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Conserved domains on  [gi|115333977|gb|AAI22566|]
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PCLO protein, partial [Homo sapiens]

Protein Classification

FYVE zinc finger domain-containing protein( domain architecture ID 707074)

FYVE (Fab1, YOTB, Vac1, and EEA1) zinc finger domain-containing protein may bind phosphoinositide 3-kinase product PtdIns 3-phosphate (PtdIns(3)P); similar to Homo sapiens DNA (cytosine-5)-methyltransferase 3-like, which is a catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context

Gene Ontology:  GO:0046872|GO:0008270|GO:0032266
PubMed:  10564636|9697764

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FYVE_like_SF super family cl28890
FYVE domain like superfamily; FYVE domain is a 60-80 residue double zinc finger ...
 567-628 1.36e-40

FYVE domain like superfamily; FYVE domain is a 60-80 residue double zinc finger motif-containing module named after the four proteins, Fab1, YOTB, Vac1, and EEA1. The canonical FYVE domains are distinguished from other zinc fingers by three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif, which form a compact phosphatidylinositol 3-phosphate (PtdIns3P, also termed PI3P)-binding site. They are found in many membrane trafficking regulators, including EEA1, Hrs, Vac1p, Vps27p, and FENS-1, which locate to early endosomes, specifically bind PtdIns3P, and play important roles in vesicular traffic and in signal transduction. Some proteins, such as rabphilin-3A and alpha-Rab3-interacting molecules (RIMs), are also involved in membrane trafficking and bind to members of the Rab subfamily of GTP hydrolases. However, they contain FYVE-related domains that are structurally similar to the canonical FYVE domains but lack the three signature sequences. At this point, they may not bind to phosphoinositides. In addition, this superfamily also contains the third group of proteins, caspase-associated ring proteins CARP1 and CARP2. They do not localize to membranes in the cell and are involved in the negative regulation of apoptosis, specifically targeting two initiator caspases, caspase 8 and caspase 10, which are distinguished from other FYVE-type proteins. Moreover, these proteins have an altered sequence in the basic ligand binding patch and lack the WxxD motif that is conserved only in phosphoinositide binding FYVE domains. Thus they constitute a family of unique FYVE-type domains called FYVE-like domains. The FYVE domain is structurally similar to the RING domain and the PHD finger. This superfamily also includes ADDz zinc finger domain, which is a PHD-like zinc finger motif that contains two parts, a C2-C2 and a PHD-like zinc finger.


The actual alignment was detected with superfamily member cd15774:

Pssm-ID: 333710 [Multi-domain]  Cd Length: 62  Bit Score: 142.09  E-value: 1.36e-40
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 115333977 567 TICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGG 628
Cdd:cd15774    1 TICPLCKTTELLLHTPEKANYNTCTQCQTTVCSLCGFNPNPHITEKKEWLCLNCQMQRALGG 62
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 205-565 9.67e-20

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 94.62  E-value: 9.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  205 PGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQtpqtdhaklPLQRDASRPQTKQADivrgeSVKPSLPSPSKP 284
Cdd:PHA03247 2647 PPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRR---------RAARPTVGSLTSLAD-----PPPPPPTPEPAP 2712

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  285 PIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLaqqPGTVKPPVQPPGTTKP--PAQPLGPAKPPAQQTGSEKPS 362
Cdd:PHA03247 2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT---PGGPARPARPPTTAGPpaPAPPAAPAAGPPRRLTRPAVA 2789

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  363 SEQPGPKALAQPPGVGKTPAQQPGP--AKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPG---PGKIPAQQAGPG 437
Cdd:PHA03247 2790 SLSESRESLPSPWDPADPPAAVLAPaaALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGsvaPGGDVRRRPPSR 2869

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  438 KTSAQQTGPTKPP-SQLPGPAKPPPQQPGPAKPPPQQP---GSAKPPPqQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQ 513
Cdd:PHA03247 2870 SPAAKPAAPARPPvRRLARPAVSRSTESFALPPDQPERppqPQAPPPP-QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 115333977  514 P-GSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPlQPPTVSPSAKQPPSQGLP 565
Cdd:PHA03247 2949 PaGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQP-APSREAPASSTPPLTGHS 3000
 
Name Accession Description Interval E-value
FYVE1_PCLO cd15774
FYVE-related domain 1 found in protein piccolo; Protein piccolo, also termed aczonin, is a ...
 567-628 1.36e-40

FYVE-related domain 1 found in protein piccolo; Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Piccolo is a multi-domain protein containing two N-terminal FYVE zinc fingers, a polyproline tract, and a PDZ domain and two C-terminal C2 domains. This family corresponds to the first FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277313 [Multi-domain]  Cd Length: 62  Bit Score: 142.09  E-value: 1.36e-40
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 115333977 567 TICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGG 628
Cdd:cd15774    1 TICPLCKTTELLLHTPEKANYNTCTQCQTTVCSLCGFNPNPHITEKKEWLCLNCQMQRALGG 62
zf-piccolo pfam05715
Piccolo Zn-finger; This (predicted) Zinc finger is found in the bassoon and piccolo proteins. ...
 567-626 4.98e-33

Piccolo Zn-finger; This (predicted) Zinc finger is found in the bassoon and piccolo proteins. There are eight conserved cysteines, suggesting that it coordinates two zinc ligands.


Pssm-ID: 461722 [Multi-domain]  Cd Length: 60  Bit Score: 120.60  E-value: 4.98e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  567 TICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRAL 626
Cdd:pfam05715   1 TLCPLCKTTELNVGSKEPPNYNTCTECKSQVCNLCGFNPTPHLTEKKEWLCLNCQTQRAL 60
PHA03247 PHA03247
large tegument protein UL36; Provisional
 205-565 9.67e-20

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 94.62  E-value: 9.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  205 PGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQtpqtdhaklPLQRDASRPQTKQADivrgeSVKPSLPSPSKP 284
Cdd:PHA03247 2647 PPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRR---------RAARPTVGSLTSLAD-----PPPPPPTPEPAP 2712

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  285 PIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLaqqPGTVKPPVQPPGTTKP--PAQPLGPAKPPAQQTGSEKPS 362
Cdd:PHA03247 2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT---PGGPARPARPPTTAGPpaPAPPAAPAAGPPRRLTRPAVA 2789

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  363 SEQPGPKALAQPPGVGKTPAQQPGP--AKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPG---PGKIPAQQAGPG 437
Cdd:PHA03247 2790 SLSESRESLPSPWDPADPPAAVLAPaaALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGsvaPGGDVRRRPPSR 2869

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  438 KTSAQQTGPTKPP-SQLPGPAKPPPQQPGPAKPPPQQP---GSAKPPPqQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQ 513
Cdd:PHA03247 2870 SPAAKPAAPARPPvRRLARPAVSRSTESFALPPDQPERppqPQAPPPP-QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 115333977  514 P-GSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPlQPPTVSPSAKQPPSQGLP 565
Cdd:PHA03247 2949 PaGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQP-APSREAPASSTPPLTGHS 3000
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 287-539 2.63e-13

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 73.15  E-value: 2.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  287 QQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLA------QQPGTVkPPVQPPGTT--KPPAQPlgPAKPPAQQTGS 358
Cdd:pfam09770 105 QQPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRtgyekyKEPEPI-PDLQVDASLwgVAPKKA--AAPAPAPQPAA 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  359 EKPSSEQPGPKALAqppgVGKTPAQQPGPAKPPTQQVgtPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGk 438
Cdd:pfam09770 182 QPASLPAPSRKMMS----LEEVEAAMRAQAKKPAQQP--APAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQ- 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  439 tsaQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKP---PPQQPGPAKPSPQQPgstkPPSQQPG 515
Cdd:pfam09770 255 ---QHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQIlqnPNRLSAARVGYPQNP----QPGVQPA 327

                         250       260
                  ....*....|....*....|....
gi 115333977  516 SAKPSAQQPSPAKPSAQQSTKPVS 539
Cdd:pfam09770 328 PAHQAHRQQGSFGRQAPIITHPQQ 351
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 423-546 1.67e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 47.88  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  423 QPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGpaKPPPQQPGPAKPPPQQPGSAKPP--PQQPGSTKPPPQQPGPAKPS 500
Cdd:TIGR01628 379 QPRMRQLPMGSPMGGAMGQPPYYGQGPQQQFNG--QPLGWPRMSMMPTPMGPGGPLRPngLAPMNAVRAPSRNAQNAAQK 456

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 115333977  501 PQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKP 546
Cdd:TIGR01628 457 PPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATP 502
BimA_second NF040983
trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia ...
 438-543 1.34e-04

trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia intracellular motility A), WP_004266405.1-like proteins in Burkholderia mallei or B. pseudomallei. The term BimA has also been used for WP_011205626.1-like homologs that have a very different N-terminal half.


Pssm-ID: 468913 [Multi-domain]  Cd Length: 382  Bit Score: 44.51  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 438 KTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSA 517
Cdd:NF040983  83 RTLPNKVPPPPPPPPPPPPPPPTPPPPPPPPPPPPPPSPPPPPPPSPPPSPPPPTTTPPTRTTPSTTTPTPSMHPIQPTQ 162

                         90       100
                 ....*....|....*....|....*.
gi 115333977 518 KPSAQQPSPAKPSAQQSTKPVSQTGS 543
Cdd:NF040983 163 LPSIPNATPTSGSATNVTINFNSTGA 188
BimA_second NF040983
trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia ...
 433-520 2.35e-04

trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia intracellular motility A), WP_004266405.1-like proteins in Burkholderia mallei or B. pseudomallei. The term BimA has also been used for WP_011205626.1-like homologs that have a very different N-terminal half.


Pssm-ID: 468913 [Multi-domain]  Cd Length: 382  Bit Score: 43.74  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 433 QAGPGKTSAQQTGPTKPPSQLPGPakPPPQQPGPAKPPPQQPGSAKPPPqqPGSTKPPPQQPGPAKPSPQQPGSTKPPSQ 512
Cdd:NF040983  69 QIKKGDFKLKPVGDRTLPNKVPPP--PPPPPPPPPPPPTPPPPPPPPPP--PPPPSPPPPPPPSPPPSPPPPTTTPPTRT 144


                 ....*...
gi 115333977 513 QPGSAKPS 520
Cdd:NF040983 145 TPSTTTPT 152
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 441-532 2.40e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 44.22  E-value: 2.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 441 AQQTGPTKPPsqlpgPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPS 520
Cdd:NF041121  12 AAQMGRAAAP-----PSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPGPAGAAPG 86

                         90
                 ....*....|....
gi 115333977 521 AQQP--SPAKPSAQ 532
Cdd:NF041121  87 AALPvrVPAPPALP 100
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 317-541 7.54e-04

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 42.45  E-value: 7.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 317 GLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSE-KPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQqv 395
Cdd:NF033839 278 GLTQDTPKEPGNKKPSAPKPGMQPSPQPEKKEVKPEPETPKPEvKPQLEKPKPEVKPQPEKPKPEVKPQLETPKPEVK-- 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 396 gtPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPG 475
Cdd:NF033839 356 --PQPEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKP 433

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115333977 476 SAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQT 541
Cdd:NF033839 434 QPEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPDNSKPQADDKKPSTP 499
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 429-504 9.02e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 42.30  E-value: 9.02e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115333977 429 IPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQP 504
Cdd:NF041121  15 MGRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPGPAGAAPGAALP 90
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 432-523 4.58e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 40.00  E-value: 4.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 432 QQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAkpppQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPS 511
Cdd:NF033838 404 RKAAEEDKVKEKPAEQPQPAPAPQPEKPAPKPEKPA----EQPKAEKPADQQAEEDYARRSEEEYNRLTQQQPPKTEKPA 479

                         90
                 ....*....|..
gi 115333977 512 qQPGSAKPSAQQ 523
Cdd:NF033838 480 -QPSTPKTGWKQ 490
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 489-567 7.85e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 39.23  E-value: 7.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 489 PPPQQPGPAkPSPQqpgstkPPSQQPGSAKPsAQQPSPAKPSAQQSTKPVSQTGSGKP----LQPPtvsPSAKQPPSQGL 564
Cdd:NF033838 415 KPAEQPQPA-PAPQ------PEKPAPKPEKP-AEQPKAEKPADQQAEEDYARRSEEEYnrltQQQP---PKTEKPAQPST 483


                 ...
gi 115333977 565 PKT 567
Cdd:NF033838 484 PKT 486
COG3416 COG3416
Uncharacterized conserved protein, DUF2076 domain [Function unknown];
462-509 9.60e-03

Uncharacterized conserved protein, DUF2076 domain [Function unknown];


Pssm-ID: 442642 [Multi-domain]  Cd Length: 237  Bit Score: 38.08  E-value: 9.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 115333977 462 QQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKP 509
Cdd:COG3416   94 QRPPPAPQPSQPGPQQQPAPPSGPWGQAAPQQPGYGQPQYGQPAAGPS 141
 
Name Accession Description Interval E-value
FYVE1_PCLO cd15774
FYVE-related domain 1 found in protein piccolo; Protein piccolo, also termed aczonin, is a ...
 567-628 1.36e-40

FYVE-related domain 1 found in protein piccolo; Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Piccolo is a multi-domain protein containing two N-terminal FYVE zinc fingers, a polyproline tract, and a PDZ domain and two C-terminal C2 domains. This family corresponds to the first FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277313 [Multi-domain]  Cd Length: 62  Bit Score: 142.09  E-value: 1.36e-40
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 115333977 567 TICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGG 628
Cdd:cd15774    1 TICPLCKTTELLLHTPEKANYNTCTQCQTTVCSLCGFNPNPHITEKKEWLCLNCQMQRALGG 62
FYVE1_BSN_PCLO cd15771
FYVE-related domain 1 found in protein bassoon and piccolo; This family includes protein ...
 567-628 3.66e-34

FYVE-related domain 1 found in protein bassoon and piccolo; This family includes protein bassoon and piccolo. Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Both bassoon and piccolo contain two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. Their FYVE domain resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. This model corresponds to the first FYVE-related domain.


Pssm-ID: 277310 [Multi-domain]  Cd Length: 61  Bit Score: 123.96  E-value: 3.66e-34
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 115333977 567 TICPLCNTTELLLHVPeKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGG 628
Cdd:cd15771    1 TLCPLCNTTELTLHVP-KPNFNTCTQCHTTVCNQCGFNPNPHLTEVKEWLCLNCQMQRALGM 61
zf-piccolo pfam05715
Piccolo Zn-finger; This (predicted) Zinc finger is found in the bassoon and piccolo proteins. ...
 567-626 4.98e-33

Piccolo Zn-finger; This (predicted) Zinc finger is found in the bassoon and piccolo proteins. There are eight conserved cysteines, suggesting that it coordinates two zinc ligands.


Pssm-ID: 461722 [Multi-domain]  Cd Length: 60  Bit Score: 120.60  E-value: 4.98e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  567 TICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRAL 626
Cdd:pfam05715   1 TLCPLCKTTELNVGSKEPPNYNTCTECKSQVCNLCGFNPTPHLTEKKEWLCLNCQTQRAL 60
FYVE1_BSN cd15773
FYVE-related domain 1 found in protein bassoon; Protein bassoon, also termed zinc finger ...
 567-627 2.37e-25

FYVE-related domain 1 found in protein bassoon; Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Bassoon contains two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. This family corresponds to the first FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277312 [Multi-domain]  Cd Length: 64  Bit Score: 99.39  E-value: 2.37e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115333977 567 TICPLCNTTELLlHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALG 627
Cdd:cd15773    4 TLCPICNTTELT-SFPSQPNFNTCTQCHNKVCNQCGFNPNPHLTEVKEWLCLNCQMQRALG 63
FYVE_BSN_PCLO cd15751
FYVE-related domain found in protein bassoon and piccolo; This family includes protein bassoon ...
 567-627 5.96e-25

FYVE-related domain found in protein bassoon and piccolo; This family includes protein bassoon and piccolo. Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Both bassoon and piccolo contain two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. Their FYVE domain resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277290 [Multi-domain]  Cd Length: 62  Bit Score: 97.91  E-value: 5.96e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115333977 567 TICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALG 627
Cdd:cd15751    1 SACPLCGTSELPLGSKSPPNYNTCTDCKNRVCNQCGFNSTPPVTKVKEWLCLNCQKKRALG 61
FYVE2_BSN_PCLO cd15772
FYVE-related domain 2 found in protein bassoon and piccolo; This family includes protein ...
 567-630 3.78e-22

FYVE-related domain 2 found in protein bassoon and piccolo; This family includes protein bassoon and piccolo. Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Both bassoon and piccolo contain two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. Their FYVE domain resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. This model corresponds to the second FYVE-related domain.


