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Conserved domains on  [gi|133777841|gb|AAI15410|]
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PCDHGA3 protein, partial [Homo sapiens]

Protein Classification

protocadherin( domain architecture ID 10550026)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-112 9.97e-41

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 143.44  E-value: 9.97e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841   30 QIRYSVSEELDKGSFVGNIANDLGLEPRELAERGVRIVSRGRTQLFSLNPQSGSLVTAERIDREELCAQIPLCLVKINIL 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 133777841  110 VED 112
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-343 6.49e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.56  E-value: 6.49e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841 246 EYRVSVWENVPVGTRLLTVNATDPDEGFNAQVSYILdkMPGKIAEIFHLNSVSGEVSILKSLDYEDAMFYEIKIEAQDG- 324
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGg 78

                         90       100
                 ....*....|....*....|
gi 133777841 325 -PGLLSRAKILVTVLDVNDN 343
Cdd:cd11304   79 gPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-558 6.68e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 6.68e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841 456 SYSAYIPENNPRGASIFSVTAQDPDSNNNARITYALtedtLQGAPLSSFvSINSNTGVLYALRSFDYEQFRDLKLLVTAS 535
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI----VSGNEDGLF-SIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 133777841 536 DSGNPPLSSNVSLNLFVLDQNDN 558
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 579-666 1.30e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 1.30e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841 579 PRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSAT 657
Cdd:cd11304    7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP-LDREEQSSyTLTVTATDGGGPPLSST 85


                 ....*....
gi 133777841 658 VTLTVAVAD 666
Cdd:cd11304   86 ATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 355-448 3.71e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.22  E-value: 3.71e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841 355 SVPEEGTVGREIALIDVHDRDSGQNGQVEVFVLGNLP---FKLEKSidqYYRLVTATSLDREQISEYNISLRASDGGSPP 431
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDPS---TGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 133777841 432 LSTETHITLHVIDINDN 448
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 137-238 1.48e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 1.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841 137 ELEIKIGELTVPGTRFPLKTAFDPDVGINSLQNYKLSPNDYFSL-AVNSVSeGakypELVLERALDREKKEIHQLVLVAS 215
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPST-G----EITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 133777841 216 DGGDPVHSGNLHIQVIVLDANDN 238
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-112 9.97e-41

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 143.44  E-value: 9.97e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841   30 QIRYSVSEELDKGSFVGNIANDLGLEPRELAERGVRIVSRGRTQLFSLNPQSGSLVTAERIDREELCAQIPLCLVKINIL 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 133777841  110 VED 112
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-343 6.49e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.56  E-value: 6.49e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841 246 EYRVSVWENVPVGTRLLTVNATDPDEGFNAQVSYILdkMPGKIAEIFHLNSVSGEVSILKSLDYEDAMFYEIKIEAQDG- 324
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGg 78

                         90       100
                 ....*....|....*....|
gi 133777841 325 -PGLLSRAKILVTVLDVNDN 343
Cdd:cd11304   79 gPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-558 6.68e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 6.68e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841 456 SYSAYIPENNPRGASIFSVTAQDPDSNNNARITYALtedtLQGAPLSSFvSINSNTGVLYALRSFDYEQFRDLKLLVTAS 535
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI----VSGNEDGLF-SIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 133777841 536 DSGNPPLSSNVSLNLFVLDQNDN 558
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 579-666 1.30e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 1.30e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841 579 PRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSAT 657
Cdd:cd11304    7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP-LDREEQSSyTLTVTATDGGGPPLSST 85


