAKAHKFAIESFAESLL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 114 EVADILEktakccsegAEPEDHRRTLEKVFQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAgvGVQPGT 193
Cdd:PRK14139  90 PVKDSLE---------AALADESGDLEKLREGVELTLKQLTSAFEKGRVVEINPVGEKFDPHQHQAISMVPA--EQEPNT 158
                        170       180
                 ....*....|....*....|....
gi 127799456 194 VALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14139 159 VVAVLQKGYTIADRVLRPALVTVA 182
PRK14150 PRK14150
heat shock protein GrpE; Provisional
36-217 1.37e-23

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 93.06  E-value: 1.37e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  36 QRTAGEDCSSEDPPDGLGPSLAEQALRLKAvkLEKEVQDLTLRyqrAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEV 115
Cdd:PRK14150  23 QQEEADEAELEDELDEADARIAELEAQLAE--AQAEERDSVLR---ARAEVENIRRRAEQDVEKAHKFALEKFANELLPV 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 116 ADILEKTAkccsEGAEPEDhrRTLEKVFQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQPGTVA 195
Cdd:PRK14150  98 IDNLERAL----QAADKEN--EALKALIEGVELTLKSLLDTVAKFGVEVVGPVGEPFNPEVHQAISMQESE-DHEPNTVM 170
                        170       180
                 ....*....|....*....|..
gi 127799456 196 LVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14150 171 MVMQKGYTLNGRLLRPAMVMVS 192
PRK14144 PRK14144
heat shock protein GrpE; Provisional
29-217 6.21e-21

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 86.70  E-value: 6.21e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  29 HPFSTATQRTAGEDCSSEDPPDGLGPSLAEqaLRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSF 108
Cdd:PRK14144  20 HKVENEILEEETDEESQHQEPALGHPSYTA--LEEQLTLAEQKAHENWEKSVRALAELENVRRRMEREVANAHKYGVEKL 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 109 CKDLVEVADILEKTAKCCSEGAEPEDHrrtlekvfQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvG 188
Cdd:PRK14144  98 ISALLPVVDSLEQALQLADKNSDPSMH--------EGLELTMKLFLDALQKFDVEQIDPLGQTFDPQQHEAMSMQPAP-G 168
                        170       180
                 ....*....|....*....|....*....
gi 127799456 189 VQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14144 169 APPNSVITVFQKGYKLSDRVIRPARVIVS 197
PRK14140 PRK14140
heat shock protein GrpE; Provisional
68-217 6.62e-21

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 86.21  E-value: 6.62e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  68 LEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKccsegAEPEDHrrTLEKVFQGLS 147
Cdd:PRK14140  49 LEAKLDELEERYLRLQADFENYKRRIQKENEAAEKYRAQSLASDLLPALDNFERALQ-----IEADDE--QTKSLLKGVE 121
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 148 LLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14140 122 MVHRQLLEALKKEGVEVIEAVGEQFDPNLHQAVMQDEDE-DFESNEVVEELQKGYKLKDRVIRPSMVKVN 190
PRK14148 PRK14148
heat shock protein GrpE; Provisional
55-214 1.23e-20

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 85.57  E-value: 1.23e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  55 SLAEQALRLKAV--KLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKccsegaep 132
Cdd:PRK14148  37 SVEEQLERAKDTikELEDSCDQFKDEALRAKAEMENIRKRAERDVSNARKFGIEKFAKELLPVIDSIEQALK-------- 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 133 edHRRTLEKVF---QGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPaGVGVQPGTVALVRQDGYKLHGRTI 209
Cdd:PRK14148 109 --HEVKLEEAIamkEGIELTAKMLVDILKKNGVEELDPKGEKFDPNLHEAMAMIP-NPEFEDNTIFDVFQKGYMLNGRIV 185

                 ....*
gi 127799456 210 RLAQV 214
Cdd:PRK14148 186 RAAKV 190
PRK14151 PRK14151
heat shock protein GrpE; Provisional
57-217 2.17e-20