Pssm-ID: 277311 [Multi-domain]  Cd Length: 64  Bit Score: 90.09  E-value: 3.78e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115333977 567 TICPLCNTtELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDL 630
Cdd:cd15772    1 VTCPLCKT-ELNVGSKEPPNYNTCTQCHTQVCNLCGFNPTPHLVEKKEWLCLNCQTQRLMSGGL 63
FYVE2_BSN cd15775
FYVE-related domain 2 found in protein bassoon; Protein bassoon, also termed zinc finger ...
 566-631 9.06e-22

FYVE-related domain 2 found in protein bassoon; Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Bassoon contains two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. This family corresponds to the second FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277314 [Multi-domain]  Cd Length: 65  Bit Score: 89.21  E-value: 9.06e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115333977 566 KTICPLCNTtELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLA 631
Cdd:cd15775    1 RVTCPLCKT-ELNVGSTEPPNYNTCTSCRTQVCNLCGFNPTPHLVEKNEWLCLNCQTQRLLEGSLG 65
FYVE2_PCLO cd15776
FYVE-related domain 2 found in protein piccolo; Protein piccolo, also termed aczonin, is a ...
 569-630 1.90e-20

FYVE-related domain 2 found in protein piccolo; Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Piccolo is a multi-domain protein containing two N-terminal FYVE zinc fingers, a polyproline tract, and a PDZ domain and two C-terminal C2 domains. This family corresponds to the second FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277315 [Multi-domain]  Cd Length: 64  Bit Score: 85.12  E-value: 1.90e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 115333977 569 CPLCNTtELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDL 630
Cdd:cd15776    3 CPLCKT-ELNIGSKDPPNFNTCTECKKTVCNLCGFNPTPHLTEVKEWLCLNCQTQRAMSGQL 63
PHA03247 PHA03247
large tegument protein UL36; Provisional
 205-565 9.67e-20

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 94.62  E-value: 9.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  205 PGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQtpqtdhaklPLQRDASRPQTKQADivrgeSVKPSLPSPSKP 284
Cdd:PHA03247 2647 PPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRR---------RAARPTVGSLTSLAD-----PPPPPPTPEPAP 2712

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  285 PIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLaqqPGTVKPPVQPPGTTKP--PAQPLGPAKPPAQQTGSEKPS 362
Cdd:PHA03247 2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT---PGGPARPARPPTTAGPpaPAPPAAPAAGPPRRLTRPAVA 2789

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  363 SEQPGPKALAQPPGVGKTPAQQPGP--AKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPG---PGKIPAQQAGPG 437
Cdd:PHA03247 2790 SLSESRESLPSPWDPADPPAAVLAPaaALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGsvaPGGDVRRRPPSR 2869

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  438 KTSAQQTGPTKPP-SQLPGPAKPPPQQPGPAKPPPQQP---GSAKPPPqQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQ 513
Cdd:PHA03247 2870 SPAAKPAAPARPPvRRLARPAVSRSTESFALPPDQPERppqPQAPPPP-QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 115333977  514 P-GSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPlQPPTVSPSAKQPPSQGLP 565
Cdd:PHA03247 2949 PaGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQP-APSREAPASSTPPLTGHS 3000
PHA03247 PHA03247
large tegument protein UL36; Provisional
 204-559 1.30e-17

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 87.69  E-value: 1.30e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  204 GPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPqtdhaklPLQRDASRPQTKQADIVRGESVKPSLPSPSK 283
Cdd:PHA03247 2606 GDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVP-------PPERPRDDPAPGRVSRPRRARRLGRAAQASS 2678

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  284 PPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPsgltKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAkPPAQQTGSEKPSs 363
Cdd:PHA03247 2679 PPQRPRRRAARPTVGSLTSLADPPPPPPTPEP----APHALVSATPLPPGPAAARQASPALPAAPA-PPAVPAGPATPG- 2752

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  364 eqpGPKALAQPPgvgkTPAQQPGPAkPPTQQVGTPKPLAQQPGLQSPAKA---------PGPTKTPVQQPGPGKIPAQQA 434
Cdd:PHA03247 2753 ---GPARPARPP----TTAGPPAPA-PPAAPAAGPPRRLTRPAVASLSESreslpspwdPADPPAAVLAPAAALPPAASP 2824

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  435 GPG---KTSAQQTGPTKPPSQLP------------------GPAKPPPQQPG------------PAKPPPQQPGSAKPPP 481
Cdd:PHA03247 2825 AGPlppPTSAQPTAPPPPPGPPPpslplggsvapggdvrrrPPSRSPAAKPAaparppvrrlarPAVSRSTESFALPPDQ 2904

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115333977  482 QQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQP 559
Cdd:PHA03247 2905 PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQP 2982
PHA03247 PHA03247
large tegument protein UL36; Provisional
 256-562 1.18e-15

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 81.52  E-value: 1.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  256 RDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPP--- 332
Cdd:PHA03247 2588 RPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPrra 2667

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  333 ---VQPPGTTKPPAQPLGPAKPPAQQTGSekpsseqpgpkALAQPPGVGKTPAQQPGPAKPPTQ-QVGTPKPLAQQPGLQ 408
Cdd:PHA03247 2668 rrlGRAAQASSPPQRPRRRAARPTVGSLT-----------SLADPPPPPPTPEPAPHALVSATPlPPGPAAARQASPALP 2736

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  409 SPAKAPGPTKTPVQQPGPGKI--PAQQAGPGKTSAQQTGPTKPPSQLPGPA----------KPPPQQPGPAKPPPQQPGS 476
Cdd:PHA03247 2737 AAPAPPAVPAGPATPGGPARParPPTTAGPPAPAPPAAPAAGPPRRLTRPAvaslsesresLPSPWDPADPPAAVLAPAA 2816

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  477 AKPPPQQPGSTKPPPQQPGPAKPS-----------------PQQPGSTKPPSQQPgSAKPSAQQPSP----AKPSAQQST 535
Cdd:PHA03247 2817 ALPPAASPAGPLPPPTSAQPTAPPpppgppppslplggsvaPGGDVRRRPPSRSP-AAKPAAPARPPvrrlARPAVSRST 2895

                         330       340
                  ....*....|....*....|....*..
gi 115333977  536 KPVSQTGSGKPLQPPTVSPSAKQPPSQ 562
Cdd:PHA03247 2896 ESFALPPDQPERPPQPQAPPPPQPQPQ 2922
PHA03378 PHA03378
EBNA-3B; Provisional
 295-533 4.69e-15

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 78.96  E-value: 4.69e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 295 PAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQ----------PPGTTKPPAQPLGPAKPPAQQTGSEKPSSE 364
Cdd:PHA03378 565 PAPGLGPLQIQPLTSPTTSQLASSAPSYAQTPWPVPHPSQtpeppttqshIPETSAPRQWPMPLRPIPMRPLRMQPITFN 644

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 365 QPGPKALAQPPGVGKTPAQQ------PGPAKPPTQQVGTPKPLAQQPG-LQSPAKAPGPTKTPVQQPGPGKIPAQQAGPG 437
Cdd:PHA03378 645 VLVFPTPHQPPQVEITPYKPtwtqigHIPYQPSPTGANTMLPIQWAPGtMQPPPRAPTPMRPPAAPPGRAQRPAAATGRA 724

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 438 KTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGstKPPPQQPGPAKPSPQQPGSTKPPSQQPGSA 517
Cdd:PHA03378 725 RPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPG--APTPQPPPQAPPAPQQRPRGAPTPQPPPQA 802

                        250
                 ....*....|....*.
gi 115333977 518 KPSAQQPSPAKPSAQQ 533
Cdd:PHA03378 803 GPTSMQLMPRAAPGQQ 818
PHA03247 PHA03247
large tegument protein UL36; Provisional
 288-570 1.01e-14

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 78.44  E-value: 1.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  288 QPTPgKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPG 367
Cdd:PHA03247 2572 RPAP-RPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPE 2650

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  368 PKALAQPPGVGKTPAQQPGPAKPPTQQVGT--PKPLAQQPG---LQSPAKAPGPTKTPVQQPGPgKIPAQQAGPGKTSAQ 442
Cdd:PHA03247 2651 RPRDDPAPGRVSRPRRARRLGRAAQASSPPqrPRRRAARPTvgsLTSLADPPPPPPTPEPAPHA-LVSATPLPPGPAAAR 2729

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  443 QTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGS---TKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKP 519
Cdd:PHA03247 2730 QASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAapaAGPPRRLTRPAVASLSESRESLPSPWDPADPPA 2809

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 115333977  520 SAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTvsPSAKQPPSQGLPKTICP 570
Cdd:PHA03247 2810 AVLAPAAALPPAASPAGPLPPPTSAQPTAPPP--PPGPPPPSLPLGGSVAP 2858
PHA03247 PHA03247
large tegument protein UL36; Provisional
 224-537 2.52e-13

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 73.82  E-value: 2.52e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  224 PEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPghEK 303
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP--PR 2781

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  304 SQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQ-PLGPAKPPAqqTGSEKPSSEQPGPKALAQPPGVGKTPA 382
Cdd:PHA03247 2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAsPAGPLPPPT--SAQPTAPPPPPGPPPPSLPLGGSVAPG 2859

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  383 QQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGkiPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQ 462
Cdd:PHA03247 2860 GDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQ--PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP 2937

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115333977  463 QPgpakPPPQQPGSAKPPPQQPGSTKPPPQQPGPAkpspqqPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKP 537
Cdd:PHA03247 2938 RP----QPPLAPTTDPAGAGEPSGAVPQPWLGALV------PGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 287-539 2.63e-13

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 73.15  E-value: 2.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  287 QQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLA------QQPGTVkPPVQPPGTT--KPPAQPlgPAKPPAQQTGS 358
Cdd:pfam09770 105 QQPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRtgyekyKEPEPI-PDLQVDASLwgVAPKKA--AAPAPAPQPAA 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  359 EKPSSEQPGPKALAqppgVGKTPAQQPGPAKPPTQQVgtPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGk 438
Cdd:pfam09770 182 QPASLPAPSRKMMS----LEEVEAAMRAQAKKPAQQP--APAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQ- 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  439 tsaQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKP---PPQQPGPAKPSPQQPgstkPPSQQPG 515
Cdd:pfam09770 255 ---QHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQIlqnPNRLSAARVGYPQNP----QPGVQPA 327

                         250       260
                  ....*....|....*....|....
gi 115333977  516 SAKPSAQQPSPAKPSAQQSTKPVS 539
Cdd:pfam09770 328 PAHQAHRQQGSFGRQAPIITHPQQ 351
PHA03247 PHA03247
large tegument protein UL36; Provisional
 289-571 4.48e-13

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 73.05  E-value: 4.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  289 PTPGKPPAQQPGHEKSQPGPAKPPAQPSG-LTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPG 367
Cdd:PHA03247 2551 PPPPLPPAAPPAAPDRSVPPPRPAPRPSEpAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPS 2630

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  368 PKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIpaqqaGPGKTSAQQTGPT 447
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV-----GSLTSLADPPPPP 2705

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  448 KPPSQLPGPAKPP-PQQPGPA---KPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQ 523
Cdd:PHA03247 2706 PTPEPAPHALVSAtPLPPGPAaarQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR 2785

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 115333977  524 P--SPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPL 571
Cdd:PHA03247 2786 PavASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQ 2835
PHA03378 PHA03378
EBNA-3B; Provisional
 290-559 1.20e-12

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 71.25  E-value: 1.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 290 TPGKPPAQQPGHEKSQPGPAKPPAQPSGLtKPLAQQPGTVKPPVQPPgTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPK 369
Cdd:PHA03378 605 TPEPPTTQSHIPETSAPRQWPMPLRPIPM-RPLRMQPITFNVLVFPT-PHQPPQVEITPYKPTWTQIGHIPYQPSPTGAN 682

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 370 ALAQP---PGVGKTPAQQPGPAKPPTQQVGTPKPlaqqpglqsPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGP 446
Cdd:PHA03378 683 TMLPIqwaPGTMQPPPRAPTPMRPPAAPPGRAQR---------PAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGR 753

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 447 TKPPSQLPGPAKPPPQQPGpaKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPG----------- 515
Cdd:PHA03378 754 ARPPAAAPGRARPPAAAPG--APTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQGPtkqilrqlltg 831

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 115333977 516 ---SAKPSAQQPSPAKPSAQQSTKPVSQTGSG-KPLQPPTVSPSAKQP 559
Cdd:PHA03378 832 gvkRGRPSLKKPAALERQAAAGPTPSPGSGTSdKIVQAPVFYPPVLQP 879
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
296-521 1.34e-12

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 70.68  E-value: 1.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 296 AQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKP-PVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQP 374
Cdd:PRK12323 362 AFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPaPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASA 441

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 375 PGVGKTPAQQPGPAKPPtqqVGTPKPLAQQPGlqsPAKAPGPTKTPVQQPGPGKIPAQQAGPgktsAQQTGPTKPPSqlP 454
Cdd:PRK12323 442 RGPGGAPAPAPAPAAAP---AAAARPAAAGPR---PVAAAAAAAPARAAPAAAPAPADDDPP----PWEELPPEFAS--P 509

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115333977 455 GPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSA 521
Cdd:PRK12323 510 APAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDM 576
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 336-533 2.14e-12

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 70.40  E-value: 2.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 336 PGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPG 415
Cdd:PRK07764 588 VGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGD 667

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 416 PTKTPVQQPGPGKiPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPG 495
Cdd:PRK07764 668 GWPAKAGGAAPAA-PPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPD 746

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 115333977 496 PAkPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQ 533
Cdd:PRK07764 747 DP-PDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEE 783
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 298-504 2.82e-12

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 70.01  E-value: 2.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 298 QPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGtTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAqppgv 377
Cdd:PRK07764 587 VVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAA-PAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVP----- 660

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 378 gkTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPA 457
Cdd:PRK07764 661 --DASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDP 738

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 115333977 458 KPPPQQPGPAKPPPQQPGSAkPPPQQPGSTKPPPQQPGPAKPSPQQP 504
Cdd:PRK07764 739 VPLPPEPDDPPDPAGAPAQP-PPPPAPAPAAAPAAAPPPSPPSEEEE 784
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 325-565 1.16e-11

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 68.14  E-value: 1.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  325 QPGTVKPPVQPPGTTKPPAQPLGPAKPPAQqTGSEKPSSEQPGPK--ALAQPPGVG-KTPAQQPGPAKPPTQQVGTPKP- 400
Cdd:pfam09770 112 AQSSAQPPASSLPQYQYASQQSQQPSKPVR-TGYEKYKEPEPIPDlqVDASLWGVApKKAAAPAPAPQPAAQPASLPAPs 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  401 --------LAQQPGLQSPAKAPGPTKTPVQQPGPgkIPAQQAGPGktsaQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQ 472
Cdd:pfam09770 191 rkmmsleeVEAAMRAQAKKPAQQPAPAPAQPPAA--PPAQQAQQQ----QQFPPQIQQQQQPQQQPQQPQQHPGQGHPVT 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  473 QPgsakpppQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPlQPPTV 552
Cdd:pfam09770 265 IL-------QRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQPAPAHQ-AHRQQ 336

                         250
                  ....*....|...
gi 115333977  553 SPSAKQPPSQGLP 565
Cdd:pfam09770 337 GSFGRQAPIITHP 349
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 292-563 1.77e-11

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 67.32  E-value: 1.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 292 GKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKAL 371
Cdd:PRK07764 392 GAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPA 471

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 372 AQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQ----------------------SPAKAPGPTKTPVQ------- 422
Cdd:PRK07764 472 AAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDaatlrerwpeilaavpkrsrktWAILLPEATVLGVRgdtlvlg 551

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 423 -----------QPGPGKIPAQ--------------QAGPGKTSAQQTGPTKPPSQLPGPAKP-PPQQPGPAKPPPQQPGS 476
Cdd:PRK07764 552 fstgglarrfaSPGNAEVLVTalaeelggdwqveaVVGPAPGAAGGEGPPAPASSGPPEEAArPAAPAAPAAPAAPAPAG 631

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 477 AKPPPQQPGSTKPPPQQPGPAKPSPQ-------------QPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGS 543
Cdd:PRK07764 632 AAAAPAEASAAPAPGVAAPEHHPKHVavpdasdggdgwpAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPA 711

                        330       340
                 ....*....|....*....|
gi 115333977 544 GKPLQPPTVSPSAKQPPSQG 563
Cdd:PRK07764 712 GQADDPAAQPPQAAQGASAP 731
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 331-526 2.01e-11

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 67.32  E-value: 2.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 331 PPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSP 410
Cdd:PRK07764 591 APGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWP 670

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 411 AKAPGPT-KTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPgstkP 489
Cdd:PRK07764 671 AKAGGAApAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEP----D 746

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 115333977 490 PPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSP 526
Cdd:PRK07764 747 DPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEE 783
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 287-565 2.76e-11

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 66.93  E-value: 2.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 287 QQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKP-PAQQTGSEKPSSEQ 365
Cdd:PRK07764 396 AAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAaPSAQPAPAPAAAPE 475

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 366 PGPKALAQPPGVGKTPAQQPGPAKPPTQQ--------------------------------------------------- 394
Cdd:PRK07764 476 PTAAPAPAPPAAPAPAAAPAAPAAPAAPAgaddaatlrerwpeilaavpkrsrktwaillpeatvlgvrgdtlvlgfstg 555

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 395 --------------------------------VGTPKPLAQQPGlqSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQ 442
Cdd:PRK07764 556 glarrfaspgnaevlvtalaeelggdwqveavVGPAPGAAGGEG--PPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAA 633

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 443 QTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQ 522
Cdd:PRK07764 634 AAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQ 713

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 115333977 523 QPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLP 565
Cdd:PRK07764 714 ADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPA 756
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 235-565 4.17e-11

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 66.16  E-value: 4.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 235 GKPIQGPTQTPQTDHaklPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPA- 313
Cdd:PRK07764 384 RLGVAGGAGAPAAAA---PSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAa 460

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 314 --QPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPG------VGKTPAQQP 385
Cdd:PRK07764 461 apSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRERWPEILAAVPKrsrktwAILLPEATV 540

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 386 GPAKPPTQQVGTPKPLAQQ--------------------------------PGLQSPAKAPGPTK----TPVQQPGPGKI 429
Cdd:PRK07764 541 LGVRGDTLVLGFSTGGLARrfaspgnaevlvtalaeelggdwqveavvgpaPGAAGGEGPPAPASsgppEEAARPAAPAA 620

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 430 PAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQ---QPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGS 506
Cdd:PRK07764 621 PAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASdggDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQ 700

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 507 TKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQP-PTVSPSAKQPPSQGLP 565
Cdd:PRK07764 701 PAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPePDDPPDPAGAPAQPPP 760
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
352-567 6.87e-11

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 65.28  E-value: 6.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 352 PAQQTGSEKPSSEQPGP-----KALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGP 426
Cdd:PRK12323 365 PGQSGGGAGPATAAAAPvaqpaPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP 444

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 427 GKIPAQQAGPGKTSAQQTGPtkppsqlpgPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPG-PAKPSPQQPG 505
Cdd:PRK12323 445 GGAPAPAPAPAAAPAAAARP---------AAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPeFASPAPAQPD 515

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 115333977 506 STKPPSQQPGSAKPSAQQPSPAKPsAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKT 567
Cdd:PRK12323 516 AAPAGWVAESIPDPATADPDDAFE-TLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDM 576
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
318-563 1.48e-10

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 64.13  E-value: 1.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 318 LTKPLAQQPGTVKPPVQPPGTTKPP-AQPLGPAKPPAQQTgsEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPtqqvg 396
Cdd:PRK12323 357 LLRMLAFRPGQSGGGAGPATAAAAPvAQPAPAAAAPAAAA--PAPAAPPAAPAAAPAAAAAARAVAAAPARRSPA----- 429

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 397 tpkPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAgpgktsaqqtgPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGS 476
Cdd:PRK12323 430 ---PEALAAARQASARGPGGAPAPAPAPAAAPAAAARP-----------AAAGPRPVAAAAAAAPARAAPAAAPAPADDD 495

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 477 AKPPPQQPgstkPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPA-KPSAQQSTKPVSQTGSGKPLQPPTVSPS 555
Cdd:PRK12323 496 PPPWEELP----PEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLApAPAAAPAPRAAAATEPVVAPRPPRASAS 571


                 ....*...
gi 115333977 556 AKQPPSQG 563
Cdd:PRK12323 572 GLPDMFDG 579
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 346-541 3.18e-10

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 63.47  E-value: 3.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 346 LGPAKPPAQQTGSEKPSSEQPGPkALAQPPGVGKtPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPG 425
Cdd:PRK07764 588 VGPAPGAAGGEGPPAPASSGPPE-EAARPAAPAA-PAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDG 665

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 426 PGKIPAQqAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKP--PPQQPGSTKPPPQQPGPAKPSPQQ 503
Cdd:PRK07764 666 GDGWPAK-AGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAaqPPQAAQGASAPSPAADDPVPLPPE 744

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 115333977 504 PGSTKPPSQQPGsakPSAQQPSPAKPSAQQSTKPVSQT 541
Cdd:PRK07764 745 PDDPPDPAGAPA---QPPPPPAPAPAAAPAAAPPPSPP 779
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
304-562 6.28e-10

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 62.56  E-value: 6.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 304 SQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGttkpPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKtpAQ 383
Cdd:PRK07003 366 GAPGGGVPARVAGAVPAPGARAAAAVGASAVPAV----TAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATAD--RG 439

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 384 QPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQ 463
Cdd:PRK07003 440 DDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASRE 519

