BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                        10        20        30
                ....*....|....*....|....*....|....*...
gi 21779933   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18217   1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLA 38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|....*...
gi 21779933   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18217   1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLA 38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|....*...
gi 21779933   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18217   1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLA 38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 21779933   1 MQYSHHCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18324   1 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLA 43

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 21779933   1 MQYSHHCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18323   1 MEFPDHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLA 43

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 21779933   4 SHHCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18213   2 SSHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLA 41

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|....*...
gi 21779933   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18195   1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLA 38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 21779933   4 SHHCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18193   2 ANHGLILLQQLNAQREFGFLCDCTVAIGDVYFKAHKSVLA 41

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|....*...
gi 21779933   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18223   1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLA 38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|....*....
gi 21779933   4 SHHCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVL 42
Cdd:cd18329   2 SSHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVL 40

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|....
gi 21779933  10 LLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18227  12 ILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLA 45

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|....*..
gi 21779933   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVL 42
Cdd:cd18201   4 YCYQLLQELNEQRKKGILCDVNIVVSGKVFRAHKNIL 40

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 21779933   4 SHHCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18216   1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLA 40

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 21779933   1 MQYSHHCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18290   5 MEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLA 47

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|....*...
gi 21779933   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18233   1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLA 38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|....*...
gi 21779933   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18209   1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLA 38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 21779933   1 MQYSHHCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18225   1 MELPNYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLA 43

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|....
gi 21779933  10 LLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18210   8 LLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLA 41

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 21779933   2 QYSHHCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18266   4 RWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLA 45

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 21779933   4 SHHCEHLLERLNKQREAGFLCDCTVVIGE---FQFKAHRNVLA 43
Cdd:cd18241   4 SSHCSELSWRQNEQRKQGLFCDITLAFGGaggREFRAHRSVLA 46

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|....
gi 21779933  10 LLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18219   8 LLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILS 41

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 21779933   3 YSHHCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18328   5 FPNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLA 45

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|....*...
gi 21779933   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18242   4 HAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLA 41

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 21779933   4 SHHCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18277   8 SVHSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLA 47

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                       10        20
               ....*....|....*....|.
gi 21779933 23 LCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18186  1 LCDVTLVVGGREFPAHRAVLA 21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|....*...
gi 21779933   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18202   2 HGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLA 39

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|....
gi 21779933  10 LLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18245   1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLA 34

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|
gi 21779933  14 LNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18289  20 LNEQRLMGLYCDVSIVVKGQAFKAHRAVLA 49

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|....*...
gi 21779933   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18200   1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLA 38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|....*...
gi 21779933   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18306   1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLA 38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|....*...
gi 21779933   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18204   1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLA 38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30
                ....*....|....*....|....*....|....*..
gi 21779933   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVL 42
Cdd:cd18332   2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVL 38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

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gi 21779933   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18215   2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLM 39

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

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gi 21779933   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18218   1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLA 38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

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gi 21779933  10 LLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18208  12 VLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLA 45

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

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gi 21779933   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18256   3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLA 40

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

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gi 21779933  11 LERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18240   5 CNVFNELRLEGKLCDVVIRVNGVEFPAHRNILC 37

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

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gi 21779933   6 HCEHLLERLNKQREAGFLCDCTVVIGEFQFKAHRNVLA 43
Cdd:cd18339   4 HMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLA 41