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 84.44  E-value: 2.17e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  57 AEQALRLKAVKLEKEVQDLTLRYQ-------RAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAkccsEG 129
Cdd:PRK14151  14 AAQAEAAAGDDLTARVQELEEQLAaakdqslRAAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPVVDSLERGL----EL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 130 AEPEDhrRTLEKVFQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELIChMPAGVGVQPGTVALVRQDGYKLHGRTI 209
Cdd:PRK14151  90 SSADD--EAIKPMREGVELTLKMFQDTLKRYQLEAVDPHGEPFNPEHHQAMA-MQESADVEPNSVLKVFQKGYLLNGRLL 166

                 ....*...
gi 127799456 210 RLAQVEVA 217
Cdd:PRK14151 167 RPAMVVVS 174
PRK14154 PRK14154
heat shock protein GrpE; Provisional
36-217 1.21e-18

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 80.62  E-value: 1.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  36 QRTAGEDCSSEDPP--DGLG-PSlaEQALRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDL 112
Cdd:PRK14154  31 QEEGGGDGSQEMEPhrEGLEfPS--REKLEGQLTRMERKVDEYKTQYLRAQAEMDNLRKRIEREKADIIKFGSKQLITDL 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 113 VEVADILektakccSEGAE-PEDHRRTLEKVFQGLSLLEARLKSVFTKHGLEKMTP-IGDKYDPHEHELIcHMPAGVGVQ 190
Cdd:PRK14154 109 LPVADSL-------IHGLEsPASEDPQVKSMRDGMSLTLDLLHNTLAKHGVQVINPnPGDPFDPALHEAM-SVQAVPDAK 180
                        170       180
                 ....*....|....*....|....*..
gi 127799456 191 PGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14154 181 PDTIIQVLQKGYQLNGRVLRAARVIVA 207
PRK14147 PRK14147
heat shock protein GrpE; Provisional
45-217 4.21e-18

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 78.45  E-value: 4.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  45 SEDPPDGLGPSLAEQALRLKAVKLEKEvqdlTLRYQ---------RAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEV 115
Cdd:PRK14147   2 NQDHPEFDSEDLAQNPPETDPLKAEVE----SLRSEialvkadalRERADLENQRKRIARDVEQARKFANEKLLGELLPV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 116 ADILEktAKCCSEGAEPEDHRrtlekvfQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAgVGVQPGTVA 195
Cdd:PRK14147  78 FDSLD--AGLTAAGTEPSPLR-------DGLELTYKQLLKVAADNGLTLLDPVGQPFNPEHHQAISQGEA-EGVAPGHVV 147
                        170       180
                 ....*....|....*....|..
gi 127799456 196 LVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14147 148 QVFQKGYLLNERLLRPALVVVA 169
PRK14159 PRK14159
heat shock protein GrpE; Provisional
67-217 4.63e-18

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 78.19  E-value: 4.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  67 KLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKCcseGAEPEDHRRTLEKVFQGL 146
Cdd:PRK14159  34 KLQKDYDELKDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDVLDALEAAVNV---ECHDEISLKIKEGVQNTL 110
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 127799456 147 SLLEARLKsvftKHGLEKMTPIGDkYDPHEHELICHMPaGVGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14159 111 DLFLKKLE----KHGVALIKEEKE-FDPNLHEAMFHVD-SENHQSGEVVQVLQKGYKIADRVIRPTKVSVA 175
PRK10325 PRK10325
heat shock protein GrpE; Provisional
42-217 6.26e-17