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 464 PGPAKPPPQQPGSAKPppqQPGSTKPPPQQPGPAKP-----SPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPV 538
Cdd:PRK07003 520 DAPAAAAPPAPEARPP---TPAAAAPAARAGGAAAAldvlrNAGMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQV 596

                        250       260
                 ....*....|....*....|....
gi 115333977 539 SQTGSGKPLQPPTVSPSAKQPPSQ 562
Cdd:PRK07003 597 PTPRARAATGDAPPNGAARAEQAA 620
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 287-567 7.00e-10

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 62.50  E-value: 7.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  287 QQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGltkplaqqpgtvkPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQP 366
Cdd:PHA03307  111 PSSPDPPPPTPPPASPPPSPAPDLSEMLRPV-------------GSPGPPPAASPPAAGASPAAVASDAASSRQAALPLS 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  367 GPKALAQPPGvgkTPAQQPGPAKPPTQqvGTPKPLAQQPGLQSPAKAPGPT--KTPVQQPGPGKIPAQQAGPGKTSAQQT 444
Cdd:PHA03307  178 SPEETARAPS---SPPAEPPPSTPPAA--ASPRPPRRSSPISASASSPAPApgRSAADDAGASSSDSSSSESSGCGWGPE 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  445 GPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKP--PPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQ 522
Cdd:PHA03307  253 NECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSssSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSS 332

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 115333977  523 QPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKT 567
Cdd:PHA03307  333 SESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSS 377
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 287-510 8.03e-10

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 61.93  E-value: 8.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 287 QQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAqqtgsekPSSEQP 366
Cdd:PRK07764 596 GGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA-------SDGGDG 668

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 367 GPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPkplaqqpglqsPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGP 446
Cdd:PRK07764 669 WPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQ-----------PAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADD 737

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115333977 447 TKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPP 510
Cdd:PRK07764 738 PVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDA 801
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 362-565 2.63e-09

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 60.43  E-value: 2.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  362 SSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLA----QQPG----LQSPAKAPG-PTKTPVQQPGPGKIPAQ 432
Cdd:pfam09770 103 NRQQPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTGyekyKEPEpipdLQVDASLWGvAPKKAAAPAPAPQPAAQ 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  433 QAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPP---QQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKP 509
Cdd:pfam09770 183 PASLPAPSRKMMSLEEVEAAMRAQAKKPAQQPAPAPAQPpaaPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHP 262

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  510 PS----QQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSgKPLQPPTVSPSAKQPPSQGLP 565
Cdd:pfam09770 263 VTilqrPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPT-QILQNPNRLSAARVGYPQNPQ 321
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 300-544 3.83e-09

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 60.10  E-value: 3.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  300 GHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVqpPGTTKPPAQPLGPAKP-PAQQTG----SEKPSSEQPGPKaLAQP 374
Cdd:PRK10263  313 GAPITEPVAVAAAATTATQSWAAPVEPVTQTPPV--ASVDVPPAQPTVAWQPvPGPQTGepviAPAPEGYPQQSQ-YAQP 389

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  375 PGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLP 454
Cdd:PRK10263  390 AVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQ 469

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  455 GPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPP-----PQQPGPAKPSPQQPGSTKP---PSQQPGSAKPSAQQPSP 526
Cdd:PRK10263  470 QPAAQEPLYQQPQPVEQQPVVEPEPVVEETKPARPPlyyfeEVEEKRAREREQLAAWYQPipePVKEPEPIKSSLKAPSV 549

                         250
                  ....*....|....*...
gi 115333977  527 AKPSAQQSTKPVSQTGSG 544
Cdd:PRK10263  550 AAVPPVEAAAAVSPLASG 567
PHA03378 PHA03378
EBNA-3B; Provisional
 382-561 6.09e-09

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 59.31  E-value: 6.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 382 AQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKtpvqqPGPGKIPAQQAGPGKTSAQQTgPTKPPSQLPGPAKPPP 461
Cdd:PHA03378 593 AQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLR-----PIPMRPLRMQPITFNVLVFPT-PHQPPQVEITPYKPTW 666

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 462 QQPG--PAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVS 539
Cdd:PHA03378 667 TQIGhiPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARP 746

                        170       180
                 ....*....|....*....|..
gi 115333977 540 QTGSGKPLQPPTVSPSAKQPPS 561
Cdd:PHA03378 747 PAAAPGRARPPAAAPGRARPPA 768
PHA03378 PHA03378
EBNA-3B; Provisional
 289-501 1.47e-08

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 58.15  E-value: 1.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 289 PTPGKPPAQQPGHEK---SQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQ 365
Cdd:PHA03378 691 PGTMQPPPRAPTPMRppaAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAA 770

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 366 PGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPkPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIP------------AQQ 433
Cdd:PHA03378 771 PGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAG-PTSMQLMPRAAPGQQGPTKQILRQLLTGGVKrgrpslkkpaalERQ 849

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 434 AGPGKTSAQQTG-------------PTKPPSQLPGP------------AKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTK 488
Cdd:PHA03378 850 AAAGPTPSPGSGtsdkivqapvfypPVLQPIQVMRQlgsvraaaastvTQAPTEYTGERRGVGPMHPTDIPPSKRAKTDA 929

                        250
                 ....*....|...
gi 115333977 489 PPPQQPGPAKPSP 501
Cdd:PHA03378 930 YVESQPPHGGQSH 942
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
381-570 1.50e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 57.96  E-value: 1.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 381 PAQQPGPAKPPTQQ---VGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTS--------AQQTGPTKP 449
Cdd:PRK12323 365 PGQSGGGAGPATAAaapVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSpapealaaARQASARGP 444

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 450 PSQlPGPAKPPPQQPGPAKPPPQQPgsAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKP 529
Cdd:PRK12323 445 GGA-PAPAPAPAAAPAAAARPAAAG--PRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGW 521

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 115333977 530 SAQQSTKP-VSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICP 570
Cdd:PRK12323 522 VAESIPDPaTADPDDAFETLAPAPAAAPAPRAAAATEPVVAP 563
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 445-571 3.85e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 56.26  E-value: 3.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 445 GPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAkPPPQQPGSTKPPPQQPGPAKPSP-QQPGSTKPPSQQPGSAKPSAQQ 523
Cdd:PRK14951 370 AEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPA-PAAAPAAAASAPAAPPAAAPPAPvAAPAAAAPAAAPAAAPAAVALA 448

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 115333977 524 PSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPL 571
Cdd:PRK14951 449 PAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEGDV 496
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 401-529 4.09e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 56.26  E-value: 4.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 401 LAQQPGLQSPAKAPGPTKTPVQ--QPGPGKIPAQQAGPGKTSAqqtgPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAK 478
Cdd:PRK14951 362 LAFKPAAAAEAAAPAEKKTPARpeAAAPAAAPVAQAAAAPAPA----AAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAA 437

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 115333977 479 PPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKP 529
Cdd:PRK14951 438 PAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARL 488
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 426-551 7.29e-08

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 55.86  E-value: 7.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  426 PGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPgpAKPPPQQPGSAKPPPQQPGStkppPQQPGPAKPSPQQPG 505
Cdd:PRK10263  751 PVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQP--QYQQPQQPVAPQPQYQQPQQ----PVAPQPQYQQPQQPV 824

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 115333977  506 STKPPSQQPgsakpsaQQPSPAKPSAQQSTKPVSQTGSGKPLQPPT 551
Cdd:PRK10263  825 APQPQYQQP-------QQPVAPQPQDTLLHPLLMRNGDSRPLHKPT 863
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 206-559 1.05e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 55.16  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  206 GRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPP 285
Cdd:pfam03154 169 TQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPP 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  286 IQQPTPGKPPAQQPG--------HEKSQPGPAKPPAQPSGLTKPLAQQPGTVKP-------PVQPPGTTKPPAQPLGPAK 350
Cdd:pfam03154 249 LQPMTQPPPPSQVSPqplpqpslHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPqssqsqvPPGPSPAAPGQSQQRIHTP 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  351 PPAQQTGSEKPSSEQPGPKALAQPPGVgKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGP------TKTPVQQP 424
Cdd:pfam03154 329 PSQSQLQSQQPPREQPLPPAPLSMPHI-KPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPpalkplSSLSTHHP 407

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  425 GPGKIPAQQAGPgKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQP 504
Cdd:pfam03154 408 PSAHPPPLQLMP-QSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTS 486

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 115333977  505 gSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQP 559
Cdd:pfam03154 487 -SAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSP 540
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
405-537 1.09e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 54.78  E-value: 1.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 405 PGLQSPAKAPGPTKT---PVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPP 481
Cdd:PRK14971 370 SGGRGPKQHIKPVFTqpaAAPQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNPPSTAPQAVRP 449

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 115333977 482 QQPGSTKPPPqqpgpakpsPQQPGSTKPPSQQPgsAKPSAQQPSPAKPSAQQSTKP 537
Cdd:PRK14971 450 AQFKEEKKIP---------VSKVSSLGPSTLRP--IQEKAEQATGNIKEAPTGTQK 494
PHA03247 PHA03247
large tegument protein UL36; Provisional
 291-570 1.31e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.33  E-value: 1.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  291 PGKPPAQQPGHEKSqPGPAKPPAQPSGLTKPLAQQPgtvkPPVQPPGTTKPPAQPLGPAKPPAQQT---GSEKPSSEQPG 367
Cdd:PHA03247 2475 PGAPVYRRPAEARF-PFAAGAAPDPGGGGPPDPDAP----PAPSRLAPAILPDEPVGEPVHPRMLTwirGLEELASDDAG 2549

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  368 PKALAQPPGVgktpaqqpgPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPvqQPGPGKIPAQQAGPGKTSAqqtgpt 447
Cdd:PHA03247 2550 DPPPPLPPAA---------PPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPP--QSARPRAPVDDRGDPRGPA------ 2612

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  448 kPPSQLPgPAKPPPqqpgpaKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPA 527
Cdd:PHA03247 2613 -PPSPLP-PDTHAP------DPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPR 2684

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 115333977  528 KPSAQQSTKPVsqTGSGKPLQPPTVSPSAKQPPSQGLPKTICP 570
Cdd:PHA03247 2685 RRAARPTVGSL--TSLADPPPPPPTPEPAPHALVSATPLPPGP 2725
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 265-566 2.02e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 54.41  E-value: 2.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  265 QADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPgttkPPAQ 344
Cdd:PHA03307   47 SAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPP----PTPP 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  345 PLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQ-QVGTPKPLAQQPGLQSPAKAPGPTKTPVQQ 423
Cdd:PHA03307  123 PASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQaALPLSSPEETARAPSSPPAEPPPSTPPAAA 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  424 PGPG---------KIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQP 494
Cdd:PHA03307  203 SPRPprrsspisaSASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRP 282

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 115333977  495 GPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPK 566
Cdd:PHA03307  283 GPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPS 354
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
289-529 2.02e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 54.47  E-value: 2.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 289 PTPGKPPAQQPGhekSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPpgtTKPPAQPLGPAKPPAQQTGSEKPSSEQPGP 368
Cdd:PRK07003 367 APGGGVPARVAG---AVPAPGARAAAAVGASAVPAVTAVTGAAGAAL---APKAAAAAAATRAEAPPAAPAPPATADRGD 440

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 369 KALAQPPGVgktPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTK 448
Cdd:PRK07003 441 DAADGDAPV---PAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAAS 517

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 449 PPSQLPGPAKPPPQ----QPGPAKPPPQQ-------------------------PGSAKPPPQQPGSTKPPPQQPGPAKP 499
Cdd:PRK07003 518 REDAPAAAAPPAPEarppTPAAAAPAARAggaaaaldvlrnagmrvssdrgaraAAAAKPAAAPAAAPKPAAPRVAVQVP 597

                        250       260       270
                 ....*....|....*....|....*....|
gi 115333977 500 SPQQPGSTKPPSQQPGSAKPSAQQPSPAKP 529
Cdd:PRK07003 598 TPRARAATGDAPPNGAARAEQAAESRGAPP 627
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
365-537 2.42e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 54.09  E-value: 2.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 365 QPGPKALAQPPGVGKT--PAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQ 442
Cdd:PRK07003 359 EPAVTGGGAPGGGVPArvAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADR 438

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 443 QTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPG--SAKPS 520
Cdd:PRK07003 439 GDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARapAAASR 518

                        170
                 ....*....|....*..
gi 115333977 521 AQQPSPAKPSAQQSTKP 537
Cdd:PRK07003 519 EDAPAAAAPPAPEARPP 535
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
256-447 3.23e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 53.73  E-value: 3.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 256 RDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAK---PPAQPSGLTKPLAQQPGTVKPP 332
Cdd:PRK12323 376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPealAAARQASARGPGGAPAPAPAPA 455

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 333 VQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPP------GVGKTPAQQPGPAKPPTQQVGTPKPLAQQPG 406
Cdd:PRK12323 456 AAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPweelppEFASPAPAQPDAAPAGWVAESIPDPATADPD 535

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 115333977 407 LQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPT 447
Cdd:PRK12323 536 DAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDM 576
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
426-545 3.58e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 53.24  E-value: 3.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 426 PGKIPAQQAGP---GKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQ 502
Cdd:PRK14971 371 GGRGPKQHIKPvftQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNPPSTAPQAVRPA 450

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 115333977 503 QPGSTKPPS-QQPGSAKPSAQQpsPAKPSAQQSTK--PVSQTGSGK 545
Cdd:PRK14971 451 QFKEEKKIPvSKVSSLGPSTLR--PIQEKAEQATGniKEAPTGTQK 494
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
266-510 4.61e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 53.31  E-value: 4.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 266 ADIVRGESVKPSLPSPSKPPIQQPTPgKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQP 345
Cdd:PRK07003 387 AAAAVGASAVPAVTAVTGAAGAALAP-KAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDE 465

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 346 LGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVgtpkplAQQPGLQSPAKAPGPTKTPvQQPG 425
Cdd:PRK07003 466 RDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAA------ASREDAPAAAAPPAPEARP-PTPA 538

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 426 PGKIPAQQAGPGKT-----SAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTkpPPQQPGPAKPS 500
Cdd:PRK07003 539 AAAPAARAGGAAAAldvlrNAGMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQVPTPRARAAT--GDAPPNGAARA 616

                        250
                 ....*....|
gi 115333977 501 PQQPGSTKPP 510
Cdd:PRK07003 617 EQAAESRGAP 626
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 366-497 6.02e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 52.41  E-value: 6.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 366 PGPKALAQPPGVGKTPAQQPGP---AKPPTQQVGTPKPLAQQPGLQSPAKAPgptkTPVQQPGPGKIPAQQAGPGKTSAQ 442
Cdd:PRK14951 366 PAAAAEAAAPAEKKTPARPEAAapaAAPVAQAAAAPAPAAAPAAAASAPAAP----PAAAPPAPVAAPAAAAPAAAPAAA 441

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 115333977 443 QTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPA 497
Cdd:PRK14951 442 PAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEGDV 496
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 230-554 6.60e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 52.87  E-value: 6.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  230 QPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSkppiqQPTPGKPPAQQPGHEKSQPGPA 309
Cdd:PHA03307   99 SPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAAS-----PPAAGASPAAVASDAASSRQAA 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  310 KPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPA-------------QPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPG 376
Cdd:PHA03307  174 LPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPrrsspisasasspAPAPGRSAADDAGASSSDSSSSESSGCGWGPEN 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  377 VGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGP 456
Cdd:PHA03307  254 ECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSS 333

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  457 AKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTK 536
Cdd:PHA03307  334 ESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPR 413

                         330
                  ....*....|....*...
gi 115333977  537 PVSQTGSGKPLQPPTVSP 554
Cdd:PHA03307  414 PSPLDAGAASGAFYARYP 431
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 385-550 8.29e-07

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 52.39  E-value: 8.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  385 PGPAKPPTQQVGTPKPLAQQPGLQSpAKAPGP-TKTPVQQPGPGKIP-----AQQAGPGKTSAQQTGPTKPPSQLPgPAK 458
Cdd:PRK10263  336 PVEPVTQTPPVASVDVPPAQPTVAW-QPVPGPqTGEPVIAPAPEGYPqqsqyAQPAVQYNEPLQQPVQPQQPYYAP-AAE 413

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  459 PPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKP--SPQQPGSTKPPSQQPGSAKPSAQQPSPAKPsaQQSTK 536
Cdd:PRK10263  414 QPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQStfAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQ--QPVVE 491

                         170
                  ....*....|....
gi 115333977  537 PVSQTGSGKPLQPP 550
Cdd:PRK10263  492 PEPVVEETKPARPP 505
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
443-564 1.02e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 51.70  E-value: 1.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 443 QTGPTKPPSQLPG-PAKPPPQQPGPAKPPPQQPGsakpPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAK--P 519
Cdd:PRK14971 364 QKGDDASGGRGPKqHIKPVFTQPAAAPQPSAAAA----ASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPvnP 439

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 115333977 520 SAQQPSPAKPSAQQSTK--PVSQTGSgkpLQPPTVSPsaKQPPSQGL 564
Cdd:PRK14971 440 PSTAPQAVRPAQFKEEKkiPVSKVSS---LGPSTLRP--IQEKAEQA 481
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
353-474 1.09e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 51.70  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 353 AQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQS-PAKAPGPTKTPVQQPGPGKIPA 431
Cdd:PRK14971 360 AQLTQKGDDASGGRGPKQHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQSaTQPAGTPPTVSVDPPAAVPVNP 439

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 115333977 432 QQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQpGPAKPPPQQP 474
Cdd:PRK14971 440 PSTAPQAVRPAQFKEEKKIPVSKVSSLGPSTL-RPIQEKAEQA 481
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 418-560 1.10e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 51.79  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 418 KTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSA-----KPPPQQPGSTKPP-- 490
Cdd:PRK07994 362 AAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQllaarQQLQRAQGATKAKks 441

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115333977 491 -PQQPGPAKP--SPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTgsgKPLQPPTVSPSAKQPP 560
Cdd:PRK07994 442 ePAAASRARPvnSALERLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVA---TPKALKKALEHEKTPE 511
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 434-518 1.14e-06

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 51.81  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  434 AGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPgSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQ 513
Cdd:PRK12270   40 STAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAP-AAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEDEVT 118


                  ....*..
gi 115333977  514 P--GSAK 518
Cdd:PRK12270  119 PlrGAAA 125
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 371-515 1.35e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 51.64  E-value: 1.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 371 LAQPPGVGkTPAQQPGPAKPPTQqvgtpkplaqqPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPP 450
Cdd:PRK14951 362 LAFKPAAA-AEAAAPAEKKTPAR-----------PEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAP 429

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115333977 451 SQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPG 515
Cdd:PRK14951 430 AAAAPAAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEG 494
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 410-552 1.37e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 51.61  E-value: 1.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 410 PAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQL-------PGPAK--PPPQQPGPAKPP--PQQPGSAK 478
Cdd:PTZ00449 510 PPEGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKegevgkkPGPAKehKPSKIPTLSKKPefPKDPKHPK 589