                 ....*....
gi 133777841 658 VTLTVAVAD 666
Cdd:cd11304   86 ATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 355-448 3.71e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.22  E-value: 3.71e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841 355 SVPEEGTVGREIALIDVHDRDSGQNGQVEVFVLGNLP---FKLEKSidqYYRLVTATSLDREQISEYNISLRASDGGSPP 431
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDPS---TGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 133777841 432 LSTETHITLHVIDINDN 448
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 475-560 2.75e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 2.75e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841   475 TAQDPDSNNNARITYALtedtLQGAPLSSFvSINSNTGVLYALRSFDYEQFRDLKLLVTASDSGNPPLSSNVSLNLFVLD 554
Cdd:smart00112   1 SATDADSGENGKVTYSI----LSGNDDGLF-SIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 133777841   555 QNDNAP 560
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-345 6.86e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.32  E-value: 6.86e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841   265 NATDPDEGFNAQVSYILDkmPGKIAEIFHLNSVSGEVSILKSLDYEDAMFYEIKIEAQDG--PGLLSRAKILVTVLDVND 342
Cdd:smart00112   1 SATDADSGENGKVTYSIL--SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggPPLSSTATVTITVLDVND 78


                   ...
gi 133777841   343 NAP 345
Cdd:smart00112  79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 137-238 1.48e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 1.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841 137 ELEIKIGELTVPGTRFPLKTAFDPDVGINSLQNYKLSPNDYFSL-AVNSVSeGakypELVLERALDREKKEIHQLVLVAS 215
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPST-G----EITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 133777841 216 DGGDPVHSGNLHIQVIVLDANDN 238
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
457-553 8.91e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 8.91e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841  457 YSAYIPENNPRGASIFSVTAQDPDSNNNARITYALTEDtlqgaPLSSFVSINSNTGVLYALRSFDYEQFRDLKLLVTASD 536
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG-----GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 133777841  537 SGNPPLSSNVSLNLFVL 553
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 371-450 1.58e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.47  E-value: 1.58e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841   371 VHDRDSGQNGQVEVFVLGN---LPFKLEKSIDQyyrLVTATSLDREQISEYNISLRASDGGSPPLSTETHITLHVIDIND 447
Cdd:smart00112   2 ATDADSGENGKVTYSILSGnddGLFSIDPETGE---ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 133777841   448 NPP 450
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
247-338 6.55e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 6.55e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841  247 YRVSVWENVPVGTRLLTVNATDPDEGFNAQVSYilDKMPGKIAEIFHLNSVSGEVSILKSLDYEDAMFYEIKIEAQD--G 324
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFY--SILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDsgG 78

                          90
                  ....*....|....
gi 133777841  325 PGLLSRAKILVTVL 338
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 156-240 7.61e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.85  E-value: 7.61e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841   156 TAFDPDVGINSLQNYKLSPNDYFSL-AVNSVSEgakypELVLERALDREKKEIHQLVLVASDGGDPVHSGNLHIQVIVLD 234
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLfSIDPETG-----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 133777841   235 ANDNPP 240
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 592-666 1.11e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.08  E-value: 1.11e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 133777841   592 VAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSATVTLTVAVAD 666
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP-LDREEQPEyTLTVEATDGGGPPLSSTATVTITVLD 75
Cadherin pfam00028
Cadherin domain;
355-443 1.23e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.72  E-value: 1.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841  355 SVPEEGTVGREIALIDVHDRDSGQNGQVEVFVLGNLP---FKLEKSIDQyyrLVTATSLDREQISEYNISLRASDGGSPP 431
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPggnFRIDPDTGD---ISTTKPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|..
gi 133777841  432 LSTETHITLHVI 443
Cdd:pfam00028  81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
579-664 6.97e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 6.97e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841  579 PRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSAT 657
Cdd:pfam00028   6 PENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEyELTVEATDSGGPPLSST 84


                  ....*..
gi 133777841  658 VTLTVAV 664
Cdd:pfam00028  85 ATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 30-129 2.31e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.71  E-value: 2.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841  30 QIRYSVSEELDKGSFVGNI-ANDLGLEPreLAERGVRIVSRGRTQLFSLNPQSGSLVTAERIDREElcaqipLCLVKINI 108
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVsATDPDSGE--NGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREE------QSSYTLTV 72

