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Conserved domains on  [gi|133777599|gb|AAI23816|]
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SUPT5H protein [Bos taurus]

Protein Classification

KOW domain-containing RNA-binding protein; 50S ribosomal protein L24( domain architecture ID 10149538)

KOW domain-containing RNA-binding protein similar to the KOW motif in 60S ribosomal protein L27, which is a component of the large ribosomal subunit; the KOW domain is known as an RNA-binding motif that is shared among some families of ribosomal proteins; 50S ribosomal protein L24 is one of two assembly initiator proteins; it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KOW_Spt5_6 cd06086
KOW domain of Spt5, repeat 6; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 281-337 1.94e-28

KOW domain of Spt5, repeat 6; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


:

Pssm-ID: 240510  Cd Length: 58  Bit Score: 104.52  E-value: 1.94e-28
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 133777599 281 EHLEPITPTKNNKVKVILGEDREATGVLLSIDGEDGIVRMDLDEQLKILNLRFLGKL 337
Cdd:cd06086    1 EHLEPVPPEKGDRVKVIKGEDRGSTGELISIDGADGIVKMDSDGDIKILPMNFLAKL 57
PHA03269 super family cl29788
envelope glycoprotein C; Provisional
 99-223 2.41e-05

envelope glycoprotein C; Provisional


The actual alignment was detected with superfamily member PHA03269:

Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 45.87  E-value: 2.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599  99 ILEKEEIEASNPQ--TPGYPDPSSPQVNPQYNPQTPGTPAMYNTDQFS----PYAAPSPQGSYQPSPSPQSYHQV--APS 170
Cdd:PHA03269  18 IIANLNTNIPIPElhTSAATQKPDPAPAPHQAASRAPDPAVAPTSAASrkpdLAQAPTPAASEKFDPAPAPHQAAsrAPD 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 133777599 171 PAGYQNTHSPASYHPTPSPM-AYQASPSPSPVGYSPMTPgAPSPGGYNPHTPGS 223
Cdd:PHA03269  98 PAVAPQLAAAPKPDAAEAFTsAAQAHEAPADAGTSAASK-KPDPAAHTQHSPPP 150
 
Name Accession Description Interval E-value
KOW_Spt5_6 cd06086
KOW domain of Spt5, repeat 6; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 281-337 1.94e-28

KOW domain of Spt5, repeat 6; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


Pssm-ID: 240510  Cd Length: 58  Bit Score: 104.52  E-value: 1.94e-28
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 133777599 281 EHLEPITPTKNNKVKVILGEDREATGVLLSIDGEDGIVRMDLDEQLKILNLRFLGKL 337
Cdd:cd06086    1 EHLEPVPPEKGDRVKVIKGEDRGSTGELISIDGADGIVKMDSDGDIKILPMNFLAKL 57
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 99-223 2.41e-05

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 45.87  E-value: 2.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599  99 ILEKEEIEASNPQ--TPGYPDPSSPQVNPQYNPQTPGTPAMYNTDQFS----PYAAPSPQGSYQPSPSPQSYHQV--APS 170
Cdd:PHA03269  18 IIANLNTNIPIPElhTSAATQKPDPAPAPHQAASRAPDPAVAPTSAASrkpdLAQAPTPAASEKFDPAPAPHQAAsrAPD 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 133777599 171 PAGYQNTHSPASYHPTPSPM-AYQASPSPSPVGYSPMTPgAPSPGGYNPHTPGS 223
Cdd:PHA03269  98 PAVAPQLAAAPKPDAAEAFTsAAQAHEAPADAGTSAASK-KPDPAAHTQHSPPP 150
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 122-224 8.50e-04

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 41.15  E-value: 8.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599  122 QVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASyHPTPSPmAYQASPSPSPV 201
Cdd:pfam09606 357 FGGLGANPMQRGQPGMMSSPSPVPGQQVRQVTPNQFMRQSPQPSVPSPQGPGSQPPQSHPG-GMIPSP-ALIPSPSPQMS 434

                          90       100
                  ....*....|....*....|....*
gi 133777599  202 GY--SPMTPGAPSPGGyNPHTPGSG 224
Cdd:pfam09606 435 QQpaQQRTIGQDSPGG-SLNTPGQS 458
 
Name Accession Description Interval E-value
KOW_Spt5_6 cd06086
KOW domain of Spt5, repeat 6; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 281-337 1.94e-28