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115333977 479 PPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPP--SQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTV 552
Cdd:PTZ00449 590 DPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPksPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKP 665
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 262-560 2.54e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.92  E-value: 2.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  262 QTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKP 341
Cdd:pfam03154 168 QTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHP 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  342 PAQPLGPAKPPAQQTGSEKPSSEQPGP-KALAQPPGVGKTPAQQPGPAKPptqqVGTPKPLAQQPGLQSPAKAPGPTKTP 420
Cdd:pfam03154 248 PLQPMTQPPPPSQVSPQPLPQPSLHGQmPPMPHSLQTGPSHMQHPVPPQP----FPLTPQSSQSQVPPGPSPAAPGQSQQ 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  421 VQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPS 500
Cdd:pfam03154 324 RIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSLS 403

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  501 PQQPGSTKPPSQQPGSaKPSAQQPSPAKPSAQQSTKPVSQTGSGKPlQPPTVSPSAKQPP 560
Cdd:pfam03154 404 THHPPSAHPPPLQLMP-QSQQLPPPPAQPPVLTQSQSLPPPAASHP-PTSGLHQVPSQSP 461
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 444-524 2.76e-06

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 50.66  E-value: 2.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  444 TGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQ 523
Cdd:PRK12270   39 GSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEDEVT 118


                  .
gi 115333977  524 P 524
Cdd:PRK12270  119 P 119
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 292-563 2.96e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.46  E-value: 2.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 292 GKPPAQQPGHEKSQPGPAKPpAQPSGLtkplaqqPGTVKPPvQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKAL 371
Cdd:PTZ00449 547 GKPGETKEGEVGKKPGPAKE-HKPSKI-------PTLSKKP-EFPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPEL 617

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 372 AQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKI------PAQQAGPGKTSAQQTG 445
Cdd:PTZ00449 618 LDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKPPFDPKFKEKFyddyldAAAKSKETKTTVVLDE 697

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 446 PTKPPSQLPGPAKPPPQQPGPAKPPPQQpgsakppPQQPGSTKPPPQQPGPAKPSPQQPgSTKPPSQQPGSAKPSAQQPS 525
Cdd:PTZ00449 698 SFESILKETLPETPGTPFTTPRPLPPKL-------PRDEEFPFEPIGDPDAEQPDDIEF-FTPPEEERTFFHETPADTPL 769

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 115333977 526 PAKPSAQQSTKPV-SQTGSGKPLQPPTVSPSAKQPPSQG 563
Cdd:PTZ00449 770 PDILAEEFKEEDIhAETGEPDEAMKRPDSPSEHEDKPPG 808
PHA03247 PHA03247
large tegument protein UL36; Provisional
 291-502 3.23e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 3.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  291 PGKPPAQQPGHEKSqPGPAKPPAQPSGLTKPLAQQPGTVKPP----VQPPGTtkPPAQPLGPAKPPAQQTGSEKPSSEQP 366
Cdd:PHA03247  255 PAPPPVVGEGADRA-PETARGATGPPPPPEAAAPNGAAAPPDgvwgAALAGA--PLALPAPPDPPPPAPAGDAEEEDDED 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  367 GPKALAQPpgVGKTPAQQPGPAKPPTQQVGTPKPLAQQ--PGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQT 444
Cdd:PHA03247  332 GAMEVVSP--LPRPRQHYPLGFPKRRRPTWTPPSSLEDlsAGRHHPKRASLPTRKRRSARHAATPFARGPGGDDQTRPAA 409

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115333977  445 -----GPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQ 502
Cdd:PHA03247  410 pvpasVPTPAPTPVPASAPPPPATPLPSAEPGSDDGPAPPPERQPPAPATEPAPDDPDDATRK 472
PHA03379 PHA03379
EBNA-3A; Provisional
 318-565 3.25e-06

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 50.44  E-value: 3.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 318 LTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQtgSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGT 397
Cdd:PHA03379 405 LEKASEPTYGTPRPPVEKPRPEVPQSLETATSHGSAQV--PEPPPVHDLEPGPLHDQHSMAPCPVAQLPPGPLQDLEPGD 482

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 398 PKPLAQQPGLQSPAKAPGPTKTPVQ--QPGPGKIPAQQAGPGKTSAQQTGPT-KPPSQLPGPAKPPP-----QQPGPAKP 469
Cdd:PHA03379 483 QLPGVVQDGRPACAPVPAPAGPIVRpwEASLSQVPGVAFAPVMPQPMPVEPVpVPTVALERPVCPAPpliamQGPGETSG 562

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 470 PPQQPGSAKPPPQQPGSTKPPPQQP---GPAKPSPQQPGSTKPPSQQPGS---AKPSAQQPSPAKPSAQ-------QSTK 536
Cdd:PHA03379 563 IVRVRERWRPAPWTPNPPRSPSQMSvrdRLARLRAEAQPYQASVEVQPPQltqVSPQQPMEYPLEPEQQmfpgspfSQVA 642

                        250       260
                 ....*....|....*....|....*....
gi 115333977 537 PVSQTGSGKPLQPPTVSPSAKQPPSQGLP 565
Cdd:PHA03379 643 DVMRAGGVPAMQPQYFDLPLQQPISQGAP 671
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
471-568 3.36e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 50.16  E-value: 3.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 471 PQQPGSAKPPPQQPGSTKPPPQQPGpakpSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPV--SQTGSGKPLQ 548
Cdd:PRK14971 363 TQKGDDASGGRGPKQHIKPVFTQPA----AAPQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTvsVDPPAAVPVN 438

                         90       100
                 ....*....|....*....|
gi 115333977 549 PPTVSPSAKQPPSQGLPKTI 568
Cdd:PRK14971 439 PPSTAPQAVRPAQFKEEKKI 458
PHA03247 PHA03247
large tegument protein UL36; Provisional
 331-555 4.47e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 4.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  331 PPVQPPGTTKPPAQPLGPAKPPAqqtgseKPSSEQPGPKAlAQPPGV------GKTPAQQPGPAKPPTQQVGTPKPLAQQ 404
Cdd:PHA03247  258 PPVVGEGADRAPETARGATGPPP------PPEAAAPNGAA-APPDGVwgaalaGAPLALPAPPDPPPPAPAGDAEEEDDE 330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  405 PG---LQSPAKAPG------------PTKTP---VQQPGPGKIPAQQAGPGKTSAQQTGPTKPP--SQLPGPAKPPPQQP 464
Cdd:PHA03247  331 DGameVVSPLPRPRqhyplgfpkrrrPTWTPpssLEDLSAGRHHPKRASLPTRKRRSARHAATPfaRGPGGDDQTRPAAP 410

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  465 GPAKPPpqqpgsAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPakpsAQQSTKPVSQTGSG 544
Cdd:PHA03247  411 VPASVP------TPAPTPVPASAPPPPATPLPSAEPGSDDGPAPPPERQPPAPATEPAPDDP----DDATRKALDALRER 480

                         250
                  ....*....|.
gi 115333977  545 KPLQPPTVSPS 555
Cdd:PHA03247  481 RPPEPPGADLA 491
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 370-548 4.56e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 49.86  E-value: 4.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 370 ALA-QPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPgpgkiPAQQAGPGKTSAQQTGPTK 448
Cdd:PRK07994 356 MLAfHPAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAP-----AVPLPETTSQLLAARQQLQ 430

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 449 PPSQLPGPAKPPPQQPGPAKP--PPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPgSTKPPSQQPGSAKPSAQQ--- 523
Cdd:PRK07994 431 RAQGATKAKKSEPAAASRARPvnSALERLASVRPAPSALEKAPAKKEAYRWKATNPVE-VKKEPVATPKALKKALEHekt 509

                        170       180       190
                 ....*....|....*....|....*....|.
gi 115333977 524 PSPAKPSAQQSTKP------VSQTGSGKPLQ 548
Cdd:PRK07994 510 PELAAKLAAEAIERdpwaalVSQLGLPGLVE 540
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 448-562 4.64e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 49.86  E-value: 4.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 448 KPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQ--QPGSAKPSAQQPS 525
Cdd:PRK07994 360 HPAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAarQQLQRAQGATKAK 439

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 115333977 526 PAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQ 562
Cdd:PRK07994 440 KSEPAAASRARPVNSALERLASVRPAPSALEKAPAKK 476
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 411-568 6.01e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.78  E-value: 6.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  411 AKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKP--PPQQPGPAKPPPQQPGSAKPPPQQPGSTK 488
Cdd:PHA03307   58 GAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPtpPGPSSPDPPPPTPPPASPPPSPAPDLSEM 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  489 PPPQQPGPAKPSPQQPGSTKPPSqQPGSAKPSAQQPSPAKPSAQQSTKPVSqtgSGKPLQPPTVSPSAKQPPSQGLPKTI 568
Cdd:PHA03307  138 LRPVGSPGPPPAASPPAAGASPA-AVASDAASSRQAALPLSSPEETARAPS---SPPAEPPPSTPPAAASPRPPRRSSPI 213
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 249-402 6.27e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 49.48  E-value: 6.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 249 HAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKP-PAQQPgheksQPGPAKPPAQPSGLTKPLAQQPG 327
Cdd:PRK07994 360 HPAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASaPQQAP-----AVPLPETTSQLLAARQQLQRAQG 434

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 328 TVKPPVQPPGTTKPP-----AQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLA 402
Cdd:PRK07994 435 ATKAKKSEPAAASRArpvnsALERLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKALKKALEHEKTPELAA 514
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 455-537 6.32e-06

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 49.50  E-value: 6.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  455 GPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQS 534
Cdd:PRK12270   37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEDE 116


                  ...
gi 115333977  535 TKP 537
Cdd:PRK12270  117 VTP 119
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
309-414 7.05e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 49.00  E-value: 7.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 309 AKPPAQPSGLTKPL------AQQPGTVKPPVQPPGTTKPPAQPlgPAKPPA-QQTGSEKPSSEQPGPKALAQPPGVGK-- 379
Cdd:PRK14971 369 ASGGRGPKQHIKPVftqpaaAPQPSAAAAASPSPSQSSAAAQP--SAPQSAtQPAGTPPTVSVDPPAAVPVNPPSTAPqa 446

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 115333977 380 -TPAQQPGPAKPPTQQVGTPKPLAQQPgLQSPAKAP 414
Cdd:PRK14971 447 vRPAQFKEEKKIPVSKVSSLGPSTLRP-IQEKAEQA 481
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 406-540 7.55e-06

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 49.31  E-value: 7.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  406 GLQSPAKAPG--PTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPP-PQQPGPAKPPPQQPGSAKPPPQ 482
Cdd:PRK10263  739 GPHEPLFTPIvePVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQqPVAPQPQYQQPQQPVAPQPQYQ 818

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115333977  483 QPGS-TKPPPQQPGPAKPSPQQPGST--KPPSQQPGSAKPsAQQPSPAKPSAQQSTKPVSQ 540
Cdd:PRK10263  819 QPQQpVAPQPQYQQPQQPVAPQPQDTllHPLLMRNGDSRP-LHKPTTPLPSLDLLTPPPSE 878
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 448-529 1.06e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 48.73  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  448 KPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQ-PGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSP 526
Cdd:PRK12270   37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAApPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEDE 116


                  ...
gi 115333977  527 AKP 529
Cdd:PRK12270  117 VTP 119
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 408-498 1.23e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 48.73  E-value: 1.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  408 QSPAKAPGPTK--TPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPqqpgsAKPPPQQPG 485
Cdd:PRK12270   36 YGPGSTAAPTAaaAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPA-----AAAAAAPAA 110

                          90
                  ....*....|....*
gi 115333977  486 STKPPPQQP--GPAK 498
Cdd:PRK12270  111 AAVEDEVTPlrGAAA 125
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 422-502 1.27e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 48.73  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  422 QQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSP 501
Cdd:PRK12270   36 YGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVED 115


                  .
gi 115333977  502 Q 502
Cdd:PRK12270  116 E 116
PHA03379 PHA03379
EBNA-3A; Provisional
 349-571 1.59e-05

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 48.13  E-value: 1.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 349 AKPPAQQTGSEKPSSEQPGPKA---LAQPPGVGktPAQQPgpaKPPTQQVGTPKPLAQQPGLqspakAPGPtktpVQQPG 425
Cdd:PHA03379 406 EKASEPTYGTPRPPVEKPRPEVpqsLETATSHG--SAQVP---EPPPVHDLEPGPLHDQHSM-----APCP----VAQLP 471

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 426 PGKIPAQQAGPgktsaQQTGPTKPPSQLPGPAKPP------PQQPGPAKPPPQQPGSAKPPPQ------QPGSTKPPPQQ 493
Cdd:PHA03379 472 PGPLQDLEPGD-----QLPGVVQDGRPACAPVPAPagpivrPWEASLSQVPGVAFAPVMPQPMpvepvpVPTVALERPVC 546

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115333977 494 PGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKpvSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPL 571
Cdd:PHA03379 547 PAPPLIAMQGPGETSGIVRVRERWRPAPWTPNPPRSPSQMSVR--DRLARLRAEAQPYQASVEVQPPQLTQVSPQQPM 622
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 423-546 1.67e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 47.88  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  423 QPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGpaKPPPQQPGPAKPPPQQPGSAKPP--PQQPGSTKPPPQQPGPAKPS 500
Cdd:TIGR01628 379 QPRMRQLPMGSPMGGAMGQPPYYGQGPQQQFNG--QPLGWPRMSMMPTPMGPGGPLRPngLAPMNAVRAPSRNAQNAAQK 456

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 115333977  501 PQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKP 546
Cdd:TIGR01628 457 PPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATP 502
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
461-567 1.71e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 47.85  E-value: 1.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 461 PQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQpgpAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQ 540
Cdd:PRK14971 363 TQKGDDASGGRGPKQHIKPVFTQPAAAPQPSAA---AAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNP 439

                         90       100
                 ....*....|....*....|....*..
gi 115333977 541 TGSGKPLQPPTVSPSAKQPPSQGLPKT 567
Cdd:PRK14971 440 PSTAPQAVRPAQFKEEKKIPVSKVSSL 466
dnaA PRK14086
chromosomal replication initiator protein DnaA;
331-554 1.74e-05

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 47.90  E-value: 1.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 331 PPVQPPGTTKPPAQPLGPAKPPAQQTgsEKPSSEQPGPKALaqpPGVGKTPAQQPGPAKPPTQQVGTPKPLAqqpglqsp 410
Cdd:PRK14086  80 RPIRIAITVDPSAGEPAPPPPHARRT--SEPELPRPGRRPY---EGYGGPRADDRPPGLPRQDQLPTARPAY-------- 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 411 akapgPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSqlpgpakpppqqpgPAKPPPQQPGSAKPPPQQPGSTKPP 490
Cdd:PRK14086 147 -----PAYQQRPEPGAWPRAADDYGWQQQRLGFPPRAPYAS--------------PASYAPEQERDREPYDAGRPEYDQR 207

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115333977 491 PQQPGPAKPSPQQPG--STKPPSQQPGS-AKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSP 554
Cdd:PRK14086 208 RRDYDHPRPDWDRPRrdRTDRPEPPPGAgHVHRGGPGPPERDDAPVVPIRPSAPGPLAAQPAPAPGP 274
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 337-584 1.78e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 48.15  E-value: 1.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 337 GTTKPPAQPLGPAKPPAQQTGSEK---PSSEQPGPKALAQPPGVGKTPA-QQPGPAKPptqqvgtpkplaqqpglQSPAK 412
Cdd:PTZ00449 509 EPPEGPEASGLPPKAPGDKEGEEGeheDSKESDEPKEGGKPGETKEGEVgKKPGPAKE-----------------HKPSK 571

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 413 APGPTKTPvQQPGPGKIPAQQAGPGKTSAQQT--GPTKPPS-QLPGPAKPPPQQPGPAKP-PPQQPgsakPPPQQPGSTK 488
Cdd:PTZ00449 572 IPTLSKKP-EFPKDPKHPKDPEEPKKPKRPRSaqRPTRPKSpKLPELLDIPKSPKRPESPkSPKRP----PPPQRPSSPE 646

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 489 PPPqqpGPAKP-SPQQPGSTKPPSqQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQglPKT 567
Cdd:PTZ00449 647 RPE---GPKIIkSPKPPKSPKPPF-DPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTT--PRP 720

                        250
                 ....*....|....*..
gi 115333977 568 ICPLCNTTELLLHVPEK 584
Cdd:PTZ00449 721 LPPKLPRDEEFPFEPIG 737
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 322-485 1.95e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 47.79  E-value: 1.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 322 LAQQPGTvKPPVQPPGTTKPPAQPlgPAKPPAQqtgseKPSSEQPGPKALAQPPgvgktPAQQPGPAKPPTQQVGTPkpl 401
Cdd:PRK14951 362 LAFKPAA-AAEAAAPAEKKTPARP--EAAAPAA-----APVAQAAAAPAPAAAP-----AAAASAPAAPPAAAPPAP--- 425

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 402 AQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQqagpgktsaqqtgptKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPP 481
Cdd:PRK14951 426 VAAPAAAAPAAAPAAAPAAVALAPAPPAQAA---------------PETVAIPVRVAPEPAVASAAPAPAAAPAAARLTP 490


                 ....
gi 115333977 482 QQPG 485
Cdd:PRK14951 491 TEEG 494
Glutenin_hmw pfam03157
High molecular weight glutenin subunit; Members of this family include high molecular weight ...
 230-566 1.96e-05

High molecular weight glutenin subunit; Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.