                         90       100
                 ....*....|....*....|....*.
gi 133777841 109 LVEDKLKIF-----EVEIEIKDINDN 129
Cdd:cd11304   73 TATDGGGPPlsstaTVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 65-131 7.37e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 47.34  E-value: 7.37e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 133777841    65 RIVSRGRTQLFSLNPQSGSLVTAERIDREElcaqipLCLVKINILVEDKLKIF-----EVEIEIKDINDNAP 131
Cdd:smart00112  16 SILSGNDDGLFSIDPETGEITTTKPLDREE------QPEYTLTVEATDGGGPPlsstaTVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
139-233 1.13e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.30  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841  139 EIKIGELTVPGTRFPLKTAFDPDVGINSLQNYKLS---PNDYFSLAVNSvsegakyPELVLERALDREKKEIHQLVLVAS 215
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPDT-------GDISTTKPLDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 133777841  216 DGGDPVHSGNLHIQVIVL 233
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-112 9.97e-41

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 143.44  E-value: 9.97e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841   30 QIRYSVSEELDKGSFVGNIANDLGLEPRELAERGVRIVSRGRTQLFSLNPQSGSLVTAERIDREELCAQIPLCLVKINIL 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 133777841  110 VED 112
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-343 6.49e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.56  E-value: 6.49e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841 246 EYRVSVWENVPVGTRLLTVNATDPDEGFNAQVSYILdkMPGKIAEIFHLNSVSGEVSILKSLDYEDAMFYEIKIEAQDG- 324
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGg 78

                         90       100
                 ....*....|....*....|
gi 133777841 325 -PGLLSRAKILVTVLDVNDN 343
Cdd:cd11304   79 gPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-558 6.68e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 6.68e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841 456 SYSAYIPENNPRGASIFSVTAQDPDSNNNARITYALtedtLQGAPLSSFvSINSNTGVLYALRSFDYEQFRDLKLLVTAS 535
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI----VSGNEDGLF-SIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 133777841 536 DSGNPPLSSNVSLNLFVLDQNDN 558
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 579-666 1.30e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.76  E-value: 1.30e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841 579 PRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSAT 657
Cdd:cd11304    7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP-LDREEQSSyTLTVTATDGGGPPLSST 85


                 ....*....
gi 133777841 658 VTLTVAVAD 666
Cdd:cd11304   86 ATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 355-448 3.71e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.22  E-value: 3.71e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841 355 SVPEEGTVGREIALIDVHDRDSGQNGQVEVFVLGNLP---FKLEKSidqYYRLVTATSLDREQISEYNISLRASDGGSPP 431
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDPS---TGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                         90
                 ....*....|....*..
gi 133777841 432 LSTETHITLHVIDINDN 448
Cdd:cd11304   82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 475-560 2.75e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 2.75e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841   475 TAQDPDSNNNARITYALtedtLQGAPLSSFvSINSNTGVLYALRSFDYEQFRDLKLLVTASDSGNPPLSSNVSLNLFVLD 554
Cdd:smart00112   1 SATDADSGENGKVTYSI----LSGNDDGLF-SIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 133777841   555 QNDNAP 560
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-345 6.86e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.32  E-value: 6.86e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841   265 NATDPDEGFNAQVSYILDkmPGKIAEIFHLNSVSGEVSILKSLDYEDAMFYEIKIEAQDG--PGLLSRAKILVTVLDVND 342
Cdd:smart00112   1 SATDADSGENGKVTYSIL--SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggPPLSSTATVTITVLDVND 78