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 75.86  E-value: 6.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  42 DCSSE--DPPDglgpslaEQALRLKA--VKLEKEVQDLTLRYQravADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVAD 117
Cdd:PRK10325  31 EASAEqvDPRD-------EKIANLEAqlAEAQTRERDGILRVK---AEMENLRRRTELDIEKAHKFALEKFINELLPVID 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 118 ILEKTAKcCSEGAEPEdhrrtLEKVFQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELIChMPAGVGVQPGTVALV 197
Cdd:PRK10325 101 SLDRALE-VADKANPD-----MSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIA-MVESDDVAPGNVLGI 173
                        170       180
                 ....*....|....*....|
gi 127799456 198 RQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK10325 174 MQKGYTLNGRTIRAAMVTVA 193
PRK14153 PRK14153
heat shock protein GrpE; Provisional
32-217 8.10e-17

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 75.26  E-value: 8.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  32 STATQRTAGEDCSSEDPPDGLGPSLAEQALRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKD 111
Cdd:PRK14153   9 DKAENSEARNSGSSAEEAEELKEEPEDSTADSETEKCREEIESLKEQLFRLAAEFDNFRKRTAREMEENRKFVLEQVLLD 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 112 LVEVADILEKTAKccsEGAEPEDhrrtLEKVFQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQP 191
Cdd:PRK14153  89 LLEVTDNFERALE---SARTAED----MNSIVEGIEMVSKQFFSILEKYGLERIECEGEEFDPHRHEAMMHVETS-EVPD 160
                        170       180
                 ....*....|....*....|....*.
gi 127799456 192 GTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14153 161 NTIVDVCKPGYALNSKVIRPAMVSVA 186
PRK14161 PRK14161
heat shock protein GrpE; Provisional
66-217 1.54e-15

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 71.54  E-value: 1.54e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  66 VKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAkccseGAEPEDHRRTLEKVFQG 145
Cdd:PRK14161  29 TALKAEIEELKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVSDNLSRAL-----AHKPANSDVEVTNIIAG 103
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 127799456 146 LSLLEARLKSVFTKHGLEKMTP-IGDKYDPHEHELICHMpAGVGVQPGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14161 104 VQMTKDELDKVFHKHHIEEIKPeIGSMFDYNLHNAISQI-EHPDHAPNSIITLMQSGYKIRDRLLRPATVQVV 175
PRK14149 PRK14149
heat shock protein GrpE; Provisional
43-217 3.04e-15

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 71.06  E-value: 3.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  43 CSSEDPPDGLGPSLAEQALRLKAvKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKT 122
Cdd:PRK14149  24 CACKEQQGEEKQEASEKEGEIKE-DFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGA 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 123 AKCCSEGAEPedhrrtlEKVFQGLSLLEARLKSVFTKHGLEKMTPIGDkYDPHEHELICHMPAGvGVQPGTVALVRQDGY 202
Cdd:PRK14149 103 LKSAAEVDKE-------SALTKGLELTMEKLHEVLARHGIEGIECLEE-FDPNFHNAIMQVKSE-EKENGKIVQVLQQGY 173
                        170
                 ....*....|....*
gi 127799456 203 KLHGRTIRLAQVEVA 217
Cdd:PRK14149 174 KYKGRVLRPAMVSIA 188
PRK14143 PRK14143
heat shock protein GrpE; Provisional
39-217 3.91e-14

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 68.99  E-value: 3.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  39 AGEDCSSEDPPDGLGPSLAEQALRLKAVK-----LEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLV 113
Cdd:PRK14143  45 AAEAESSPDSGSAASETAADNAARLAQLEqelesLKQELEELNSQYMRIAADFDNFRKRTSREQEDLRLQLKCNTLSEIL 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 114 EVADILEKTakccSEGAEPE-DHRRTLEKVFQGLSlleARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGVGVQpG 192
Cdd:PRK14143 125 PVVDNFERA----RQQLKPEgEEAQALHRSYQGLY---KQLVDVLKRLGVSPMRVVGQEFDPNLHEAVLREPSDEHPE-D 196
                        170       180
                 ....*....|....*....|....*
gi 127799456 193 TVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14143 197 VVLEELQRGYHLGGRVLRHAMVKVS 221
PRK14162 PRK14162
heat shock protein GrpE; Provisional
54-217 1.12e-11