Pssm-ID: 367362 [Multi-domain]  Cd Length: 786  Bit Score: 48.02  E-value: 1.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  230 QPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQP----GHEKSQ 305
Cdd:pfam03157 252 QQLGQGQQGYYPISPQQPRQWQQSGQGQQGYYPTSLQQPGQGQSGYYPTSQQQAGQLQQEQQLGQEQQDQqpgqGRQGQQ 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  306 PGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQ-Q 384
Cdd:pfam03157 332 PGQGQQGQQPAQGQQPGQGQPGYYPTSPQQPGQGQPGYYPTSQQQPQQGQQPEQGQQGQQQGQGQQGQQPGQGQQPGQgQ 411

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  385 PGPAKPPTQQVGTPKPLAQQPGLQSPAKApgptktpvQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQP 464
Cdd:pfam03157 412 PGYYPTSPQQSGQGQPGYYPTSPQQSGQG--------QQPGQGQQPGQEQPGQGQQPGQGQQGQQPGQPEQGQQPGQGQP 483

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  465 GPAKPPPQQPGSAKPPPQQpgstkpppQQPGPAkpspqQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSG 544
Cdd:pfam03157 484 GYYPTSPQQSGQGQQLGQW--------QQQGQG-----QPGYYPTSPLQPGQGQPGYYPTSPQQPGQGQQLGQLQQPTQG 550

                         330       340
                  ....*....|....*....|..
gi 115333977  545 KPLQPPTVSPSAKQPPSQGLPK 566
Cdd:pfam03157 551 QQGQQSGQGQQGQQPGQGQQGQ 572
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 436-528 2.21e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 47.50  E-value: 2.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 436 PGKTSAQQTGPTKPPSQ-LPGPAKPPPqqPGPAKPPPQQPGSAKPPPQQPgstkPPPQQPGPAKPSPQQPGSTKPPSQQP 514
Cdd:PRK14950 364 PAPQPAKPTAAAPSPVRpTPAPSTRPK--AAAAANIPPKEPVRETATPPP----VPPRPVAPPVPHTPESAPKLTRAAIP 437

                         90
                 ....*....|....
gi 115333977 515 GSAKPSAQQPSPAK 528
Cdd:PRK14950 438 VDEKPKYTPPAPPK 451
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 293-414 2.36e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 47.40  E-value: 2.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 293 KPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKP-PAQQTGSEKPSSEQPGPKAL 371
Cdd:PRK14951 365 KPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPaPVAAPAAAAPAAAPAAAPAA 444

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 115333977 372 AQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAP 414
Cdd:PRK14951 445 VALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAAR 487
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 423-546 2.74e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 47.25  E-value: 2.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 423 QPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPpqQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQ 502
Cdd:PRK14954 375 RNDGGVAPSPAGSPDVKKKAPEPDLPQPDRHPGPAKPEAPGARPAELP--SPASAPTPEQQPPVARSAPLPPSPQASAPR 452

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 115333977 503 QPGSTKpPSQQPGS---------AKPSAQQPspakpsAQQSTKPVSQTGSGKP 546
Cdd:PRK14954 453 NVASGK-PGVDLGSwqgkfmnftRNGSRKQP------VQASSSDAAQTGVFEG 498
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 465-549 2.81e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 47.58  E-value: 2.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  465 GPAKPPPQQPGSAKPPPQQPGsTKPPPQQPGPAKPSPQQPGSTkPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSG 544
Cdd:PRK12270   37 GPGSTAAPTAAAAAAAAAASA-PAAAPAAKAPAAPAPAPPAAA-APAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVE 114


                  ....*
gi 115333977  545 KPLQP 549
Cdd:PRK12270  115 DEVTP 119
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
371-494 2.94e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 47.08  E-value: 2.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 371 LAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPP 450
Cdd:PRK14971 359 LAQLTQKGDDASGGRGPKQHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVN 438

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 115333977 451 SQLPGPAKPPPQQPGPAKP-PPQQPGSAKPPPQQPgsTKPPPQQP 494
Cdd:PRK14971 439 PPSTAPQAVRPAQFKEEKKiPVSKVSSLGPSTLRP--IQEKAEQA 481
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 430-560 3.13e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 47.17  E-value: 3.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 430 PAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGStkPPPQQPGPAKPSPQQPGSTKP 509
Cdd:PRK07994 361 PAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPE--TTSQLLAARQQLQRAQGATKA 438

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 115333977 510 PSQQPGSAKPSAQQPSPAKPSAQQStkPVSQTGSGKPLQPPTVSPSAKQPP 560
Cdd:PRK07994 439 KKSEPAAASRARPVNSALERLASVR--PAPSALEKAPAKKEAYRWKATNPV 487
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
349-464 3.15e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 47.08  E-value: 3.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 349 AKPPAQQTGSEKPSSEQPgpkALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQS-PAKAPGPTKTPVQQPGPG 427
Cdd:PRK14971 369 ASGGRGPKQHIKPVFTQP---AAAPQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTvSVDPPAAVPVNPPSTAPQ 445

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 115333977 428 KIPAQQAGPGKTSAQQTGPTKPPSQLpGPAKPPPQQP 464
Cdd:PRK14971 446 AVRPAQFKEEKKIPVSKVSSLGPSTL-RPIQEKAEQA 481
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 445-536 3.33e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 47.19  E-value: 3.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  445 GPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPspqqpgstkPPSQQPGSAKPSAQQP 524
Cdd:PRK12270   37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAA---------AAAAPAAPPAAAAAAA 107

                          90
                  ....*....|..
gi 115333977  525 SPAKPSAQQSTK 536
Cdd:PRK12270  108 PAAAAVEDEVTP 119
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
405-565 4.20e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.77  E-value: 4.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 405 PGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPqQPGPAKPPPQQPGSAKPPPQQP 484
Cdd:PRK07003 368 PGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAE-APPAAPAPPATADRGDDAADGD 446

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 485 GSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSG-KPLQPPTVSPSAKQPPSQG 563
Cdd:PRK07003 447 APVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAvPDARAPAAASREDAPAAAA 526


                 ..
gi 115333977 564 LP 565
Cdd:PRK07003 527 PP 528
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 424-504 4.69e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 46.81  E-value: 4.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  424 PGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPgPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQ 503
Cdd:PRK12270   40 STAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAP-AAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEDEVT 118


                  .
gi 115333977  504 P 504
Cdd:PRK12270  119 P 119
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 465-570 4.73e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 46.63  E-value: 4.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 465 GPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSqtgsg 544
Cdd:PRK14951 369 AAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPA----- 443

                         90       100
                 ....*....|....*....|....*.
gi 115333977 545 kPLQPPTVSPSAKQPPSQGLPKTICP 570
Cdd:PRK14951 444 -AVALAPAPPAQAAPETVAIPVRVAP 468
Glutenin_hmw pfam03157
High molecular weight glutenin subunit; Members of this family include high molecular weight ...
 212-558 5.04e-05

High molecular weight glutenin subunit; Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.


Pssm-ID: 367362 [Multi-domain]  Cd Length: 786  Bit Score: 46.48  E-value: 5.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  212 QDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTD-----HAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPI 286
Cdd:pfam03157 387 QQGQQQGQGQQGQQPGQGQQPGQGQPGYYPTSPQQSGqgqpgYYPTSPQQSGQGQQPGQGQQPGQEQPGQGQQPGQGQQG 466

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  287 QQPTPG----KPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPS 362
Cdd:pfam03157 467 QQPGQPeqgqQPGQGQPGYYPTSPQQSGQGQQLGQWQQQGQGQPGYYPTSPLQPGQGQPGYYPTSPQQPGQGQQLGQLQQ 546

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  363 SEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKipAQQAGPGKTSAQ 442
Cdd:pfam03157 547 PTQGQQGQQSGQGQQGQQPGQGQQGQQPGQGQQGQQPGQGQQPGQGQPGYYPTSPQQSGQGQQPGQ--WQQPGQGQPGYY 624

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  443 QTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKpppQQPGSTKPPPQQPGpakpSPQQPGSTKPPSQ--QPGSAKPS 520
Cdd:pfam03157 625 PTSSLQLGQGQQGYYPTSPQQPGQGQQPGQWQQSGQ---GQQGYYPTSPQQSG----QAQQPGQGQQPGQwlQPGQGQQG 697

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 115333977  521 AQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQ 558
Cdd:pfam03157 698 YYPTSPQQPGQGQQLGQGQQSGQGQQGYYPTSPGQGQQ 735
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 464-556 5.90e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 45.96  E-value: 5.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 464 PGPAkPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGS 543
Cdd:PRK14950 362 PVPA-PQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTPESAPKLTRAAIPVDE 440

                         90
                 ....*....|...
gi 115333977 544 GKPLQPPTVSPSA 556
Cdd:PRK14950 441 KPKYTPPAPPKEE 453
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 464-541 6.94e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 46.04  E-value: 6.94e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115333977  464 PGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQT 541
Cdd:PRK12270   40 STAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEDEV 117
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 488-571 8.30e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 46.04  E-value: 8.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  488 KPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKT 567
Cdd:PRK12270   37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEDE 116


                  ....
gi 115333977  568 ICPL 571
Cdd:PRK12270  117 VTPL 120
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
442-530 8.57e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 45.72  E-value: 8.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 442 QQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPgstkPPPQQPGPAKPSPQQPGSTKPPSQQPgsakPSA 521
Cdd:PRK14948 512 SQSGSASNTAKTPPPPQKSPPPPAPTPPLPQPTATAPPPTPPP----PPPTATQASSNAPAQIPADSSPPPPI----PEE 583


                 ....*....
gi 115333977 522 QQPSPAKPS 530
Cdd:PRK14948 584 PTPSPTKDS 592
PHA03160 PHA03160
hypothetical protein; Provisional
 450-540 1.18e-04

hypothetical protein; Provisional


Pssm-ID: 165431  Cd Length: 499  Bit Score: 45.08  E-value: 1.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 450 PSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPgPAKPSPQQPGSTKPPSQQpgSAKPSAQQPSPAKP 529
Cdd:PHA03160 402 PYGAPKNDHHLLPPLACSQQLPMQPLHVQQAPMQAPHVAPPPMQP-PHVQQPRVLPSTDGASNE--APKPSAQEPVHIDA 478

                         90
                 ....*....|.
gi 115333977 530 SAQQStkPVSQ 540
Cdd:PHA03160 479 SFAQD--PVSK 487
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 230-533 1.26e-04

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 45.38  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  230 QPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPA 309
Cdd:pfam09606 165 QPGSGTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMPPQMGVPGMPGPADAGAQMGQQAQANGGMNPQQMGGAPNQVAMQ 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  310 KPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGvgKTPAQQPGPAK 389
Cdd:pfam09606 245 QQQPQQQGQQSQLGMGINQMQQMPQGVGGGAGQGGPGQPMGPPGQQPGAMPNVMSIGDQNNYQQQQT--RQQQQQQGGNH 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  390 PPTQQVGTPKPLAQQPGLQS-PAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPaKPPPQQPGPAK 468
Cdd:pfam09606 323 PAAHQQQMNQSVGQGGQVVAlGGLNHLETWNPGNFGGLGANPMQRGQPGMMSSPSPVPGQQVRQVTPN-QFMRQSPQPSV 401

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115333977  469 PPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAK----PSAQQPSPAKPSAQQ 533
Cdd:pfam09606 402 PSPQGPGSQPPQSHPGGMIPSPALIPSPSPQMSQQPAQQRTIGQDSPGGSlntpGQSAVNSPLNPQEEQ 470
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 461-566 1.29e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 45.24  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 461 PQQPGPAkpPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQqpgsakPSAQQPSPAKPSAQQSTKPVSQ 540
Cdd:PRK07994 361 PAAPLPE--PEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQA------PAVPLPETTSQLLAARQQLQRA 432

                         90       100
                 ....*....|....*....|....*.
gi 115333977 541 TGSGKPLQPPTVSPSAKQPPSQGLPK 566
Cdd:PRK07994 433 QGATKAKKSEPAAASRARPVNSALER 458
BimA_second NF040983
trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia ...
 438-543 1.34e-04

trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia intracellular motility A), WP_004266405.1-like proteins in Burkholderia mallei or B. pseudomallei. The term BimA has also been used for WP_011205626.1-like homologs that have a very different N-terminal half.


Pssm-ID: 468913 [Multi-domain]  Cd Length: 382  Bit Score: 44.51  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 438 KTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSA 517
Cdd:NF040983  83 RTLPNKVPPPPPPPPPPPPPPPTPPPPPPPPPPPPPPSPPPPPPPSPPPSPPPPTTTPPTRTTPSTTTPTPSMHPIQPTQ 162

                         90       100
                 ....*....|....*....|....*.
gi 115333977 518 KPSAQQPSPAKPSAQQSTKPVSQTGS 543
Cdd:NF040983 163 LPSIPNATPTSGSATNVTINFNSTGA 188
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 402-532 1.84e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 44.41  E-value: 1.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  402 AQQPGLQSPAKAPGPT---KTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQlPGPAKPPPQQPGPAKPPPQQPGSAK 478
Cdd:TIGR01628 378 LQPRMRQLPMGSPMGGamgQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGP-LRPNGLAPMNAVRAPSRNAQNAAQK 456

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 115333977  479 PPPqqPGSTKPPPQQPGPAKPSPQQPGSTKppsQQPGSAKPSAQQPSPAKPSAQ 532
Cdd:TIGR01628 457 PPM--QPVMYPPNYQSLPLSQDLPQPQSTA---SQGGQNKKLAQVLASATPQMQ 505
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 288-559 1.92e-04

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 44.53  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 288 QPTPGKPPAQQPGHEKSQPGPAKPPAQpsgLTKPLAqqPGTVKPPVQPPgTTKPPAQPLGPAKPPAQQTGSEKPSSEQPG 367
Cdd:PLN03209 340 KPVPTKPVTPEAPSPPIEEEPPQPKAV---VPRPLS--PYTAYEDLKPP-TSPIPTPPSSSPASSKSVDAVAKPAEPDVV 413

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 368 PKAlAQPPGVGKTPaqqpgPAKPPTQQVGTPKPLAQQPGLQSPAKapgPTKTPVQQPGPGKIPAqqagpgkTSAQQTGPT 447
Cdd:PLN03209 414 PSP-GSASNVPEVE-----PAQVEAKKTRPLSPYARYEDLKPPTS---PSPTAPTGVSPSVSST-------SSVPAVPDT 477

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 448 KPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPppqqpgsTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPA 527
Cdd:PLN03209 478 APATAATDAAAPPPANMRPLSPYAVYDDLKPP-------TSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALADEQHHAQP 550

                        250       260       270
                 ....*....|....*....|....*....|..
gi 115333977 528 KPsaqqstKPVSQTGSGKPLQPPTvSPSAKQP 559
Cdd:PLN03209 551 KP------RPLSPYTMYEDLKPPT-SPTPSPV 575
PHA03377 PHA03377
EBNA-3C; Provisional
 296-562 2.05e-04

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 44.66  E-value: 2.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  296 AQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTV----KPPVQPPGTTKPPAQPLGPAKPPA------------QQTGSE 359
Cdd:PHA03377  443 AEQAQSTPERPGPSDQPSVPVEPAHLTPVEHTTVilhqPPQSPPTVAIKPAPPPSRRRRGACvvydddiievidVETTEE 522

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  360 KPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPgpgkipaQQAGPGKT 439
Cdd:PHA03377  523 EESVTQPAKPHRKVQDGFQRSGRRQKRATPPKVSPSDRGPPKASPPVMAPPSTGPRVMATPSTGP-------RDMAPPST 595

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  440 SAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGsakp 519
Cdd:PHA03377  596 GPRQQAKCKDGPPASGPHEKQPPSSAPRDMAPSVVRMFLRERLLEQSTGPKPKSFWEMRAGRDGSGIQQEPSSRRQ---- 671

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 115333977  520 SAQQPSPAKPSAQQS--TKPVSQTGSGKPLQPPTVSP-SAKQPPSQ 562
Cdd:PHA03377  672 PATQSTPPRPSWLPSvfVLPSVDAGRAQPSEESHLSSmSPTQPISH 717
SAP130_C pfam16014
Histone deacetylase complex subunit SAP130 C-terminus;
426-565 2.28e-04

Histone deacetylase complex subunit SAP130 C-terminus;


Pssm-ID: 464973 [Multi-domain]  Cd Length: 371  Bit Score: 43.77  E-value: 2.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  426 PGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPppQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPG 505
Cdd:pfam16014  32 PPVTVAVEALPGQNSEQQTASASPPSQHPAQAIP--TILAPAAPPSQPSVVLSTLPAAMAVTPPIPASMANVVAPPTQPA 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  506 STKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPlQPPTVSPSAKQPPSQGLP 565
Cdd:pfam16014 110 ASSTAACAVSSVLPEIKIKQEAEPMDTSQSVPPLTPTSISP-ALTSLANNLSVPAGDLLP 168
BimA_second NF040983
trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia ...
 433-520 2.35e-04

trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia intracellular motility A), WP_004266405.1-like proteins in Burkholderia mallei or B. pseudomallei. The term BimA has also been used for WP_011205626.1-like homologs that have a very different N-terminal half.


Pssm-ID: 468913 [Multi-domain]  Cd Length: 382  Bit Score: 43.74  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 433 QAGPGKTSAQQTGPTKPPSQLPGPakPPPQQPGPAKPPPQQPGSAKPPPqqPGSTKPPPQQPGPAKPSPQQPGSTKPPSQ 512
Cdd:NF040983  69 QIKKGDFKLKPVGDRTLPNKVPPP--PPPPPPPPPPPPTPPPPPPPPPP--PPPPSPPPPPPPSPPPSPPPPTTTPPTRT 144


                 ....*...
gi 115333977 513 QPGSAKPS 520
Cdd:NF040983 145 TPSTTTPT 152
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 441-532 2.40e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 44.22  E-value: 2.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 441 AQQTGPTKPPsqlpgPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPS 520
Cdd:NF041121  12 AAQMGRAAAP-----PSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPGPAGAAPG 86

                         90
                 ....*....|....
gi 115333977 521 AQQP--SPAKPSAQ 532
Cdd:NF041121  87 AALPvrVPAPPALP 100
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 288-433 2.54e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 44.09  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 288 QPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPG 367
Cdd:PRK07994 365 LPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKSEPA 444

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115333977 368 PKALAQPpgvgKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQ 433
Cdd:PRK07994 445 AASRARP----VNSALERLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKALKKALEH 506
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
323-526 2.58e-04

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 44.21  E-value: 2.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 323 AQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQP---------GPKALAQPPGVgktPAQQPGPAkpPTQ 393
Cdd:PRK12727  57 TARSDTPATAAAPAPAPQAPTKPAAPVHAPLKLSANANMSQRQRvasaaedmiAAMALRQPVSV---PRQAPAAA--PVR 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 394 QVGTPKPLAQQpglqsPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAK-PPPQQPGPAKPPPQ 472
Cdd:PRK12727 132 AASIPSPAAQA-----LAHAAAVRTAPRQEHALSAVPEQLFADFLTTAPVPRAPVQAPVVAAPAPvPAIAAALAAHAAYA 206

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 115333977 473 QPGSAKPPPQQPGSTKPPPqqpgPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSP 526
Cdd:PRK12727 207 QDDDEQLDDDGFDLDDALP----QILPPAALPPIVVAPAAPAALAAVAAAAPAP 256
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
322-448 2.63e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 44.00  E-value: 2.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 322 LAQQPGTVKPPVQP-----PGTTKPPAQPLGPAKP-PAQQTGSEKPSSEQPGPKALAQPPGVGKT-PAQQPGPAKPPTQQ 394
Cdd:PRK14971 362 LTQKGDDASGGRGPkqhikPVFTQPAAAPQPSAAAaASPSPSQSSAAAQPSAPQSATQPAGTPPTvSVDPPAAVPVNPPS 441

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 115333977 395 VGTPK-PLAQQPGLQSPAKAPGPTKTP-VQQPgpgKIPAQQAGPGKTSAQQTGPTK 448
Cdd:PRK14971 442 TAPQAvRPAQFKEEKKIPVSKVSSLGPsTLRP---IQEKAEQATGNIKEAPTGTQK 494
Glutenin_hmw pfam03157
High molecular weight glutenin subunit; Members of this family include high molecular weight ...
 287-563 2.99e-04

High molecular weight glutenin subunit; Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.