KOW domain of Spt5, repeat 6; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


Pssm-ID: 240510  Cd Length: 58  Bit Score: 104.52  E-value: 1.94e-28
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 133777599 281 EHLEPITPTKNNKVKVILGEDREATGVLLSIDGEDGIVRMDLDEQLKILNLRFLGKL 337
Cdd:cd06086    1 EHLEPVPPEKGDRVKVIKGEDRGSTGELISIDGADGIVKMDSDGDIKILPMNFLAKL 57
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 99-223 2.41e-05

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 45.87  E-value: 2.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599  99 ILEKEEIEASNPQ--TPGYPDPSSPQVNPQYNPQTPGTPAMYNTDQFS----PYAAPSPQGSYQPSPSPQSYHQV--APS 170
Cdd:PHA03269  18 IIANLNTNIPIPElhTSAATQKPDPAPAPHQAASRAPDPAVAPTSAASrkpdLAQAPTPAASEKFDPAPAPHQAAsrAPD 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 133777599 171 PAGYQNTHSPASYHPTPSPM-AYQASPSPSPVGYSPMTPgAPSPGGYNPHTPGS 223
Cdd:PHA03269  98 PAVAPQLAAAPKPDAAEAFTsAAQAHEAPADAGTSAASK-KPDPAAHTQHSPPP 150
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 118-229 6.03e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.08  E-value: 6.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599  118 PSSPQVNPQYNPQTpgtpamynTDQFSPYAAPSPQGSYQPSPSPQSYHQ-VAPSPAGYQNTHSPASYHPTPSPMAYQASP 196
Cdd:PRK10263  740 PHEPLFTPIVEPVQ--------QPQQPVAPQQQYQQPQQPVAPQPQYQQpQQPVAPQPQYQQPQQPVAPQPQYQQPQQPV 811

                          90       100       110
                  ....*....|....*....|....*....|...
gi 133777599  197 SPSPVGYSPMTPGAPSPGGYNPHTPGSGIEQNS 229
Cdd:PRK10263  812 APQPQYQQPQQPVAPQPQYQQPQQPVAPQPQDT 844
PHA03247 PHA03247
large tegument protein UL36; Provisional
 110-215 1.60e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599  110 PQTPGYPDPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPqgsyqPSPSPQSYHQVAPSPAgYQNTHSPASYHPTPSP 189
Cdd:PHA03247 2760 PPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSP-----WDPADPPAAVLAPAAA-LPPAASPAGPLPPPTS 2833

                          90       100
                  ....*....|....*....|....*..
gi 133777599  190 MAYQASPSPSPVGYSPMTP-GAPSPGG 215
Cdd:PHA03247 2834 AQPTAPPPPPGPPPPSLPLgGSVAPGG 2860
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 108-222 2.25e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.15  E-value: 2.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599  108 SNPQTPGYPDPSSPQVNP---QYNPQTPGTPAMYNTDQFSPYAAPSP-QGSYQPSPSPQSYHQVAPSPAGYQNTHSPasY 183
Cdd:PRK10263  379 GYPQQSQYAQPAVQYNEPlqqPVQPQQPYYAPAAEQPAQQPYYAPAPeQPAQQPYYAPAPEQPVAGNAWQAEEQQST--F 456

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 133777599  184 HPTPSPMAYQASPSPSPVGYSPMTPGAPSPGGYNPHTPG 222
Cdd:PRK10263  457 APQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPV 495
PHA03247 PHA03247
large tegument protein UL36; Provisional
 107-222 2.51e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 2.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599  107 ASNPQTPGYPDPS-SPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASYHP 185
Cdd:PHA03247 2890 AVSRSTESFALPPdQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVP 2969

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 133777599  186 TPSPMAYQASPSPSPvgySPMTPGAPSPGGYNPHTPG 222
Cdd:PHA03247 2970 GRVAVPRFRVPQPAP---SREAPASSTPPLTGHSLSR 3003
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 110-219 7.22e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 7.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599 110 PQTPGYPDPSSPQVNPQynPQTPGTPAMYNTDQfsPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASYHPTPSP 189
Cdd:PRK07764 400 SAAAAAPAAAPAPAAAA--PAAAAAPAPAAAPQ--PAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPE 475