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 61.39  E-value: 1.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  54 PSLAEQALRLKAVKLEKEVQDLTLR-------YQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEK--TAK 124
Cdd:PRK14162  30 PKEEDQEKQNPVEDLEKEIADLKAKnkdledkYLRSQAEIQNMQNRYAKERAQLIKYESQSLAKDVLPAMDNLERalAVK 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 125 CCSEGAepedhrRTLEKvfqGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGVGVQPGTVALVRQDGYKL 204
Cdd:PRK14162 110 ADDEAA------KQLKK---GVQMTLDHLVKALKDHGVTEIKADGEKFDPTLHQAVQTVAAENDDQKDHVVQVLQKGYQY 180
                        170
                 ....*....|...
gi 127799456 205 HGRTIRLAQVEVA 217
Cdd:PRK14162 181 KDRTLRPAMVVVA 193
PRK14157 PRK14157
heat shock protein GrpE; Provisional
32-217 9.54e-10

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 56.50  E-value: 9.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  32 STATQRTAGEDCSSEDPPDGLGPSLAEQALRLKAVklekevqdltlryQRAVADCENIRRRTQRCVEDAKIFGIQSFCKD 111
Cdd:PRK14157  66 KAAAEKTGEAQSDSDDTLTPLGQAKKEAAEYLEAL-------------QRERAEFINYRNRTQKEQDRFRQHGIIDVLTA 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 112 LVEVADILEKTakccSEGAEPEDHrrtlekvFQGLSlleARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPaGVGVQP 191
Cdd:PRK14157 133 LLPALDDIDRI----REHSEMDDS-------FKAVA---AKIDKAFEKFGVEKFGEKGEDFDPTKHDAILHKP-DPDAEK 197
                        170       180
                 ....*....|....*....|....*.
gi 127799456 192 GTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14157 198 ETVDTVVEAGYRIGDRVIRAARVVVA 223
PRK14145 PRK14145
heat shock protein GrpE; Provisional
41-217 1.57e-09

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 55.70  E-value: 1.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  41 EDCSSEDPPDGL--------GPSLAE-QALRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKD 111
Cdd:PRK14145  21 SNEQMEGPPEDEqaqqnqpqQQTVDEiEELKQKLQQKEVEAQEYLDIAQRLKAEFENYRKRTEKEKSEMVEYGKEQVILE 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 112 LVEVADILEKTAKccSEGaepeDHRRTLEkvfqGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGvGVQP 191
Cdd:PRK14145 101 LLPVMDNFERALA--SSG----DYNSLKE----GIELIYRQFKKILDKFGVKEIEAEGQIFDPYKHHAVMQEEVE-GKQP 169
                        170       180
                 ....*....|....*....|....*.
gi 127799456 192 GTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14145 170 NEIIEVFQKGYYLKDKVIRPSLVKVA 195
PRK14163 PRK14163
heat shock protein GrpE; Provisional
32-217 5.40e-09

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 54.36  E-value: 5.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  32 STATQRTAGEDCSSEDPPDGLGPSLAEQALRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKD 111
Cdd:PRK14163  16 SGATPDDAEPKAASEEGAAPAGDAAATAGLTAQLDQVRTALGERTADLQRLQAEYQNYRRRVERDRVTVKEIAVANLLSE 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 112 LVEVADILEKTakccsegaepedhrRTLEKVFQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGVGVQP 191
Cdd:PRK14163  96 LLPVLDDVGRA--------------REHGELVGGFKSVAESLETTVAKLGLQQFGKEGEPFDPTIHEALMHSYAPDVTET 161
                        170       180
                 ....*....|....*....|....*.
gi 127799456 192 GTVALVrQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14163 162 TCVAIL-QPGYRIGERTIRPARVAVA 186
PRK14160 PRK14160
heat shock protein GrpE; Provisional
41-217 1.38e-07