Pssm-ID: 367362 [Multi-domain]  Cd Length: 786  Bit Score: 44.17  E-value: 2.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  287 QQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQP 366
Cdd:pfam03157 175 QRQQPGQGQQLRQGQQGQQSGQGQPGYYPTSSQQPGQLQQTGQGQQGQQPERGQQGQQPGQGQQPGQGQQGQQPGQPQQL 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  367 GPKALAQPPGVGKTPAQ-------QPGPAKPPTQQVGTPK----PLAQQPGLQSPAKAPGPTKTPVQQPGPGKiPAQQAG 435
Cdd:pfam03157 255 GQGQQGYYPISPQQPRQwqqsgqgQQGYYPTSLQQPGQGQsgyyPTSQQQAGQLQQEQQLGQEQQDQQPGQGR-QGQQPG 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  436 PGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKP-----PPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPP 510
Cdd:pfam03157 334 QGQQGQQPAQGQQPGQGQPGYYPTSPQQPGQGQPgyyptSQQQPQQGQQPEQGQQGQQQGQGQQGQQPGQGQQPGQGQPG 413

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 115333977  511 SQQPGSAKPSAQQPSPAKPSAQQSTKpvsQTGSGKPLQPPTVSPSAKQPPSQG 563
Cdd:pfam03157 414 YYPTSPQQSGQGQPGYYPTSPQQSGQ---GQQPGQGQQPGQEQPGQGQQPGQG 463
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
345-531 3.01e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.07  E-value: 3.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 345 PLGPAKPPAQQTGSEKPSSEQPGPKAlAQPPGVGKTPAQQPGPAKPPtqqvGTPKPLAQQPGLQSPAKAPGPTKTPVQQP 424
Cdd:PRK07003 362 VTGGGAPGGGVPARVAGAVPAPGARA-AAAVGASAVPAVTAVTGAAG----AALAPKAAAAAAATRAEAPPAAPAPPATA 436

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 425 GPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKpPPQQPGSTKPPPQQPGPAKPSPQQP 504
Cdd:PRK07003 437 DRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAF-EPAPRAAAPSAATPAAVPDARAPAA 515

                        170       180
                 ....*....|....*....|....*..
gi 115333977 505 GSTKPPSQQPGSAKPSAQQPSPAKPSA 531
Cdd:PRK07003 516 ASREDAPAAAAPPAPEARPPTPAAAAP 542
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 330-501 3.29e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 43.70  E-value: 3.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 330 KPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPgvgktPAQQPGPAKPPTQQVGTPKPLAQQPGLQS 409
Cdd:PRK07994 362 AAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAP-----QQAPAVPLPETTSQLLAARQQLQRAQGAT 436

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 410 PAKAPGPTKTPVQQPGPgkipaqqagpgktSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPgSAKPPPQQPGSTKP 489
Cdd:PRK07994 437 KAKKSEPAAASRARPVN-------------SALERLASVRPAPSALEKAPAKKEAYRWKATNPVE-VKKEPVATPKALKK 502

                        170
                 ....*....|..
gi 115333977 490 PPQQPGPAKPSP 501
Cdd:PRK07994 503 ALEHEKTPELAA 514
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
371-559 3.51e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.68  E-value: 3.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 371 LAQPPGVGKTPAqqPGPAKPPTQQVGTPKPLAQqpglqsPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPP 450
Cdd:PRK07003 356 LAFEPAVTGGGA--PGGGVPARVAGAVPAPGAR------AAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPP 427

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 451 SQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGStKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPS 530
Cdd:PRK07003 428 AAPAPPATADRGDDAADGDAPVPAKANARASADSRC-DERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAA 506

                        170       180
                 ....*....|....*....|....*....
gi 115333977 531 AQQSTKPVSQTGSGKPLQPPTVSPSAKQP 559
Cdd:PRK07003 507 VPDARAPAAASREDAPAAAAPPAPEARPP 535
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 355-522 3.73e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 43.64  E-value: 3.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  355 QTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPaKPPTQQVGTPKPLAQQPGLQSPAKAPGPtktpvqqpgpgkiPAQQA 434
Cdd:TIGR01628 379 QPRMRQLPMGSPMGGAMGQPPYYGQGPQQQFNG-QPLGWPRMSMMPTPMGPGGPLRPNGLAP-------------MNAVR 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  435 GPGKTsaqqtgptkppsqlpgpakpppQQPGPAKPPPQqpgsakPPPQQPGSTKPPPQQPGPAKPS-PQQPGSTKPPSQQ 513
Cdd:TIGR01628 445 APSRN----------------------AQNAAQKPPMQ------PVMYPPNYQSLPLSQDLPQPQStASQGGQNKKLAQV 496


                  ....*....
gi 115333977  514 PGSAKPSAQ 522
Cdd:TIGR01628 497 LASATPQMQ 505
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 307-467 3.82e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.55  E-value: 3.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 307 GPAKPPAQPSGLTKPLAQQPGTVKPPvqppgttkPPAQPLGPAKPPAQQTgsekpsSEQPGPKALAQPPGVGKTPAQQPG 386
Cdd:PRK14951 370 AEAAAPAEKKTPARPEAAAPAAAPVA--------QAAAAPAPAAAPAAAA------SAPAAPPAAAPPAPVAAPAAAAPA 435

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 387 PAKPPtqqvgTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPgkiPAQQAGPgktsaqqtgptkPPSQLPGPAKPPPQQPGP 466
Cdd:PRK14951 436 AAPAA-----APAAVALAPAPPAQAAPETVAIPVRVAPEP---AVASAAP------------APAAAPAAARLTPTEEGD 495


                 .
gi 115333977 467 A 467
Cdd:PRK14951 496 V 496
dnaA PRK14086
chromosomal replication initiator protein DnaA;
308-522 3.92e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 43.66  E-value: 3.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 308 PAKPPAQPSGLTKPLAQQPGTVKPPVQP-PGTTKPPAQPLGPAKPPaqqtGSEKPSSeQPGPKALAQPPgvgktpaqQPG 386
Cdd:PRK14086  90 PSAGEPAPPPPHARRTSEPELPRPGRRPyEGYGGPRADDRPPGLPR----QDQLPTA-RPAYPAYQQRP--------EPG 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 387 PAKPPTQQVGtpkplAQQPGLQSPAKAPgptKTPVQQPGPGkiPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGP 466
Cdd:PRK14086 157 AWPRAADDYG-----WQQQRLGFPPRAP---YASPASYAPE--QERDREPYDAGRPEYDQRRRDYDHPRPDWDRPRRDRT 226

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 115333977 467 AKPPPqQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPgSTKPPSQQPGSAKPSAQ 522
Cdd:PRK14086 227 DRPEP-PPGAGHVHRGGPGPPERDDAPVVPIRPSAPGP-LAAQPAPAPGPGEPTAR 280
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 305-389 4.02e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 43.73  E-value: 4.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  305 QPGPAKPPAQPSGLTKPlAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQ 384
Cdd:PRK12270   40 STAAPTAAAAAAAAAAS-APAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEDEVT 118


                  ....*..
gi 115333977  385 P--GPAK 389
Cdd:PRK12270  119 PlrGAAA 125
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 307-424 4.03e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.92  E-value: 4.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  307 GPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPP----AQPLGPAKPPAQQTGSEKPSSEQPGPKALAQP--PGVGKT 380
Cdd:PRK10263  739 GPHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPqpqyQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPvaPQPQYQ 818

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 115333977  381 PAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQP 424
Cdd:PRK10263  819 QPQQPVAPQPQYQQPQQPVAPQPQDTLLHPLLMRNGDSRPLHKP 862
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 417-512 4.05e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 43.26  E-value: 4.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 417 TKTPVQQPGPGKIPAQQAGPGKTsAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPqqPGSAKPPPQQPgstKPPPQQPGP 496
Cdd:PRK14950 361 VPVPAPQPAKPTAAAPSPVRPTP-APSTRPKAAAAANIPPKEPVRETATPPPVPP--RPVAPPVPHTP---ESAPKLTRA 434

                         90
                 ....*....|....*.
gi 115333977 497 AKPSPQQPGSTKPPSQ 512
Cdd:PRK14950 435 AIPVDEKPKYTPPAPP 450
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 289-370 4.27e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 43.26  E-value: 4.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 289 PTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQ-QPGTVKPPVQPP---GTTKPPAQPLGPAKPPAQQTGSEKPSSE 364
Cdd:PRK14950 366 PQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEpVRETATPPPVPPrpvAPPVPHTPESAPKLTRAAIPVDEKPKYT 445


                 ....*.
gi 115333977 365 QPGPKA 370
Cdd:PRK14950 446 PPAPPK 451
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 368-523 4.72e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 43.32  E-value: 4.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 368 PKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPlaQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPT 447
Cdd:PRK07994 361 PAAPLPEPEVPPQSAAPAASAQATAAPTAAVAP--PQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKA 438

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 448 KPPS-QLPGPAKP--PPQQPGPAKPPPQQPGSAKPP--------PQQPGSTKPPPQ-QPGPAKPSPQQPgstKPPSQQPG 515
Cdd:PRK07994 439 KKSEpAAASRARPvnSALERLASVRPAPSALEKAPAkkeayrwkATNPVEVKKEPVaTPKALKKALEHE---KTPELAAK 515


                 ....*...
gi 115333977 516 SAKPSAQQ 523
Cdd:PRK07994 516 LAAEAIER 523
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 441-515 4.72e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 43.19  E-value: 4.72e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115333977 441 AQQTGPTKPPSQLPGPAKPPPQQPGP--AKPPPQQPGSAKPPPQQPgstKPPPQQPGPAKPSPQQPGSTKPPSQQPG 515
Cdd:PRK14965 376 ALERGAPAPPSAAWGAPTPAAPAAPPpaAAPPVPPAAPARPAAARP---APAPAPPAAAAPPARSADPAAAASAGDR 449
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 431-567 4.90e-04

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 43.53  E-value: 4.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  431 AQQAGPGKTSAQ--QTGPTKPPSQLPGPAKPPPQQPGPAKPP-PQQPGSAKPPPQQPGSTKP--------PPQQPGPAKP 499
Cdd:PTZ00395  397 AAQSNAAQSNAGfsNAGYSNPGNSNPGYNNAPNSNTPYNNPPnSNTPYSNPPNSNPPYSNLPysntpysnAPLSNAPPSS 476

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115333977  500 SPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQstkpvSQTGSGKPLQPPTVSPSAKQPPSQGLPKT 567
Cdd:PTZ00395  477 AKDHHSAYHAAYQHRAANQPAANLPTANQPAANN-----FHGAAGNSVGNPFASRPFGSAPYGGNAAT 539
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 475-539 4.99e-04

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 42.98  E-value: 4.99e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115333977 475 GSAKPPPQQPGstkPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVS 539
Cdd:PRK01297  10 GKGEAEQPAPA---PPSPAAAPAPPPPAKTAAPATKAAAPAAAAPRAEKPKKDKPRRERKPKPAS 71
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 377-468 5.07e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 43.26  E-value: 5.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 377 VGKTPAQQPGPAKPPTQQVGTPKPLAQQPgLQSPAKAPGPTKTPVQQPG-PGKIPAQQAGPGKTSAQQTGPTKPPSQLPG 455
Cdd:PRK14950 360 LVPVPAPQPAKPTAAAPSPVRPTPAPSTR-PKAAAAANIPPKEPVRETAtPPPVPPRPVAPPVPHTPESAPKLTRAAIPV 438

                         90
                 ....*....|...
gi 115333977 456 PAKPPPQQPGPAK 468
Cdd:PRK14950 439 DEKPKYTPPAPPK 451
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 405-482 5.28e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 43.34  E-value: 5.28e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115333977  405 PGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQ 482
Cdd:PRK12270   39 GSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEDE 116
PRK12373 PRK12373
NADH-quinone oxidoreductase subunit E;
378-546 6.57e-04

NADH-quinone oxidoreductase subunit E;


Pssm-ID: 237082 [Multi-domain]  Cd Length: 400  Bit Score: 42.48  E-value: 6.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 378 GKTPAQQPGPakpptqQVG--TPKPLAqqpGLQSPAKAPGPTKTpvqqpGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPG 455
Cdd:PRK12373 172 GKGPVVKPGP------QIGryASEPAG---GLTSLTEEAGKARY-----NASKALAEDIGDTVKRIDGTEVPLLAPWQGD 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 456 PAKPPPQQPGPAKPPPQQPGSAKPPPqqpgstKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQST 535
Cdd:PRK12373 238 AAPVPPSEAARPKSADAETNAALKTP------ATAPKAAAKNAKAPEAQPVSGTAAAEPAPKEAAKAAAAAAKPALEDKP 311

                        170
                 ....*....|.
gi 115333977 536 KPVSQTGSGKP 546
Cdd:PRK12373 312 RPLGIARPGGA 322
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 450-553 6.59e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 42.87  E-value: 6.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  450 PSQLPGPAKPPP-QQPGPAKPPPQQP-----GSAKPPPQQPGStkpPPQQPGPAKPSPQQpgstKPPSQQPGSAKPSAQQ 523
Cdd:TIGR01628 388 GSPMGGAMGQPPyYGQGPQQQFNGQPlgwprMSMMPTPMGPGG---PLRPNGLAPMNAVR----APSRNAQNAAQKPPMQ 460

                          90       100       110
                  ....*....|....*....|....*....|
gi 115333977  524 PSPAKPSAQQstKPVSQtgsGKPLQPPTVS 553
Cdd:TIGR01628 461 PVMYPPNYQS--LPLSQ---DLPQPQSTAS 485
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 317-541 7.54e-04

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 42.45  E-value: 7.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 317 GLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSE-KPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQqv 395
Cdd:NF033839 278 GLTQDTPKEPGNKKPSAPKPGMQPSPQPEKKEVKPEPETPKPEvKPQLEKPKPEVKPQPEKPKPEVKPQLETPKPEVK-- 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 396 gtPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPG 475
Cdd:NF033839 356 --PQPEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKP 433

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115333977 476 SAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQT 541
Cdd:NF033839 434 QPEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPDNSKPQADDKKPSTP 499
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 392-524 7.86e-04

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 42.41  E-value: 7.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 392 TQQVGTPKPLAQ---QPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQqtGPTKPPSQLPGPAKPPPQQPGPAK 468
Cdd:PHA03269  19 IANLNTNIPIPElhtSAATQKPDPAPAPHQAASRAPDPAVAPTSAASRKPDLAQ--APTPAASEKFDPAPAPHQAASRAP 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 115333977 469 PPPQQPGSAKPPPQQPGStkpPPQQPGPAKPSP-QQPGSTKPPSQQPGSAKPSAQQP 524
Cdd:PHA03269  97 DPAVAPQLAAAPKPDAAE---AFTSAAQAHEAPaDAGTSAASKKPDPAAHTQHSPPP 150
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 429-504 9.02e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 42.30  E-value: 9.02e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115333977 429 IPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQP 504
Cdd:NF041121  15 MGRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPGPAGAAPGAALP 90
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 447-560 9.59e-04

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 42.41  E-value: 9.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 447 TKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPgSTKPPPQ---QPGPAkPSPQQPGSTKP-PSQQPGSAKPSAQ 522
Cdd:PHA03269  33 TSAATQKPDPAPAPHQAASRAPDPAVAPTSAASRKPDL-AQAPTPAaseKFDPA-PAPHQAASRAPdPAVAPQLAAAPKP 110

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 115333977 523 QPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPP 560
Cdd:PHA03269 111 DAAEAFTSAAQAHEAPADAGTSAASKKPDPAAHTQHSP 148
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 478-564 1.02e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 42.57  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  478 KPPPQQPGSTKPPPQQPGPAKPSPQQPgstKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAK 557
Cdd:PRK12270   37 GPGSTAAPTAAAAAAAAAASAPAAAPA---AKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAV 113


                  ....*..
gi 115333977  558 QPPSQGL 564
Cdd:PRK12270  114 EDEVTPL 120
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
287-380 1.07e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 42.07  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 287 QQPTPGKPPAQQPGHEKSQPGPAKPPA--QPSGLTKPLAQQPGT---VKPPVQPPGTTKPPAQPlGPAKPPAQQTGSEKP 361
Cdd:PRK14971 390 PQPSAAAAASPSPSQSSAAAQPSAPQSatQPAGTPPTVSVDPPAavpVNPPSTAPQAVRPAQFK-EEKKIPVSKVSSLGP 468

                         90
                 ....*....|....*....
gi 115333977 362 SSEQPGPKALAQPPGVGKT 380
Cdd:PRK14971 469 STLRPIQEKAEQATGNIKE 487
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 211-458 1.21e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.99  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  211 QQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPT 290
Cdd:PRK10263  376 APEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQST 455

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  291 PGKPPAQQPGHEKSQPGPAKPPAQPsgltKPLAQQPGTVKPpvqppgttKPPAQPLGPAKPPAQ--QTGSEKPSSE---- 364
Cdd:PRK10263  456 FAPQSTYQTEQTYQQPAAQEPLYQQ----PQPVEQQPVVEP--------EPVVEETKPARPPLYyfEEVEEKRAREreql 523

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  365 ----QPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQqpGLQSPAKAPGPTKTPVqqpGPGKIPAQQAGPGKTS 440
Cdd:PRK10263  524 aawyQPIPEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPLAS--GVKKATLATGAAATVA---APVFSLANSGGPRPQV 598

                         250
                  ....*....|....*...
gi 115333977  441 AQQTGPtkppsQLPGPAK 458
Cdd:PRK10263  599 KEGIGP-----QLPRPKR 611
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 455-510 1.23e-03

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 41.82  E-value: 1.23e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 115333977 455 GPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGS--TKPPPQQPGPAKPSPQQPGSTKPP 510
Cdd:PRK01297  10 GKGEAEQPAPAPPSPAAAPAPPPPAKTAAPATkaAAPAAAAPRAEKPKKDKPRRERKP 67
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 473-537 1.23e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 42.04  E-value: 1.23e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115333977 473 QPGSAKPPPQQPGSTKPPPQQPGP--AKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKP 537
Cdd:PRK14965 378 ERGAPAPPSAAWGAPTPAAPAAPPpaAAPPVPPAAPARPAAARPAPAPAPPAAAAPPARSADPAAAA 444
Totivirus_coat pfam05518
Totivirus coat protein;
345-503 1.26e-03

Totivirus coat protein;


Pssm-ID: 428505  Cd Length: 727  Bit Score: 42.05  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  345 PLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGK-TPAQQPGPAKPPTQQVGTPKPlaqqpGLQSPAKAPGPTktpvqQ 423
Cdd:pfam05518 589 PTGLASGASNAEDPEVRRARTRGARALAQARTFGRaTVGEMIISGFPPVFKTALPRP-----DYNRGGEAGGPG-----V 658

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  424 PGPGkipaQQAGPGKTsaqqtgpTKPPSQLPGPAKPPPQ--QPGPAKPPPQQPGSAKPPPqqPGSTKPPPQQPGPAKPSP 501
Cdd:pfam05518 659 PGPV----PVGMEAHT-------VRPSRVARGDPVRPTAhhAALRAPQAPRGPSSLIPSP--TAPPEPEPPGAEQADRAE 725


                  ..
gi 115333977  502 QQ 503
Cdd:pfam05518 726 NQ 727
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 384-479 1.36e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 41.85  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 384 QPGPAK-PPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAqqagpgktsaqqtgptkpPSQLPGPAKPPPQ 462
Cdd:PRK14954 381 APSPAGsPDVKKKAPEPDLPQPDRHPGPAKPEAPGARPAELPSPASAPT------------------PEQQPPVARSAPL 442