                         90       100       110
                 ....*....|....*....|....*....|
gi 133777599 190 MAYQASPSPSPVGYSPMTPGAPSPGGYNPH 219
Cdd:PRK07764 476 PTAAPAPAPPAAPAPAAAPAAPAAPAAPAG 505
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 122-224 8.50e-04

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 41.15  E-value: 8.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599  122 QVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASyHPTPSPmAYQASPSPSPV 201
Cdd:pfam09606 357 FGGLGANPMQRGQPGMMSSPSPVPGQQVRQVTPNQFMRQSPQPSVPSPQGPGSQPPQSHPG-GMIPSP-ALIPSPSPQMS 434

                          90       100
                  ....*....|....*....|....*
gi 133777599  202 GY--SPMTPGAPSPGGyNPHTPGSG 224
Cdd:pfam09606 435 QQpaQQRTIGQDSPGG-SLNTPGQS 458
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
103-230 9.64e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 9.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599 103 EEIEASNPQTPGYPDPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPAS 182
Cdd:PRK12323 396 APAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAA 475

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 133777599 183 YHPTPSPMAYQASPSPSPVGYSP---MTPGAPSPGGYNPHTPGSGIEQNSS 230
Cdd:PRK12323 476 AAAAPARAAPAAAPAPADDDPPPweeLPPEFASPAPAQPDAAPAGWVAESI 526
PHA03247 PHA03247
large tegument protein UL36; Provisional
 101-223 1.67e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599  101 EKEEIEASNPQTPGYPDPSSPQVNPQYNPQTPGTPAMYNTDQ-----FSPYAAPSPQG-SYQPSPSPQSYHQVAPSPAGY 174
Cdd:PHA03247 2705 PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAgpatpGGPARPARPPTtAGPPAPAPPAAPAAGPPRRLT 2784

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 133777599  175 QNTHSPASYHPTPSPMAYQASPSPSPV-GYSPMTPGAPSPGGYNPHTPGS 223
Cdd:PHA03247 2785 RPAVASLSESRESLPSPWDPADPPAAVlAPAAALPPAASPAGPLPPPTSA 2834
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 100-294 2.13e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 39.79  E-value: 2.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599 100 LEKEEIEAS-NPQTPGYP----DPSSPQVNPQYNPQTPGTPAMyntdqfspyAAPSPQGSYQPSPSPQSyhQVAPSPAGY 174
Cdd:PRK14950 351 LELAVIEALlVPVPAPQPakptAAAPSPVRPTPAPSTRPKAAA---------AANIPPKEPVRETATPP--PVPPRPVAP 419

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599 175 QNTHSPASYHPTPspmayqasPSPSPVGYSPMTPGAPSPGGYNP--HTPGSGIEQNSSDWVTTDIQVKVRDTYLdtQVVG 252
Cdd:PRK14950 420 PVPHTPESAPKLT--------RAAIPVDEKPKYTPPAPPKEEEKalIADGDVLEQLEAIWKQILRDVPPRSPAV--QALL 489

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 133777599 253 QTGViRSVTggmcsvyLKDSEKVVSISSE-HLEPITPTKNNKV 294
Cdd:PRK14950 490 SSGV-RPVS-------VEKNTLTLSFKSKfHKDKIEEPENRKI 524
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
125-213 2.61e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 39.37  E-value: 2.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599 125 PQYNPQTPGTPAMyntdqFSPYAAPSPQGSYQPSPSPQSYH----QVAPSPAGYQNTHSPASYHPTPSPmayqaSPSPSP 200
Cdd:PRK14971 371 GGRGPKQHIKPVF-----TQPAAAPQPSAAAAASPSPSQSSaaaqPSAPQSATQPAGTPPTVSVDPPAA-----VPVNPP 440

                         90
                 ....*....|...
gi 133777599 201 VGYSPMTPGAPSP 213
Cdd:PRK14971 441 STAPQAVRPAQFK 453
KOW cd00380
KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); KOW domain is known ...
 291-333 2.80e-03

KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. The KOW motif contains an invariants glycine residue and comprises alternating blocks of hydrophilic and hydrophobic residues.