                   ...
gi 133777841   343 NAP 345
Cdd:smart00112  79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 137-238 1.48e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 83.90  E-value: 1.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841 137 ELEIKIGELTVPGTRFPLKTAFDPDVGINSLQNYKLSPNDYFSL-AVNSVSeGakypELVLERALDREKKEIHQLVLVAS 215
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPST-G----EITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|...
gi 133777841 216 DGGDPVHSGNLHIQVIVLDANDN 238
Cdd:cd11304   76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
457-553 8.91e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 8.91e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841  457 YSAYIPENNPRGASIFSVTAQDPDSNNNARITYALTEDtlqgaPLSSFVSINSNTGVLYALRSFDYEQFRDLKLLVTASD 536
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG-----GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 133777841  537 SGNPPLSSNVSLNLFVL 553
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 371-450 1.58e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.47  E-value: 1.58e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841   371 VHDRDSGQNGQVEVFVLGN---LPFKLEKSIDQyyrLVTATSLDREQISEYNISLRASDGGSPPLSTETHITLHVIDIND 447
Cdd:smart00112   2 ATDADSGENGKVTYSILSGnddGLFSIDPETGE---ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 133777841   448 NPP 450
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
247-338 6.55e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 6.55e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841  247 YRVSVWENVPVGTRLLTVNATDPDEGFNAQVSYilDKMPGKIAEIFHLNSVSGEVSILKSLDYEDAMFYEIKIEAQD--G 324
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFY--SILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDsgG 78

                          90
                  ....*....|....
gi 133777841  325 PGLLSRAKILVTVL 338
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 156-240 7.61e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.85  E-value: 7.61e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841   156 TAFDPDVGINSLQNYKLSPNDYFSL-AVNSVSEgakypELVLERALDREKKEIHQLVLVASDGGDPVHSGNLHIQVIVLD 234
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLfSIDPETG-----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 133777841   235 ANDNPP 240
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 592-666 1.11e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.08  E-value: 1.11e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 133777841   592 VAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSATVTLTVAVAD 666
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP-LDREEQPEyTLTVEATDGGGPPLSSTATVTITVLD 75
Cadherin pfam00028
Cadherin domain;
355-443 1.23e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.72  E-value: 1.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841  355 SVPEEGTVGREIALIDVHDRDSGQNGQVEVFVLGNLP---FKLEKSIDQyyrLVTATSLDREQISEYNISLRASDGGSPP 431
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPggnFRIDPDTGD---ISTTKPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|..
gi 133777841  432 LSTETHITLHVI 443
Cdd:pfam00028  81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
579-664 6.97e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 6.97e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841  579 PRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSAT 657
Cdd:pfam00028   6 PENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEyELTVEATDSGGPPLSST 84


                  ....*..
gi 133777841  658 VTLTVAV 664
Cdd:pfam00028  85 ATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 30-129 2.31e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.71  E-value: 2.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841  30 QIRYSVSEELDKGSFVGNI-ANDLGLEPreLAERGVRIVSRGRTQLFSLNPQSGSLVTAERIDREElcaqipLCLVKINI 108
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVsATDPDSGE--NGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREE------QSSYTLTV 72

                         90       100
                 ....*....|....*....|....*.
gi 133777841 109 LVEDKLKIF-----EVEIEIKDINDN 129
Cdd:cd11304   73 TATDGGGPPlsstaTVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 31-129 7.82e-09

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 53.50  E-value: 7.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841  31 IRYSVSEELDKGSFVGNIANDLGleprELAERGVRIVSRGR---TQLFSLNPQSGSLVTAERIDREELCAQIPLCLVKiN 107
Cdd:cd00031    2 PDGSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKealPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAA-S 76

                         90       100
                 ....*....|....*....|..
gi 133777841 108 ILVEDKLKIFEVEIEIKDINDN 129
Cdd:cd00031   77 LGANVPQTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 65-131 7.37e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 47.34  E-value: 7.37e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 133777841    65 RIVSRGRTQLFSLNPQSGSLVTAERIDREElcaqipLCLVKINILVEDKLKIF-----EVEIEIKDINDNAP 131
Cdd:smart00112  16 SILSGNDDGLFSIDPETGEITTTKPLDREE------QPEYTLTVEATDGGGPPlsstaTVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
139-233 1.13e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.30  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777841  139 EIKIGELTVPGTRFPLKTAFDPDVGINSLQNYKLS---PNDYFSLAVNSvsegakyPELVLERALDREKKEIHQLVLVAS 215
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgggPGGNFRIDPDT-------GDISTTKPLDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 133777841  216 DGGDPVHSGNLHIQVIVL 233
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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