                         90
                 ....*....|....*..
gi 115333977 463 QPGPAKPPPQQPGSAKP 479
Cdd:PRK14954 443 PPSPQASAPRNVASGKP 459
motB PRK12799
flagellar motor protein MotB; Reviewed
 427-541 1.37e-03

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 41.62  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 427 GKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQ---PGPAKPSPQQ 503
Cdd:PRK12799 297 GTVPVAAVTPSSAVTQSSAITPSSAAIPSPAVIPSSVTTQSATTTQASAVALSSAGVLPSDVTLPGTvalPAAEPVNMQP 376

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 115333977 504 PGSTKPPSQQP--GSAKPSAQQPSPAKPSAQQSTKPVSQT 541
Cdd:PRK12799 377 QPMSTTETQQSstGNITSTANGPTTSLPAAPASNIPVSPT 416
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 391-514 1.41e-03

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 40.02  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  391 PTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQqagPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPP 470
Cdd:pfam15240  38 QSQQGGQGPQGPPPGGFPPQPPASDDPPGPPPPGGPQQPPPQ---GGKQKPQGPPPQGGPRPPPGKPQGPPPQGGNQQQG 114

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 115333977  471 PQQPGSAKPPPQQPGStkPPPQQPGPAKPSPQQPGSTKPPSQQP 514
Cdd:pfam15240 115 PPPPGKPQGPPPQGGG--PPPQGGNQQGPPPPPPGNPQGPPQRP 156
motB PRK05996
MotB family protein;
350-540 1.46e-03

MotB family protein;


Pssm-ID: 235665 [Multi-domain]  Cd Length: 423  Bit Score: 41.61  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 350 KPPAQQTGSEKP--SSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKP------LAQQPGLQSPAKAPGPTKTpv 421
Cdd:PRK05996  85 DPVDGAEGEQKPgkSKFEEDQRVEGSSAVTGDDTTRTSGDQTNYSEADLFRNPyavlaeIAQEVGQQANVSAKGDGGA-- 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 422 QQPGPgkipAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPqQPGPAKPSP 501
Cdd:PRK05996 163 AQSGP----ATGADGGEAYRDPFDPDFWSKQVEVTTAGDLLPPGQAREQAQGAKSATAAPATVPQAAPLP-QAQPKKAAT 237

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 115333977 502 QQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQ 540
Cdd:PRK05996 238 EEELIADAKKAATGEPAANAAKAAKPEPMPDDQQKEAEQ 276
PRK12373 PRK12373
NADH-quinone oxidoreductase subunit E;
427-558 1.54e-03

NADH-quinone oxidoreductase subunit E;


Pssm-ID: 237082 [Multi-domain]  Cd Length: 400  Bit Score: 41.33  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 427 GKIPAQQAGP--GKTSAQqtgPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQP 504
Cdd:PRK12373 172 GKGPVVKPGPqiGRYASE---PAGGLTSLTEEAGKARYNASKALAEDIGDTVKRIDGTEVPLLAPWQGDAAPVPPSEAAR 248

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 115333977 505 GSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQ 558
Cdd:PRK12373 249 PKSADAETNAALKTPATAPKAAAKNAKAPEAQPVSGTAAAEPAPKEAAKAAAAA 302
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 410-508 1.58e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 41.72  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 410 PAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSqlPGPAKPPPQQPGPAKPPPqqpgsakPPPQQPGSTKP 489
Cdd:PRK14950 362 PVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPV--RETATPPPVPPRPVAPPV-------PHTPESAPKLT 432

                         90
                 ....*....|....*....
gi 115333977 490 PPQQPGPAKPSPQQPGSTK 508
Cdd:PRK14950 433 RAAIPVDEKPKYTPPAPPK 451
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 468-554 1.68e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.80  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  468 KPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPqqpgSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPL 547
Cdd:PRK12270   37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAP----APAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAA 112


                  ....*..
gi 115333977  548 QPPTVSP 554
Cdd:PRK12270  113 VEDEVTP 119
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 330-420 1.71e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.80  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  330 KPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAqppgvgktPAQQPGPAKPPTQQVGTPKPLAQQPGLQS 409
Cdd:PRK12270   37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAA--------PAAPPKPAAAAAAAAAPAAPPAAAAAAAP 108

                          90
                  ....*....|.
gi 115333977  410 PAKAPGPTKTP 420
Cdd:PRK12270  109 AAAAVEDEVTP 119
dnaA PRK14086
chromosomal replication initiator protein DnaA;
261-469 1.75e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 41.35  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 261 PQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTK 340
Cdd:PRK14086  80 RPIRIAITVDPSAGEPAPPPPHARRTSEPELPRPGRRPYEGYGGPRADDRPPGLPRQDQLPTARPAYPAYQQRPEPGAWP 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 341 PPAQPLGPAKPPAQQTGSE---KPSSEQPGPKALAQPPGvgktpaQQPGPAKPPTQQVGTPKPLAQQPGLQSpakapgpT 417
Cdd:PRK14086 160 RAADDYGWQQQRLGFPPRApyaSPASYAPEQERDREPYD------AGRPEYDQRRRDYDHPRPDWDRPRRDR-------T 226

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 115333977 418 KTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPqQPGPAKP 469
Cdd:PRK14086 227 DRPEPPPGAGHVHRGGPGPPERDDAPVVPIRPSAPGPLAAQPAP-APGPGEP 277
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
230-454 1.84e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 1.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 230 QPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQAdivrGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPA 309
Cdd:PRK07003 399 VTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPAT----ADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADS 474

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 310 KPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAkppAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPA- 388
Cdd:PRK07003 475 GSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPA---AASREDAPAAAAPPAPEARPPTPAAAAPAARAGGAAa 551

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 389 ----------KPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPG------KIPAQQAGPGKTSAQQTGPTKPPSQ 452
Cdd:PRK07003 552 aldvlrnagmRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQVPTPRaraatgDAPPNGAARAEQAAESRGAPPPWED 631


                 ..
gi 115333977 453 LP 454
Cdd:PRK07003 632 IP 633
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 450-540 2.06e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 41.33  E-value: 2.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 450 PSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPpqQPGPAKPSPQQP---GSTKPPSQQPGSAKPSAQQPSP 526
Cdd:PRK14950 362 PVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEP--VRETATPPPVPPrpvAPPVPHTPESAPKLTRAAIPVD 439

                         90
                 ....*....|....
gi 115333977 527 AKPSAQQSTKPVSQ 540
Cdd:PRK14950 440 EKPKYTPPAPPKEE 453
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 424-508 2.11e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 41.20  E-value: 2.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 424 PGPGKIPAQQAGP--GKTSAQQTGPTKPPSQLPGPAKP-------PPQQPGPAKPPPQQPGsAKPPPQQPGSTKP----P 490
Cdd:PRK14959 398 PTPGTQGPQGTAPaaGMTPSSAAPATPAPSAAPSPRVPwddappaPPRSGIPPRPAPRMPE-ASPVPGAPDSVASasdaP 476

                         90
                 ....*....|....*...
gi 115333977 491 PQQPGPAKPSPQQPGSTK 508
Cdd:PRK14959 477 PTLGDPSDTAEHTPSGPR 494
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 432-507 2.11e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 41.27  E-value: 2.11e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115333977 432 QQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPgpakPPPQQPGSAKPPPQQPGstkPPPQQPGPAKPSPQQPGST 507
Cdd:PRK14965 378 ERGAPAPPSAAWGAPTPAAPAAPPPAAAPPVPP----AAPARPAAARPAPAPAP---PAAAAPPARSADPAAAASA 446
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 477-565 2.28e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.95  E-value: 2.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 477 AKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGsAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSA 556
Cdd:PRK14950 361 VPVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPP-KEPVRETATPPPVPPRPVAPPVPHTPESAPKLTRAAIPVD 439


                 ....*....
gi 115333977 557 KQPPSQGLP 565
Cdd:PRK14950 440 EKPKYTPPA 448
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 465-527 2.32e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 40.88  E-value: 2.32e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115333977 465 GPAKPPPQQPGSAKPPPQQPGST-KPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPA 527
Cdd:PRK14965 381 APAPPSAAWGAPTPAAPAAPPPAaAPPVPPAAPARPAAARPAPAPAPPAAAAPPARSADPAAAA 444
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 288-480 2.41e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 2.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  288 QPTPGKPPAQQPGHEK-SQPGPAKPPAQPSGLTKPlAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEqp 366
Cdd:PRK10263  381 PQQSQYAQPAVQYNEPlQQPVQPQQPYYAPAAEQP-AQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFA-- 457

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  367 gPKALAQPPGVGKTPAQQPGPAKPPtQQVGTPKPLAQQPGLQS--PAKAPGPTKTPVQQpgpgkipaQQAGPGKTSAQQT 444
Cdd:PRK10263  458 -PQSTYQTEQTYQQPAAQEPLYQQP-QPVEQQPVVEPEPVVEEtkPARPPLYYFEEVEE--------KRAREREQLAAWY 527

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 115333977  445 GPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPP 480
Cdd:PRK10263  528 QPIPEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSP 563
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 417-535 2.47e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 40.87  E-value: 2.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 417 TKTPVQQPGPGKIPAQQAGPGKTSAqqTGPTKPPSQLPGPAKPPP----QQPGPAKPPPQQPGSAKPPPQQPGSTKPPpq 492
Cdd:PHA03269  33 TSAATQKPDPAPAPHQAASRAPDPA--VAPTSAASRKPDLAQAPTpaasEKFDPAPAPHQAASRAPDPAVAPQLAAAP-- 108

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 115333977 493 QPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQST 535
Cdd:PHA03269 109 KPDAAEAFTSAAQAHEAPADAGTSAASKKPDPAAHTQHSPPPF 151
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 467-563 2.60e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.95  E-value: 2.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 467 AKPPPQQPGSAKPPpqqpgstKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQ--STKPVSQTGSG 544
Cdd:PRK14950 361 VPVPAPQPAKPTAA-------APSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPvpHTPESAPKLTR 433

                         90
                 ....*....|....*....
gi 115333977 545 KPLqPPTVSPSAKQPPSQG 563
Cdd:PRK14950 434 AAI-PVDEKPKYTPPAPPK 451
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 453-520 2.62e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 40.88  E-value: 2.62e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 453 LPGPAKPPPQQPGPAKPPPQqpgSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPS--QQPGSAKPS 520
Cdd:PRK14965 383 APPSAAWGAPTPAAPAAPPP---AAAPPVPPAAPARPAAARPAPAPAPPAAAAPPARSAdpAAAASAGDR 449
PTZ00144 PTZ00144
dihydrolipoamide succinyltransferase; Provisional
 465-530 2.63e-03

dihydrolipoamide succinyltransferase; Provisional


Pssm-ID: 240289 [Multi-domain]  Cd Length: 418  Bit Score: 40.44  E-value: 2.63e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115333977 465 GPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPgSAKPSAQQPSPAKPS 530
Cdd:PTZ00144 124 PPAAAPAAAAAAKAEKTTPEKPKAAAPTPEPPAASKPTPPAAAKPPEPAP-AAKPPPTPVARADPR 188
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
294-482 2.63e-03

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 40.74  E-value: 2.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 294 PPAQQPgheksqpgPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPL-GPAKPPAQQTGSEK-PSSEQPGPKAL 371
Cdd:PRK12727  70 APAPQA--------PTKPAAPVHAPLKLSANANMSQRQRVASAAEDMIAAMALrQPVSVPRQAPAAAPvRAASIPSPAAQ 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 372 AQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPgLQSPAKAPGPTKTPVQQPG-PGKIPAQQAGPGKTSAQQTGPTKPP 450
Cdd:PRK12727 142 ALAHAAAVRTAPRQEHALSAVPEQLFADFLTTAP-VPRAPVQAPVVAAPAPVPAiAAALAAHAAYAQDDDEQLDDDGFDL 220

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 115333977 451 SQLPGPAKPPPQQPGPAKPPPQQP-----GSAKPPPQ 482
Cdd:PRK12727 221 DDALPQILPPAALPPIVVAPAAPAalaavAAAAPAPQ 257
PHA03160 PHA03160
hypothetical protein; Provisional
 306-385 2.68e-03

hypothetical protein; Provisional


Pssm-ID: 165431  Cd Length: 499  Bit Score: 40.84  E-value: 2.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 306 PGPAKPPAQPSGLTKPLAQQPGTVK-PPVQPPGTTKPPAQPLGPAKPPAQQTgSEKPSSEQPGPKAlAQPPGVGKTPAQQ 384
Cdd:PHA03160 406 PKNDHHLLPPLACSQQLPMQPLHVQqAPMQAPHVAPPPMQPPHVQQPRVLPS-TDGASNEAPKPSA-QEPVHIDASFAQD 483


                 .
gi 115333977 385 P 385
Cdd:PHA03160 484 P 484
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 416-537 2.73e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 40.82  E-value: 2.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 416 PTKTPVQQPGPGkipAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPA---KPPPQQPG----SAKPPPQQPGSTK 488
Cdd:PRK14959 363 PRLMPVESLRPS---GGGASAPSGSAAEGPASGGAATIPTPGTQGPQGTAPAagmTPSSAAPAtpapSAAPSPRVPWDDA 439

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 115333977 489 PP--PQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKP 537
Cdd:PRK14959 440 PPapPRSGIPPRPAPRMPEASPVPGAPDSVASASDAPPTLGDPSDTAEHTP 490
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 390-524 2.79e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.84  E-value: 2.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  390 PPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPpsQLPGPAKPPPQQPgpAKP 469
Cdd:PRK10263  751 PVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQP--VAPQPQYQQPQQP--VAP 826

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 115333977  470 PPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQP 524
Cdd:PRK10263  827 QPQYQQPQQPVAPQPQDTLLHPLLMRNGDSRPLHKPTTPLPSLDLLTPPPSEVEP 881
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 427-490 2.89e-03

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 40.67  E-value: 2.89e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115333977 427 GKIPAQQAGPGKTSAQQTGPTKPPsqlpgpAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPP 490
Cdd:PRK01297  10 GKGEAEQPAPAPPSPAAAPAPPPP------AKTAAPATKAAAPAAAAPRAEKPKKDKPRRERKP 67
PHA03377 PHA03377
EBNA-3C; Provisional
 332-530 2.89e-03

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 40.81  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  332 PVQPPGTTKPPAQPLGPAKPPAQQTgsEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPptQQVGTPKPLAQQPGLQSPA 411
Cdd:PHA03377  412 PWRKPRTLPWPTPKTHPVKRTLVKT--SGRSDEAEQAQSTPERPGPSDQPSVPVEPAHL--TPVEHTTVILHQPPQSPPT 487

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  412 KAPGPTKTPVQQPGPGKI-----------------------PAQQAGPGKTSAQQTGPTKPPSQLPgPAKPPPQQPGPAK 468
Cdd:PHA03377  488 VAIKPAPPPSRRRRGACVvydddiievidvetteeeesvtqPAKPHRKVQDGFQRSGRRQKRATPP-KVSPSDRGPPKAS 566

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 115333977  469 PPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPS 530
Cdd:PHA03377  567 PPVMAPPSTGPRVMATPSTGPRDMAPPSTGPRQQAKCKDGPPASGPHEKQPPSSAPRDMAPS 628
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 455-521 3.00e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 40.50  E-value: 3.00e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115333977 455 GPAKPPPQQPGPAKPPPQQPGSAKPPPQQPgstkPPPQQPGPAKPSPQQPGSTKPPSQQPgSAKPSA 521
Cdd:PRK14965 381 APAPPSAAWGAPTPAAPAAPPPAAAPPVPP----AAPARPAAARPAPAPAPPAAAAPPAR-SADPAA 442
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 223-565 3.07e-03

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 40.76  E-value: 3.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  223 QPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPghe 302
Cdd:pfam09606  95 RPQMMGPMGPGPGGPMGQQMGGPGTASNLLASLGRPQMPMGGAGFPSQMSRVGRMQPGGQAGGMMQPSSGQPGSGTP--- 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  303 kSQPGPAKPPAQPSGLTKPLAQQPGtvkPPVQPPGTTKPPAqPLGPAKPPAQqTGSEKPSSEQPGPKALAQPPGVGKTPA 382
Cdd:pfam09606 172 -NQMGPNGGPGQGQAGGMNGGQQGP---MGGQMPPQMGVPG-MPGPADAGAQ-MGQQAQANGGMNPQQMGGAPNQVAMQQ 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  383 QQPGPAKPPTQ---QVGTPKPLAQQPGLQSPAKAPGPTKTPVQQpGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKP 459
Cdd:pfam09606 246 QQPQQQGQQSQlgmGINQMQQMPQGVGGGAGQGGPGQPMGPPGQ-QPGAMPNVMSIGDQNNYQQQQTRQQQQQQGGNHPA 324

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  460 -----PPQQPGPAKPPPQQPGSAKPPPQQPGSTKP---PPQQPGPA--KPSPQQPGSTKPPSQQPGSAKPSAQQPSpaKP 529
Cdd:pfam09606 325 ahqqqMNQSVGQGGQVVALGGLNHLETWNPGNFGGlgaNPMQRGQPgmMSSPSPVPGQQVRQVTPNQFMRQSPQPS--VP 402

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 115333977  530 SAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLP 565
Cdd:pfam09606 403 SPQGPGSQPPQSHPGGMIPSPALIPSPSPQMSQQPA 438
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 440-567 3.21e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.83  E-value: 3.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 440 SAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPP-QQPGSTKPPP--QQPGPA---KPS-----------PQ 502
Cdd:PTZ00449 504 SDKHDEPPEGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEgGKPGETKEGEvgKKPGPAkehKPSkiptlskkpefPK 583

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115333977 503 QPGSTKPP-----SQQPGSAKPSAQQPSPAKPSAQ---QSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKT 567
Cdd:PTZ00449 584 DPKHPKDPeepkkPKRPRSAQRPTRPKSPKLPELLdipKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKS 656
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 290-414 3.51e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.84  E-value: 3.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  290 TPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPpaQQTGSEKPSSEQPGPK 369
Cdd:PRK10263  746 TPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQP--QQPVAPQPQYQQPQQP 823

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 115333977  370 ALAQPpgvgktPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAP 414
Cdd:PRK10263  824 VAPQP------QYQQPQQPVAPQPQDTLLHPLLMRNGDSRPLHKP 862
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 388-571 3.66e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 40.29  E-value: 3.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 388 AKPPTQQVGTPKPLAqqpglqspAKAPGPTKTPVQQPGPgKIPAQQAGPGKTSAQQTGPTKPPS---QLPGPAKPPPQQP 464
Cdd:PLN03209 321 AKIPSQRVPPKESDA--------ADGPKPVPTKPVTPEA-PSPPIEEEPPQPKAVVPRPLSPYTayeDLKPPTSPIPTPP 391

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 465 --GPAKPPP----QQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGStkPPSQQPGSAKPSAQQPSPAKPSAQQSTKPV 538
Cdd:PLN03209 392 ssSPASSKSvdavAKPAEPDVVPSPGSASNVPEVEPAQVEAKKTRPLS--PYARYEDLKPPTSPSPTAPTGVSPSVSSTS 469