Pssm-ID: 240504  Cd Length: 49  Bit Score: 35.27  E-value: 2.80e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 133777599 291 NNKVKVILGEDREATGVLLSIDGEDGIVRMDLDEQLK--ILNLRF 333
Cdd:cd00380    1 GDVVRVLRGPYKGREGVVVDIDPRFGIVTVKGATGSKgaELKVRF 45
PHA03247 PHA03247
large tegument protein UL36; Provisional
 107-218 3.11e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 3.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599  107 ASNPQTPGYPDPSSP-------------QVNPQYNPQTPGTPAMYNTDQFS-PYAAPSPQGSYQPSPSPQSYHQVAPSPA 172
Cdd:PHA03247 2837 TAPPPPPGPPPPSLPlggsvapggdvrrRPPSRSPAAKPAAPARPPVRRLArPAVSRSTESFALPPDQPERPPQPQAPPP 2916

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 133777599  173 GYQNTHSPASYHPTPSPMAYQASPSPSPVGYSPMTPGAPSPGGYNP 218
Cdd:PHA03247 2917 PQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 107-222 3.46e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 39.31  E-value: 3.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599 107 ASNPQTPGYPDPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAG----YQNTHSPAS 182
Cdd:PRK14951 375 PAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAApaavALAPAPPAQ 454

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 133777599 183 YHPTPSPMAYQASPSPSPVGYSPMTPGAPSPGGYNPHTPG 222
Cdd:PRK14951 455 AAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEG 494
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 108-235 3.95e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 38.98  E-value: 3.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599  108 SNPQTPGYPDPSSPQVNPQYNPQTPGTPAMYNTDQFSPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASyhPTP 187
Cdd:pfam03154 202 SAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMP--PMP 279

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 133777599  188 SPMAYQASPSPSPVGYSPMTPGAPSPGGYNPHTPGSGIEQNSSDWVTT 235
Cdd:pfam03154 280 HSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHT 327
PHA03378 PHA03378
EBNA-3B; Provisional
 107-213 7.38e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 38.12  E-value: 7.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599 107 ASNPQTPGYPDPSSPQVN--PQYNPQTPGTPAMYNTDQFSPYAAPS----PQGSYQPSPSPQSYHQVAPSPAGYQNTHSP 180
Cdd:PHA03378 667 TQIGHIPYQPSPTGANTMlpIQWAPGTMQPPPRAPTPMRPPAAPPGraqrPAAATGRARPPAAAPGRARPPAAAPGRARP 746

                         90       100       110
                 ....*....|....*....|....*....|....
gi 133777599 181 ASYHPTPS-PMAYQASPSPSPVGyspmTPGAPSP 213
Cdd:PHA03378 747 PAAAPGRArPPAAAPGRARPPAA----APGAPTP 776
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 112-211 7.70e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 38.12  E-value: 7.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599 112 TPGY--PDPSSPQVNPQYNPQTPGTPAmyntdqfsPYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASYHPTPSP 189
Cdd:PRK14959 399 TPGTqgPQGTAPAAGMTPSSAAPATPA--------PSAAPSPRVPWDDAPPAPPRSGIPPRPAPRMPEASPVPGAPDSVA 470

                         90       100
                 ....*....|....*....|...
gi 133777599 190 MAYQASPSPS-PVGYSPMTPGAP 211
Cdd:PRK14959 471 SASDAPPTLGdPSDTAEHTPSGP 493
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 145-231 8.56e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 37.79  E-value: 8.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599 145 PYAAPSPQGSYQPSPSPQSYHQVAPSPAGYQNTHSPASYHPTPSPMAYQASPSPSPVGYSPMTPGAPSPGGYNPHTPGSG 224
Cdd:PHA03269  42 PAPAPHQAASRAPDPAVAPTSAASRKPDLAQAPTPAASEKFDPAPAPHQAASRAPDPAVAPQLAAAPKPDAAEAFTSAAQ 121


                 ....*..
gi 133777599 225 IEQNSSD 231
Cdd:PHA03269 122 AHEAPAD 128
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 108-223 9.03e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 37.82  E-value: 9.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777599  108 SNPQTPGYPDPSSPQVNPQYNPQTPGTPAMyntdqfsPYAAPSPQGSYQPSPSPQSY----HQVAPSPAGYQN------- 176
Cdd:pfam03154 323 QRIHTPPSQSQLQSQQPPREQPLPPAPLSM-------PHIKPPPTTPIPQLPNPQSHkhppHLSGPSPFQMNSnlppppa 395

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 133777599  177 --------THSPASYHPTPSPMAYQASPSPSPVGYSPM---TPGAPSPGGYNPHTPGS 223
Cdd:pfam03154 396 lkplsslsTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVltqSQSLPPPAASHPPTSGL 453
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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