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Conserved domains on  [gi|71682797|gb|AAI01129|]
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Pyroglutamylated RFamide peptide [Homo sapiens]

Protein Classification

RFamide_26RFa domain-containing protein( domain architecture ID 10567494)

RFamide_26RFa domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RFamide_26RFa pfam11109
Orexigenic neuropeptide Qrfp/P518; Qrfp/P518 has a direct role in maintaining bone mineral ...
 5-135 2.43e-79

Orexigenic neuropeptide Qrfp/P518; Qrfp/P518 has a direct role in maintaining bone mineral density. Qrfp has also found to be important in energy homeostasis by regulating appetite and energy expenditure in mice. The c-terminal 28 residues are the functional 26RFa.


:

Pssm-ID: 431659  Cd Length: 131  Bit Score: 229.96  E-value: 2.43e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71682797     5 YPLIYFLFLPLGACFPLLDRREPTDAMGGLGAGERWADLAMGPRPHSVWGSSRWLRASQPQALLVIARGLQTSGREHAGC 84
Cdd:pfam11109   1 YSLSYLLLLPLGACFPLLDRREPTDAMGGIGAGMSWADLAEGHRPHFVWGSSRWLRAPQPQALLVMAKELQMSGRERAGF 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 71682797    85 SFRFGRQDEGSEATGFLPAAGEKTSGPLGNLAEELNGYSRKKGGFSFRFGR 135
Cdd:pfam11109  81 RFRFGRQDEGSEATGFLPADGEKASGPLGTLAEELSGYSRKKGGFSFRFGR 131
 
Name Accession Description Interval E-value
RFamide_26RFa pfam11109
Orexigenic neuropeptide Qrfp/P518; Qrfp/P518 has a direct role in maintaining bone mineral ...
 5-135 2.43e-79

Orexigenic neuropeptide Qrfp/P518; Qrfp/P518 has a direct role in maintaining bone mineral density. Qrfp has also found to be important in energy homeostasis by regulating appetite and energy expenditure in mice. The c-terminal 28 residues are the functional 26RFa.


Pssm-ID: 431659  Cd Length: 131  Bit Score: 229.96  E-value: 2.43e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71682797     5 YPLIYFLFLPLGACFPLLDRREPTDAMGGLGAGERWADLAMGPRPHSVWGSSRWLRASQPQALLVIARGLQTSGREHAGC 84
Cdd:pfam11109   1 YSLSYLLLLPLGACFPLLDRREPTDAMGGIGAGMSWADLAEGHRPHFVWGSSRWLRAPQPQALLVMAKELQMSGRERAGF 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 71682797    85 SFRFGRQDEGSEATGFLPAAGEKTSGPLGNLAEELNGYSRKKGGFSFRFGR 135
Cdd:pfam11109  81 RFRFGRQDEGSEATGFLPADGEKASGPLGTLAEELSGYSRKKGGFSFRFGR 131
 
Name Accession Description Interval E-value
RFamide_26RFa pfam11109
Orexigenic neuropeptide Qrfp/P518; Qrfp/P518 has a direct role in maintaining bone mineral ...
 5-135 2.43e-79

Orexigenic neuropeptide Qrfp/P518; Qrfp/P518 has a direct role in maintaining bone mineral density. Qrfp has also found to be important in energy homeostasis by regulating appetite and energy expenditure in mice. The c-terminal 28 residues are the functional 26RFa.


Pssm-ID: 431659  Cd Length: 131  Bit Score: 229.96  E-value: 2.43e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71682797     5 YPLIYFLFLPLGACFPLLDRREPTDAMGGLGAGERWADLAMGPRPHSVWGSSRWLRASQPQALLVIARGLQTSGREHAGC 84
Cdd:pfam11109   1 YSLSYLLLLPLGACFPLLDRREPTDAMGGIGAGMSWADLAEGHRPHFVWGSSRWLRAPQPQALLVMAKELQMSGRERAGF 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 71682797    85 SFRFGRQDEGSEATGFLPAAGEKTSGPLGNLAEELNGYSRKKGGFSFRFGR 135
Cdd:pfam11109  81 RFRFGRQDEGSEATGFLPADGEKASGPLGTLAEELSGYSRKKGGFSFRFGR 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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