                        170       180       190
                 ....*....|....*....|....*....|...
gi 115333977 539 SQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPL 571
Cdd:PLN03209 470 SVPAVPDTAPATAATDAAAPPPANMRPLSPYAV 502
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 347-426 3.74e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 40.64  E-value: 3.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  347 GPAKPPAQQTGSEKPSSEQPGPKAlaQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGP 426
Cdd:PRK12270   37 GPGSTAAPTAAAAAAAAAASAPAA--APAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVE 114
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 224-493 3.95e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.45  E-value: 3.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  224 PEKIKSQPPGTGKPIQGPtQTPQTDHAKLPlqrDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPaQQPGHEK 303
Cdd:PRK10263  349 VDVPPAQPTVAWQPVPGP-QTGEPVIAPAP---EGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPA-QQPYYAP 423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  304 SQPGPAKPPAQPSGLTKPLAQQPGTVKPPvQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPaq 383
Cdd:PRK10263  424 APEQPAQQPYYAPAPEQPVAGNAWQAEEQ-QSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEETK-- 500

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  384 qpgPAKPP--------TQQVGTPKPLAQ--QPgLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTS--AQQTGPTKPPS 451
Cdd:PRK10263  501 ---PARPPlyyfeeveEKRAREREQLAAwyQP-IPEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPlaSGVKKATLATG 576

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 115333977  452 QLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQ 493
Cdd:PRK10263  577 AAATVAAPVFSLANSGGPRPQVKEGIGPQLPRPKRIRVPTRR 618
flhF PRK06995
flagellar biosynthesis protein FlhF;
444-536 4.06e-03

flagellar biosynthesis protein FlhF;


Pssm-ID: 235904 [Multi-domain]  Cd Length: 484  Bit Score: 39.95  E-value: 4.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 444 TGPTKPPSQLPGPAKPPPQQPGPAKPPP-----------QQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQ 512
Cdd:PRK06995  54 PAAAAPAAAQPPPAAAPAAVSRPAAPAAepapwlvehakRLTAQREQLVARAAAPAAPEAQAPAAPAERAAAENAARRLA 133

                         90       100
                 ....*....|....*....|....
gi 115333977 513 QPGSAKPSAQQPSPAKPSAQQSTK 536
Cdd:PRK06995 134 RAAAAAPRPRVPADAAAAVADAVK 157
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
430-565 4.30e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.22  E-value: 4.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 430 PAQQAGPGKTSAQqtgPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPP---------PQQPGSTKPPPQQPGPAKPS 500
Cdd:PRK07003 360 PAVTGGGAPGGGV---PARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGaalapkaaaAAAATRAEAPPAAPAPPATA 436

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 115333977 501 PQ-QPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTV---SPSAKQPPSQGLP 565
Cdd:PRK07003 437 DRgDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAfepAPRAAAPSAATPA 505
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 432-523 4.58e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 40.00  E-value: 4.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 432 QQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAkpppQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPS 511
Cdd:NF033838 404 RKAAEEDKVKEKPAEQPQPAPAPQPEKPAPKPEKPA----EQPKAEKPADQQAEEDYARRSEEEYNRLTQQQPPKTEKPA 479

                         90
                 ....*....|..
gi 115333977 512 qQPGSAKPSAQQ 523
Cdd:NF033838 480 -QPSTPKTGWKQ 490
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
482-568 4.61e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 39.95  E-value: 4.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 482 QQPGSTKPPPQQPGPAKPSPQQPgsTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPS 561
Cdd:PRK14948 513 QSGSASNTAKTPPPPQKSPPPPA--PTPPLPQPTATAPPPTPPPPPPTATQASSNAPAQIPADSSPPPPIPEEPTPSPTK 590


                 ....*..
gi 115333977 562 QGLPKTI 568
Cdd:PRK14948 591 DSSPEEI 597
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 204-550 5.18e-03

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 39.99  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  204 GPGRDPLQQDGTPKSISSQQPEKIKSQPPgtgkpiQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSK 283
Cdd:pfam09606 105 GPGGPMGQQMGGPGTASNLLASLGRPQMP------MGGAGFPSQMSRVGRMQPGGQAGGMMQPSSGQPGSGTPNQMGPNG 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  284 PPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPsGLTKPLAQQPGTVKP--PVQPPGTTKPPAQPLGPAKPPAQQTGSEKP 361
Cdd:pfam09606 179 GPGQGQAGGMNGGQQGPMGGQMPPQMGVPGMP-GPADAGAQMGQQAQAngGMNPQQMGGAPNQVAMQQQQPQQQGQQSQL 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  362 SS--EQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGL-QSPAKAPGPTKTPVQQPGPGKI-PAQQAGPG 437
Cdd:pfam09606 258 GMgiNQMQQMPQGVGGGAGQGGPGQPMGPPGQQPGAMPNVMSIGDQNNyQQQQTRQQQQQQGGNHPAAHQQqMNQSVGQG 337

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  438 KTSAQQTGPTKPPSQLPG---PAKPPPQQPGPA--KPPPQQPGSAKPPPQQPGSTKPPPQQPgpAKPSPQQPGSTKPPSQ 512
Cdd:pfam09606 338 GQVVALGGLNHLETWNPGnfgGLGANPMQRGQPgmMSSPSPVPGQQVRQVTPNQFMRQSPQP--SVPSPQGPGSQPPQSH 415

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 115333977  513 QPGSAKPSA--QQPSPAKPSAQQSTKPVSQTGSGKPLQPP 550
Cdd:pfam09606 416 PGGMIPSPAliPSPSPQMSQQPAQQRTIGQDSPGGSLNTP 455
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 229-391 5.37e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 5.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 229 SQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPgheKSQPGP 308
Cdd:PRK07764 633 AAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAP---APAATP 709

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 309 AKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQqtgsekPSSEQPGPKALAQPPGVGKTPAQQPGPA 388
Cdd:PRK07764 710 PAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAP------AQPPPPPAPAPAAAPAAAPPPSPPSEEE 783


                 ...
gi 115333977 389 KPP 391
Cdd:PRK07764 784 EMA 786
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 222-566 5.84e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.07  E-value: 5.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  222 QQPEKIKSQPPGTGKPIQGPTQTPQTDHAklPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGH 301
Cdd:PRK10263  367 QTGEPVIAPAPEGYPQQSQYAQPAVQYNE--PLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAG 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  302 EKSQPGPAKPPAQP-------SGLTKPLAQQPGTVKPPVQPPGTT---KPPAQPLGPAKPPAQ--QTGSEKPSSE----- 364
Cdd:PRK10263  445 NAWQAEEQQSTFAPqstyqteQTYQQPAAQEPLYQQPQPVEQQPVvepEPVVEETKPARPPLYyfEEVEEKRAREreqla 524

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  365 ---QPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQ-----------QPGLQSPAKAPGPTKTPVQQPGPG--- 427
Cdd:PRK10263  525 awyQPIPEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPLASgvkkatlatgaAATVAAPVFSLANSGGPRPQVKEGigp 604

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  428 ---------------------KIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQ-------------- 472
Cdd:PRK10263  605 qlprpkrirvptrrelasygiKLPSQRAAEEKAREAQRNQYDSGDQYNDDEIDAMQQDELARQFAQtqqqrygeqyqhdv 684

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  473 ------------------------------QPGSAKP-------------------------PPQQPGSTKPPPQQPGPA 497
Cdd:PRK10263  685 pvnaedadaaaeaelarqfaqtqqqrysgeQPAGANPfslddfefspmkallddgpheplftPIVEPVQQPQQPVAPQQQ 764

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  498 KPSPQQPGSTKPPSQQPgsakpsaQQPSPAKPSAQQSTKPVS-QTGSGKPLQPPTVSPSAKQPPSQGLPK 566
Cdd:PRK10263  765 YQQPQQPVAPQPQYQQP-------QQPVAPQPQYQQPQQPVApQPQYQQPQQPVAPQPQYQQPQQPVAPQ 827
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
433-518 6.02e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 39.56  E-value: 6.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 433 QAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPgsTKPPPQQPGPAKPSPQQPGSTKPPSQ 512
Cdd:PRK14948 517 ASNTAKTPPPPQKSPPPPAPTPPLPQPTATAPPPTPPPPPPTATQASSNAPA--QIPADSSPPPPIPEEPTPSPTKDSSP 594


                 ....*.
gi 115333977 513 QPGSAK 518
Cdd:PRK14948 595 EEIDKA 600
sucB TIGR01347
2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); This ...
 321-426 6.02e-03

2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); This model describes the TCA cycle 2-oxoglutarate system E2 component, dihydrolipoamide succinyltransferase. It is closely related to the pyruvate dehydrogenase E2 component, dihydrolipoamide acetyltransferase. The seed for this model includes mitochondrial and Gram-negative bacterial forms. Mycobacterial candidates are highly derived, differ in having and extra copy of the lipoyl-binding domain at the N-terminus. They score below the trusted cutoff, but above the noise cutoff and above all examples of dihydrolipoamide acetyltransferase. [Energy metabolism, TCA cycle]


Pssm-ID: 273565 [Multi-domain]  Cd Length: 403  Bit Score: 39.33  E-value: 6.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  321 PLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQvGTPKP 400
Cdd:TIGR01347  70 VLAILEEGNDATAAPPAKSGEEKEETPAASAAAAPTAAANRPSLSPAARRLAKEHGIDLSAVPGTGVTGRVTKE-DIIKK 148

                          90       100
                  ....*....|....*....|....*.
gi 115333977  401 LAQQPGLQSPAkAPGPTKTPVQQPGP 426
Cdd:TIGR01347 149 TEAPASAQPPA-AAAAAAAPAAATRP 173
Neisseria_TspB pfam05616
Neisseria meningitidis TspB protein; This family consists of several Neisseria meningitidis ...
 390-495 6.24e-03

Neisseria meningitidis TspB protein; This family consists of several Neisseria meningitidis TspB virulence factor proteins.


Pssm-ID: 283306 [Multi-domain]  Cd Length: 517  Bit Score: 39.69  E-value: 6.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  390 PPTQQVGTPKPLAQQPGlqspAKAPGPTKTPVQQ-PGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAK 468
Cdd:pfam05616 295 PVTDRNGNPVQVAATFG----RDAQGNTTADVQViPRPDLTPASAEAPHAQPLPEVSPAENPANNPDPDENPGTRPNPEP 370

                          90       100
                  ....*....|....*....|....*..
gi 115333977  469 PPPQQPGSAKPPPQQPGSTKPPPQQPG 495
Cdd:pfam05616 371 DPDLNPDANPDTDGQPGTRPDSPAVPD 397
PTZ00144 PTZ00144
dihydrolipoamide succinyltransferase; Provisional
 420-511 7.18e-03

dihydrolipoamide succinyltransferase; Provisional


Pssm-ID: 240289 [Multi-domain]  Cd Length: 418  Bit Score: 39.28  E-value: 7.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 420 PVQQPGPGKIPAQQAGPGKT-------SAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPgsAKPPPQQPGSTKPP-- 490
Cdd:PTZ00144  89 DIRAPASGVITKIFAEEGDTvevgaplSEIDTGGAPPAAAPAAAAAAKAEKTTPEKPKAAAP--TPEPPAASKPTPPAaa 166

                         90       100
                 ....*....|....*....|..
gi 115333977 491 -PQQPGPAKPSPQQPGSTKPPS 511
Cdd:PTZ00144 167 kPPEPAPAAKPPPTPVARADPR 188
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 489-567 7.85e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 39.23  E-value: 7.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 489 PPPQQPGPAkPSPQqpgstkPPSQQPGSAKPsAQQPSPAKPSAQQSTKPVSQTGSGKP----LQPPtvsPSAKQPPSQGL 564
Cdd:NF033838 415 KPAEQPQPA-PAPQ------PEKPAPKPEKP-AEQPKAEKPADQQAEEDYARRSEEEYnrltQQQP---PKTEKPAQPST 483


                 ...
gi 115333977 565 PKT 567
Cdd:NF033838 484 PKT 486
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 359-567 7.93e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 39.14  E-value: 7.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 359 EKPSSEQPGPKALAQPPGVGKTPAQQPGPAKP-PTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQqPGPGKIPAQQAGPG 437
Cdd:PLN03209 321 AKIPSQRVPPKESDAADGPKPVPTKPVTPEAPsPPIEEEPPQPKAVVPRPLSPYTAYEDLKPPTS-PIPTPPSSSPASSK 399

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 438 KTSAQQTGPTKPPSQLPGPAKPPPQ-QPGPAKPPPQQPGSakppPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPS--QQP 514
Cdd:PLN03209 400 SVDAVAKPAEPDVVPSPGSASNVPEvEPAQVEAKKTRPLS----PYARYEDLKPPTSPSPTAPTGVSPSVSSTSSvpAVP 475

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 115333977 515 GSAKPSAQQPSPAKPSAQQStkPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKT 567
Cdd:PLN03209 476 DTAPATAATDAAAPPPANMR--PLSPYAVYDDLKPPTSPSPAAPVGKVAPSST 526
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 437-501 7.99e-03

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 39.13  E-value: 7.99e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115333977 437 GKTSAQQTGPTkPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPppQQPGPAKPSP 501
Cdd:PRK01297  10 GKGEAEQPAPA-PPSPAAAPAPPPPAKTAAPATKAAAPAAAAPRAEKPKKDKP--RRERKPKPAS 71
PRK11633 PRK11633
cell division protein DedD; Provisional
 449-540 8.65e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 38.06  E-value: 8.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 449 PPSQLPGPAKPPP-----QQPGPAKPPPQQPgSAKPPPQQPGSTKPPPQQPGPAKPSPQqpgsTKPPSQQPGSAKPSAQQ 523
Cdd:PRK11633  57 PAATQALPTQPPEgaaeaVRAGDAAAPSLDP-ATVAPPNTPVEPEPAPVEPPKPKPVEK----PKPKPKPQQKVEAPPAP 131

                         90
                 ....*....|....*..
gi 115333977 524 PSPAKPSAQQSTKPVSQ 540
Cdd:PRK11633 132 KPEPKPVVEEKAAPTGK 148
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 426-567 8.84e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 39.28  E-value: 8.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 426 PGKIPAQQAGPGKtsaqqtGPTKPPSqlpGPAKPPPQQPGPAKPPPqqPGSAKPPPQQPGSTKPP----PQQPGPAK-PS 500
Cdd:PRK14959 363 PRLMPVESLRPSG------GGASAPS---GSAAEGPASGGAATIPT--PGTQGPQGTAPAAGMTPssaaPATPAPSAaPS 431

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115333977 501 PQQPGSTKPPSQQPGSAKPsaqQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKT 567
Cdd:PRK14959 432 PRVPWDDAPPAPPRSGIPP---RPAPRMPEASPVPGAPDSVASASDAPPTLGDPSDTAEHTPSGPRT 495
sucB TIGR01347
2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); This ...
 418-531 9.37e-03

2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); This model describes the TCA cycle 2-oxoglutarate system E2 component, dihydrolipoamide succinyltransferase. It is closely related to the pyruvate dehydrogenase E2 component, dihydrolipoamide acetyltransferase. The seed for this model includes mitochondrial and Gram-negative bacterial forms. Mycobacterial candidates are highly derived, differ in having and extra copy of the lipoyl-binding domain at the N-terminus. They score below the trusted cutoff, but above the noise cutoff and above all examples of dihydrolipoamide acetyltransferase. [Energy metabolism, TCA cycle]


Pssm-ID: 273565 [Multi-domain]  Cd Length: 403  Bit Score: 38.95  E-value: 9.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  418 KTPVQQPGP--GKIPAQQAGPGKT--SAQQTGPTKPPSqlpGPAKPPPQQPGPAKPPPQqpgSAKPPPQQPGSTKPPPQQ 493
Cdd:TIGR01347  41 KVVLEVPSPadGVLQEILFKEGDTveSGQVLAILEEGN---DATAAPPAKSGEEKEETP---AASAAAAPTAAANRPSLS 114

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 115333977  494 PGPAK------PSPQQPGSTKPPSQ-------QPGSAKPSAQQPSPAKPSA 531
Cdd:TIGR01347 115 PAARRlakehgIDLSAVPGTGVTGRvtkediiKKTEAPASAQPPAAAAAAA 165
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
311-512 9.57e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 39.18  E-value: 9.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 311 PPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPA-- 388
Cdd:PRK14948 361 PSAFISEIANASAPANPTPAPNPSPPPAPIQPSAPKTKQAATTPSPPPAKASPPIPVPAEPTEPSPTPPANAANAPPSln 440

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977 389 -KPPTQQV-------GTPKPLAQQ----------------PGLQSPAKAPGPT-----KTPVQQPGPGKIPAQQAGPGKT 439
Cdd:PRK14948 441 lEELWQQIlaklelpSTRMLLSQQaelvsldsnraviavsPNWLGMVQSRKPLleqafAKVLGRSIKLNLESQSGSASNT 520

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115333977 440 SAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQ 512
Cdd:PRK14948 521 AKTPPPPQKSPPPPAPTPPLPQPTATAPPPTPPPPPPTATQASSNAPAQIPADSSPPPPIPEEPTPSPTKDSS 593
COG3416 COG3416
Uncharacterized conserved protein, DUF2076 domain [Function unknown];
462-509 9.60e-03

Uncharacterized conserved protein, DUF2076 domain [Function unknown];


Pssm-ID: 442642 [Multi-domain]  Cd Length: 237  Bit Score: 38.08  E-value: 9.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 115333977 462 QQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQPGPAKPSPQQPGSTKP 509
Cdd:COG3416   94 QRPPPAPQPSQPGPQQQPAPPSGPWGQAAPQQPGYGQPQYGQPAAGPS 141
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 304-565 9.78e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 38.98  E-value: 9.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  304 SQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKAlaqPPGVGKTPAQ 383
Cdd:pfam03154 144 TSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQG---SPATSQPPNQ 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  384 QPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPA---QQAGPGKTSAQQTGPTKPPSQLPGPAKPP 460
Cdd:pfam03154 221 TQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQpslHGQMPPMPHSLQTGPSHMQHPVPPQPFPL 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  461 PQQPGPAKPPPQQPGSAKPPPQQPGSTkpPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQ 540
Cdd:pfam03154 301 TPQSSQSQVPPGPSPAAPGQSQQRIHT--PPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHL 378

                         250       260
                  ....*....|....*....|....*
gi 115333977  541 TGSGKPLQPPTVSPSAKQPPSQGLP 565
Cdd:pfam03154 379 SGPSPFQMNSNLPPPPALKPLSSLS 403
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 358-494 9.97e-03

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 37.32  E-value: 9.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115333977  358 SEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPaKAPGPTKTPVQQPGPGKIPAQQAGPG 437
Cdd:pfam15240  33 SEEEGQSQQGGQGPQGPPPGGFPPQPPASDDPPGPPPPGGPQQPPPQGGKQKP-QGPPPQGGPRPPPGKPQGPPPQGGNQ 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 115333977  438 KTSAQQTGPTKPPSQLPGPakPPPQQPGPAKPPPQQPGSAKPPPQQPGSTKPPPQQP 494
Cdd:pfam15240 112 QQGPPPPGKPQGPPPQGGG--PPPQGGNQQGPPPPPPGNPQGPPQRPPQPGNPQGPP 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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