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 50.14  E-value: 1.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  41 EDCSSEDPPDGLGPS---LAEQALRLKA--VKLEKEVQDLTLRYQRAVADCENIRRRTQRcvEDAKIFgiQSFCKD---- 111
Cdd:PRK14160  41 KEEIIEDSEESNEVKieeLKDENNKLKEenKKLENELEALKDRLLRTVAEYDNYRKRTAK--EKEGIY--SDACEDvlke 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 112 LVEVADILEKTAKccSEGaepedhrrTLEKVFQGLSLLEARLKSVFTKHGLEKMTPIGDkYDPHEHELICHMPAGvGVQP 191
Cdd:PRK14160 117 LLPVLDNLERAAA--VEG--------SVEDLKKGIEMTVKQFKTSLEKLGVEEISTEGE-FDPNLHNAVMHVEDE-NYGE 184
                        170       180
                 ....*....|....*....|....*.
gi 127799456 192 GTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14160 185 NEIVEVFQKGYKRGDKVIRYSMVKVA 210
PRK14146 PRK14146
heat shock protein GrpE; Provisional
69-216 6.75e-07

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 48.19  E-value: 6.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  69 EKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKCCSEGAEpedhrrtLEKVFQGLSL 148
Cdd:PRK14146  67 KKEIESLKDSWARERAEFQNFKRRSAQEFVSIRKEAVKSLVSGFLNPIDNLERVGATQNQSEE-------LKPFVEGVKM 139
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 127799456 149 LEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHmPAGVGVQPGTVALVRQDGYKLH----GRTIRLAQVEV 216
Cdd:PRK14146 140 ILKEFYSVLEKSNVIRFDPKGEPFDPMSMEALSS-EEGDQYSEETVIDVYQAGYYYKenedKFTLRPARVRI 210
PRK14142 PRK14142
heat shock protein GrpE; Provisional
47-216 1.51e-05

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 44.61  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  47 DPPDGLGPSlaeqalrlKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKCC 126
Cdd:PRK14142  32 DMPGGTAAA--------DAAHTEDKVAELTADLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDLERARKHG 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 127 SEGAEPedhrrtlekvfqgLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHM-PAGVGVQPGTVALVRQdGYKLH 205
Cdd:PRK14142 104 DLESGP-------------LKSVADKLDSALTGLGLVAFGAEGEDFDPVLHEAVQHEgDGGQGSKPVIGTVMRQ-GYQLG 169
                        170
                 ....*....|.
gi 127799456 206 GRTIRLAQVEV 216
Cdd:PRK14142 170 EQVLRHALVGV 180
PRK14156 PRK14156
heat shock protein GrpE; Provisional
41-217 1.58e-05

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 44.05  E-value: 1.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456  41 EDCSSEDPPDGLGPSLAEQALRlKAVKLEKEVQDLTL----------RYQRAVADCENIRRRTQRCVEDAKIFGIQSFCK 110
Cdd:PRK14156   3 EEIKNEEVEEEVEATETEETVE-EVVEETPEKSELELaneradefenKYLRAHAEMQNIQRRANEERQQLQRYRSQDLAK 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127799456 111 DLVEVADILEKTAKCcsEGAEpedhrrtlEKVFQGLSLLEARLKSVFTKHGLEKMTpiGDKYDPHEHELICHMPAGVGVQ 190
Cdd:PRK14156  82 AILPSLDNLERALAV--EGLT--------DDVKKGLEMVQESLIQALKEEGVEEVA--VDSFDHNLHMAVQTLPADDEHP 149
                        170       180
                 ....*....|....*....|....*..
gi 127799456 191 PGTVALVRQDGYKLHGRTIRLAQVEVA 217
Cdd:PRK14156 150 ADSIAQVFQKGYKLHERLLRPAMVVVY 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH